Q8WVN6 (SCTM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secreted and transmembrane protein 1

Alternative name(s):
Protein K-12

Gene names

Name:	SECTM1
Synonyms:	K12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in thymocyte signaling. Ref.6
Subunit structure	Interacts with CD7. Ref.5 Ref.6
Subcellular location	Cell membrane; Single-pass type I membrane protein Probable. Secreted Ref.1 Ref.5.
Tissue specificity	Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts. Ref.1 Ref.6
Induction	By IFNG/IFN-gamma (at protein level). Ref.6
Sequence similarities	Belongs to the SECTM family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Traceable author statement Ref.1. Source: ProtInc mesoderm development Traceable author statement Ref.1. Source: ProtInc positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Cellular_component	Golgi apparatus Traceable author statement Ref.1. Source: ProtInc extracellular space Traceable author statement Ref.1. Source: ProtInc integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytokine activity Traceable author statement Ref.1. Source: ProtInc signal transducer activity Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 248	220	Secreted and transmembrane protein 1		PRO_0000022286
Regions
	Topological domain	29 – 145	117	Extracellular Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Topological domain	167 – 248	82	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Disulfide bond	38 ↔ 55		Potential
Experimental info
	Sequence conflict	191	1	V → F in AAH17716. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8WVN6 [UniParc]. Last modified November 8, 2002. Version 2. Checksum: 21E3066B67920487	FASTA	248	27,039
	10 20 30 40 50 60 MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA 70 80 90 100 110 120 FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV 130 140 150 160 170 180 GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK 190 200 210 220 230 240 KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP LFPYAADP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms." Slentz-Kesler K.A., Hale L.P., Kaufman R.E. Genomics 47:327-340(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"Identification of CD7 as a cognate of the human K12 (SECTM1) protein." Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C. J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CD7, SUBCELLULAR LOCATION.
[6]	"Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma." Lam G.K., Liao H.X., Xue Y., Alam S.M., Scearce R.M., Kaufman R.E., Sempowski G.D., Haynes B.F. J. Clin. Immunol. 25:41-49(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CD7, TISSUE SPECIFICITY, INDUCTION BY IFNG, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77643 mRNA. Translation: AAC52044.1. AK312980 mRNA. Translation: BAG35817.1. CH471099 Genomic DNA. Translation: EAW89766.1. BC017716 mRNA. Translation: AAH17716.1.
IPI	IPI00170635.
RefSeq	NP_002995.1. NM_003004.2.
UniGene	Hs.558009.
3D structure databases
ProteinModelPortal	Q8WVN6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WVN6. 1 interaction.
PTM databases
PhosphoSite	Q8WVN6.
Polymorphism databases
DMDM	25009245.
Proteomic databases
PaxDb	Q8WVN6.
PeptideAtlas	Q8WVN6.
PRIDE	Q8WVN6.
Protocols and materials databases
DNASU	6398.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269389; ENSP00000269389; ENSG00000141574.
GeneID	6398.
KEGG	hsa:6398.
UCSC	uc002keo.3. human.
Organism-specific databases
CTD	6398.
GeneCards	GC17M080278.
HGNC	HGNC:10707. SECTM1.
HPA	HPA051214.
MIM	602602. gene.
neXtProt	NX_Q8WVN6.
PharmGKB	PA35630.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38953.
HOGENOM	HOG000231222.
HOVERGEN	HBG061092.
InParanoid	Q8WVN6.
OMA	CNISNAF.
OrthoDB	EOG4Z36FK.
PhylomeDB	Q8WVN6.
Gene expression databases
Bgee	Q8WVN6.
CleanEx	HS_SECTM1.
Genevestigator	Q8WVN6.
GermOnline	ENSG00000141574. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	6398.
NextBio	24856.
SOURCE	Search...

Entry information

Entry name

SCTM1_HUMAN

Accession

Primary (citable) accession number: Q8WVN6
Secondary accession number(s): B2R7H0, O00466

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.