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Q8WVN6

- SCTM1_HUMAN

UniProt

Q8WVN6 - SCTM1_HUMAN

Protein

Secreted and transmembrane protein 1

Gene

SECTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (08 Nov 2002)
      Previous versions | rss
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    Functioni

    May be involved in thymocyte signaling.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: ProtInc
    2. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. immune response Source: ProtInc
    2. mesoderm development Source: ProtInc
    3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    4. signal transduction Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted and transmembrane protein 1
    Alternative name(s):
    Protein K-12
    Gene namesi
    Name:SECTM1
    Synonyms:K12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10707. SECTM1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi apparatus Source: ProtInc
    4. integral component of membrane Source: ProtInc
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35630.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 248220Secreted and transmembrane protein 1PRO_0000022286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 55Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8WVN6.
    PaxDbiQ8WVN6.
    PeptideAtlasiQ8WVN6.
    PRIDEiQ8WVN6.

    PTM databases

    PhosphoSiteiQ8WVN6.

    Expressioni

    Tissue specificityi

    Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.2 Publications

    Inductioni

    By IFNG/IFN-gamma (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ8WVN6.
    BgeeiQ8WVN6.
    CleanExiHS_SECTM1.
    GenevestigatoriQ8WVN6.

    Organism-specific databases

    HPAiHPA051214.

    Interactioni

    Subunit structurei

    Interacts with CD7.2 Publications

    Protein-protein interaction databases

    BioGridi112298. 3 interactions.
    IntActiQ8WVN6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 145117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 24882CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SECTM family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38953.
    HOGENOMiHOG000231222.
    HOVERGENiHBG061092.
    InParanoidiQ8WVN6.
    OMAiMFAWYRC.
    OrthoDBiEOG71RXKJ.
    PhylomeDBiQ8WVN6.
    TreeFamiTF336992.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WVN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN    50
    TVMSCNISNA FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA 100
    QLVIKGARDS HAGLYMWHLV GHQRNNRQVT LEVSGAEPQS APDTGFWPVP 150
    AVVTAVFILL VALVMFAWYR CRCSQQRREK KFFLLEPQMK VAALRAGAQQ 200
    GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP LFPYAADP 248
    Length:248
    Mass (Da):27,039
    Last modified:November 8, 2002 - v2
    Checksum:i21E3066B67920487
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911V → F in AAH17716. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77643 mRNA. Translation: AAC52044.1.
    AK312980 mRNA. Translation: BAG35817.1.
    CH471099 Genomic DNA. Translation: EAW89766.1.
    BC017716 mRNA. Translation: AAH17716.1.
    CCDSiCCDS11808.1.
    RefSeqiNP_002995.1. NM_003004.2.
    XP_005256449.1. XM_005256392.2.
    UniGeneiHs.558009.

    Genome annotation databases

    EnsembliENST00000269389; ENSP00000269389; ENSG00000141574.
    GeneIDi6398.
    KEGGihsa:6398.
    UCSCiuc002keo.3. human.

    Polymorphism databases

    DMDMi25009245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77643 mRNA. Translation: AAC52044.1 .
    AK312980 mRNA. Translation: BAG35817.1 .
    CH471099 Genomic DNA. Translation: EAW89766.1 .
    BC017716 mRNA. Translation: AAH17716.1 .
    CCDSi CCDS11808.1.
    RefSeqi NP_002995.1. NM_003004.2.
    XP_005256449.1. XM_005256392.2.
    UniGenei Hs.558009.

    3D structure databases

    ProteinModelPortali Q8WVN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112298. 3 interactions.
    IntActi Q8WVN6. 1 interaction.

    PTM databases

    PhosphoSitei Q8WVN6.

    Polymorphism databases

    DMDMi 25009245.

    Proteomic databases

    MaxQBi Q8WVN6.
    PaxDbi Q8WVN6.
    PeptideAtlasi Q8WVN6.
    PRIDEi Q8WVN6.

    Protocols and materials databases

    DNASUi 6398.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269389 ; ENSP00000269389 ; ENSG00000141574 .
    GeneIDi 6398.
    KEGGi hsa:6398.
    UCSCi uc002keo.3. human.

    Organism-specific databases

    CTDi 6398.
    GeneCardsi GC17M080278.
    HGNCi HGNC:10707. SECTM1.
    HPAi HPA051214.
    MIMi 602602. gene.
    neXtProti NX_Q8WVN6.
    PharmGKBi PA35630.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38953.
    HOGENOMi HOG000231222.
    HOVERGENi HBG061092.
    InParanoidi Q8WVN6.
    OMAi MFAWYRC.
    OrthoDBi EOG71RXKJ.
    PhylomeDBi Q8WVN6.
    TreeFami TF336992.

    Miscellaneous databases

    GeneWikii SECTM1.
    GenomeRNAii 6398.
    NextBioi 24856.
    PROi Q8WVN6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WVN6.
    Bgeei Q8WVN6.
    CleanExi HS_SECTM1.
    Genevestigatori Q8WVN6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms."
      Slentz-Kesler K.A., Hale L.P., Kaufman R.E.
      Genomics 47:327-340(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Urinary bladder.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    5. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
      Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
      J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD7, SUBCELLULAR LOCATION.
    6. "Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma."
      Lam G.K., Liao H.X., Xue Y., Alam S.M., Scearce R.M., Kaufman R.E., Sempowski G.D., Haynes B.F.
      J. Clin. Immunol. 25:41-49(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD7, TISSUE SPECIFICITY, INDUCTION BY IFNG, FUNCTION.

    Entry informationi

    Entry nameiSCTM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVN6
    Secondary accession number(s): B2R7H0, O00466
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3