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Q8WVL7

- ANR49_HUMAN

UniProt

Q8WVL7 - ANR49_HUMAN

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Protein

Ankyrin repeat domain-containing protein 49

Gene

ANKRD49

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 49
Alternative name(s):
Fetal globin-inducing factor
Gene namesi
Name:ANKRD49
Synonyms:FGIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25970. ANKRD49.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Ankyrin repeat domain-containing protein 49PRO_0000244585Add
BLAST

Proteomic databases

MaxQBiQ8WVL7.
PaxDbiQ8WVL7.
PRIDEiQ8WVL7.

PTM databases

PhosphoSiteiQ8WVL7.

Expressioni

Tissue specificityi

Widely expressed in fetus, at a high level in fetal liver, brain and lung.1 Publication

Gene expression databases

BgeeiQ8WVL7.
CleanExiHS_ANKRD49.
ExpressionAtlasiQ8WVL7. baseline and differential.
GenevestigatoriQ8WVL7.

Organism-specific databases

HPAiHPA040273.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBPLQ9UIM32EBI-9381820,EBI-719882

Protein-protein interaction databases

BioGridi120201. 1 interaction.
IntActiQ8WVL7. 1 interaction.
STRINGi9606.ENSP00000303518.

Structurei

3D structure databases

ProteinModelPortaliQ8WVL7.
SMRiQ8WVL7. Positions 44-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati73 – 10331ANK 1Add
BLAST
Repeati107 – 13630ANK 2Add
BLAST
Repeati140 – 16930ANK 3Add
BLAST
Repeati173 – 20634ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000003919.
HOGENOMiHOG000021411.
HOVERGENiHBG054416.
InParanoidiQ8WVL7.
OMAiLHSACRW.
OrthoDBiEOG7R832G.
PhylomeDBiQ8WVL7.
TreeFamiTF351259.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD
60 70 80 90 100
EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH
110 120 130 140 150
VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK
160 170 180 190 200
WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV
210 220 230
KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
Length:239
Mass (Da):27,290
Last modified:March 1, 2002 - v1
Checksum:i97103467E8F1EA50
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251N → S in AAK60412. (PubMed:11162141)Curated
Sequence conflicti201 – 2011K → R in BAA91003. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025354 mRNA. Translation: AAK60412.1.
AK000196 mRNA. Translation: BAA91003.1.
AL833977 mRNA. Translation: CAD38821.2.
BC017798 mRNA. Translation: AAH17798.1.
CCDSiCCDS8300.1.
RefSeqiNP_060174.2. NM_017704.2.
UniGeneiHs.29052.

Genome annotation databases

EnsembliENST00000302755; ENSP00000303518; ENSG00000168876.
ENST00000544612; ENSP00000440396; ENSG00000168876.
GeneIDi54851.
KEGGihsa:54851.
UCSCiuc001pew.3. human.

Polymorphism databases

DMDMi74751554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025354 mRNA. Translation: AAK60412.1 .
AK000196 mRNA. Translation: BAA91003.1 .
AL833977 mRNA. Translation: CAD38821.2 .
BC017798 mRNA. Translation: AAH17798.1 .
CCDSi CCDS8300.1.
RefSeqi NP_060174.2. NM_017704.2.
UniGenei Hs.29052.

3D structure databases

ProteinModelPortali Q8WVL7.
SMRi Q8WVL7. Positions 44-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120201. 1 interaction.
IntActi Q8WVL7. 1 interaction.
STRINGi 9606.ENSP00000303518.

PTM databases

PhosphoSitei Q8WVL7.

Polymorphism databases

DMDMi 74751554.

Proteomic databases

MaxQBi Q8WVL7.
PaxDbi Q8WVL7.
PRIDEi Q8WVL7.

Protocols and materials databases

DNASUi 54851.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302755 ; ENSP00000303518 ; ENSG00000168876 .
ENST00000544612 ; ENSP00000440396 ; ENSG00000168876 .
GeneIDi 54851.
KEGGi hsa:54851.
UCSCi uc001pew.3. human.

Organism-specific databases

CTDi 54851.
GeneCardsi GC11P094227.
HGNCi HGNC:25970. ANKRD49.
HPAi HPA040273.
neXtProti NX_Q8WVL7.
PharmGKBi PA142672615.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00390000003919.
HOGENOMi HOG000021411.
HOVERGENi HBG054416.
InParanoidi Q8WVL7.
OMAi LHSACRW.
OrthoDBi EOG7R832G.
PhylomeDBi Q8WVL7.
TreeFami TF351259.

Miscellaneous databases

GenomeRNAii 54851.
NextBioi 57700.
PROi Q8WVL7.

Gene expression databases

Bgeei Q8WVL7.
CleanExi HS_ANKRD49.
ExpressionAtlasi Q8WVL7. baseline and differential.
Genevestigatori Q8WVL7.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a potential transcriptional activator of human gamma-globin genes."
    Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T., Stamatoyannopoulos G.
    Blood Cells Mol. Dis. 27:1-15(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Fetal liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon mucosa.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANR49_HUMAN
AccessioniPrimary (citable) accession number: Q8WVL7
Secondary accession number(s): Q8NDF2, Q96JE5, Q9NXK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3