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Q8WVP5 (TP8L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 1

Short name=TNF alpha-induced protein 8-like protein 1
Short name=TNFAIP8-like protein 1
Gene names
Name:TNFAIP8L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TNFAIP8 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Tumor necrosis factor alpha-induced protein 8-like protein 1
PRO_0000285724

Natural variations

Natural variant1181A → V. Ref.3
Corresponds to variant rs17851549 [ dbSNP | Ensembl ].
VAR_032048

Sequences

Sequence LengthMass (Da)Tools
Q8WVP5 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 352B0E7A2FB6D216

FASTA18620,827
        10         20         30         40         50         60 
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT RSRKEAQKML 

        70         80         90        100        110        120 
KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT AVSFHQVDFT FDRRVLAAGL 

       130        140        150        160        170        180 
LECRDLLHQA VGPHLTAKSH GRINHVFGHL ADCDFLAALY GPAEPYRSHL RRICEGLGRM 


LDEGSL 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005339 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69204.1.
CH471139 Genomic DNA. Translation: EAW69205.1.
BC017672 mRNA. Translation: AAH17672.1.
CCDSCCDS12132.1.
RefSeqNP_001161414.1. NM_001167942.1.
NP_689575.2. NM_152362.2.
XP_005259544.1. XM_005259487.1.
UniGeneHs.465643.

3D structure databases

ProteinModelPortalQ8WVP5.
SMRQ8WVP5. Positions 31-186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125973. 5 interactions.
IntActQ8WVP5. 1 interaction.
MINTMINT-1448559.
STRING9606.ENSP00000331827.

Polymorphism databases

DMDM146325794.

Proteomic databases

PaxDbQ8WVP5.
PRIDEQ8WVP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327473; ENSP00000331827; ENSG00000185361.
ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneID126282.
KEGGhsa:126282.
UCSCuc002max.3. human.

Organism-specific databases

CTD126282.
GeneCardsGC19P004639.
HGNCHGNC:28279. TNFAIP8L1.
neXtProtNX_Q8WVP5.
PharmGKBPA142670722.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81900.
HOGENOMHOG000007708.
HOVERGENHBG053286.
InParanoidQ8WVP5.
OMASRINHVF.
OrthoDBEOG7P5T2H.
PhylomeDBQ8WVP5.
TreeFamTF323415.

Gene expression databases

BgeeQ8WVP5.
CleanExHS_TNFAIP8L1.
GenevestigatorQ8WVP5.

Family and domain databases

InterProIPR008477. DUF758.
[Graphical view]
PANTHERPTHR12757. PTHR12757. 1 hit.
PfamPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi126282.
NextBio81749.
PROQ8WVP5.

Entry information

Entry nameTP8L1_HUMAN
AccessionPrimary (citable) accession number: Q8WVP5
Secondary accession number(s): D6W627
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM