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Protein

Complexin-3

Gene

CPLX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-3
Alternative name(s):
Complexin III
Short name:
CPX III
Gene namesi
Name:CPLX3
ORF Names:Nbla11589
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:27652. CPLX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672081.

Polymorphism and mutation databases

BioMutaiCPLX3.
DMDMi74751549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Complexin-3PRO_0000239272Add
BLAST
Propeptidei156 – 1583Removed in mature formBy similarityPRO_0000240233

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551Cysteine methyl esterBy similarity
Lipidationi155 – 1551S-farnesyl cysteineBy similarity

Post-translational modificationi

Farnesylation mediates presynaptic targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ8WVH0.
PRIDEiQ8WVH0.

Expressioni

Gene expression databases

CleanExiHS_CPLX3.
GenevisibleiQ8WVH0. HS.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000378464.

Structurei

3D structure databases

ProteinModelPortaliQ8WVH0.
SMRiQ8WVH0. Positions 44-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 7436Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG38928.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8WVH0.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG70CR8H.
PhylomeDBiQ8WVH0.
TreeFamiTF331867.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ
60 70 80 90 100
LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE
110 120 130 140 150
LPRELAKMIE EDTEEEEEKA SVLGQLASLP GLNLGSLKDK AQATLGDLKQ

SAEKCHVM
Length:158
Mass (Da):17,557
Last modified:March 1, 2002 - v1
Checksum:i057B4DE06DB6EA0F
GO

Sequence cautioni

The sequence BAB84922.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → G in BAB14805 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286501 mRNA. Translation: AAP41127.1.
AK074096 mRNA. Translation: BAB84922.1. Different initiation.
AB072900 mRNA. Translation: BAE45711.1.
AK024055 mRNA. Translation: BAB14805.1.
CH471136 Genomic DNA. Translation: EAW99306.1.
CH471136 Genomic DNA. Translation: EAW99307.1.
BC018026 mRNA. Translation: AAH18026.1.
CCDSiCCDS32294.1.
RefSeqiNP_001025176.1. NM_001030005.2.
UniGeneiHs.187694.

Genome annotation databases

EnsembliENST00000395018; ENSP00000378464; ENSG00000213578.
GeneIDi594855.
KEGGihsa:594855.
UCSCiuc002ayu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286501 mRNA. Translation: AAP41127.1.
AK074096 mRNA. Translation: BAB84922.1. Different initiation.
AB072900 mRNA. Translation: BAE45711.1.
AK024055 mRNA. Translation: BAB14805.1.
CH471136 Genomic DNA. Translation: EAW99306.1.
CH471136 Genomic DNA. Translation: EAW99307.1.
BC018026 mRNA. Translation: AAH18026.1.
CCDSiCCDS32294.1.
RefSeqiNP_001025176.1. NM_001030005.2.
UniGeneiHs.187694.

3D structure databases

ProteinModelPortaliQ8WVH0.
SMRiQ8WVH0. Positions 44-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378464.

Polymorphism and mutation databases

BioMutaiCPLX3.
DMDMi74751549.

Proteomic databases

PaxDbiQ8WVH0.
PRIDEiQ8WVH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395018; ENSP00000378464; ENSG00000213578.
GeneIDi594855.
KEGGihsa:594855.
UCSCiuc002ayu.1. human.

Organism-specific databases

CTDi594855.
GeneCardsiGC15P075118.
HGNCiHGNC:27652. CPLX3.
MIMi609585. gene.
neXtProtiNX_Q8WVH0.
PharmGKBiPA142672081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG38928.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8WVH0.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG70CR8H.
PhylomeDBiQ8WVH0.
TreeFamiTF331867.

Miscellaneous databases

GenomeRNAii594855.
NextBioi112775.
PROiQ8WVH0.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CPLX3.
GenevisibleiQ8WVH0. HS.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structurally and functionally unique complexins at retinal ribbon synapses."
    Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
    J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCPLX3_HUMAN
AccessioniPrimary (citable) accession number: Q8WVH0
Secondary accession number(s): D3DW66, Q8TEM6, Q9H818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.