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Q8WVV5

- BT2A2_HUMAN

UniProt

Q8WVV5 - BT2A2_HUMAN

Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

    GO - Biological processi

    1. negative regulation of activated T cell proliferation Source: UniProtKB
    2. negative regulation of cellular metabolic process Source: UniProtKB
    3. negative regulation of cytokine secretion Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrophilin subfamily 2 member A2
    Gene namesi
    Name:BTN2A2
    Synonyms:BT2.2, BTF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1137. BTN2A2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25457.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 523491Butyrophilin subfamily 2 member A2PRO_0000014530Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 129PROSITE-ProRule annotation
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8WVV5.
    PaxDbiQ8WVV5.
    PRIDEiQ8WVV5.

    PTM databases

    PhosphoSiteiQ8WVV5.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8WVV5.
    BgeeiQ8WVV5.
    CleanExiHS_BTN2A2.
    GenevestigatoriQ8WVV5.

    Organism-specific databases

    HPAiHPA051504.

    Interactioni

    Protein-protein interaction databases

    BioGridi115658. 1 interaction.
    IntActiQ8WVV5. 1 interaction.
    STRINGi9606.ENSP00000349143.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVV5.
    SMRiQ8WVV5. Positions 32-241, 325-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 265233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 523237CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 145112Ig-like V-typeAdd
    BLAST
    Domaini153 – 23482Ig-like C2-typeAdd
    BLAST
    Domaini309 – 502194B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili286 – 32136Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45068.
    HOGENOMiHOG000230860.
    HOVERGENiHBG050747.
    InParanoidiQ8WVV5.
    KOiK06712.
    OMAiEPLTVWR.
    OrthoDBiEOG7XM2XG.
    PhylomeDBiQ8WVV5.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR013162. CD80_C2-set.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00409. IG. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WVV5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN    50
    TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI 100
    TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG 150
    SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD 200
    ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP 250
    WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK 300
    KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR 350
    RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR 400
    HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL 450
    DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT 500
    GASGVMVPEE GLKLHRVGTH QSL 523
    Length:523
    Mass (Da):59,070
    Last modified:February 1, 2005 - v2
    Checksum:i122099CE635F279D
    GO
    Isoform 2 (identifier: Q8WVV5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         327-336: ADVVLDPDTA → DVNLTGLRNT
         337-523: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:336
    Mass (Da):37,714
    Checksum:i5AEE282BA52506FF
    GO
    Isoform 3 (identifier: Q8WVV5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-241: Missing.
         327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
         351-523: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):28,927
    Checksum:i283491E103090795
    GO
    Isoform 4 (identifier: Q8WVV5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-147: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:407
    Mass (Da):45,827
    Checksum:i7BFB2302A387BF64
    GO
    Isoform 5 (identifier: Q8WVV5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-241: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:313
    Mass (Da):35,493
    Checksum:i1242D946AE321E50
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431S → P in BAG57008. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti479 – 4791P → S.
    Corresponds to variant rs16891646 [ dbSNP | Ensembl ].
    VAR_049829

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 241210Missing in isoform 5. 1 PublicationVSP_044861Add
    BLAST
    Alternative sequencei32 – 147116Missing in isoform 4. 1 PublicationVSP_043561Add
    BLAST
    Alternative sequencei148 – 24194Missing in isoform 3. 1 PublicationVSP_043562Add
    BLAST
    Alternative sequencei327 – 35024ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3. 1 PublicationVSP_043563Add
    BLAST
    Alternative sequencei327 – 33610ADVVLDPDTA → DVNLTGLRNT in isoform 2. 1 PublicationVSP_012712
    Alternative sequencei337 – 523187Missing in isoform 2. 1 PublicationVSP_012713Add
    BLAST
    Alternative sequencei351 – 523173Missing in isoform 3. 1 PublicationVSP_043564Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90550 mRNA. Translation: AAB53428.1.
    AK289883 mRNA. Translation: BAF82572.1.
    AK293526 mRNA. Translation: BAG57008.1.
    AK298570 mRNA. Translation: BAG60763.1.
    AL021917 Genomic DNA. Translation: CAC03425.1.
    CH471087 Genomic DNA. Translation: EAW55565.1.
    BC014021 mRNA. Translation: AAH14021.1.
    BC017497 mRNA. Translation: AAH17497.1.
    CCDSiCCDS4606.1. [Q8WVV5-1]
    CCDS4607.1. [Q8WVV5-4]
    CCDS56401.1. [Q8WVV5-2]
    CCDS56402.1. [Q8WVV5-3]
    CCDS56403.1. [Q8WVV5-5]
    RefSeqiNP_001184166.1. NM_001197237.1. [Q8WVV5-1]
    NP_001184167.1. NM_001197238.1. [Q8WVV5-2]
    NP_001184168.1. NM_001197239.1. [Q8WVV5-5]
    NP_001184169.1. NM_001197240.1. [Q8WVV5-3]
    NP_008926.2. NM_006995.4. [Q8WVV5-1]
    NP_853509.1. NM_181531.2. [Q8WVV5-4]
    XP_005248854.1. XM_005248797.1. [Q8WVV5-1]
    XP_005248855.1. XM_005248798.2. [Q8WVV5-4]
    XP_006715016.1. XM_006714953.1. [Q8WVV5-1]
    UniGeneiHs.373938.

    Genome annotation databases

    EnsembliENST00000352867; ENSP00000337117; ENSG00000124508. [Q8WVV5-4]
    ENST00000356709; ENSP00000349143; ENSG00000124508. [Q8WVV5-1]
    ENST00000416795; ENSP00000399308; ENSG00000124508. [Q8WVV5-1]
    ENST00000432533; ENSP00000394241; ENSG00000124508. [Q8WVV5-3]
    ENST00000469230; ENSP00000417472; ENSG00000124508. [Q8WVV5-2]
    ENST00000482536; ENSP00000419451; ENSG00000124508. [Q8WVV5-5]
    GeneIDi10385.
    KEGGihsa:10385.
    UCSCiuc003nhq.3. human. [Q8WVV5-1]
    uc003nhr.3. human. [Q8WVV5-4]
    uc003nhs.3. human. [Q8WVV5-2]
    uc011dkg.2. human. [Q8WVV5-3]

    Polymorphism databases

    DMDMi83288459.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90550 mRNA. Translation: AAB53428.1 .
    AK289883 mRNA. Translation: BAF82572.1 .
    AK293526 mRNA. Translation: BAG57008.1 .
    AK298570 mRNA. Translation: BAG60763.1 .
    AL021917 Genomic DNA. Translation: CAC03425.1 .
    CH471087 Genomic DNA. Translation: EAW55565.1 .
    BC014021 mRNA. Translation: AAH14021.1 .
    BC017497 mRNA. Translation: AAH17497.1 .
    CCDSi CCDS4606.1. [Q8WVV5-1 ]
    CCDS4607.1. [Q8WVV5-4 ]
    CCDS56401.1. [Q8WVV5-2 ]
    CCDS56402.1. [Q8WVV5-3 ]
    CCDS56403.1. [Q8WVV5-5 ]
    RefSeqi NP_001184166.1. NM_001197237.1. [Q8WVV5-1 ]
    NP_001184167.1. NM_001197238.1. [Q8WVV5-2 ]
    NP_001184168.1. NM_001197239.1. [Q8WVV5-5 ]
    NP_001184169.1. NM_001197240.1. [Q8WVV5-3 ]
    NP_008926.2. NM_006995.4. [Q8WVV5-1 ]
    NP_853509.1. NM_181531.2. [Q8WVV5-4 ]
    XP_005248854.1. XM_005248797.1. [Q8WVV5-1 ]
    XP_005248855.1. XM_005248798.2. [Q8WVV5-4 ]
    XP_006715016.1. XM_006714953.1. [Q8WVV5-1 ]
    UniGenei Hs.373938.

    3D structure databases

    ProteinModelPortali Q8WVV5.
    SMRi Q8WVV5. Positions 32-241, 325-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115658. 1 interaction.
    IntActi Q8WVV5. 1 interaction.
    STRINGi 9606.ENSP00000349143.

    PTM databases

    PhosphoSitei Q8WVV5.

    Polymorphism databases

    DMDMi 83288459.

    Proteomic databases

    MaxQBi Q8WVV5.
    PaxDbi Q8WVV5.
    PRIDEi Q8WVV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000352867 ; ENSP00000337117 ; ENSG00000124508 . [Q8WVV5-4 ]
    ENST00000356709 ; ENSP00000349143 ; ENSG00000124508 . [Q8WVV5-1 ]
    ENST00000416795 ; ENSP00000399308 ; ENSG00000124508 . [Q8WVV5-1 ]
    ENST00000432533 ; ENSP00000394241 ; ENSG00000124508 . [Q8WVV5-3 ]
    ENST00000469230 ; ENSP00000417472 ; ENSG00000124508 . [Q8WVV5-2 ]
    ENST00000482536 ; ENSP00000419451 ; ENSG00000124508 . [Q8WVV5-5 ]
    GeneIDi 10385.
    KEGGi hsa:10385.
    UCSCi uc003nhq.3. human. [Q8WVV5-1 ]
    uc003nhr.3. human. [Q8WVV5-4 ]
    uc003nhs.3. human. [Q8WVV5-2 ]
    uc011dkg.2. human. [Q8WVV5-3 ]

    Organism-specific databases

    CTDi 10385.
    GeneCardsi GC06P026383.
    HGNCi HGNC:1137. BTN2A2.
    HPAi HPA051504.
    MIMi 613591. gene.
    neXtProti NX_Q8WVV5.
    PharmGKBi PA25457.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45068.
    HOGENOMi HOG000230860.
    HOVERGENi HBG050747.
    InParanoidi Q8WVV5.
    KOi K06712.
    OMAi EPLTVWR.
    OrthoDBi EOG7XM2XG.
    PhylomeDBi Q8WVV5.
    TreeFami TF331083.

    Miscellaneous databases

    GeneWikii Butyrophilin,_subfamily_2,_member_A2.
    GenomeRNAii 10385.
    NextBioi 39345.
    PROi Q8WVV5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WVV5.
    Bgeei Q8WVV5.
    CleanExi HS_BTN2A2.
    Genevestigatori Q8WVV5.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR013162. CD80_C2-set.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00409. IG. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
      Tissue: Caudate nucleus and Cerebellum.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiBT2A2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVV5
    Secondary accession number(s): A6NM84
    , B4DE97, B4DQ01, E9PH07, O00480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3