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Protein

Uncharacterized protein C4orf3

Gene

C4orf3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf3
Alternative name(s):
Hepatitis C virus F protein-transactivated protein 1
Short name:
HCV F-transactivated protein 1
Gene namesi
Name:C4orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164096.12.
HGNCiHGNC:19225. C4orf3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164096.
PharmGKBiPA164717306.

Polymorphism and mutation databases

BioMutaiC4orf3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257841 – 66Uncharacterized protein C4orf3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WVX3.
MaxQBiQ8WVX3.
PaxDbiQ8WVX3.
PeptideAtlasiQ8WVX3.
PRIDEiQ8WVX3.
TopDownProteomicsiQ8WVX3-1. [Q8WVX3-1]

PTM databases

iPTMnetiQ8WVX3.
PhosphoSitePlusiQ8WVX3.

Expressioni

Gene expression databases

BgeeiENSG00000164096.
GenevisibleiQ8WVX3. HS.

Organism-specific databases

HPAiHPA026907.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLCO3A1Q9UIG8-24EBI-12003442,EBI-13041931

Protein-protein interaction databases

BioGridi134952. 8 interactors.
IntActiQ8WVX3. 15 interactors.
STRINGi9606.ENSP00000382026.

Structurei

3D structure databases

ProteinModelPortaliQ8WVX3.
SMRiQ8WVX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCJ6. Eukaryota.
ENOG41117U8. LUCA.
GeneTreeiENSGT00530000064570.
InParanoidiQ8WVX3.
OMAiVEGNNRC.
OrthoDBiEOG091G0MWY.
PhylomeDBiQ8WVX3.
TreeFamiTF343305.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVDAPGVDG RDGLRERRGF SEGGRQNFDV RPQSGANGLP KHSYWLDLWL
60
FILFDVVVFL FVYFLP
Length:66
Mass (Da):7,604
Last modified:May 18, 2010 - v2
Checksum:i6973371B80AE75CC
GO
Isoform 2 (identifier: Q8WVX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSLINSPIN...GLLRSCRSEM

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,558
Checksum:i78988F83DB793925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03991117R → Q1 PublicationCorresponds to variant dbSNP:rs17851522Ensembl.1
Natural variantiVAR_03991232P → H. Corresponds to variant dbSNP:rs11544530Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0324051M → MTSLINSPINRRPLQNVEGN NRCQRKAKNYGNKYFIHCLD LEKITLSPRRKHDIEGGDKL NVKFSQLRSRRQRKAEPGAC ALGRVGSECIPEPGARRTAQ AAGLRSVSGAANTKVRELKH FRFLGLLRSCRSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605045 mRNA. Translation: AAT35812.1.
AC092656 Genomic DNA. No translation available.
BC017399 mRNA. Translation: AAH17399.1.
CCDSiCCDS43266.1. [Q8WVX3-1]
CCDS54798.1. [Q8WVX3-2]
RefSeqiNP_001001701.2. NM_001001701.3. [Q8WVX3-1]
NP_001163801.1. NM_001170330.1. [Q8WVX3-2]
UniGeneiHs.173705.

Genome annotation databases

EnsembliENST00000399075; ENSP00000382026; ENSG00000164096. [Q8WVX3-2]
ENST00000504110; ENSP00000485697; ENSG00000164096. [Q8WVX3-1]
GeneIDi401152.
KEGGihsa:401152.
UCSCiuc003icv.5. human. [Q8WVX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD003_HUMAN
AccessioniPrimary (citable) accession number: Q8WVX3
Secondary accession number(s): Q6J203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations