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Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A2
Gene namesi
Name:BTN2A2
Synonyms:BT2.2, BTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1137. BTN2A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 265ExtracellularSequence analysisAdd BLAST233
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 523CytoplasmicSequence analysisAdd BLAST237

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10385.
OpenTargetsiENSG00000124508.
PharmGKBiPA25457.

Polymorphism and mutation databases

BioMutaiBTN2A2.
DMDMi83288459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001453033 – 523Butyrophilin subfamily 2 member A2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 129PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8WVV5.
MaxQBiQ8WVV5.
PaxDbiQ8WVV5.
PeptideAtlasiQ8WVV5.
PRIDEiQ8WVV5.

PTM databases

iPTMnetiQ8WVV5.
PhosphoSitePlusiQ8WVV5.

Expressioni

Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000124508.
CleanExiHS_BTN2A2.
ExpressionAtlasiQ8WVV5. baseline and differential.
GenevisibleiQ8WVV5. HS.

Organism-specific databases

HPAiHPA051504.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-8648738,EBI-743099
PSMA3P257883EBI-8648738,EBI-348380

Protein-protein interaction databases

BioGridi115658. 25 interactors.
IntActiQ8WVV5. 5 interactors.
STRINGi9606.ENSP00000349143.

Structurei

3D structure databases

ProteinModelPortaliQ8WVV5.
SMRiQ8WVV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 145Ig-like V-typeAdd BLAST112
Domaini153 – 234Ig-like C2-typeAdd BLAST82
Domaini309 – 502B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili286 – 321Sequence analysisAdd BLAST36

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJI4. Eukaryota.
ENOG410YA6W. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ8WVV5.
KOiK06712.
OMAiHSVERKG.
OrthoDBiEOG091G07OP.
PhylomeDBiQ8WVV5.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN
60 70 80 90 100
TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI
110 120 130 140 150
TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG
160 170 180 190 200
SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD
210 220 230 240 250
ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP
260 270 280 290 300
WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK
310 320 330 340 350
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR
360 370 380 390 400
RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR
410 420 430 440 450
HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL
460 470 480 490 500
DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT
510 520
GASGVMVPEE GLKLHRVGTH QSL
Length:523
Mass (Da):59,070
Last modified:February 1, 2005 - v2
Checksum:i122099CE635F279D
GO
Isoform 2 (identifier: Q8WVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-336: ADVVLDPDTA → DVNLTGLRNT
     337-523: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,714
Checksum:i5AEE282BA52506FF
GO
Isoform 3 (identifier: Q8WVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-241: Missing.
     327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
     351-523: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,927
Checksum:i283491E103090795
GO
Isoform 4 (identifier: Q8WVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-147: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,827
Checksum:i7BFB2302A387BF64
GO
Isoform 5 (identifier: Q8WVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-241: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,493
Checksum:i1242D946AE321E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243S → P in BAG57008 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049829479P → S.Corresponds to variant rs16891646dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04486132 – 241Missing in isoform 5. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_04356132 – 147Missing in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_043562148 – 241Missing in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_043563327 – 350ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_012712327 – 336ADVVLDPDTA → DVNLTGLRNT in isoform 2. 1 Publication10
Alternative sequenceiVSP_012713337 – 523Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_043564351 – 523Missing in isoform 3. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA. Translation: AAB53428.1.
AK289883 mRNA. Translation: BAF82572.1.
AK293526 mRNA. Translation: BAG57008.1.
AK298570 mRNA. Translation: BAG60763.1.
AL021917 Genomic DNA. Translation: CAC03425.1.
CH471087 Genomic DNA. Translation: EAW55565.1.
BC014021 mRNA. Translation: AAH14021.1.
BC017497 mRNA. Translation: AAH17497.1.
CCDSiCCDS4606.1. [Q8WVV5-1]
CCDS4607.1. [Q8WVV5-4]
CCDS56401.1. [Q8WVV5-2]
CCDS56402.1. [Q8WVV5-3]
CCDS56403.1. [Q8WVV5-5]
RefSeqiNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
NP_008926.2. NM_006995.4. [Q8WVV5-1]
NP_853509.1. NM_181531.2. [Q8WVV5-4]
XP_005248854.1. XM_005248797.3. [Q8WVV5-1]
XP_005248855.1. XM_005248798.4. [Q8WVV5-4]
XP_006715016.1. XM_006714953.3. [Q8WVV5-1]
XP_011512530.1. XM_011514228.2. [Q8WVV5-1]
XP_011512533.1. XM_011514231.2. [Q8WVV5-5]
XP_016865656.1. XM_017010167.1. [Q8WVV5-4]
UniGeneiHs.373938.

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508. [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508. [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
GeneIDi10385.
KEGGihsa:10385.
UCSCiuc003nhq.4. human. [Q8WVV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA. Translation: AAB53428.1.
AK289883 mRNA. Translation: BAF82572.1.
AK293526 mRNA. Translation: BAG57008.1.
AK298570 mRNA. Translation: BAG60763.1.
AL021917 Genomic DNA. Translation: CAC03425.1.
CH471087 Genomic DNA. Translation: EAW55565.1.
BC014021 mRNA. Translation: AAH14021.1.
BC017497 mRNA. Translation: AAH17497.1.
CCDSiCCDS4606.1. [Q8WVV5-1]
CCDS4607.1. [Q8WVV5-4]
CCDS56401.1. [Q8WVV5-2]
CCDS56402.1. [Q8WVV5-3]
CCDS56403.1. [Q8WVV5-5]
RefSeqiNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
NP_008926.2. NM_006995.4. [Q8WVV5-1]
NP_853509.1. NM_181531.2. [Q8WVV5-4]
XP_005248854.1. XM_005248797.3. [Q8WVV5-1]
XP_005248855.1. XM_005248798.4. [Q8WVV5-4]
XP_006715016.1. XM_006714953.3. [Q8WVV5-1]
XP_011512530.1. XM_011514228.2. [Q8WVV5-1]
XP_011512533.1. XM_011514231.2. [Q8WVV5-5]
XP_016865656.1. XM_017010167.1. [Q8WVV5-4]
UniGeneiHs.373938.

3D structure databases

ProteinModelPortaliQ8WVV5.
SMRiQ8WVV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115658. 25 interactors.
IntActiQ8WVV5. 5 interactors.
STRINGi9606.ENSP00000349143.

PTM databases

iPTMnetiQ8WVV5.
PhosphoSitePlusiQ8WVV5.

Polymorphism and mutation databases

BioMutaiBTN2A2.
DMDMi83288459.

Proteomic databases

EPDiQ8WVV5.
MaxQBiQ8WVV5.
PaxDbiQ8WVV5.
PeptideAtlasiQ8WVV5.
PRIDEiQ8WVV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508. [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508. [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
GeneIDi10385.
KEGGihsa:10385.
UCSCiuc003nhq.4. human. [Q8WVV5-1]

Organism-specific databases

CTDi10385.
DisGeNETi10385.
GeneCardsiBTN2A2.
HGNCiHGNC:1137. BTN2A2.
HPAiHPA051504.
MIMi613591. gene.
neXtProtiNX_Q8WVV5.
OpenTargetsiENSG00000124508.
PharmGKBiPA25457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJI4. Eukaryota.
ENOG410YA6W. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ8WVV5.
KOiK06712.
OMAiHSVERKG.
OrthoDBiEOG091G07OP.
PhylomeDBiQ8WVV5.
TreeFamiTF331083.

Miscellaneous databases

ChiTaRSiBTN2A2. human.
GeneWikiiButyrophilin,_subfamily_2,_member_A2.
GenomeRNAii10385.
PROiQ8WVV5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124508.
CleanExiHS_BTN2A2.
ExpressionAtlasiQ8WVV5. baseline and differential.
GenevisibleiQ8WVV5. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBT2A2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVV5
Secondary accession number(s): A6NM84
, B4DE97, B4DQ01, E9PH07, O00480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.