Q8WVL7 (ANR49_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 49

Alternative name(s):
Fetal globin-inducing factor

Gene names

Name:	ANKRD49
Synonyms:	FGIF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Widely expressed in fetus, at a high level in fetal liver, brain and lung. Ref.1
Sequence similarities	Contains 4 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	nucleus Inferred by curator. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Ankyrin repeat domain-containing protein 49		PRO_0000244585
Regions
	Repeat	73 – 103	31	ANK 1
	Repeat	107 – 136	30	ANK 2
	Repeat	140 – 169	30	ANK 3
	Repeat	173 – 206	34	ANK 4
Amino acid modifications
	Modified residue	49	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	25	1	N → S in AAK60412. Ref.1
	Sequence conflict	201	1	K → R in BAA91003. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8WVL7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 97103467E8F1EA50	FASTA	239	27,290
	10 20 30 40 50 60 MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE 70 80 90 100 110 120 EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH 130 140 150 160 170 180 LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL 190 200 210 220 230 AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a potential transcriptional activator of human gamma-globin genes." Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T., Stamatoyannopoulos G. Blood Cells Mol. Dis. 27:1-15(2001) [PubMed: 11162141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION. Tissue: Fetal liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon mucosa.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF025354 mRNA. Translation: AAK60412.1. AK000196 mRNA. Translation: BAA91003.1. AL833977 mRNA. Translation: CAD38821.2. BC017798 mRNA. Translation: AAH17798.1.
IPI	IPI00549612.
RefSeq	NP_060174.2. NM_017704.2.
UniGene	Hs.29052.
3D structure databases
ProteinModelPortal	Q8WVL7.
SMR	Q8WVL7. Positions 4-230.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WVL7.
PTM databases
PhosphoSite	Q8WVL7.
Polymorphism databases
DMDM	74751554.
Proteomic databases
PRIDE	Q8WVL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302755; ENSP00000303518; ENSG00000168876.
GeneID	54851.
KEGG	hsa:54851.
UCSC	uc001pew.1. human.
Organism-specific databases
CTD	54851.
GeneCards	GC11P094227.
H-InvDB	HIX0010031.
HGNC	HGNC:25970. ANKRD49.
HPA	HPA040273.
neXtProt	NX_Q8WVL7.
PharmGKB	PA142672615.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14849.
GeneTree	ENSGT00390000003919.
HOGENOM	HBG278609.
HOVERGEN	HBG054416.
InParanoid	Q8WVL7.
OMA	THGHLIP.
OrthoDB	EOG4PG620.
PhylomeDB	Q8WVL7.
Gene expression databases
ArrayExpress	Q8WVL7.
Bgee	Q8WVL7.
CleanEx	HS_ANKRD49.
Genevestigator	Q8WVL7.
GermOnline	ENSG00000168876. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	57700.

Entry information

Entry name

ANR49_HUMAN

Accession

Primary (citable) accession number: Q8WVL7
Secondary accession number(s): Q8NDF2, Q96JE5, Q9NXK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.