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Q8WVJ2

- NUDC2_HUMAN

UniProt

Q8WVJ2 - NUDC2_HUMAN

Protein

NudC domain-containing protein 2

Gene

NUDCD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NudC domain-containing protein 2
    Gene namesi
    Name:NUDCD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30535. NUDCD2.

    Subcellular locationi

    Chromosomecentromerekinetochore 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle pole 1 Publication
    Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: HPA
    3. extracellular vesicular exosome Source: UniProt
    4. intracellular Source: LIFEdb
    5. microtubule cytoskeleton Source: HPA
    6. microtubule organizing center Source: UniProtKB-SubCell
    7. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991349.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 157156NudC domain-containing protein 2PRO_0000057982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei145 – 1451PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WVJ2.
    PaxDbiQ8WVJ2.
    PeptideAtlasiQ8WVJ2.
    PRIDEiQ8WVJ2.

    PTM databases

    PhosphoSiteiQ8WVJ2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WVJ2.
    BgeeiQ8WVJ2.
    CleanExiHS_NUDCD2.
    GenevestigatoriQ8WVJ2.

    Organism-specific databases

    HPAiHPA037385.

    Interactioni

    Subunit structurei

    Interacts with LIS1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FBXO24O754262EBI-1052153,EBI-6425658
    PRMT5O147442EBI-1052153,EBI-351098

    Protein-protein interaction databases

    BioGridi126402. 41 interactions.
    DIPiDIP-59509N.
    IntActiQ8WVJ2. 22 interactions.
    MINTiMINT-4714215.
    STRINGi9606.ENSP00000304854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVJ2.
    SMRiQ8WVJ2. Positions 5-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 10491CSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG319794.
    HOGENOMiHOG000282991.
    HOVERGENiHBG056555.
    InParanoidiQ8WVJ2.
    OMAiNREAGNC.
    OrthoDBiEOG7KH9N4.
    PhylomeDBiQ8WVJ2.
    TreeFamiTF332391.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    PfamiPF04969. CS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS51203. CS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WVJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR    50
    HVALSVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW 100
    TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP 150
    DFSNLEK 157
    Length:157
    Mass (Da):17,676
    Last modified:March 1, 2002 - v1
    Checksum:i8A425EA4F6F321FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ215684 mRNA. Translation: ACJ05660.1.
    AK311957 mRNA. Translation: BAG34897.1.
    BX538290 mRNA. Translation: CAD98085.1.
    CH471062 Genomic DNA. Translation: EAW61527.1.
    BC017934 mRNA. Translation: AAH17934.1.
    CCDSiCCDS4361.1.
    RefSeqiNP_660309.1. NM_145266.4.
    UniGeneiHs.140443.

    Genome annotation databases

    EnsembliENST00000302764; ENSP00000304854; ENSG00000170584.
    GeneIDi134492.
    KEGGihsa:134492.
    UCSCiuc003lze.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ215684 mRNA. Translation: ACJ05660.1 .
    AK311957 mRNA. Translation: BAG34897.1 .
    BX538290 mRNA. Translation: CAD98085.1 .
    CH471062 Genomic DNA. Translation: EAW61527.1 .
    BC017934 mRNA. Translation: AAH17934.1 .
    CCDSi CCDS4361.1.
    RefSeqi NP_660309.1. NM_145266.4.
    UniGenei Hs.140443.

    3D structure databases

    ProteinModelPortali Q8WVJ2.
    SMRi Q8WVJ2. Positions 5-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126402. 41 interactions.
    DIPi DIP-59509N.
    IntActi Q8WVJ2. 22 interactions.
    MINTi MINT-4714215.
    STRINGi 9606.ENSP00000304854.

    PTM databases

    PhosphoSitei Q8WVJ2.

    Proteomic databases

    MaxQBi Q8WVJ2.
    PaxDbi Q8WVJ2.
    PeptideAtlasi Q8WVJ2.
    PRIDEi Q8WVJ2.

    Protocols and materials databases

    DNASUi 134492.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302764 ; ENSP00000304854 ; ENSG00000170584 .
    GeneIDi 134492.
    KEGGi hsa:134492.
    UCSCi uc003lze.3. human.

    Organism-specific databases

    CTDi 134492.
    GeneCardsi GC05M162880.
    HGNCi HGNC:30535. NUDCD2.
    HPAi HPA037385.
    neXtProti NX_Q8WVJ2.
    PharmGKBi PA134991349.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319794.
    HOGENOMi HOG000282991.
    HOVERGENi HBG056555.
    InParanoidi Q8WVJ2.
    OMAi NREAGNC.
    OrthoDBi EOG7KH9N4.
    PhylomeDBi Q8WVJ2.
    TreeFami TF332391.

    Miscellaneous databases

    GeneWikii NUDCD2.
    GenomeRNAii 134492.
    NextBioi 83386.
    PROi Q8WVJ2.

    Gene expression databases

    ArrayExpressi Q8WVJ2.
    Bgeei Q8WVJ2.
    CleanExi HS_NUDCD2.
    Genevestigatori Q8WVJ2.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    Pfami PF04969. CS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS51203. CS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90."
      Yang Y., Yan X., Cai Y., Lu Y., Si J., Zhou T.
      Proc. Natl. Acad. Sci. U.S.A. 107:3499-3504(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH LIS1.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNUDC2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVJ2
    Secondary accession number(s): B2R4V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3