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Q8WVV5 (BT2A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Butyrophilin subfamily 2 member A2
Gene names
Name:BTN2A2
Synonyms:BT2.2, BTF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney. Ref.1

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 B30.2/SPRY domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WVV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WVV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     327-336: ADVVLDPDTA → DVNLTGLRNT
     337-523: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8WVV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     148-241: Missing.
     327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
     351-523: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8WVV5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     32-147: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q8WVV5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     32-241: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 523491Butyrophilin subfamily 2 member A2
PRO_0000014530

Regions

Topological domain33 – 265233Extracellular Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 523237Cytoplasmic Potential
Domain34 – 145112Ig-like V-type
Domain153 – 23482Ig-like C2-type
Domain309 – 502194B30.2/SPRY
Coiled coil286 – 32136 Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Disulfide bond55 ↔ 129 By similarity

Natural variations

Alternative sequence32 – 241210Missing in isoform 5.
VSP_044861
Alternative sequence32 – 147116Missing in isoform 4.
VSP_043561
Alternative sequence148 – 24194Missing in isoform 3.
VSP_043562
Alternative sequence327 – 35024ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3.
VSP_043563
Alternative sequence327 – 33610ADVVLDPDTA → DVNLTGLRNT in isoform 2.
VSP_012712
Alternative sequence337 – 523187Missing in isoform 2.
VSP_012713
Alternative sequence351 – 523173Missing in isoform 3.
VSP_043564
Natural variant4791P → S.
Corresponds to variant rs16891646 [ dbSNP | Ensembl ].
VAR_049829

Experimental info

Sequence conflict2431S → P in BAG57008. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 122099CE635F279D

FASTA52359,070
        10         20         30         40         50         60 
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN TTLRCHLSPE 

        70         80         90        100        110        120 
KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI TFVSKDINRG SVALVIHNVT 

       130        140        150        160        170        180 
AQENGIYRCY FQEGRSYDEA ILRLVVAGLG SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT 

       190        200        210        220        230        240 
VWRDPYGEVV PALKEVSIAD ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI 

       250        260        270        280        290        300 
PESFMPSASP WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK 

       310        320        330        340        350        360 
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR RGPYRQRVPD 

       370        380        390        400        410        420 
NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR HSVERKGEVL LIPQNGFWTL 

       430        440        450        460        470        480 
EMFGNQYRAL SSPERILPLK ESLCRVGVFL DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV 

       490        500        510        520 
RPFFRLGSDD SPIFICPALT GASGVMVPEE GLKLHRVGTH QSL 

« Hide

Isoform 2 [UniParc].

Checksum: 5AEE282BA52506FF
Show »

FASTA33637,714
Isoform 3 [UniParc].

Checksum: 283491E103090795
Show »

FASTA25628,927
Isoform 4 [UniParc].

Checksum: 7BFB2302A387BF64
Show »

FASTA40745,827
Isoform 5 [UniParc].

Checksum: 1242D946AE321E50
Show »

FASTA31335,493

References

« Hide 'large scale' references
[1]"A 1.1-Mb transcript map of the hereditary hemochromatosis locus."
Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L., Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A., Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z., Wolff R.K., Schatzman R.C., Feder J.N.
Genome Res. 7:441-456(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
Tissue: Caudate nucleus and Cerebellum.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90550 mRNA. Translation: AAB53428.1.
AK289883 mRNA. Translation: BAF82572.1.
AK293526 mRNA. Translation: BAG57008.1.
AK298570 mRNA. Translation: BAG60763.1.
AL021917 Genomic DNA. Translation: CAC03425.1.
CH471087 Genomic DNA. Translation: EAW55565.1.
BC014021 mRNA. Translation: AAH14021.1.
BC017497 mRNA. Translation: AAH17497.1.
CCDSCCDS4606.1. [Q8WVV5-1]
CCDS4607.1. [Q8WVV5-4]
CCDS56401.1. [Q8WVV5-2]
CCDS56402.1. [Q8WVV5-3]
CCDS56403.1. [Q8WVV5-5]
RefSeqNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
NP_008926.2. NM_006995.4. [Q8WVV5-1]
NP_853509.1. NM_181531.2. [Q8WVV5-4]
XP_005248854.1. XM_005248797.1. [Q8WVV5-1]
XP_005248855.1. XM_005248798.2. [Q8WVV5-4]
XP_006715016.1. XM_006714953.1. [Q8WVV5-1]
UniGeneHs.373938.

3D structure databases

ProteinModelPortalQ8WVV5.
SMRQ8WVV5. Positions 32-241, 325-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115658. 1 interaction.
IntActQ8WVV5. 1 interaction.
STRING9606.ENSP00000349143.

PTM databases

PhosphoSiteQ8WVV5.

Polymorphism databases

DMDM83288459.

Proteomic databases

MaxQBQ8WVV5.
PaxDbQ8WVV5.
PRIDEQ8WVV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508. [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508. [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
GeneID10385.
KEGGhsa:10385.
UCSCuc003nhq.3. human. [Q8WVV5-1]
uc003nhr.3. human. [Q8WVV5-4]
uc003nhs.3. human. [Q8WVV5-2]
uc011dkg.2. human. [Q8WVV5-3]

Organism-specific databases

CTD10385.
GeneCardsGC06P026383.
HGNCHGNC:1137. BTN2A2.
HPAHPA051504.
MIM613591. gene.
neXtProtNX_Q8WVV5.
PharmGKBPA25457.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45068.
HOGENOMHOG000230860.
HOVERGENHBG050747.
InParanoidQ8WVV5.
KOK06712.
OMAEPLTVWR.
OrthoDBEOG7XM2XG.
PhylomeDBQ8WVV5.
TreeFamTF331083.

Gene expression databases

ArrayExpressQ8WVV5.
BgeeQ8WVV5.
CleanExHS_BTN2A2.
GenevestigatorQ8WVV5.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiButyrophilin,_subfamily_2,_member_A2.
GenomeRNAi10385.
NextBio39345.
PROQ8WVV5.
SOURCESearch...

Entry information

Entry nameBT2A2_HUMAN
AccessionPrimary (citable) accession number: Q8WVV5
Secondary accession number(s): A6NM84 expand/collapse secondary AC list , B4DE97, B4DQ01, E9PH07, O00480
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM