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Q8WVM8

- SCFD1_HUMAN

UniProt

Q8WVM8 - SCFD1_HUMAN

Protein

Sec1 family domain-containing protein 1

Gene

SCFD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. syntaxin binding Source: UniProtKB

    GO - Biological processi

    1. post-Golgi vesicle-mediated transport Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
    4. response to hypoxia Source: Ensembl
    5. response to toxic substance Source: UniProtKB
    6. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
    7. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sec1 family domain-containing protein 1
    Alternative name(s):
    SLY1 homolog
    Short name:
    Sly1p
    Syntaxin-binding protein 1-like 2
    Gene namesi
    Name:SCFD1
    Synonyms:C14orf163, KIAA0917, STXBP1L2
    ORF Names:FKSG23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20726. SCFD1.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi-associated vesicle Source: UniProtKB
    4. Golgi cisterna membrane Source: UniProtKB-SubCell
    5. Golgi transport complex Source: Ensembl
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134946073.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed5 Publications
    Chaini2 – 642641Sec1 family domain-containing protein 1PRO_0000206287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine4 Publications
    Modified residuei303 – 3031Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WVM8.
    PaxDbiQ8WVM8.
    PRIDEiQ8WVM8.

    PTM databases

    PhosphoSiteiQ8WVM8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WVM8.
    BgeeiQ8WVM8.
    CleanExiHS_SCFD1.
    GenevestigatoriQ8WVM8.

    Organism-specific databases

    HPAiHPA003579.

    Interactioni

    Subunit structurei

    Interacts with STX17. Interacts with STX5A. Interacts with the COG complex via COG4 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COG4Q9H9E310EBI-722569,EBI-368382

    Protein-protein interaction databases

    BioGridi116860. 30 interactions.
    IntActiQ8WVM8. 10 interactions.
    MINTiMINT-1394008.
    STRINGi9606.ENSP00000390783.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVM8.
    SMRiQ8WVM8. Positions 13-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 1312Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the STXBP/unc-18/SEC1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5158.
    HOVERGENiHBG061536.
    OMAiKGKQGKH.
    PhylomeDBiQ8WVM8.
    TreeFamiTF105740.

    Family and domain databases

    Gene3Di3.40.50.1910. 2 hits.
    InterProiIPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view]
    PANTHERiPTHR11679. PTHR11679. 1 hit.
    PfamiPF00995. Sec1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMiSSF56815. SSF56815. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WVM8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR    50
    FGQDIISPLL SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID 100
    RMCQDLRNQL YESYYLNFIS AISRSKLEDI ANAALAASAV TQVAKVFDQY 150
    LNFITLEDDM FVLCNQNKEL VSYRAINRPD ITDTEMETVM DTIVDSLFCF 200
    FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL FTGDTLGAGQ 250
    FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV 300
    ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA 350
    QEDEVKRLKS IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID 400
    LHTNVATAVL EHIKARKLDV YFEYEEKIMS KTTLDKSLLD IISDPDAGTP 450
    EDKMRLFLIY YISTQQAPSE ADLEQYKKAL TDAGCNLNPL QYIKQWKAFT 500
    KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL KQQNLPVTRI 550
    LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN 600
    YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK 642
    Length:642
    Mass (Da):72,380
    Last modified:January 23, 2007 - v4
    Checksum:i0340FB9F05CD24CE
    GO
    Isoform 2 (identifier: Q8WVM8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-92: Missing.

    Show »
    Length:550
    Mass (Da):62,260
    Checksum:iB920BFF92CE3533B
    GO
    Isoform 3 (identifier: Q8WVM8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.

    Show »
    Length:575
    Mass (Da):65,061
    Checksum:iD661C294F7170C05
    GO

    Sequence cautioni

    The sequence AAD40381.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAD48586.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAP97146.1 differs from that shown. Reason: Frameshift at position 5.
    The sequence BAA74940.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421V → I in AAG50273. 1 PublicationCurated
    Sequence conflicti136 – 1372AA → EL in AAD40381. 1 PublicationCurated
    Sequence conflicti201 – 2066FVTLGA → YGTRGD in AAD48586. 1 PublicationCurated
    Sequence conflicti201 – 2022FV → YG in AAD40381. 1 PublicationCurated
    Sequence conflicti201 – 2022FV → YG in AAP97146. 1 PublicationCurated
    Sequence conflicti206 – 2061A → D in AAP97146. 1 PublicationCurated
    Sequence conflicti453 – 4531K → N in AAD48586. 1 PublicationCurated
    Sequence conflicti484 – 4852GC → EM in AAD40381. 1 PublicationCurated
    Sequence conflicti485 – 4851Missing in AAD48586. 1 PublicationCurated
    Sequence conflicti562 – 5632ET → KL in AAD40381. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631K → R.2 Publications
    Corresponds to variant rs229150 [ dbSNP | Ensembl ].
    VAR_019616

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_047070Add
    BLAST
    Alternative sequencei1 – 6767Missing in isoform 3. 1 PublicationVSP_047071Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020724 mRNA. Translation: BAA74940.2. Different initiation.
    AF092139 mRNA. Translation: AAD40381.1. Frameshift.
    AF110646 mRNA. Translation: AAD48586.1. Frameshift.
    AF319958 mRNA. Translation: AAG50273.1.
    AF086916 mRNA. Translation: AAP97146.1. Frameshift.
    AK290410 mRNA. Translation: BAF83099.1.
    AK298622 mRNA. Translation: BAH12830.1.
    AK297873 mRNA. Translation: BAH12683.1.
    AK316212 mRNA. Translation: BAH14583.1.
    AL121852 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65968.1.
    BC017734 mRNA. Translation: AAH17734.1.
    AF067205 mRNA. Translation: AAC17907.1.
    CCDSiCCDS45092.1. [Q8WVM8-3]
    CCDS58308.1. [Q8WVM8-2]
    CCDS9639.1. [Q8WVM8-1]
    RefSeqiNP_001244305.1. NM_001257376.1. [Q8WVM8-2]
    NP_001269961.1. NM_001283032.1.
    NP_057190.2. NM_016106.3. [Q8WVM8-1]
    NP_878255.1. NM_182835.2. [Q8WVM8-3]
    UniGeneiHs.369168.

    Genome annotation databases

    EnsembliENST00000396629; ENSP00000379870; ENSG00000092108. [Q8WVM8-2]
    ENST00000458591; ENSP00000390783; ENSG00000092108. [Q8WVM8-1]
    ENST00000544052; ENSP00000443010; ENSG00000092108. [Q8WVM8-3]
    GeneIDi23256.
    KEGGihsa:23256.
    UCSCiuc001wqm.2. human. [Q8WVM8-1]

    Polymorphism databases

    DMDMi51316882.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020724 mRNA. Translation: BAA74940.2 . Different initiation.
    AF092139 mRNA. Translation: AAD40381.1 . Frameshift.
    AF110646 mRNA. Translation: AAD48586.1 . Frameshift.
    AF319958 mRNA. Translation: AAG50273.1 .
    AF086916 mRNA. Translation: AAP97146.1 . Frameshift.
    AK290410 mRNA. Translation: BAF83099.1 .
    AK298622 mRNA. Translation: BAH12830.1 .
    AK297873 mRNA. Translation: BAH12683.1 .
    AK316212 mRNA. Translation: BAH14583.1 .
    AL121852 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65968.1 .
    BC017734 mRNA. Translation: AAH17734.1 .
    AF067205 mRNA. Translation: AAC17907.1 .
    CCDSi CCDS45092.1. [Q8WVM8-3 ]
    CCDS58308.1. [Q8WVM8-2 ]
    CCDS9639.1. [Q8WVM8-1 ]
    RefSeqi NP_001244305.1. NM_001257376.1. [Q8WVM8-2 ]
    NP_001269961.1. NM_001283032.1.
    NP_057190.2. NM_016106.3. [Q8WVM8-1 ]
    NP_878255.1. NM_182835.2. [Q8WVM8-3 ]
    UniGenei Hs.369168.

    3D structure databases

    ProteinModelPortali Q8WVM8.
    SMRi Q8WVM8. Positions 13-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116860. 30 interactions.
    IntActi Q8WVM8. 10 interactions.
    MINTi MINT-1394008.
    STRINGi 9606.ENSP00000390783.

    PTM databases

    PhosphoSitei Q8WVM8.

    Polymorphism databases

    DMDMi 51316882.

    Proteomic databases

    MaxQBi Q8WVM8.
    PaxDbi Q8WVM8.
    PRIDEi Q8WVM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396629 ; ENSP00000379870 ; ENSG00000092108 . [Q8WVM8-2 ]
    ENST00000458591 ; ENSP00000390783 ; ENSG00000092108 . [Q8WVM8-1 ]
    ENST00000544052 ; ENSP00000443010 ; ENSG00000092108 . [Q8WVM8-3 ]
    GeneIDi 23256.
    KEGGi hsa:23256.
    UCSCi uc001wqm.2. human. [Q8WVM8-1 ]

    Organism-specific databases

    CTDi 23256.
    GeneCardsi GC14P031091.
    HGNCi HGNC:20726. SCFD1.
    HPAi HPA003579.
    neXtProti NX_Q8WVM8.
    PharmGKBi PA134946073.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5158.
    HOVERGENi HBG061536.
    OMAi KGKQGKH.
    PhylomeDBi Q8WVM8.
    TreeFami TF105740.

    Miscellaneous databases

    ChiTaRSi SCFD1. human.
    GeneWikii SCFD1.
    GenomeRNAii 23256.
    NextBioi 44982.
    PROi Q8WVM8.

    Gene expression databases

    ArrayExpressi Q8WVM8.
    Bgeei Q8WVM8.
    CleanExi HS_SCFD1.
    Genevestigatori Q8WVM8.

    Family and domain databases

    Gene3Di 3.40.50.1910. 2 hits.
    InterProi IPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view ]
    PANTHERi PTHR11679. PTHR11679. 1 hit.
    Pfami PF00995. Sec1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMi SSF56815. SSF56815. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Human vesicle transport-related protein gene."
      Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    3. "Identification of FKSG23, a vesicle transport-related protein."
      Wang Y.-G., Gong L.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cloning of a novel human cDNA homology to R.norvegicus rsly1p mRNA."
      Dai F.Y., Yu L., Ding J.B., Lin W., Yang Y.M., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ARG-63.
      Tissue: Heart and Umbilical cord blood.
    6. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-63.
      Tissue: Lymph.
    9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16.
      Tissue: Platelet.
    10. Bienvenut W.V., Gao M., Leug H., Campbell A., Ozanne B.W.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-16; 125-145; 382-395 AND 502-536, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Foreskin fibroblast and Prostatic carcinoma.
    11. "Differential display of placental genes."
      Page N.M., Butlin D.J., Manyonda I., Bicknell A.B., Lowry P.J.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 572-642.
      Tissue: Placenta.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCFD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVM8
    Secondary accession number(s): A8K2Z5
    , B7Z4U7, B7Z594, O60754, O94990, Q7Z529, Q9BZI3, Q9UNL3, Q9Y6A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 121 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3