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Protein

Trafficking protein particle complex subunit 12

Gene

TRAPPC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 12
Alternative name(s):
Tetratricopeptide repeat protein 15
Short name:
TPR repeat protein 15
Short name:
TTC-15
Gene namesi
Name:TRAPPC12
Synonyms:TTC15
ORF Names:CGI-87
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24284. TRAPPC12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944710.

Polymorphism and mutation databases

BioMutaiTRAPPC12.
DMDMi116242834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Trafficking protein particle complex subunit 12PRO_0000106401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphoserineBy similarity
Modified residuei184 – 1841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVT3.
MaxQBiQ8WVT3.
PaxDbiQ8WVT3.
PeptideAtlasiQ8WVT3.
PRIDEiQ8WVT3.

PTM databases

iPTMnetiQ8WVT3.
PhosphoSiteiQ8WVT3.

Expressioni

Gene expression databases

BgeeiQ8WVT3.
CleanExiHS_TTC15.
ExpressionAtlasiQ8WVT3. baseline and differential.
GenevisibleiQ8WVT3. HS.

Organism-specific databases

HPAiHPA034799.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Protein-protein interaction databases

BioGridi119301. 25 interactions.
DIPiDIP-48283N.
IntActiQ8WVT3. 6 interactions.
STRINGi9606.ENSP00000324318.

Structurei

3D structure databases

ProteinModelPortaliQ8WVT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati545 – 57834TPR 1Add
BLAST
Repeati580 – 61334TPR 2Add
BLAST
Repeati620 – 65334TPR 3Add
BLAST
Repeati654 – 68734TPR 4Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2796. Eukaryota.
ENOG410XSX3. LUCA.
GeneTreeiENSGT00390000002448.
HOGENOMiHOG000154703.
HOVERGENiHBG068968.
InParanoidiQ8WVT3.
OMAiEPFAHIQ.
OrthoDBiEOG7WX09H.
PhylomeDBiQ8WVT3.
TreeFamiTF320881.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAGGGEET PAPEAPHPPQ LAPPEEQGLL FQEETIDLGG DEFGSEENET
60 70 80 90 100
ASEGSSPLAD KLNEHMMESV LISDSPNSEG DAGDLGRVRD EAEPGGEGDP
110 120 130 140 150
GPEPAGTPSP SGEADGDCAP EDAAPSSGGA PRQDAAREVP GSEAARPEQE
160 170 180 190 200
PPVAEPVPVC TIFSQRAPPA SGDGFEPQMV KSPSFGGASE ASARTPPQVV
210 220 230 240 250
QPSPSLSTFF GDTAASHSLA SDFFDSFTTS AFISVSNPGA GSPAPASPPP
260 270 280 290 300
LAVPGTEGRP EPVAMRGPQA AAPPASPEPF AHIQAVFAGS DDPFATALSM
310 320 330 340 350
SEMDRRNDAW LPGEATRGVL RAVATQQRGA VFVDKENLTM PGLRFDNIQG
360 370 380 390 400
DAVKDLMLRF LGEKAAAKRQ VLNADSVEQS FVGLKQLISC RNWRAAVDLC
410 420 430 440 450
GRLLTAHGQG YGKSGLLTSH TTDSLQLWFV RLALLVKLGL FQNAEMEFEP
460 470 480 490 500
FGNLDQPDLY YEYYPHVYPG RRGSMVPFSM RILHAELQQY LGNPQESLDR
510 520 530 540 550
LHKVKTVCSK ILANLEQGLA EDGGMSSVTQ EGRQASIRLW RSRLGRVMYS
560 570 580 590 600
MANCLLLMKD YVLAVEAYHS VIKYYPEQEP QLLSGIGRIS LQIGDIKTAE
610 620 630 640 650
KYFQDVEKVT QKLDGLQGKI MVLMNSAFLH LGQNNFAEAH RFFTEILRMD
660 670 680 690 700
PRNAVANNNA AVCLLYLGKL KDSLRQLEAM VQQDPRHYLH ESVLFNLTTM
710 720 730
YELESSRSMQ KKQALLEAVA GKEGDSFNTQ CLKLA
Length:735
Mass (Da):79,375
Last modified:October 17, 2006 - v3
Checksum:iB844FB3749866E3F
GO

Sequence cautioni

The sequence AAD34082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti451 – 4511F → V in AAD34082 (PubMed:10810093).Curated
Sequence conflicti486 – 4861E → D in AAD34082 (PubMed:10810093).Curated
Sequence conflicti566 – 5661E → D in AAH14164 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011S → G.1 Publication
Corresponds to variant rs11686212 [ dbSNP | Ensembl ].
VAR_028442
Natural varianti717 – 7171E → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035869

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098327 mRNA. Translation: BAG53613.1.
CH471053 Genomic DNA. Translation: EAX01067.1.
CH471053 Genomic DNA. Translation: EAX01068.1.
BC014164 mRNA. Translation: AAH14164.2.
BC017475 mRNA. Translation: AAH17475.2.
AF151845 mRNA. Translation: AAD34082.1. Different initiation.
CCDSiCCDS1652.1.
RefSeqiNP_001308031.1. NM_001321102.1.
NP_057114.5. NM_016030.5.
UniGeneiHs.252713.
Hs.661278.

Genome annotation databases

EnsembliENST00000324266; ENSP00000324318; ENSG00000171853.
ENST00000382110; ENSP00000371544; ENSG00000171853.
GeneIDi51112.
KEGGihsa:51112.
UCSCiuc002qxm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098327 mRNA. Translation: BAG53613.1.
CH471053 Genomic DNA. Translation: EAX01067.1.
CH471053 Genomic DNA. Translation: EAX01068.1.
BC014164 mRNA. Translation: AAH14164.2.
BC017475 mRNA. Translation: AAH17475.2.
AF151845 mRNA. Translation: AAD34082.1. Different initiation.
CCDSiCCDS1652.1.
RefSeqiNP_001308031.1. NM_001321102.1.
NP_057114.5. NM_016030.5.
UniGeneiHs.252713.
Hs.661278.

3D structure databases

ProteinModelPortaliQ8WVT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119301. 25 interactions.
DIPiDIP-48283N.
IntActiQ8WVT3. 6 interactions.
STRINGi9606.ENSP00000324318.

PTM databases

iPTMnetiQ8WVT3.
PhosphoSiteiQ8WVT3.

Polymorphism and mutation databases

BioMutaiTRAPPC12.
DMDMi116242834.

Proteomic databases

EPDiQ8WVT3.
MaxQBiQ8WVT3.
PaxDbiQ8WVT3.
PeptideAtlasiQ8WVT3.
PRIDEiQ8WVT3.

Protocols and materials databases

DNASUi51112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324266; ENSP00000324318; ENSG00000171853.
ENST00000382110; ENSP00000371544; ENSG00000171853.
GeneIDi51112.
KEGGihsa:51112.
UCSCiuc002qxm.2. human.

Organism-specific databases

CTDi51112.
GeneCardsiTRAPPC12.
HGNCiHGNC:24284. TRAPPC12.
HPAiHPA034799.
MIMi614139. gene.
neXtProtiNX_Q8WVT3.
PharmGKBiPA134944710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2796. Eukaryota.
ENOG410XSX3. LUCA.
GeneTreeiENSGT00390000002448.
HOGENOMiHOG000154703.
HOVERGENiHBG068968.
InParanoidiQ8WVT3.
OMAiEPFAHIQ.
OrthoDBiEOG7WX09H.
PhylomeDBiQ8WVT3.
TreeFamiTF320881.

Miscellaneous databases

ChiTaRSiTRAPPC12. human.
GenomeRNAii51112.
PROiQ8WVT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WVT3.
CleanExiHS_TTC15.
ExpressionAtlasiQ8WVT3. baseline and differential.
GenevisibleiQ8WVT3. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-301.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Muscle.
  4. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-735.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN TRAPP COMPLEX, SUBCELLULAR LOCATION.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-717.

Entry informationi

Entry nameiTPC12_HUMAN
AccessioniPrimary (citable) accession number: Q8WVT3
Secondary accession number(s): B3KV01
, D6W4Y2, Q8WVW1, Q9Y395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.