UniProtKB - Q8WVP5 (TP8L1_HUMAN)
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Protein
Tumor necrosis factor alpha-induced protein 8-like protein 1
Gene
TNFAIP8L1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a negative regulator of mTOR activity.By similarity
GO - Biological processi
- negative regulation of TOR signaling Source: UniProtKB
- regulation of apoptotic process Source: InterPro
Enzyme and pathway databases
Reactomei | R-HSA-1483255 PI Metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor alpha-induced protein 8-like protein 1Short name: TIPE1By similarity Short name: TNF alpha-induced protein 8-like protein 1 Short name: TNFAIP8-like protein 1 Alternative name(s): Oxidative stress-regulated gene-beta1 Publication Short name: Oxy-beta1 Publication |
Gene namesi | Name:TNFAIP8L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185361.8 |
HGNCi | HGNC:28279 TNFAIP8L1 |
MIMi | 615869 gene |
neXtProti | NX_Q8WVP5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 126282 |
OpenTargetsi | ENSG00000185361 |
PharmGKBi | PA142670722 |
Polymorphism and mutation databases
BioMutai | TNFAIP8L1 |
DMDMi | 146325794 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285724 | 1 – 186 | Tumor necrosis factor alpha-induced protein 8-like protein 1Add BLAST | 186 |
Proteomic databases
EPDi | Q8WVP5 |
PaxDbi | Q8WVP5 |
PeptideAtlasi | Q8WVP5 |
PRIDEi | Q8WVP5 |
PTM databases
PhosphoSitePlusi | Q8WVP5 |
Expressioni
Tissue specificityi
High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.1 Publication
Inductioni
Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.1 Publication
Gene expression databases
Bgeei | ENSG00000185361 |
CleanExi | HS_TNFAIP8L1 |
Genevisiblei | Q8WVP5 HS |
Interactioni
Subunit structurei
Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity
Binary interactionsi
Protein-protein interaction databases
BioGridi | 1259735 interactors. |
IntActi | Q8WVP5 11 interactors. |
STRINGi | 9606.ENSP00000331827 |
Structurei
3D structure databases
ProteinModelPortali | Q8WVP5 |
SMRi | Q8WVP5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TNFAIP8 family.Curated
Phylogenomic databases
eggNOGi | ENOG410IEG9 Eukaryota ENOG4111KN4 LUCA |
GeneTreei | ENSGT00390000003488 |
HOGENOMi | HOG000007708 |
HOVERGENi | HBG053286 |
InParanoidi | Q8WVP5 |
OMAi | FRKKVHT |
OrthoDBi | EOG091G0QQ9 |
PhylomeDBi | Q8WVP5 |
TreeFami | TF323415 |
Family and domain databases
Gene3Di | 1.20.1440.1601 hit |
InterProi | View protein in InterPro IPR008477 TNFAIP8-like IPR038355 TNFAIP8_sf |
PANTHERi | PTHR12757 PTHR12757, 1 hit |
Pfami | View protein in Pfam PF05527 DUF758, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WVP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT
60 70 80 90 100
RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT
110 120 130 140 150
AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL
160 170 180
ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032048 | 118 | A → V1 PublicationCorresponds to variant dbSNP:rs17851549Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005339 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69204.1 CH471139 Genomic DNA Translation: EAW69205.1 BC017672 mRNA Translation: AAH17672.1 |
CCDSi | CCDS12132.1 |
RefSeqi | NP_001161414.1, NM_001167942.1 NP_689575.2, NM_152362.2 XP_005259544.1, XM_005259487.3 XP_011525982.1, XM_011527680.2 |
UniGenei | Hs.465643 |
Genome annotation databases
Ensembli | ENST00000327473; ENSP00000331827; ENSG00000185361 ENST00000536716; ENSP00000444215; ENSG00000185361 |
GeneIDi | 126282 |
KEGGi | hsa:126282 |
UCSCi | uc002max.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TP8L1_HUMAN | |
Accessioni | Q8WVP5Primary (citable) accession number: Q8WVP5 Secondary accession number(s): D6W627 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | March 28, 2018 | |
This is version 104 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |