Q8WVH0 (CPLX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complexin-3

Alternative name(s):
Complexin III
Short name=CPX III

Gene names

Name:	CPLX3
ORF Names:	Nbla11589

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Positively regulates a late step in synaptic vesicle exocytosis By similarity.
Subunit structure	Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A By similarity.
Subcellular location	Membrane; Lipid-anchor. Cell junction › synapse By similarity. Note: Enriched at the synaptic terminal By similarity.
Post-translational modification	Farnesylation mediates presynaptic targeting By similarity.
Sequence similarities	Belongs to the complexin/synaphin family.
Sequence caution	The sequence BAB84922.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Exocytosis Neurotransmitter transport Transport
Cellular component	Cell junction Membrane Synapse
Domain	Coiled coil
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	insulin secretion Inferred from electronic annotation. Source: Compara regulation of neurotransmitter secretion Inferred from electronic annotation. Source: Compara synaptic vesicle exocytosis Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytosol Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	neurotransmitter transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	Complexin-3		PRO_0000239272
	Propeptide	156 – 158	3	Removed in mature form By similarity		PRO_0000240233
Regions
	Coiled coil	39 – 74	36	Potential
Amino acid modifications
	Modified residue	155	1	Cysteine methyl ester By similarity
	Lipidation	155	1	S-farnesyl cysteine By similarity
Experimental info
	Sequence conflict	19	1	S → G in BAB14805. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8WVH0 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 057B4DE06DB6EA0F	FASTA	158	17,557
	10 20 30 40 50 60 MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ LVEEKMERDA 70 80 90 100 110 120 QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE LPRELAKMIE EDTEEEEEKA 130 140 150 SVLGQLASLP GLNLGSLKDK AQATLGDLKQ SAEKCHVM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structurally and functionally unique complexins at retinal ribbon synapses." Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N. J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[3]	"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma." Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A. Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY286501 mRNA. Translation: AAP41127.1. AK074096 mRNA. Translation: BAB84922.1. Different initiation. AB072900 mRNA. Translation: BAE45711.1. AK024055 mRNA. Translation: BAB14805.1. CH471136 Genomic DNA. Translation: EAW99306.1. CH471136 Genomic DNA. Translation: EAW99307.1. BC018026 mRNA. Translation: AAH18026.1.
IPI	IPI00552733.
RefSeq	NP_001025176.1. NM_001030005.2.
UniGene	Hs.187694.
3D structure databases
ProteinModelPortal	Q8WVH0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000378464.
Polymorphism databases
DMDM	74751549.
Proteomic databases
PaxDb	Q8WVH0.
PRIDE	Q8WVH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395018; ENSP00000378464; ENSG00000213578.
GeneID	594855.
KEGG	hsa:594855.
UCSC	uc002ayu.1. human.
Organism-specific databases
CTD	594855.
GeneCards	GC15P075118.
HGNC	HGNC:27652. CPLX3.
MIM	609585. gene.
neXtProt	NX_Q8WVH0.
PharmGKB	PA142672081.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38928.
HOGENOM	HOG000111927.
HOVERGEN	HBG060856.
InParanoid	Q8WVH0.
KO	K15295.
OMA	TENCSLM.
OrthoDB	EOG4R7VC3.
Gene expression databases
CleanEx	HS_CPLX3.
Genevestigator	Q8WVH0.
GermOnline	ENSG00000140506. Homo sapiens.
Family and domain databases
InterPro	IPR008849. Synaphin. [Graphical view]
PANTHER	PTHR16705. PTHR16705. 1 hit.
Pfam	PF05835. Synaphin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	112775.
SOURCE	Search...

Entry information

Entry name

CPLX3_HUMAN

Accession

Primary (citable) accession number: Q8WVH0
Secondary accession number(s): D3DW66, Q8TEM6, Q9H818

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.