Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WVH0

- CPLX3_HUMAN

UniProt

Q8WVH0 - CPLX3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Complexin-3

Gene

CPLX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.By similarity

GO - Molecular functioni

  1. neurotransmitter transporter activity Source: Ensembl

GO - Biological processi

  1. insulin secretion Source: Ensembl
  2. regulation of neurotransmitter secretion Source: Ensembl
  3. synaptic vesicle exocytosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-3
Alternative name(s):
Complexin III
Short name:
CPX III
Gene namesi
Name:CPLX3
ORF Names:Nbla11589
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:27652. CPLX3.

Subcellular locationi

Membrane; Lipid-anchor. Cell junctionsynapse By similarity
Note: Enriched at the synaptic terminal.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytosol Source: Ensembl
  3. plasma membrane Source: Ensembl
  4. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Complexin-3PRO_0000239272Add
BLAST
Propeptidei156 – 1583Removed in mature formBy similarityPRO_0000240233

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551Cysteine methyl esterBy similarity
Lipidationi155 – 1551S-farnesyl cysteineBy similarity

Post-translational modificationi

Farnesylation mediates presynaptic targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ8WVH0.
PRIDEiQ8WVH0.

Expressioni

Gene expression databases

CleanExiHS_CPLX3.
GenevestigatoriQ8WVH0.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000378464.

Structurei

3D structure databases

ProteinModelPortaliQ8WVH0.
SMRiQ8WVH0. Positions 44-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 7436Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG38928.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8WVH0.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG70CR8H.
PhylomeDBiQ8WVH0.
TreeFamiTF331867.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ
60 70 80 90 100
LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE
110 120 130 140 150
LPRELAKMIE EDTEEEEEKA SVLGQLASLP GLNLGSLKDK AQATLGDLKQ

SAEKCHVM
Length:158
Mass (Da):17,557
Last modified:March 1, 2002 - v1
Checksum:i057B4DE06DB6EA0F
GO

Sequence cautioni

The sequence BAB84922.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → G in BAB14805. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY286501 mRNA. Translation: AAP41127.1.
AK074096 mRNA. Translation: BAB84922.1. Different initiation.
AB072900 mRNA. Translation: BAE45711.1.
AK024055 mRNA. Translation: BAB14805.1.
CH471136 Genomic DNA. Translation: EAW99306.1.
CH471136 Genomic DNA. Translation: EAW99307.1.
BC018026 mRNA. Translation: AAH18026.1.
CCDSiCCDS32294.1.
RefSeqiNP_001025176.1. NM_001030005.2.
UniGeneiHs.187694.

Genome annotation databases

EnsembliENST00000395018; ENSP00000378464; ENSG00000213578.
GeneIDi594855.
KEGGihsa:594855.
UCSCiuc002ayu.1. human.

Polymorphism databases

DMDMi74751549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY286501 mRNA. Translation: AAP41127.1 .
AK074096 mRNA. Translation: BAB84922.1 . Different initiation.
AB072900 mRNA. Translation: BAE45711.1 .
AK024055 mRNA. Translation: BAB14805.1 .
CH471136 Genomic DNA. Translation: EAW99306.1 .
CH471136 Genomic DNA. Translation: EAW99307.1 .
BC018026 mRNA. Translation: AAH18026.1 .
CCDSi CCDS32294.1.
RefSeqi NP_001025176.1. NM_001030005.2.
UniGenei Hs.187694.

3D structure databases

ProteinModelPortali Q8WVH0.
SMRi Q8WVH0. Positions 44-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000378464.

Polymorphism databases

DMDMi 74751549.

Proteomic databases

PaxDbi Q8WVH0.
PRIDEi Q8WVH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395018 ; ENSP00000378464 ; ENSG00000213578 .
GeneIDi 594855.
KEGGi hsa:594855.
UCSCi uc002ayu.1. human.

Organism-specific databases

CTDi 594855.
GeneCardsi GC15P075118.
HGNCi HGNC:27652. CPLX3.
MIMi 609585. gene.
neXtProti NX_Q8WVH0.
PharmGKBi PA142672081.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38928.
GeneTreei ENSGT00490000043378.
HOGENOMi HOG000111927.
HOVERGENi HBG060856.
InParanoidi Q8WVH0.
KOi K15295.
OMAi TENCSLM.
OrthoDBi EOG70CR8H.
PhylomeDBi Q8WVH0.
TreeFami TF331867.

Miscellaneous databases

GenomeRNAii 594855.
NextBioi 112775.
PROi Q8WVH0.
SOURCEi Search...

Gene expression databases

CleanExi HS_CPLX3.
Genevestigatori Q8WVH0.

Family and domain databases

InterProi IPR008849. Synaphin.
[Graphical view ]
PANTHERi PTHR16705. PTHR16705. 1 hit.
Pfami PF05835. Synaphin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structurally and functionally unique complexins at retinal ribbon synapses."
    Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
    J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCPLX3_HUMAN
AccessioniPrimary (citable) accession number: Q8WVH0
Secondary accession number(s): D3DW66, Q8TEM6, Q9H818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3