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Protein

Ankyrin repeat domain-containing protein 49

Gene

ANKRD49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces HBG1 expression (PubMed:16131492, PubMed:11162141). May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 49
Alternative name(s):
Fetal globin-inducing factor
Gene namesi
Name:ANKRD49
Synonyms:FGIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25970. ANKRD49.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168876.
PharmGKBiPA142672615.

Polymorphism and mutation databases

BioMutaiANKRD49.
DMDMi74751554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445851 – 239Ankyrin repeat domain-containing protein 49Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVL7.
MaxQBiQ8WVL7.
PaxDbiQ8WVL7.
PeptideAtlasiQ8WVL7.
PRIDEiQ8WVL7.

PTM databases

iPTMnetiQ8WVL7.
PhosphoSitePlusiQ8WVL7.

Expressioni

Tissue specificityi

Widely expressed in fetus, at a high level in fetal liver, brain and lung.1 Publication

Gene expression databases

BgeeiENSG00000168876.
CleanExiHS_ANKRD49.
ExpressionAtlasiQ8WVL7. baseline and differential.
GenevisibleiQ8WVL7. HS.

Organism-specific databases

HPAiHPA040273.
HPA048137.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBPLQ9UIM32EBI-9381820,EBI-719882
RANP628262EBI-9381820,EBI-286642

Protein-protein interaction databases

BioGridi120201. 10 interactors.
DIPiDIP-61280N.
IntActiQ8WVL7. 2 interactors.
STRINGi9606.ENSP00000303518.

Structurei

3D structure databases

ProteinModelPortaliQ8WVL7.
SMRiQ8WVL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 103ANK 1Add BLAST31
Repeati107 – 136ANK 2Add BLAST30
Repeati140 – 169ANK 3Add BLAST30
Repeati173 – 206ANK 4Add BLAST34

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0512. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000003919.
HOGENOMiHOG000021411.
HOVERGENiHBG054416.
InParanoidiQ8WVL7.
OMAiMILWAVN.
OrthoDBiEOG091G0KYS.
PhylomeDBiQ8WVL7.
TreeFamiTF351259.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD
60 70 80 90 100
EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH
110 120 130 140 150
VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK
160 170 180 190 200
WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV
210 220 230
KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
Length:239
Mass (Da):27,290
Last modified:March 1, 2002 - v1
Checksum:i97103467E8F1EA50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → S in AAK60412 (PubMed:11162141).Curated1
Sequence conflicti201K → R in BAA91003 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025354 mRNA. Translation: AAK60412.1.
AK000196 mRNA. Translation: BAA91003.1.
AL833977 mRNA. Translation: CAD38821.2.
BC017798 mRNA. Translation: AAH17798.1.
CCDSiCCDS8300.1.
RefSeqiNP_060174.2. NM_017704.2.
XP_016873430.1. XM_017017941.1.
UniGeneiHs.29052.

Genome annotation databases

EnsembliENST00000302755; ENSP00000303518; ENSG00000168876.
ENST00000544612; ENSP00000440396; ENSG00000168876.
GeneIDi54851.
KEGGihsa:54851.
UCSCiuc001pew.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025354 mRNA. Translation: AAK60412.1.
AK000196 mRNA. Translation: BAA91003.1.
AL833977 mRNA. Translation: CAD38821.2.
BC017798 mRNA. Translation: AAH17798.1.
CCDSiCCDS8300.1.
RefSeqiNP_060174.2. NM_017704.2.
XP_016873430.1. XM_017017941.1.
UniGeneiHs.29052.

3D structure databases

ProteinModelPortaliQ8WVL7.
SMRiQ8WVL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120201. 10 interactors.
DIPiDIP-61280N.
IntActiQ8WVL7. 2 interactors.
STRINGi9606.ENSP00000303518.

PTM databases

iPTMnetiQ8WVL7.
PhosphoSitePlusiQ8WVL7.

Polymorphism and mutation databases

BioMutaiANKRD49.
DMDMi74751554.

Proteomic databases

EPDiQ8WVL7.
MaxQBiQ8WVL7.
PaxDbiQ8WVL7.
PeptideAtlasiQ8WVL7.
PRIDEiQ8WVL7.

Protocols and materials databases

DNASUi54851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302755; ENSP00000303518; ENSG00000168876.
ENST00000544612; ENSP00000440396; ENSG00000168876.
GeneIDi54851.
KEGGihsa:54851.
UCSCiuc001pew.4. human.

Organism-specific databases

CTDi54851.
GeneCardsiANKRD49.
HGNCiHGNC:25970. ANKRD49.
HPAiHPA040273.
HPA048137.
neXtProtiNX_Q8WVL7.
OpenTargetsiENSG00000168876.
PharmGKBiPA142672615.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0512. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000003919.
HOGENOMiHOG000021411.
HOVERGENiHBG054416.
InParanoidiQ8WVL7.
OMAiMILWAVN.
OrthoDBiEOG091G0KYS.
PhylomeDBiQ8WVL7.
TreeFamiTF351259.

Miscellaneous databases

GenomeRNAii54851.
PROiQ8WVL7.

Gene expression databases

BgeeiENSG00000168876.
CleanExiHS_ANKRD49.
ExpressionAtlasiQ8WVL7. baseline and differential.
GenevisibleiQ8WVL7. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR49_HUMAN
AccessioniPrimary (citable) accession number: Q8WVL7
Secondary accession number(s): Q8NDF2, Q96JE5, Q9NXK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.