Q8WVS4 (WDR60_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 60

Gene names

Name:

WDR60

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1066 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 4 WD repeats.
Sequence caution	The sequence BAA91528.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cilium Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1066	1066	WD repeat-containing protein 60		PRO_0000242142
Regions
	Repeat	694 – 734	41	WD 1
	Repeat	775 – 821	47	WD 2
	Repeat	907 – 947	41	WD 3
	Repeat	952 – 992	41	WD 4
	Coiled coil	83 – 121	39	Potential
	Coiled coil	410 – 437	28	Potential
Amino acid modifications
	Modified residue	247	1	Phosphoserine Ref.4
Natural variations
	Natural variant	91	1	E → G. Corresponds to variant rs17837851 [ dbSNP | Ensembl ].		VAR_026841
	Natural variant	273	1	Q → R. Corresponds to variant rs2788478 [ dbSNP | Ensembl ].		VAR_026842
Experimental info
	Sequence conflict	225	1	N → K in AAH14491. Ref.2
	Sequence conflict	292	1	S → F in AAH14491. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8WVS4 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: A6B4A0C3DC4CD2C2	FASTA	1,066	122,571
	10 20 30 40 50 60 MEPGKRRTKD DTWKADDLRK HLWAIQSGGS KEERKHREKK LRKESEMDLP EHKEPRCRDP 70 80 90 100 110 120 DQDARSRDRV AEVHTAKESP RGERDRDRQR ERRRDAKDRE KEKLKEKHRE AEKSHSRGKD 130 140 150 160 170 180 REKEKDRRAR KEELRQTVAH HNLLGQETRD RQLLERAERK GRSVSKVRSE EKDEDSERGD 190 200 210 220 230 240 EDRERRYRER KLQYGDSKDN PLKYWLYKEE GERRHRKPRE PDRDNKHREK SSTREKREKY 250 260 270 280 290 300 SKEKSNSFSD KGEERHKEKR HKEGFHFDDE RHQSNVDRKE KSAKDEPRKR ESQNGEHRNR 310 320 330 340 350 360 GASSKRDGTS SQHAENLVRN HGKDKDSRRK HGHEEGSSVW WKLDQRPGGE ETVEIEKEET 370 380 390 400 410 420 DLENARADAY TASCEDDFED YEDDFEVCDG DDDESSNEPE SREKLEELPL AQKKEIQEIQ 430 440 450 460 470 480 RAINAENERI GELSLKLFQK RGRTEFEKEP RTDTNSSPSR ASVCGIFVDF ASASHRQKSR 490 500 510 520 530 540 TQALKQKMRS TKLLRLIDLD FSFTFSLLDL PPVNEYDMYI RNFGKKNTKQ AYVQCNEDNV 550 560 570 580 590 600 ERDIQTEEIE TREVWTQHPG ESTVVSGGSE QRDTSDAVVM PKIDTPRLCS FLRAACQVMA 610 620 630 640 650 660 VLLEEDRLAA EPSWNLRAQD RALYFSDSSS QLNTSLPFLQ NRKVSSLHTS RVQRQMVVSV 670 680 690 700 710 720 HDLPEKSFVP LLDSKYVLCV WDIWQPSGPQ KVLICESQVT CCCLSPLKAF LLFAGTAHGS 730 740 750 760 770 780 VVVWDLREDS RLHYSVTLSD GFWTFRTATF STDGILTSVN HRSPLQAVEP ISTSVHKKQS 790 800 810 820 830 840 FVLSPFSTQE EMSGLSFHIA SLDESGVLNV WVVVELPKAD IAGSISDLGL MPGGRVKLVH 850 860 870 880 890 900 SALIQLGDSL SHKGNEFWGT TQTLNVKFLP SDPNHFIIGT DMGLISHGTR QDLRVAPKLF 910 920 930 940 950 960 KPQQHGIRPV KVNVIDFSPF GEPIFLAGCS DGSIRLHQLS SAFPLLQWDS STDSHAVTGL 970 980 990 1000 1010 1020 QWSPTRPAVF LVQDDTSNIY IWDLLQSDLG PVAKQQVSPN RLVAMAAVGE PEKAGGSFLA 1030 1040 1050 1060 LVLARASGSI DIQHLKRRWA APEVDECNRL RLLLQEALWP EGKLHK

References

[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 710-1066.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004863 Genomic DNA. No translation available. AC124833 Genomic DNA. No translation available. BC014491 mRNA. Translation: AAH14491.2. AK001162 mRNA. Translation: BAA91528.1. Different initiation.
IPI	IPI00165454.
RefSeq	NP_060521.4. NM_018051.4.
UniGene	Hs.389945.
3D structure databases
ProteinModelPortal	Q8WVS4.
SMR	Q8WVS4. Positions 912-985.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WVS4. 1 interaction.
STRING	9606.ENSP00000384290.
PTM databases
PhosphoSite	Q8WVS4.
Polymorphism databases
DMDM	296453073.
Proteomic databases
PaxDb	Q8WVS4.
PRIDE	Q8WVS4.
Protocols and materials databases
DNASU	55112.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000407559; ENSP00000384290; ENSG00000126870.
GeneID	55112.
KEGG	hsa:55112.
UCSC	uc003woe.4. human.
Organism-specific databases
CTD	55112.
GeneCards	GC07P158649.
H-InvDB	HIX0007267.
HGNC	HGNC:21862. WDR60.
HPA	HPA020607. HPA021316.
neXtProt	NX_Q8WVS4.
PharmGKB	PA142670594.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325464.
HOGENOM	HOG000154850.
HOVERGEN	HBG094160.
InParanoid	Q8WVS4.
OMA	VQCNEDN.
OrthoDB	EOG4B8JCW.
Gene expression databases
ArrayExpress	Q8WVS4.
Bgee	Q8WVS4.
CleanEx	HS_WDR60.
Genevestigator	Q8WVS4.
GermOnline	ENSG00000126870. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WDR60. human.
GenomeRNAi	55112.
NextBio	58736.

Entry information

Entry name

WDR60_HUMAN

Accession

Primary (citable) accession number: Q8WVS4
Secondary accession number(s): Q9NW58

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.