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Q8WVN6 (SCTM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secreted and transmembrane protein 1
Alternative name(s):
Protein K-12
Gene names
Name:SECTM1
Synonyms:K12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in thymocyte signaling. Ref.6

Subunit structure

Interacts with CD7. Ref.5 Ref.6

Subcellular location

Cell membrane; Single-pass type I membrane protein Probable. Secreted Ref.1 Ref.5.

Tissue specificity

Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts. Ref.1 Ref.6

Induction

By IFNG/IFN-gamma (at protein level). Ref.6

Sequence similarities

Belongs to the SECTM family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 248220Secreted and transmembrane protein 1
PRO_0000022286

Regions

Topological domain29 – 145117Extracellular Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 24882Cytoplasmic Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 55 Potential

Experimental info

Sequence conflict1911V → F in AAH17716. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8WVN6 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: 21E3066B67920487

FASTA24827,039
        10         20         30         40         50         60 
MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA 

        70         80         90        100        110        120 
FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV 

       130        140        150        160        170        180 
GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK 

       190        200        210        220        230        240 
KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP 


LFPYAADP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms."
Slentz-Kesler K.A., Hale L.P., Kaufman R.E.
Genomics 47:327-340(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Urinary bladder.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[5]"Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CD7, SUBCELLULAR LOCATION.
[6]"Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma."
Lam G.K., Liao H.X., Xue Y., Alam S.M., Scearce R.M., Kaufman R.E., Sempowski G.D., Haynes B.F.
J. Clin. Immunol. 25:41-49(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CD7, TISSUE SPECIFICITY, INDUCTION BY IFNG, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77643 mRNA. Translation: AAC52044.1.
AK312980 mRNA. Translation: BAG35817.1.
CH471099 Genomic DNA. Translation: EAW89766.1.
BC017716 mRNA. Translation: AAH17716.1.
CCDSCCDS11808.1.
RefSeqNP_002995.1. NM_003004.2.
XP_005256449.1. XM_005256392.2.
UniGeneHs.558009.

3D structure databases

ProteinModelPortalQ8WVN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112298. 3 interactions.
IntActQ8WVN6. 1 interaction.

PTM databases

PhosphoSiteQ8WVN6.

Polymorphism databases

DMDM25009245.

Proteomic databases

MaxQBQ8WVN6.
PaxDbQ8WVN6.
PeptideAtlasQ8WVN6.
PRIDEQ8WVN6.

Protocols and materials databases

DNASU6398.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269389; ENSP00000269389; ENSG00000141574.
GeneID6398.
KEGGhsa:6398.
UCSCuc002keo.3. human.

Organism-specific databases

CTD6398.
GeneCardsGC17M080278.
HGNCHGNC:10707. SECTM1.
HPAHPA051214.
MIM602602. gene.
neXtProtNX_Q8WVN6.
PharmGKBPA35630.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38953.
HOGENOMHOG000231222.
HOVERGENHBG061092.
InParanoidQ8WVN6.
OMAMFAWYRC.
OrthoDBEOG71RXKJ.
PhylomeDBQ8WVN6.
TreeFamTF336992.

Gene expression databases

ArrayExpressQ8WVN6.
BgeeQ8WVN6.
CleanExHS_SECTM1.
GenevestigatorQ8WVN6.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiSECTM1.
GenomeRNAi6398.
NextBio24856.
PROQ8WVN6.
SOURCESearch...

Entry information

Entry nameSCTM1_HUMAN
AccessionPrimary (citable) accession number: Q8WVN6
Secondary accession number(s): B2R7H0, O00466
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM