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Q8WVH0 (CPLX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complexin-3
Alternative name(s):
Complexin III
Short name=CPX III
Gene names
Name:CPLX3
ORF Names:Nbla11589
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Positively regulates a late step in synaptic vesicle exocytosis By similarity.

Subunit structure

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A By similarity.

Subcellular location

Membrane; Lipid-anchor. Cell junctionsynapse By similarity. Note: Enriched at the synaptic terminal By similarity.

Post-translational modification

Farnesylation mediates presynaptic targeting By similarity.

Sequence similarities

Belongs to the complexin/synaphin family.

Sequence caution

The sequence BAB84922.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 155155Complexin-3
PRO_0000239272
Propeptide156 – 1583Removed in mature form By similarity
PRO_0000240233

Regions

Coiled coil39 – 7436 Potential

Amino acid modifications

Modified residue1551Cysteine methyl ester By similarity
Lipidation1551S-farnesyl cysteine By similarity

Experimental info

Sequence conflict191S → G in BAB14805. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8WVH0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 057B4DE06DB6EA0F

FASTA15817,557
        10         20         30         40         50         60 
MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ LVEEKMERDA 

        70         80         90        100        110        120 
QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE LPRELAKMIE EDTEEEEEKA 

       130        140        150 
SVLGQLASLP GLNLGSLKDK AQATLGDLKQ SAEKCHVM 

« Hide

References

« Hide 'large scale' references
[1]"Structurally and functionally unique complexins at retinal ribbon synapses."
Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[3]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neuroblastoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY286501 mRNA. Translation: AAP41127.1.
AK074096 mRNA. Translation: BAB84922.1. Different initiation.
AB072900 mRNA. Translation: BAE45711.1.
AK024055 mRNA. Translation: BAB14805.1.
CH471136 Genomic DNA. Translation: EAW99306.1.
CH471136 Genomic DNA. Translation: EAW99307.1.
BC018026 mRNA. Translation: AAH18026.1.
CCDSCCDS32294.1.
RefSeqNP_001025176.1. NM_001030005.2.
UniGeneHs.187694.

3D structure databases

ProteinModelPortalQ8WVH0.
SMRQ8WVH0. Positions 44-82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000378464.

Polymorphism databases

DMDM74751549.

Proteomic databases

PaxDbQ8WVH0.
PRIDEQ8WVH0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395018; ENSP00000378464; ENSG00000213578.
GeneID594855.
KEGGhsa:594855.
UCSCuc002ayu.1. human.

Organism-specific databases

CTD594855.
GeneCardsGC15P075118.
HGNCHGNC:27652. CPLX3.
MIM609585. gene.
neXtProtNX_Q8WVH0.
PharmGKBPA142672081.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38928.
HOGENOMHOG000111927.
HOVERGENHBG060856.
InParanoidQ8WVH0.
KOK15295.
OMATENCSLM.
OrthoDBEOG70CR8H.
PhylomeDBQ8WVH0.
TreeFamTF331867.

Gene expression databases

CleanExHS_CPLX3.
GenevestigatorQ8WVH0.

Family and domain databases

InterProIPR008849. Synaphin.
[Graphical view]
PANTHERPTHR16705. PTHR16705. 1 hit.
PfamPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio112775.
PROQ8WVH0.
SOURCESearch...

Entry information

Entry nameCPLX3_HUMAN
AccessionPrimary (citable) accession number: Q8WVH0
Secondary accession number(s): D3DW66, Q8TEM6, Q9H818
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM