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Protein

NudC domain-containing protein 2

Gene

NUDCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 2
Gene namesi
Name:NUDCD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30535. NUDCD2.

Subcellular locationi

  1. Chromosomecentromerekinetochore 1 Publication
  2. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
  3. Cytoplasmcytoskeletonspindle pole 1 Publication

  4. Note: Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: HPA
  3. extracellular vesicular exosome Source: UniProtKB
  4. intracellular Source: LIFEdb
  5. microtubule cytoskeleton Source: HPA
  6. microtubule organizing center Source: UniProtKB-SubCell
  7. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991349.

Polymorphism and mutation databases

BioMutaiNUDCD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 157156NudC domain-containing protein 2PRO_0000057982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei145 – 1451PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WVJ2.
PaxDbiQ8WVJ2.
PeptideAtlasiQ8WVJ2.
PRIDEiQ8WVJ2.

PTM databases

PhosphoSiteiQ8WVJ2.

Expressioni

Gene expression databases

BgeeiQ8WVJ2.
CleanExiHS_NUDCD2.
ExpressionAtlasiQ8WVJ2. baseline and differential.
GenevestigatoriQ8WVJ2.

Organism-specific databases

HPAiHPA037384.
HPA037385.

Interactioni

Subunit structurei

Interacts with LIS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXO24O754262EBI-1052153,EBI-6425658
PRMT5O147442EBI-1052153,EBI-351098

Protein-protein interaction databases

BioGridi126402. 41 interactions.
DIPiDIP-59509N.
IntActiQ8WVJ2. 22 interactions.
MINTiMINT-4714215.
STRINGi9606.ENSP00000304854.

Structurei

3D structure databases

ProteinModelPortaliQ8WVJ2.
SMRiQ8WVJ2. Positions 5-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10491CSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG319794.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ8WVJ2.
OMAiNREAGNC.
OrthoDBiEOG7KH9N4.
PhylomeDBiQ8WVJ2.
TreeFamiTF332391.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR
60 70 80 90 100
HVALSVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW
110 120 130 140 150
TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP

DFSNLEK
Length:157
Mass (Da):17,676
Last modified:March 1, 2002 - v1
Checksum:i8A425EA4F6F321FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ215684 mRNA. Translation: ACJ05660.1.
AK311957 mRNA. Translation: BAG34897.1.
BX538290 mRNA. Translation: CAD98085.1.
CH471062 Genomic DNA. Translation: EAW61527.1.
BC017934 mRNA. Translation: AAH17934.1.
CCDSiCCDS4361.1.
RefSeqiNP_660309.1. NM_145266.4.
UniGeneiHs.140443.

Genome annotation databases

EnsembliENST00000302764; ENSP00000304854; ENSG00000170584.
GeneIDi134492.
KEGGihsa:134492.
UCSCiuc003lze.3. human.

Polymorphism and mutation databases

BioMutaiNUDCD2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ215684 mRNA. Translation: ACJ05660.1.
AK311957 mRNA. Translation: BAG34897.1.
BX538290 mRNA. Translation: CAD98085.1.
CH471062 Genomic DNA. Translation: EAW61527.1.
BC017934 mRNA. Translation: AAH17934.1.
CCDSiCCDS4361.1.
RefSeqiNP_660309.1. NM_145266.4.
UniGeneiHs.140443.

3D structure databases

ProteinModelPortaliQ8WVJ2.
SMRiQ8WVJ2. Positions 5-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126402. 41 interactions.
DIPiDIP-59509N.
IntActiQ8WVJ2. 22 interactions.
MINTiMINT-4714215.
STRINGi9606.ENSP00000304854.

PTM databases

PhosphoSiteiQ8WVJ2.

Polymorphism and mutation databases

BioMutaiNUDCD2.

Proteomic databases

MaxQBiQ8WVJ2.
PaxDbiQ8WVJ2.
PeptideAtlasiQ8WVJ2.
PRIDEiQ8WVJ2.

Protocols and materials databases

DNASUi134492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302764; ENSP00000304854; ENSG00000170584.
GeneIDi134492.
KEGGihsa:134492.
UCSCiuc003lze.3. human.

Organism-specific databases

CTDi134492.
GeneCardsiGC05M162880.
HGNCiHGNC:30535. NUDCD2.
HPAiHPA037384.
HPA037385.
neXtProtiNX_Q8WVJ2.
PharmGKBiPA134991349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319794.
GeneTreeiENSGT00390000001644.
HOGENOMiHOG000282991.
HOVERGENiHBG056555.
InParanoidiQ8WVJ2.
OMAiNREAGNC.
OrthoDBiEOG7KH9N4.
PhylomeDBiQ8WVJ2.
TreeFamiTF332391.

Miscellaneous databases

ChiTaRSiNUDCD2. human.
GeneWikiiNUDCD2.
GenomeRNAii134492.
NextBioi83386.
PROiQ8WVJ2.

Gene expression databases

BgeeiQ8WVJ2.
CleanExiHS_NUDCD2.
ExpressionAtlasiQ8WVJ2. baseline and differential.
GenevestigatoriQ8WVJ2.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90."
    Yang Y., Yan X., Cai Y., Lu Y., Si J., Zhou T.
    Proc. Natl. Acad. Sci. U.S.A. 107:3499-3504(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH LIS1.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNUDC2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVJ2
Secondary accession number(s): B2R4V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.