Q8WVP5 (TP8L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 1
Short name=TNF alpha-induced protein 8-like protein 1
Short name=TNFAIP8-like protein 1

Gene names

Name:

TNFAIP8L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TNFAIP8 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Tumor necrosis factor alpha-induced protein 8-like protein 1		PRO_0000285724
Natural variations
	Natural variant	118	1	A → V. Ref.3 Corresponds to variant rs17851549 [ dbSNP | Ensembl ].		VAR_032048

Sequences

	Sequence		Length	Mass (Da)
	Q8WVP5 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 352B0E7A2FB6D216	FASTA	186	20,827
	10 20 30 40 50 60 MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT RSRKEAQKML 70 80 90 100 110 120 KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT AVSFHQVDFT FDRRVLAAGL 130 140 150 160 170 180 LECRDLLHQA VGPHLTAKSH GRINHVFGHL ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL

References

[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005339 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69204.1. CH471139 Genomic DNA. Translation: EAW69205.1. BC017672 mRNA. Translation: AAH17672.1.
RefSeq	NP_001161414.1. NM_001167942.1. NP_689575.2. NM_152362.2. XP_005259544.1. XM_005259487.1.
UniGene	Hs.465643.
3D structure databases
ProteinModelPortal	Q8WVP5.
SMR	Q8WVP5. Positions 31-186.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	125973. 4 interactions.
IntAct	Q8WVP5. 1 interaction.
MINT	MINT-1448559.
STRING	9606.ENSP00000331827.
Polymorphism databases
DMDM	146325794.
Proteomic databases
PaxDb	Q8WVP5.
PRIDE	Q8WVP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327473; ENSP00000331827; ENSG00000185361. ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneID	126282.
KEGG	hsa:126282.
UCSC	uc002max.3. human.
Organism-specific databases
CTD	126282.
GeneCards	GC19P004639.
HGNC	HGNC:28279. TNFAIP8L1.
neXtProt	NX_Q8WVP5.
PharmGKB	PA142670722.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81900.
HOGENOM	HOG000007708.
HOVERGEN	HBG053286.
InParanoid	Q8WVP5.
OMA	SRINHVF.
OrthoDB	EOG7P5T2H.
PhylomeDB	Q8WVP5.
TreeFam	TF323415.
Gene expression databases
Bgee	Q8WVP5.
CleanEx	HS_TNFAIP8L1.
Genevestigator	Q8WVP5.
Family and domain databases
InterPro	IPR008477. DUF758. [Graphical view]
PANTHER	PTHR12757. PTHR12757. 1 hit.
Pfam	PF05527. DUF758. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	126282.
NextBio	81749.
PRO	Q8WVP5.

Entry information

Entry name

TP8L1_HUMAN

Accession

Primary (citable) accession number: Q8WVP5
Secondary accession number(s): D6W627

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	February 19, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.