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Q8WVJ2 (NUDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NudC domain-containing protein 2
Gene names
Name:NUDCD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. Ref.1

Subunit structure

Interacts with LIS1. Ref.1

Subcellular location

Chromosomecentromerekinetochore. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle pole. Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis. Ref.1

Sequence similarities

Contains 1 CS domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRMT5O147442EBI-1052153,EBI-351098

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 157156NudC domain-containing protein 2
PRO_0000057982

Regions

Domain14 – 10491CS

Amino acid modifications

Modified residue21N-acetylserine Ref.7
Modified residue1451Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WVJ2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 8A425EA4F6F321FD

FASTA15717,676
        10         20         30         40         50         60 
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR HVALSVGGRE 

        70         80         90        100        110        120 
ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW TSLLESEYAA DPWVQDQMQR 

       130        140        150 
KLTLERFQKE NPGFDFSGAE ISGNYTKGGP DFSNLEK 

« Hide

References

« Hide 'large scale' references
[1]"NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90."
Yang Y., Yan X., Cai Y., Lu Y., Si J., Zhou T.
Proc. Natl. Acad. Sci. U.S.A. 107:3499-3504(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH LIS1.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ215684 mRNA. Translation: ACJ05660.1.
AK311957 mRNA. Translation: BAG34897.1.
BX538290 mRNA. Translation: CAD98085.1.
CH471062 Genomic DNA. Translation: EAW61527.1.
BC017934 mRNA. Translation: AAH17934.1.
CCDSCCDS4361.1.
RefSeqNP_660309.1. NM_145266.4.
UniGeneHs.140443.

3D structure databases

ProteinModelPortalQ8WVJ2.
SMRQ8WVJ2. Positions 5-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126402. 41 interactions.
DIPDIP-59509N.
IntActQ8WVJ2. 1 interaction.
MINTMINT-4714215.
STRING9606.ENSP00000304854.

PTM databases

PhosphoSiteQ8WVJ2.

Proteomic databases

MaxQBQ8WVJ2.
PaxDbQ8WVJ2.
PeptideAtlasQ8WVJ2.
PRIDEQ8WVJ2.

Protocols and materials databases

DNASU134492.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302764; ENSP00000304854; ENSG00000170584.
GeneID134492.
KEGGhsa:134492.
UCSCuc003lze.3. human.

Organism-specific databases

CTD134492.
GeneCardsGC05M162880.
HGNCHGNC:30535. NUDCD2.
HPAHPA037385.
neXtProtNX_Q8WVJ2.
PharmGKBPA134991349.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319794.
HOGENOMHOG000282991.
HOVERGENHBG056555.
InParanoidQ8WVJ2.
OMANREAGNC.
OrthoDBEOG7KH9N4.
PhylomeDBQ8WVJ2.
TreeFamTF332391.

Gene expression databases

ArrayExpressQ8WVJ2.
BgeeQ8WVJ2.
CleanExHS_NUDCD2.
GenevestigatorQ8WVJ2.

Family and domain databases

Gene3D2.60.40.790. 1 hit.
InterProIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamPF04969. CS. 1 hit.
[Graphical view]
SUPFAMSSF49764. SSF49764. 1 hit.
PROSITEPS51203. CS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNUDCD2.
GenomeRNAi134492.
NextBio83386.
PROQ8WVJ2.

Entry information

Entry nameNUDC2_HUMAN
AccessionPrimary (citable) accession number: Q8WVJ2
Secondary accession number(s): B2R4V0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

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Human chromosome 5: entries, gene names and cross-references to MIM