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Protein

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Gene

SNRNP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.

GO - Molecular functioni

  • nucleic acid binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Short name:
U4/U6.U5 snRNP 27 kDa protein
Short name:
U4/U6.U5-27K
Alternative name(s):
Nucleic acid-binding protein RY-1
U4/U6.U5 tri-snRNP-associated 27 kDa protein
Short name:
27K
U4/U6.U5 tri-snRNP-associated protein 3
Gene namesi
Name:SNRNP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30240. SNRNP27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726114.

Polymorphism and mutation databases

BioMutaiSNRNP27.
DMDMi74760570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155U4/U6.U5 small nuclear ribonucleoprotein 27 kDa proteinPRO_0000223965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated in vitro by snRNP-associated protein kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVK2.
MaxQBiQ8WVK2.
PaxDbiQ8WVK2.
PRIDEiQ8WVK2.

PTM databases

iPTMnetiQ8WVK2.
PhosphoSiteiQ8WVK2.

Expressioni

Gene expression databases

BgeeiQ8WVK2.
CleanExiHS_SNRNP27.
ExpressionAtlasiQ8WVK2. baseline and differential.
GenevisibleiQ8WVK2. HS.

Organism-specific databases

HPAiHPA034541.

Interactioni

Subunit structurei

Part of a tri-snRNP complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
CHERPQ8IWX82EBI-2512550,EBI-2555370
SRPK2P783625EBI-2512550,EBI-593303

Protein-protein interaction databases

BioGridi116207. 111 interactions.
IntActiQ8WVK2. 9 interactions.
MINTiMINT-4774420.
STRINGi9606.ENSP00000244227.

Structurei

3D structure databases

ProteinModelPortaliQ8WVK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 7169Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the SNUT3 family.Curated

Phylogenomic databases

eggNOGiKOG3263. Eukaryota.
ENOG410XWWQ. LUCA.
GeneTreeiENSGT00730000111237.
HOGENOMiHOG000089971.
HOVERGENiHBG094639.
InParanoidiQ8WVK2.
KOiK12846.
OMAiKMMGFAS.
OrthoDBiEOG764762.
TreeFamiTF314458.

Family and domain databases

InterProiIPR013957. DUF1777.
[Graphical view]
PfamiPF08648. DUF1777. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRSRSRSPR RERRRSRSTS RERERRRRER SRSRERDRRR SRSRSPHRRR
60 70 80 90 100
SRSPRRHRST SPSPSRLKER RDEEKKETKE TKSKERQITE EDLEGKTEEE
110 120 130 140 150
IEMMKLMGFA SFDSTKGKKV DGSVNAYAIN VSQKRKYRQY MNRKGGFNRP

LDFIA
Length:155
Mass (Da):18,860
Last modified:March 1, 2002 - v1
Checksum:i26BC291950E49B9F
GO

Sequence cautioni

The sequence CAA53949.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811T → I.1 Publication
VAR_025363
Natural varianti114 – 1141S → F.1 Publication
VAR_025364

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76302 mRNA. Translation: CAA53949.1. Different initiation.
AC019206 Genomic DNA. Translation: AAY14866.1.
BC017890 mRNA. Translation: AAH17890.1.
CCDSiCCDS33219.1.
PIRiI38191.
RefSeqiNP_006848.1. NM_006857.2.
UniGeneiHs.54649.

Genome annotation databases

EnsembliENST00000244227; ENSP00000244227; ENSG00000124380.
ENST00000450162; ENSP00000395144; ENSG00000124380.
GeneIDi11017.
KEGGihsa:11017.
UCSCiuc002sfw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76302 mRNA. Translation: CAA53949.1. Different initiation.
AC019206 Genomic DNA. Translation: AAY14866.1.
BC017890 mRNA. Translation: AAH17890.1.
CCDSiCCDS33219.1.
PIRiI38191.
RefSeqiNP_006848.1. NM_006857.2.
UniGeneiHs.54649.

3D structure databases

ProteinModelPortaliQ8WVK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116207. 111 interactions.
IntActiQ8WVK2. 9 interactions.
MINTiMINT-4774420.
STRINGi9606.ENSP00000244227.

PTM databases

iPTMnetiQ8WVK2.
PhosphoSiteiQ8WVK2.

Polymorphism and mutation databases

BioMutaiSNRNP27.
DMDMi74760570.

Proteomic databases

EPDiQ8WVK2.
MaxQBiQ8WVK2.
PaxDbiQ8WVK2.
PRIDEiQ8WVK2.

Protocols and materials databases

DNASUi11017.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244227; ENSP00000244227; ENSG00000124380.
ENST00000450162; ENSP00000395144; ENSG00000124380.
GeneIDi11017.
KEGGihsa:11017.
UCSCiuc002sfw.4. human.

Organism-specific databases

CTDi11017.
GeneCardsiSNRNP27.
HGNCiHGNC:30240. SNRNP27.
HPAiHPA034541.
neXtProtiNX_Q8WVK2.
PharmGKBiPA164726114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3263. Eukaryota.
ENOG410XWWQ. LUCA.
GeneTreeiENSGT00730000111237.
HOGENOMiHOG000089971.
HOVERGENiHBG094639.
InParanoidiQ8WVK2.
KOiK12846.
OMAiKMMGFAS.
OrthoDBiEOG764762.
TreeFamiTF314458.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiSNRNP27. human.
GenomeRNAii11017.
NextBioi41857.
PROiQ8WVK2.

Gene expression databases

BgeeiQ8WVK2.
CleanExiHS_SNRNP27.
ExpressionAtlasiQ8WVK2. baseline and differential.
GenevisibleiQ8WVK2. HS.

Family and domain databases

InterProiIPR013957. DUF1777.
[Graphical view]
PfamiPF08648. DUF1777. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Altered expression of the novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1."
    Nakamura Y., Moriuchi R., Nakayama D., Yamashita I., Higashiyama Y., Yamamoto T., Kusano Y., Hino S., Miyamoto T., Katamine S.
    J. Gen. Virol. 75:2625-2633(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase."
    Fetzer S., Lauber J., Will C.L., Luehrmann R.
    RNA 3:344-355(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 108-110 AND 141-152, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ILE-81 AND PHE-114, PHOSPHORYLATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNR27_HUMAN
AccessioniPrimary (citable) accession number: Q8WVK2
Secondary accession number(s): Q15410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: April 13, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.