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Protein

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Gene

SNRNP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.

GO - Molecular functioni

  • nucleic acid binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Short name:
U4/U6.U5 snRNP 27 kDa protein
Short name:
U4/U6.U5-27K
Alternative name(s):
Nucleic acid-binding protein RY-1
U4/U6.U5 tri-snRNP-associated 27 kDa protein
Short name:
27K
U4/U6.U5 tri-snRNP-associated protein 3
Gene namesi
Name:SNRNP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000124380.10
HGNCiHGNC:30240 SNRNP27
neXtProtiNX_Q8WVK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11017
OpenTargetsiENSG00000124380
PharmGKBiPA164726114

Polymorphism and mutation databases

BioMutaiSNRNP27
DMDMi74760570

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239651 – 155U4/U6.U5 small nuclear ribonucleoprotein 27 kDa proteinAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by snRNP-associated protein kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVK2
MaxQBiQ8WVK2
PaxDbiQ8WVK2
PeptideAtlasiQ8WVK2
PRIDEiQ8WVK2
ProteomicsDBi74800

PTM databases

iPTMnetiQ8WVK2
PhosphoSitePlusiQ8WVK2

Expressioni

Gene expression databases

BgeeiENSG00000124380
CleanExiHS_SNRNP27
ExpressionAtlasiQ8WVK2 baseline and differential
GenevisibleiQ8WVK2 HS

Organism-specific databases

HPAiHPA034541

Interactioni

Subunit structurei

Part of a tri-snRNP complex.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116207, 123 interactors
CORUMiQ8WVK2
IntActiQ8WVK2, 9 interactors
MINTiQ8WVK2
STRINGi9606.ENSP00000244227

Structurei

3D structure databases

ProteinModelPortaliQ8WVK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 71Arg-richAdd BLAST69

Sequence similaritiesi

Belongs to the SNUT3 family.Curated

Phylogenomic databases

eggNOGiKOG3263 Eukaryota
ENOG410XWWQ LUCA
GeneTreeiENSGT00730000111237
HOGENOMiHOG000089971
HOVERGENiHBG094639
InParanoidiQ8WVK2
KOiK12846
OMAiEDMQGKT
TreeFamiTF314458

Family and domain databases

InterProiView protein in InterPro
IPR013957 SNRNP27
PfamiView protein in Pfam
PF08648 DUF1777, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WVK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRSRSRSPR RERRRSRSTS RERERRRRER SRSRERDRRR SRSRSPHRRR
60 70 80 90 100
SRSPRRHRST SPSPSRLKER RDEEKKETKE TKSKERQITE EDLEGKTEEE
110 120 130 140 150
IEMMKLMGFA SFDSTKGKKV DGSVNAYAIN VSQKRKYRQY MNRKGGFNRP

LDFIA
Length:155
Mass (Da):18,860
Last modified:March 1, 2002 - v1
Checksum:i26BC291950E49B9F
GO

Sequence cautioni

The sequence CAA53949 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02536381T → I1 Publication1
Natural variantiVAR_025364114S → F1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76302 mRNA Translation: CAA53949.1 Different initiation.
AC019206 Genomic DNA Translation: AAY14866.1
BC017890 mRNA Translation: AAH17890.1
CCDSiCCDS33219.1
PIRiI38191
RefSeqiNP_006848.1, NM_006857.2
UniGeneiHs.54649

Genome annotation databases

EnsembliENST00000244227; ENSP00000244227; ENSG00000124380
ENST00000450162; ENSP00000395144; ENSG00000124380
GeneIDi11017
KEGGihsa:11017
UCSCiuc002sfw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNR27_HUMAN
AccessioniPrimary (citable) accession number: Q8WVK2
Secondary accession number(s): Q15410
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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