TNFAIP8L1

Functionⁱ

Acts as a negative regulator of mTOR activity.By similarity

GO - Biological processⁱ

negative regulation of TOR signaling Source: UniProtKB

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483255. PI Metabolism.

Reactomeⁱ

R-HSA-1483255. PI Metabolism.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor alpha-induced protein 8-like protein 1 Short name: TIPE1By similarity Short name: TNF alpha-induced protein 8-like protein 1 Short name: TNFAIP8-like protein 1 Alternative name(s): Oxidative stress-regulated gene-beta1 Publication Short name: Oxy-beta1 Publication
Gene namesⁱ	Name:TNFAIP8L1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28279. TNFAIP8L1.

HGNCⁱ

HGNC:28279. TNFAIP8L1.

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q8K288 (TP8L1_MOUSE)

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	126282.
Open Targets More...OpenTargetsⁱ	ENSG00000185361.
PharmGKBⁱ	PA142670722.

Polymorphism and mutation databases

BioMutaⁱ	TNFAIP8L1.
DMDMⁱ	146325794.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285724	1 – 186	Tumor necrosis factor alpha-induced protein 8-like protein 1Add BLAST		186

Proteomic databases

EPDⁱ	Q8WVP5.
PaxDbⁱ	Q8WVP5.
PeptideAtlas More...PeptideAtlasⁱ	Q8WVP5.
PRIDEⁱ	Q8WVP5.

Expressionⁱ

Tissue specificityⁱ

High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.1 Publication

Inductionⁱ

Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000185361.
CleanExⁱ	HS_TNFAIP8L1.
Genevisibleⁱ	Q8WVP5. HS.

Interactionⁱ

Subunit structureⁱ

Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DVL3	Q92997	3	EBI-752102,EBI-739789
PSME3	P61289	5	EBI-752102,EBI-355546

Show more details

Protein-protein interaction databases

BioGridⁱ	125973. 5 interactors.
IntActⁱ	Q8WVP5. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1448559.
STRINGⁱ	9606.ENSP00000331827.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WVP5.
SMRⁱ	Q8WVP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9. Eukaryota. ENOG4111KN4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003488.
HOGENOMⁱ	HOG000007708.
HOVERGENⁱ	HBG053286.
InParanoidⁱ	Q8WVP5.
OMAⁱ	FRKKVHT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QQ9.
PhylomeDBⁱ	Q8WVP5.
TreeFamⁱ	TF323415.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008477. DUF758.
PANTHERⁱ	PTHR12757. PTHR12757. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05527. DUF758. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WVP5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT 
        60         70         80         90        100
RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT 
       110        120        130        140        150
AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL 
       160        170        180 
ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL

Length:186

Mass (Da):20,827

Last modified:May 1, 2007 - v2

Checksum:ⁱ352B0E7A2FB6D216

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032048	118	A → V1 PublicationCorresponds to variant dbSNP:rs17851549Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005339 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69204.1. CH471139 Genomic DNA. Translation: EAW69205.1. BC017672 mRNA. Translation: AAH17672.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12132.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001161414.1. NM_001167942.1. NP_689575.2. NM_152362.2. XP_005259544.1. XM_005259487.3. XP_011525982.1. XM_011527680.2.
UniGeneⁱ	Hs.465643.

Genome annotation databases

Ensemblⁱ	ENST00000327473; ENSP00000331827; ENSG00000185361. ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneIDⁱ	126282.
KEGGⁱ	hsa:126282.
UCSC genome browser More...UCSCⁱ	uc002max.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005339 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69204.1. CH471139 Genomic DNA. Translation: EAW69205.1. BC017672 mRNA. Translation: AAH17672.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12132.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001161414.1. NM_001167942.1. NP_689575.2. NM_152362.2. XP_005259544.1. XM_005259487.3. XP_011525982.1. XM_011527680.2.
UniGeneⁱ	Hs.465643.

3D structure databases

ProteinModelPortalⁱ	Q8WVP5.
SMRⁱ	Q8WVP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125973. 5 interactors.
IntActⁱ	Q8WVP5. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1448559.
STRINGⁱ	9606.ENSP00000331827.

Polymorphism and mutation databases

BioMutaⁱ	TNFAIP8L1.
DMDMⁱ	146325794.

Proteomic databases

EPDⁱ	Q8WVP5.
PaxDbⁱ	Q8WVP5.
PeptideAtlas More...PeptideAtlasⁱ	Q8WVP5.
PRIDEⁱ	Q8WVP5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000327473; ENSP00000331827; ENSG00000185361. ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneIDⁱ	126282.
KEGGⁱ	hsa:126282.
UCSC genome browser More...UCSCⁱ	uc002max.4. human.

Organism-specific databases

CTDⁱ	126282.
DisGeNET More...DisGeNETⁱ	126282.
GeneCardsⁱ	TNFAIP8L1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28279. TNFAIP8L1.
MIMⁱ	615869. gene.
neXtProtⁱ	NX_Q8WVP5.
Open Targets More...OpenTargetsⁱ	ENSG00000185361.
PharmGKBⁱ	PA142670722.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9. Eukaryota. ENOG4111KN4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003488.
HOGENOMⁱ	HOG000007708.
HOVERGENⁱ	HBG053286.
InParanoidⁱ	Q8WVP5.
OMAⁱ	FRKKVHT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QQ9.
PhylomeDBⁱ	Q8WVP5.
TreeFamⁱ	TF323415.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483255. PI Metabolism.

Reactomeⁱ

R-HSA-1483255. PI Metabolism.

Miscellaneous databases

ChiTaRSⁱ	TNFAIP8L1. human.
GenomeRNAiⁱ	126282.
Protein Ontology More...PROⁱ	PR:Q8WVP5.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185361.
CleanExⁱ	HS_TNFAIP8L1.
Genevisibleⁱ	Q8WVP5. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008477. DUF758.
PANTHERⁱ	PTHR12757. PTHR12757. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05527. DUF758. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TP8L1_HUMAN
Accessionⁱ	Q8WVP5Primary (citable) accession number: Q8WVP5 Secondary accession number(s): D6W627
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	June 7, 2017
	This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WVP5 (TP8L1_HUMAN)

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Tumor necrosis factor alpha-induced protein 8-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ