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Q8WVL7

- ANR49_HUMAN

UniProt

Q8WVL7 - ANR49_HUMAN

Protein

Ankyrin repeat domain-containing protein 49

Gene

ANKRD49

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 49
    Alternative name(s):
    Fetal globin-inducing factor
    Gene namesi
    Name:ANKRD49
    Synonyms:FGIF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25970. ANKRD49.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672615.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Ankyrin repeat domain-containing protein 49PRO_0000244585Add
    BLAST

    Proteomic databases

    MaxQBiQ8WVL7.
    PaxDbiQ8WVL7.
    PRIDEiQ8WVL7.

    PTM databases

    PhosphoSiteiQ8WVL7.

    Expressioni

    Tissue specificityi

    Widely expressed in fetus, at a high level in fetal liver, brain and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ8WVL7.
    BgeeiQ8WVL7.
    CleanExiHS_ANKRD49.
    GenevestigatoriQ8WVL7.

    Organism-specific databases

    HPAiHPA040273.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FKBPLQ9UIM32EBI-9381820,EBI-719882

    Protein-protein interaction databases

    IntActiQ8WVL7. 1 interaction.
    STRINGi9606.ENSP00000303518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVL7.
    SMRiQ8WVL7. Positions 8-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati73 – 10331ANK 1Add
    BLAST
    Repeati107 – 13630ANK 2Add
    BLAST
    Repeati140 – 16930ANK 3Add
    BLAST
    Repeati173 – 20634ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000021411.
    HOVERGENiHBG054416.
    InParanoidiQ8WVL7.
    OMAiLHSACRW.
    OrthoDBiEOG7R832G.
    PhylomeDBiQ8WVL7.
    TreeFamiTF351259.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WVL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD    50
    EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH 100
    VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK 150
    WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV 200
    KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS 239
    Length:239
    Mass (Da):27,290
    Last modified:March 1, 2002 - v1
    Checksum:i97103467E8F1EA50
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251N → S in AAK60412. (PubMed:11162141)Curated
    Sequence conflicti201 – 2011K → R in BAA91003. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025354 mRNA. Translation: AAK60412.1.
    AK000196 mRNA. Translation: BAA91003.1.
    AL833977 mRNA. Translation: CAD38821.2.
    BC017798 mRNA. Translation: AAH17798.1.
    CCDSiCCDS8300.1.
    RefSeqiNP_060174.2. NM_017704.2.
    UniGeneiHs.29052.

    Genome annotation databases

    EnsembliENST00000302755; ENSP00000303518; ENSG00000168876.
    ENST00000544612; ENSP00000440396; ENSG00000168876.
    GeneIDi54851.
    KEGGihsa:54851.
    UCSCiuc001pew.3. human.

    Polymorphism databases

    DMDMi74751554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025354 mRNA. Translation: AAK60412.1 .
    AK000196 mRNA. Translation: BAA91003.1 .
    AL833977 mRNA. Translation: CAD38821.2 .
    BC017798 mRNA. Translation: AAH17798.1 .
    CCDSi CCDS8300.1.
    RefSeqi NP_060174.2. NM_017704.2.
    UniGenei Hs.29052.

    3D structure databases

    ProteinModelPortali Q8WVL7.
    SMRi Q8WVL7. Positions 8-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8WVL7. 1 interaction.
    STRINGi 9606.ENSP00000303518.

    PTM databases

    PhosphoSitei Q8WVL7.

    Polymorphism databases

    DMDMi 74751554.

    Proteomic databases

    MaxQBi Q8WVL7.
    PaxDbi Q8WVL7.
    PRIDEi Q8WVL7.

    Protocols and materials databases

    DNASUi 54851.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302755 ; ENSP00000303518 ; ENSG00000168876 .
    ENST00000544612 ; ENSP00000440396 ; ENSG00000168876 .
    GeneIDi 54851.
    KEGGi hsa:54851.
    UCSCi uc001pew.3. human.

    Organism-specific databases

    CTDi 54851.
    GeneCardsi GC11P094227.
    HGNCi HGNC:25970. ANKRD49.
    HPAi HPA040273.
    neXtProti NX_Q8WVL7.
    PharmGKBi PA142672615.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000021411.
    HOVERGENi HBG054416.
    InParanoidi Q8WVL7.
    OMAi LHSACRW.
    OrthoDBi EOG7R832G.
    PhylomeDBi Q8WVL7.
    TreeFami TF351259.

    Miscellaneous databases

    GenomeRNAii 54851.
    NextBioi 57700.
    PROi Q8WVL7.

    Gene expression databases

    ArrayExpressi Q8WVL7.
    Bgeei Q8WVL7.
    CleanExi HS_ANKRD49.
    Genevestigatori Q8WVL7.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a potential transcriptional activator of human gamma-globin genes."
      Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T., Stamatoyannopoulos G.
      Blood Cells Mol. Dis. 27:1-15(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Fetal liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon mucosa.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiANR49_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVL7
    Secondary accession number(s): Q8NDF2, Q96JE5, Q9NXK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3