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Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A2
Gene namesi
Name:BTN2A2
Synonyms:BT2.2, BTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1137. BTN2A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 265233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 523237CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25457.

Polymorphism and mutation databases

BioMutaiBTN2A2.
DMDMi83288459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 523491Butyrophilin subfamily 2 member A2PRO_0000014530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi55 ↔ 129PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8WVV5.
PaxDbiQ8WVV5.
PRIDEiQ8WVV5.

PTM databases

PhosphoSiteiQ8WVV5.

Expressioni

Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiQ8WVV5.
CleanExiHS_BTN2A2.
ExpressionAtlasiQ8WVV5. baseline and differential.
GenevisibleiQ8WVV5. HS.

Organism-specific databases

HPAiHPA051504.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-8648738,EBI-743099
PSMA3P257883EBI-8648738,EBI-348380

Protein-protein interaction databases

BioGridi115658. 10 interactions.
IntActiQ8WVV5. 3 interactions.
STRINGi9606.ENSP00000349143.

Structurei

3D structure databases

ProteinModelPortaliQ8WVV5.
SMRiQ8WVV5. Positions 32-241, 325-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 145112Ig-like V-typeAdd
BLAST
Domaini153 – 23482Ig-like C2-typeAdd
BLAST
Domaini309 – 502194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili286 – 32136Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45068.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ8WVV5.
KOiK06712.
OMAiHSVERKG.
OrthoDBiEOG7XM2XG.
PhylomeDBiQ8WVV5.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN
60 70 80 90 100
TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI
110 120 130 140 150
TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG
160 170 180 190 200
SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD
210 220 230 240 250
ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP
260 270 280 290 300
WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK
310 320 330 340 350
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR
360 370 380 390 400
RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR
410 420 430 440 450
HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL
460 470 480 490 500
DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT
510 520
GASGVMVPEE GLKLHRVGTH QSL
Length:523
Mass (Da):59,070
Last modified:February 1, 2005 - v2
Checksum:i122099CE635F279D
GO
Isoform 2 (identifier: Q8WVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-336: ADVVLDPDTA → DVNLTGLRNT
     337-523: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,714
Checksum:i5AEE282BA52506FF
GO
Isoform 3 (identifier: Q8WVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-241: Missing.
     327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
     351-523: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,927
Checksum:i283491E103090795
GO
Isoform 4 (identifier: Q8WVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-147: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,827
Checksum:i7BFB2302A387BF64
GO
Isoform 5 (identifier: Q8WVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-241: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,493
Checksum:i1242D946AE321E50
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431S → P in BAG57008 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti479 – 4791P → S.
Corresponds to variant rs16891646 [ dbSNP | Ensembl ].
VAR_049829

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 241210Missing in isoform 5. 1 PublicationVSP_044861Add
BLAST
Alternative sequencei32 – 147116Missing in isoform 4. 1 PublicationVSP_043561Add
BLAST
Alternative sequencei148 – 24194Missing in isoform 3. 1 PublicationVSP_043562Add
BLAST
Alternative sequencei327 – 35024ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3. 1 PublicationVSP_043563Add
BLAST
Alternative sequencei327 – 33610ADVVLDPDTA → DVNLTGLRNT in isoform 2. 1 PublicationVSP_012712
Alternative sequencei337 – 523187Missing in isoform 2. 1 PublicationVSP_012713Add
BLAST
Alternative sequencei351 – 523173Missing in isoform 3. 1 PublicationVSP_043564Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA. Translation: AAB53428.1.
AK289883 mRNA. Translation: BAF82572.1.
AK293526 mRNA. Translation: BAG57008.1.
AK298570 mRNA. Translation: BAG60763.1.
AL021917 Genomic DNA. Translation: CAC03425.1.
CH471087 Genomic DNA. Translation: EAW55565.1.
BC014021 mRNA. Translation: AAH14021.1.
BC017497 mRNA. Translation: AAH17497.1.
CCDSiCCDS4606.1. [Q8WVV5-1]
CCDS4607.1. [Q8WVV5-4]
CCDS56401.1. [Q8WVV5-2]
CCDS56402.1. [Q8WVV5-3]
CCDS56403.1. [Q8WVV5-5]
RefSeqiNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
NP_008926.2. NM_006995.4. [Q8WVV5-1]
NP_853509.1. NM_181531.2. [Q8WVV5-4]
XP_005248854.1. XM_005248797.2. [Q8WVV5-1]
XP_005248855.1. XM_005248798.3. [Q8WVV5-4]
XP_006715016.1. XM_006714953.2. [Q8WVV5-1]
XP_011512530.1. XM_011514228.1. [Q8WVV5-1]
XP_011512533.1. XM_011514231.1. [Q8WVV5-5]
UniGeneiHs.373938.

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508.
ENST00000416795; ENSP00000399308; ENSG00000124508.
ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
GeneIDi10385.
KEGGihsa:10385.
UCSCiuc003nhq.3. human. [Q8WVV5-1]
uc003nhr.3. human. [Q8WVV5-4]
uc003nhs.3. human. [Q8WVV5-2]
uc011dkg.2. human. [Q8WVV5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA. Translation: AAB53428.1.
AK289883 mRNA. Translation: BAF82572.1.
AK293526 mRNA. Translation: BAG57008.1.
AK298570 mRNA. Translation: BAG60763.1.
AL021917 Genomic DNA. Translation: CAC03425.1.
CH471087 Genomic DNA. Translation: EAW55565.1.
BC014021 mRNA. Translation: AAH14021.1.
BC017497 mRNA. Translation: AAH17497.1.
CCDSiCCDS4606.1. [Q8WVV5-1]
CCDS4607.1. [Q8WVV5-4]
CCDS56401.1. [Q8WVV5-2]
CCDS56402.1. [Q8WVV5-3]
CCDS56403.1. [Q8WVV5-5]
RefSeqiNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
NP_008926.2. NM_006995.4. [Q8WVV5-1]
NP_853509.1. NM_181531.2. [Q8WVV5-4]
XP_005248854.1. XM_005248797.2. [Q8WVV5-1]
XP_005248855.1. XM_005248798.3. [Q8WVV5-4]
XP_006715016.1. XM_006714953.2. [Q8WVV5-1]
XP_011512530.1. XM_011514228.1. [Q8WVV5-1]
XP_011512533.1. XM_011514231.1. [Q8WVV5-5]
UniGeneiHs.373938.

3D structure databases

ProteinModelPortaliQ8WVV5.
SMRiQ8WVV5. Positions 32-241, 325-497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115658. 10 interactions.
IntActiQ8WVV5. 3 interactions.
STRINGi9606.ENSP00000349143.

PTM databases

PhosphoSiteiQ8WVV5.

Polymorphism and mutation databases

BioMutaiBTN2A2.
DMDMi83288459.

Proteomic databases

MaxQBiQ8WVV5.
PaxDbiQ8WVV5.
PRIDEiQ8WVV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508.
ENST00000416795; ENSP00000399308; ENSG00000124508.
ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
GeneIDi10385.
KEGGihsa:10385.
UCSCiuc003nhq.3. human. [Q8WVV5-1]
uc003nhr.3. human. [Q8WVV5-4]
uc003nhs.3. human. [Q8WVV5-2]
uc011dkg.2. human. [Q8WVV5-3]

Organism-specific databases

CTDi10385.
GeneCardsiGC06P026383.
HGNCiHGNC:1137. BTN2A2.
HPAiHPA051504.
MIMi613591. gene.
neXtProtiNX_Q8WVV5.
PharmGKBiPA25457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45068.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ8WVV5.
KOiK06712.
OMAiHSVERKG.
OrthoDBiEOG7XM2XG.
PhylomeDBiQ8WVV5.
TreeFamiTF331083.

Miscellaneous databases

ChiTaRSiBTN2A2. human.
GeneWikiiButyrophilin,_subfamily_2,_member_A2.
GenomeRNAii10385.
NextBioi39345.
PROiQ8WVV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WVV5.
CleanExiHS_BTN2A2.
ExpressionAtlasiQ8WVV5. baseline and differential.
GenevisibleiQ8WVV5. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
    Tissue: Caudate nucleus and Cerebellum.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Eye.

Entry informationi

Entry nameiBT2A2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVV5
Secondary accession number(s): A6NM84
, B4DE97, B4DQ01, E9PH07, O00480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 22, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.