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Protein

Protein phosphatase 1 regulatory subunit 1C

Gene

PPP1R1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1C
Alternative name(s):
Inhibitor-5 of protein phosphatase 1
Short name:
IPP5
Gene namesi
Name:PPP1R1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14940. PPP1R1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi34 – 341T → A: Abolishes PP1 inhibitory activity. 1 Publication
Mutagenesisi34 – 341T → D: Constitutively active. 1 Publication

Organism-specific databases

PharmGKBiPA33640.

Polymorphism and mutation databases

BioMutaiPPP1R1C.
DMDMi74730857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Protein phosphatase 1 regulatory subunit 1CPRO_0000286443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphothreonineCurated

Post-translational modificationi

Phosphorylation of Thr-34 is required for activity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WVI7.
PRIDEiQ8WVI7.

PTM databases

iPTMnetiQ8WVI7.
PhosphoSiteiQ8WVI7.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, liver and testis (at protein level).

Gene expression databases

BgeeiQ8WVI7.
CleanExiHS_PPP1R1C.
GenevisibleiQ8WVI7. HS.

Organism-specific databases

HPAiHPA055043.

Interactioni

Subunit structurei

Interacts with PPP1CB.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000386359.

Structurei

3D structure databases

ProteinModelPortaliQ8WVI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IYYH. Eukaryota.
ENOG410YPKK. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG055965.
InParanoidiQ8WVI7.
KOiK17549.
OMAiQNDSAFP.
OrthoDBiEOG7XPZ7N.
PhylomeDBiQ8WVI7.
TreeFamiTF332576.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPNSPKKIQ FAVPVFQSQI APEAAEQIRK RRPTPASLVI LNEHNPPEID
60 70 80 90 100
DKRGPNTQGE LQNASPKQRK QSVYTPPTIK GVKHLKGQNE SAFPEEEEGT

NEREEQRDH
Length:109
Mass (Da):12,346
Last modified:March 1, 2002 - v1
Checksum:iE4219398DD303A5D
GO
Isoform 2 (identifier: Q8WVI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: Q → QLGFCRSQ

Show »
Length:116
Mass (Da):13,138
Checksum:iA289F4C6CECFFD9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841H → Y in CAI46089 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 271Q → QLGFCRSQ in isoform 2. 1 PublicationVSP_025061

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494535 mRNA. Translation: AAM18054.1.
BX647581 mRNA. Translation: CAI46089.1.
BC017943 mRNA. Translation: AAH17943.1.
CCDSiCCDS46468.1. [Q8WVI7-1]
CCDS58740.1. [Q8WVI7-2]
RefSeqiNP_001074014.1. NM_001080545.2. [Q8WVI7-1]
NP_001248353.1. NM_001261424.1. [Q8WVI7-2]
NP_001248354.1. NM_001261425.1. [Q8WVI7-1]
UniGeneiHs.10941.

Genome annotation databases

EnsembliENST00000280295; ENSP00000280295; ENSG00000150722. [Q8WVI7-2]
ENST00000409137; ENSP00000386359; ENSG00000150722. [Q8WVI7-1]
ENST00000409702; ENSP00000386778; ENSG00000150722. [Q8WVI7-1]
GeneIDi151242.
KEGGihsa:151242.
UCSCiuc002uop.3. human. [Q8WVI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494535 mRNA. Translation: AAM18054.1.
BX647581 mRNA. Translation: CAI46089.1.
BC017943 mRNA. Translation: AAH17943.1.
CCDSiCCDS46468.1. [Q8WVI7-1]
CCDS58740.1. [Q8WVI7-2]
RefSeqiNP_001074014.1. NM_001080545.2. [Q8WVI7-1]
NP_001248353.1. NM_001261424.1. [Q8WVI7-2]
NP_001248354.1. NM_001261425.1. [Q8WVI7-1]
UniGeneiHs.10941.

3D structure databases

ProteinModelPortaliQ8WVI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386359.

PTM databases

iPTMnetiQ8WVI7.
PhosphoSiteiQ8WVI7.

Polymorphism and mutation databases

BioMutaiPPP1R1C.
DMDMi74730857.

Proteomic databases

PaxDbiQ8WVI7.
PRIDEiQ8WVI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280295; ENSP00000280295; ENSG00000150722. [Q8WVI7-2]
ENST00000409137; ENSP00000386359; ENSG00000150722. [Q8WVI7-1]
ENST00000409702; ENSP00000386778; ENSG00000150722. [Q8WVI7-1]
GeneIDi151242.
KEGGihsa:151242.
UCSCiuc002uop.3. human. [Q8WVI7-1]

Organism-specific databases

CTDi151242.
GeneCardsiPPP1R1C.
HGNCiHGNC:14940. PPP1R1C.
HPAiHPA055043.
MIMi613240. gene.
neXtProtiNX_Q8WVI7.
PharmGKBiPA33640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYYH. Eukaryota.
ENOG410YPKK. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG055965.
InParanoidiQ8WVI7.
KOiK17549.
OMAiQNDSAFP.
OrthoDBiEOG7XPZ7N.
PhylomeDBiQ8WVI7.
TreeFamiTF332576.

Miscellaneous databases

GenomeRNAii151242.
PROiQ8WVI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WVI7.
CleanExiHS_PPP1R1C.
GenevisibleiQ8WVI7. HS.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Wan T., Zhang W., Cao X.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  4. "IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S progression in a Thr-40-dependent manner."
    Wang X., Liu B., Li N., Li H., Qiu J., Zhang Y., Cao X.
    J. Biol. Chem. 283:12076-12084(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PROTEIN PHOSPHATASE 1, MUTAGENESIS OF THR-34.
  5. "Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved."
    Zeng Q., Huang Y., Zeng L., Lan X., Huang Y., He S., Zhang H.
    Biotechnol. Appl. Biochem. 54:231-238(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPPR1C_HUMAN
AccessioniPrimary (citable) accession number: Q8WVI7
Secondary accession number(s): Q5HYJ5, Q8TD54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-89 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.