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Protein

Uncharacterized protein C4orf3

Gene

C4orf3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf3
Alternative name(s):
Hepatitis C virus F protein-transactivated protein 1
Short name:
HCV F-transactivated protein 1
Gene namesi
Name:C4orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19225. C4orf3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164096.
PharmGKBiPA164717306.

Polymorphism and mutation databases

BioMutaiC4orf3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257841 – 66Uncharacterized protein C4orf3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WVX3.
MaxQBiQ8WVX3.
PaxDbiQ8WVX3.
PeptideAtlasiQ8WVX3.
PRIDEiQ8WVX3.
TopDownProteomicsiQ8WVX3-1. [Q8WVX3-1]

PTM databases

iPTMnetiQ8WVX3.
PhosphoSitePlusiQ8WVX3.

Expressioni

Gene expression databases

BgeeiENSG00000164096.
GenevisibleiQ8WVX3. HS.

Organism-specific databases

HPAiHPA026907.

Interactioni

Protein-protein interaction databases

BioGridi134952. 6 interactors.
IntActiQ8WVX3. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8WVX3.
SMRiQ8WVX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCJ6. Eukaryota.
ENOG41117U8. LUCA.
GeneTreeiENSGT00530000064570.
InParanoidiQ8WVX3.
OMAiCRSEMEV.
OrthoDBiEOG091G0MWY.
PhylomeDBiQ8WVX3.
TreeFamiTF343305.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVDAPGVDG RDGLRERRGF SEGGRQNFDV RPQSGANGLP KHSYWLDLWL
60
FILFDVVVFL FVYFLP
Length:66
Mass (Da):7,604
Last modified:May 18, 2010 - v2
Checksum:i6973371B80AE75CC
GO
Isoform 2 (identifier: Q8WVX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSLINSPIN...GLLRSCRSEM

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,558
Checksum:i78988F83DB793925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03991117R → Q.1 PublicationCorresponds to variant rs17851522dbSNPEnsembl.1
Natural variantiVAR_03991232P → H.Corresponds to variant rs11544530dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0324051M → MTSLINSPINRRPLQNVEGN NRCQRKAKNYGNKYFIHCLD LEKITLSPRRKHDIEGGDKL NVKFSQLRSRRQRKAEPGAC ALGRVGSECIPEPGARRTAQ AAGLRSVSGAANTKVRELKH FRFLGLLRSCRSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605045 mRNA. Translation: AAT35812.1.
AC092656 Genomic DNA. No translation available.
BC017399 mRNA. Translation: AAH17399.1.
CCDSiCCDS43266.1. [Q8WVX3-1]
CCDS54798.1. [Q8WVX3-2]
RefSeqiNP_001001701.2. NM_001001701.3. [Q8WVX3-1]
NP_001163801.1. NM_001170330.1. [Q8WVX3-2]
UniGeneiHs.173705.

Genome annotation databases

EnsembliENST00000399075; ENSP00000382026; ENSG00000164096. [Q8WVX3-2]
ENST00000504110; ENSP00000485697; ENSG00000164096. [Q8WVX3-1]
GeneIDi401152.
KEGGihsa:401152.
UCSCiuc003icv.5. human. [Q8WVX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605045 mRNA. Translation: AAT35812.1.
AC092656 Genomic DNA. No translation available.
BC017399 mRNA. Translation: AAH17399.1.
CCDSiCCDS43266.1. [Q8WVX3-1]
CCDS54798.1. [Q8WVX3-2]
RefSeqiNP_001001701.2. NM_001001701.3. [Q8WVX3-1]
NP_001163801.1. NM_001170330.1. [Q8WVX3-2]
UniGeneiHs.173705.

3D structure databases

ProteinModelPortaliQ8WVX3.
SMRiQ8WVX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134952. 6 interactors.
IntActiQ8WVX3. 3 interactors.

PTM databases

iPTMnetiQ8WVX3.
PhosphoSitePlusiQ8WVX3.

Polymorphism and mutation databases

BioMutaiC4orf3.

Proteomic databases

EPDiQ8WVX3.
MaxQBiQ8WVX3.
PaxDbiQ8WVX3.
PeptideAtlasiQ8WVX3.
PRIDEiQ8WVX3.
TopDownProteomicsiQ8WVX3-1. [Q8WVX3-1]

Protocols and materials databases

DNASUi401152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399075; ENSP00000382026; ENSG00000164096. [Q8WVX3-2]
ENST00000504110; ENSP00000485697; ENSG00000164096. [Q8WVX3-1]
GeneIDi401152.
KEGGihsa:401152.
UCSCiuc003icv.5. human. [Q8WVX3-1]

Organism-specific databases

CTDi401152.
GeneCardsiC4orf3.
H-InvDBHIX0004468.
HGNCiHGNC:19225. C4orf3.
HPAiHPA026907.
neXtProtiNX_Q8WVX3.
OpenTargetsiENSG00000164096.
PharmGKBiPA164717306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCJ6. Eukaryota.
ENOG41117U8. LUCA.
GeneTreeiENSGT00530000064570.
InParanoidiQ8WVX3.
OMAiCRSEMEV.
OrthoDBiEOG091G0MWY.
PhylomeDBiQ8WVX3.
TreeFamiTF343305.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164096-MONOMER.

Miscellaneous databases

ChiTaRSiC4orf3. human.
GenomeRNAii401152.
PROiQ8WVX3.

Gene expression databases

BgeeiENSG00000164096.
GenevisibleiQ8WVX3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCD003_HUMAN
AccessioniPrimary (citable) accession number: Q8WVX3
Secondary accession number(s): Q6J203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.