TNFAIP8L1

Functionⁱ

Acts as a negative regulator of mTOR activity.By similarity

GO - Biological processⁱ

negative regulation of TOR signaling Source: UniProtKB
regulation of apoptotic process Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483255 PI Metabolism

Reactomeⁱ

R-HSA-1483255 PI Metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor alpha-induced protein 8-like protein 1 Short name: TIPE1By similarity Short name: TNF alpha-induced protein 8-like protein 1 Short name: TNFAIP8-like protein 1 Alternative name(s): Oxidative stress-regulated gene-beta1 Publication Short name: Oxy-beta1 Publication
Gene namesⁱ	Name:TNFAIP8L1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185361.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28279 TNFAIP8L1
MIMⁱ	615869 gene
neXtProtⁱ	NX_Q8WVP5

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	126282
Open Targets More...OpenTargetsⁱ	ENSG00000185361
PharmGKBⁱ	PA142670722

Polymorphism and mutation databases

BioMutaⁱ	TNFAIP8L1
DMDMⁱ	146325794

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285724	1 – 186	Tumor necrosis factor alpha-induced protein 8-like protein 1Add BLAST		186

Proteomic databases

EPDⁱ	Q8WVP5
PaxDbⁱ	Q8WVP5
PeptideAtlas More...PeptideAtlasⁱ	Q8WVP5
PRIDEⁱ	Q8WVP5

PTM databases

PhosphoSitePlusⁱ	Q8WVP5

PhosphoSitePlusⁱ

Q8WVP5

Expressionⁱ

Tissue specificityⁱ

High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.1 Publication

Inductionⁱ

Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000185361
CleanExⁱ	HS_TNFAIP8L1
Genevisibleⁱ	Q8WVP5 HS

Interactionⁱ

Subunit structureⁱ

Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DVL3	Q92997	3	EBI-752102,EBI-739789
PSME3	P61289	5	EBI-752102,EBI-355546

Show more details

Protein-protein interaction databases

BioGridⁱ	1259735 interactors.
IntActⁱ	Q8WVP5 11 interactors.
STRINGⁱ	9606.ENSP00000331827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WVP5
SMRⁱ	Q8WVP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9 Eukaryota ENOG4111KN4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003488
HOGENOMⁱ	HOG000007708
HOVERGENⁱ	HBG053286
InParanoidⁱ	Q8WVP5
OMAⁱ	FRKKVHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QQ9
PhylomeDBⁱ	Q8WVP5
TreeFamⁱ	TF323415

Family and domain databases

Gene3Dⁱ	1.20.1440.1601 hit
InterProⁱ	View protein in InterPro IPR008477 TNFAIP8-like IPR038355 TNFAIP8_sf
PANTHERⁱ	PTHR12757 PTHR12757, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05527 DUF758, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WVP5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT 
        60         70         80         90        100
RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT 
       110        120        130        140        150
AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL 
       160        170        180 
ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL

Length:186

Mass (Da):20,827

Last modified:May 1, 2007 - v2

Checksum:ⁱ352B0E7A2FB6D216

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032048	118	A → V1 PublicationCorresponds to variant dbSNP:rs17851549Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005339 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69204.1 CH471139 Genomic DNA Translation: EAW69205.1 BC017672 mRNA Translation: AAH17672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12132.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161414.1, NM_001167942.1 NP_689575.2, NM_152362.2 XP_005259544.1, XM_005259487.3 XP_011525982.1, XM_011527680.2
UniGeneⁱ	Hs.465643

Genome annotation databases

Ensemblⁱ	ENST00000327473; ENSP00000331827; ENSG00000185361 ENST00000536716; ENSP00000444215; ENSG00000185361
GeneIDⁱ	126282
KEGGⁱ	hsa:126282
UCSC genome browser More...UCSCⁱ	uc002max.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WVP5	H2R6G8 A0A2J8JR45 A0A2J8SBY5 H2NX36	Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	186	UniRef100_Q8WVP5	Cluster: Tumor necrosis factor alpha-induced protein 8-like protein 1	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WVP5	H2R6G8 A0A2J8JR45 A0A2J8SBY5 H2NX36 F7DXG7 A0A0A0MX21 A0A2K5KWE3 A0A2K6NGK9 A0A0D9SBU7 A0A2K6JSU8 +11	Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Callithrix jacchus (White-tufted-ear marmoset) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Colobus angolensis palliatus (Peters' Angolan colobus) Macaca mulatta (Rhesus macaque) And more	186	UniRef90_Q8WVP5	Cluster: Tumor necrosis factor alpha-induced protein 8-like protein 1	22

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WVP5	O95379 A0A2J8LK28 H2QRD4 A0A2I2ZF89 UPI0003440DA0 UPI000BB4DE27 UPI0002C449E7 UPI000CA083AE UPI0004ED57E7 UPI00077DAE20 +481	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Mustela putorius furo (European domestic ferret) (Mustela furo) Enhydra lutris kenyoni Trichechus manatus latirostris (Florida manatee) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Peromyscus maniculatus bairdii (Prairie deer mouse) Canis lupus familiaris (Dog) (Canis familiaris) Loxodonta africana (African elephant) And more	198	UniRef50_O95379	Cluster: Tumor necrosis factor alpha-induced protein 8	492

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005339 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69204.1 CH471139 Genomic DNA Translation: EAW69205.1 BC017672 mRNA Translation: AAH17672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12132.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161414.1, NM_001167942.1 NP_689575.2, NM_152362.2 XP_005259544.1, XM_005259487.3 XP_011525982.1, XM_011527680.2
UniGeneⁱ	Hs.465643

3D structure databases

ProteinModelPortalⁱ	Q8WVP5
SMRⁱ	Q8WVP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1259735 interactors.
IntActⁱ	Q8WVP5 11 interactors.
STRINGⁱ	9606.ENSP00000331827

PTM databases

PhosphoSitePlusⁱ	Q8WVP5

PhosphoSitePlusⁱ

Q8WVP5

Polymorphism and mutation databases

BioMutaⁱ	TNFAIP8L1
DMDMⁱ	146325794

Proteomic databases

EPDⁱ	Q8WVP5
PaxDbⁱ	Q8WVP5
PeptideAtlas More...PeptideAtlasⁱ	Q8WVP5
PRIDEⁱ	Q8WVP5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000327473; ENSP00000331827; ENSG00000185361 ENST00000536716; ENSP00000444215; ENSG00000185361
GeneIDⁱ	126282
KEGGⁱ	hsa:126282
UCSC genome browser More...UCSCⁱ	uc002max.4 human

Organism-specific databases

CTDⁱ	126282
DisGeNET More...DisGeNETⁱ	126282
EuPathDBⁱ	HostDB:ENSG00000185361.8
GeneCardsⁱ	TNFAIP8L1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28279 TNFAIP8L1
MIMⁱ	615869 gene
neXtProtⁱ	NX_Q8WVP5
Open Targets More...OpenTargetsⁱ	ENSG00000185361
PharmGKBⁱ	PA142670722
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9 Eukaryota ENOG4111KN4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003488
HOGENOMⁱ	HOG000007708
HOVERGENⁱ	HBG053286
InParanoidⁱ	Q8WVP5
OMAⁱ	FRKKVHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QQ9
PhylomeDBⁱ	Q8WVP5
TreeFamⁱ	TF323415

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483255 PI Metabolism

Reactomeⁱ

R-HSA-1483255 PI Metabolism

Miscellaneous databases

ChiTaRSⁱ	TNFAIP8L1 human
GenomeRNAiⁱ	126282
Protein Ontology More...PROⁱ	PR:Q8WVP5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185361
CleanExⁱ	HS_TNFAIP8L1
Genevisibleⁱ	Q8WVP5 HS

Family and domain databases

Gene3Dⁱ	1.20.1440.1601 hit
InterProⁱ	View protein in InterPro IPR008477 TNFAIP8-like IPR038355 TNFAIP8_sf
PANTHERⁱ	PTHR12757 PTHR12757, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05527 DUF758, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TP8L1_HUMAN
Accessionⁱ	Q8WVP5Primary (citable) accession number: Q8WVP5 Secondary accession number(s): D6W627
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	March 28, 2018
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WVP5 (TP8L1_HUMAN)

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Tumor necrosis factor alpha-induced protein 8-like protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ