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Q8WVN6

- SCTM1_HUMAN

UniProt

Q8WVN6 - SCTM1_HUMAN

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Protein

Secreted and transmembrane protein 1

Gene

SECTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in thymocyte signaling.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: ProtInc
  2. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. immune response Source: ProtInc
  2. mesoderm development Source: ProtInc
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  4. signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted and transmembrane protein 1
Alternative name(s):
Protein K-12
Gene namesi
Name:SECTM1
Synonyms:K12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10707. SECTM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 145117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 24882CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: ProtInc
  2. extracellular vesicular exosome Source: UniProtKB
  3. Golgi apparatus Source: ProtInc
  4. integral component of membrane Source: ProtInc
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 248220Secreted and transmembrane protein 1PRO_0000022286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 55Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8WVN6.
PaxDbiQ8WVN6.
PeptideAtlasiQ8WVN6.
PRIDEiQ8WVN6.

PTM databases

PhosphoSiteiQ8WVN6.

Expressioni

Tissue specificityi

Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.2 Publications

Inductioni

By IFNG/IFN-gamma (at protein level).1 Publication

Gene expression databases

BgeeiQ8WVN6.
CleanExiHS_SECTM1.
ExpressionAtlasiQ8WVN6. baseline and differential.
GenevestigatoriQ8WVN6.

Organism-specific databases

HPAiHPA051214.

Interactioni

Subunit structurei

Interacts with CD7.2 Publications

Protein-protein interaction databases

BioGridi112298. 3 interactions.
IntActiQ8WVN6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8WVN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SECTM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38953.
GeneTreeiENSGT00530000064499.
HOGENOMiHOG000231222.
HOVERGENiHBG061092.
InParanoidiQ8WVN6.
OMAiMFAWYRC.
OrthoDBiEOG71RXKJ.
PhylomeDBiQ8WVN6.
TreeFamiTF336992.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN
60 70 80 90 100
TVMSCNISNA FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA
110 120 130 140 150
QLVIKGARDS HAGLYMWHLV GHQRNNRQVT LEVSGAEPQS APDTGFWPVP
160 170 180 190 200
AVVTAVFILL VALVMFAWYR CRCSQQRREK KFFLLEPQMK VAALRAGAQQ
210 220 230 240
GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP LFPYAADP
Length:248
Mass (Da):27,039
Last modified:November 8, 2002 - v2
Checksum:i21E3066B67920487
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911V → F in AAH17716. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77643 mRNA. Translation: AAC52044.1.
AK312980 mRNA. Translation: BAG35817.1.
CH471099 Genomic DNA. Translation: EAW89766.1.
BC017716 mRNA. Translation: AAH17716.1.
CCDSiCCDS11808.1.
RefSeqiNP_002995.1. NM_003004.2.
XP_005256449.1. XM_005256392.2.
UniGeneiHs.558009.

Genome annotation databases

EnsembliENST00000269389; ENSP00000269389; ENSG00000141574.
GeneIDi6398.
KEGGihsa:6398.
UCSCiuc002keo.3. human.

Polymorphism databases

DMDMi25009245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77643 mRNA. Translation: AAC52044.1 .
AK312980 mRNA. Translation: BAG35817.1 .
CH471099 Genomic DNA. Translation: EAW89766.1 .
BC017716 mRNA. Translation: AAH17716.1 .
CCDSi CCDS11808.1.
RefSeqi NP_002995.1. NM_003004.2.
XP_005256449.1. XM_005256392.2.
UniGenei Hs.558009.

3D structure databases

ProteinModelPortali Q8WVN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112298. 3 interactions.
IntActi Q8WVN6. 1 interaction.

PTM databases

PhosphoSitei Q8WVN6.

Polymorphism databases

DMDMi 25009245.

Proteomic databases

MaxQBi Q8WVN6.
PaxDbi Q8WVN6.
PeptideAtlasi Q8WVN6.
PRIDEi Q8WVN6.

Protocols and materials databases

DNASUi 6398.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269389 ; ENSP00000269389 ; ENSG00000141574 .
GeneIDi 6398.
KEGGi hsa:6398.
UCSCi uc002keo.3. human.

Organism-specific databases

CTDi 6398.
GeneCardsi GC17M080278.
HGNCi HGNC:10707. SECTM1.
HPAi HPA051214.
MIMi 602602. gene.
neXtProti NX_Q8WVN6.
PharmGKBi PA35630.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38953.
GeneTreei ENSGT00530000064499.
HOGENOMi HOG000231222.
HOVERGENi HBG061092.
InParanoidi Q8WVN6.
OMAi MFAWYRC.
OrthoDBi EOG71RXKJ.
PhylomeDBi Q8WVN6.
TreeFami TF336992.

Miscellaneous databases

ChiTaRSi SECTM1. human.
GeneWikii SECTM1.
GenomeRNAii 6398.
NextBioi 24856.
PROi Q8WVN6.
SOURCEi Search...

Gene expression databases

Bgeei Q8WVN6.
CleanExi HS_SECTM1.
ExpressionAtlasi Q8WVN6. baseline and differential.
Genevestigatori Q8WVN6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms."
    Slentz-Kesler K.A., Hale L.P., Kaufman R.E.
    Genomics 47:327-340(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
    Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
    J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD7, SUBCELLULAR LOCATION.
  6. "Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma."
    Lam G.K., Liao H.X., Xue Y., Alam S.M., Scearce R.M., Kaufman R.E., Sempowski G.D., Haynes B.F.
    J. Clin. Immunol. 25:41-49(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD7, TISSUE SPECIFICITY, INDUCTION BY IFNG, FUNCTION.

Entry informationi

Entry nameiSCTM1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVN6
Secondary accession number(s): B2R7H0, O00466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3