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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 1

Gene

TNFAIP8L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of mTOR activity.By similarity

GO - Biological processi

  1. negative regulation of TOR signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 1
Short name:
TIPE1By similarity
Short name:
TNF alpha-induced protein 8-like protein 1
Short name:
TNFAIP8-like protein 1
Alternative name(s):
Oxidative stress-regulated gene-beta1 Publication
Short name:
Oxy-beta1 Publication
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28279. TNFAIP8L1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Tumor necrosis factor alpha-induced protein 8-like protein 1PRO_0000285724Add
BLAST

Proteomic databases

PaxDbiQ8WVP5.
PRIDEiQ8WVP5.

Expressioni

Tissue specificityi

High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.1 Publication

Inductioni

Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.1 Publication

Gene expression databases

BgeeiQ8WVP5.
CleanExiHS_TNFAIP8L1.
GenevestigatoriQ8WVP5.

Interactioni

Subunit structurei

Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity

Protein-protein interaction databases

BioGridi125973. 6 interactions.
IntActiQ8WVP5. 1 interaction.
MINTiMINT-1448559.
STRINGi9606.ENSP00000331827.

Structurei

3D structure databases

ProteinModelPortaliQ8WVP5.
SMRiQ8WVP5. Positions 31-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGiNOG81900.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ8WVP5.
OMAiSRINHVF.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ8WVP5.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVP5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT
60 70 80 90 100
RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT
110 120 130 140 150
AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL
160 170 180
ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL
Length:186
Mass (Da):20,827
Last modified:May 1, 2007 - v2
Checksum:i352B0E7A2FB6D216
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181A → V.1 Publication
Corresponds to variant rs17851549 [ dbSNP | Ensembl ].
VAR_032048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005339 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69204.1.
CH471139 Genomic DNA. Translation: EAW69205.1.
BC017672 mRNA. Translation: AAH17672.1.
CCDSiCCDS12132.1.
RefSeqiNP_001161414.1. NM_001167942.1.
NP_689575.2. NM_152362.2.
XP_005259544.1. XM_005259487.1.
UniGeneiHs.465643.

Genome annotation databases

EnsembliENST00000327473; ENSP00000331827; ENSG00000185361.
ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneIDi126282.
KEGGihsa:126282.
UCSCiuc002max.3. human.

Polymorphism databases

DMDMi146325794.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005339 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69204.1.
CH471139 Genomic DNA. Translation: EAW69205.1.
BC017672 mRNA. Translation: AAH17672.1.
CCDSiCCDS12132.1.
RefSeqiNP_001161414.1. NM_001167942.1.
NP_689575.2. NM_152362.2.
XP_005259544.1. XM_005259487.1.
UniGeneiHs.465643.

3D structure databases

ProteinModelPortaliQ8WVP5.
SMRiQ8WVP5. Positions 31-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125973. 6 interactions.
IntActiQ8WVP5. 1 interaction.
MINTiMINT-1448559.
STRINGi9606.ENSP00000331827.

Polymorphism databases

DMDMi146325794.

Proteomic databases

PaxDbiQ8WVP5.
PRIDEiQ8WVP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327473; ENSP00000331827; ENSG00000185361.
ENST00000536716; ENSP00000444215; ENSG00000185361.
GeneIDi126282.
KEGGihsa:126282.
UCSCiuc002max.3. human.

Organism-specific databases

CTDi126282.
GeneCardsiGC19P004639.
HGNCiHGNC:28279. TNFAIP8L1.
MIMi615869. gene.
neXtProtiNX_Q8WVP5.
PharmGKBiPA142670722.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81900.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ8WVP5.
OMAiSRINHVF.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ8WVP5.
TreeFamiTF323415.

Miscellaneous databases

ChiTaRSiTNFAIP8L1. human.
GenomeRNAii126282.
NextBioi81749.
PROiQ8WVP5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WVP5.
CleanExiHS_TNFAIP8L1.
GenevestigatoriQ8WVP5.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
    Tissue: Lung.
  4. "The expression of TIPE1 in murine tissues and human cell lines."
    Cui J., Zhang G., Hao C., Wang Y., Lou Y., Zhang W., Wang J., Liu S.
    Mol. Immunol. 48:1548-1555(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model."
    Ha J.Y., Kim J.S., Kang Y.H., Bok E., Kim Y.S., Son J.H.
    J. Neurochem. 129:527-538(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiTP8L1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVP5
Secondary accession number(s): D6W627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.