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Q8WVP5

- TP8L1_HUMAN

UniProt

Q8WVP5 - TP8L1_HUMAN

Protein

Tumor necrosis factor alpha-induced protein 8-like protein 1

Gene

TNFAIP8L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 1
    Short name:
    TNF alpha-induced protein 8-like protein 1
    Short name:
    TNFAIP8-like protein 1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28279. TNFAIP8L1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670722.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Tumor necrosis factor alpha-induced protein 8-like protein 1PRO_0000285724Add
    BLAST

    Proteomic databases

    PaxDbiQ8WVP5.
    PRIDEiQ8WVP5.

    Expressioni

    Gene expression databases

    BgeeiQ8WVP5.
    CleanExiHS_TNFAIP8L1.
    GenevestigatoriQ8WVP5.

    Interactioni

    Protein-protein interaction databases

    BioGridi125973. 5 interactions.
    IntActiQ8WVP5. 1 interaction.
    MINTiMINT-1448559.
    STRINGi9606.ENSP00000331827.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVP5.
    SMRiQ8WVP5. Positions 31-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TNFAIP8 family.Curated

    Phylogenomic databases

    eggNOGiNOG81900.
    HOGENOMiHOG000007708.
    HOVERGENiHBG053286.
    InParanoidiQ8WVP5.
    OMAiSRINHVF.
    OrthoDBiEOG7P5T2H.
    PhylomeDBiQ8WVP5.
    TreeFamiTF323415.

    Family and domain databases

    InterProiIPR008477. DUF758.
    [Graphical view]
    PANTHERiPTHR12757. PTHR12757. 1 hit.
    PfamiPF05527. DUF758. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WVP5-1 [UniParc]FASTAAdd to Basket

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    MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT    50
    RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT 100
    AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL 150
    ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL 186
    Length:186
    Mass (Da):20,827
    Last modified:May 1, 2007 - v2
    Checksum:i352B0E7A2FB6D216
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181A → V.1 Publication
    Corresponds to variant rs17851549 [ dbSNP | Ensembl ].
    VAR_032048

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005339 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69204.1.
    CH471139 Genomic DNA. Translation: EAW69205.1.
    BC017672 mRNA. Translation: AAH17672.1.
    CCDSiCCDS12132.1.
    RefSeqiNP_001161414.1. NM_001167942.1.
    NP_689575.2. NM_152362.2.
    XP_005259544.1. XM_005259487.1.
    UniGeneiHs.465643.

    Genome annotation databases

    EnsembliENST00000327473; ENSP00000331827; ENSG00000185361.
    ENST00000536716; ENSP00000444215; ENSG00000185361.
    GeneIDi126282.
    KEGGihsa:126282.
    UCSCiuc002max.3. human.

    Polymorphism databases

    DMDMi146325794.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005339 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69204.1 .
    CH471139 Genomic DNA. Translation: EAW69205.1 .
    BC017672 mRNA. Translation: AAH17672.1 .
    CCDSi CCDS12132.1.
    RefSeqi NP_001161414.1. NM_001167942.1.
    NP_689575.2. NM_152362.2.
    XP_005259544.1. XM_005259487.1.
    UniGenei Hs.465643.

    3D structure databases

    ProteinModelPortali Q8WVP5.
    SMRi Q8WVP5. Positions 31-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125973. 5 interactions.
    IntActi Q8WVP5. 1 interaction.
    MINTi MINT-1448559.
    STRINGi 9606.ENSP00000331827.

    Polymorphism databases

    DMDMi 146325794.

    Proteomic databases

    PaxDbi Q8WVP5.
    PRIDEi Q8WVP5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327473 ; ENSP00000331827 ; ENSG00000185361 .
    ENST00000536716 ; ENSP00000444215 ; ENSG00000185361 .
    GeneIDi 126282.
    KEGGi hsa:126282.
    UCSCi uc002max.3. human.

    Organism-specific databases

    CTDi 126282.
    GeneCardsi GC19P004639.
    HGNCi HGNC:28279. TNFAIP8L1.
    neXtProti NX_Q8WVP5.
    PharmGKBi PA142670722.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81900.
    HOGENOMi HOG000007708.
    HOVERGENi HBG053286.
    InParanoidi Q8WVP5.
    OMAi SRINHVF.
    OrthoDBi EOG7P5T2H.
    PhylomeDBi Q8WVP5.
    TreeFami TF323415.

    Miscellaneous databases

    GenomeRNAii 126282.
    NextBioi 81749.
    PROi Q8WVP5.

    Gene expression databases

    Bgeei Q8WVP5.
    CleanExi HS_TNFAIP8L1.
    Genevestigatori Q8WVP5.

    Family and domain databases

    InterProi IPR008477. DUF758.
    [Graphical view ]
    PANTHERi PTHR12757. PTHR12757. 1 hit.
    Pfami PF05527. DUF758. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
      Tissue: Lung.

    Entry informationi

    Entry nameiTP8L1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVP5
    Secondary accession number(s): D6W627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3