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Q8WVH0

- CPLX3_HUMAN

UniProt

Q8WVH0 - CPLX3_HUMAN

Protein

Complexin-3

Gene

CPLX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Positively regulates a late step in synaptic vesicle exocytosis.By similarity

    GO - Molecular functioni

    1. neurotransmitter transporter activity Source: Ensembl

    GO - Biological processi

    1. insulin secretion Source: Ensembl
    2. regulation of neurotransmitter secretion Source: Ensembl
    3. synaptic vesicle exocytosis Source: Ensembl

    Keywords - Biological processi

    Exocytosis, Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complexin-3
    Alternative name(s):
    Complexin III
    Short name:
    CPX III
    Gene namesi
    Name:CPLX3
    ORF Names:Nbla11589
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:27652. CPLX3.

    Subcellular locationi

    Membrane; Lipid-anchor. Cell junctionsynapse By similarity
    Note: Enriched at the synaptic terminal.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672081.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 155155Complexin-3PRO_0000239272Add
    BLAST
    Propeptidei156 – 1583Removed in mature formBy similarityPRO_0000240233

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei155 – 1551Cysteine methyl esterBy similarity
    Lipidationi155 – 1551S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylation mediates presynaptic targeting.By similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ8WVH0.
    PRIDEiQ8WVH0.

    Expressioni

    Gene expression databases

    CleanExiHS_CPLX3.
    GenevestigatoriQ8WVH0.

    Interactioni

    Subunit structurei

    Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000378464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVH0.
    SMRiQ8WVH0. Positions 44-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili39 – 7436Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complexin/synaphin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG38928.
    HOGENOMiHOG000111927.
    HOVERGENiHBG060856.
    InParanoidiQ8WVH0.
    KOiK15295.
    OMAiTENCSLM.
    OrthoDBiEOG70CR8H.
    PhylomeDBiQ8WVH0.
    TreeFamiTF331867.

    Family and domain databases

    InterProiIPR008849. Synaphin.
    [Graphical view]
    PANTHERiPTHR16705. PTHR16705. 1 hit.
    PfamiPF05835. Synaphin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WVH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ    50
    LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE 100
    LPRELAKMIE EDTEEEEEKA SVLGQLASLP GLNLGSLKDK AQATLGDLKQ 150
    SAEKCHVM 158
    Length:158
    Mass (Da):17,557
    Last modified:March 1, 2002 - v1
    Checksum:i057B4DE06DB6EA0F
    GO

    Sequence cautioni

    The sequence BAB84922.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191S → G in BAB14805. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY286501 mRNA. Translation: AAP41127.1.
    AK074096 mRNA. Translation: BAB84922.1. Different initiation.
    AB072900 mRNA. Translation: BAE45711.1.
    AK024055 mRNA. Translation: BAB14805.1.
    CH471136 Genomic DNA. Translation: EAW99306.1.
    CH471136 Genomic DNA. Translation: EAW99307.1.
    BC018026 mRNA. Translation: AAH18026.1.
    CCDSiCCDS32294.1.
    RefSeqiNP_001025176.1. NM_001030005.2.
    UniGeneiHs.187694.

    Genome annotation databases

    EnsembliENST00000395018; ENSP00000378464; ENSG00000213578.
    GeneIDi594855.
    KEGGihsa:594855.
    UCSCiuc002ayu.1. human.

    Polymorphism databases

    DMDMi74751549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY286501 mRNA. Translation: AAP41127.1 .
    AK074096 mRNA. Translation: BAB84922.1 . Different initiation.
    AB072900 mRNA. Translation: BAE45711.1 .
    AK024055 mRNA. Translation: BAB14805.1 .
    CH471136 Genomic DNA. Translation: EAW99306.1 .
    CH471136 Genomic DNA. Translation: EAW99307.1 .
    BC018026 mRNA. Translation: AAH18026.1 .
    CCDSi CCDS32294.1.
    RefSeqi NP_001025176.1. NM_001030005.2.
    UniGenei Hs.187694.

    3D structure databases

    ProteinModelPortali Q8WVH0.
    SMRi Q8WVH0. Positions 44-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000378464.

    Polymorphism databases

    DMDMi 74751549.

    Proteomic databases

    PaxDbi Q8WVH0.
    PRIDEi Q8WVH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395018 ; ENSP00000378464 ; ENSG00000213578 .
    GeneIDi 594855.
    KEGGi hsa:594855.
    UCSCi uc002ayu.1. human.

    Organism-specific databases

    CTDi 594855.
    GeneCardsi GC15P075118.
    HGNCi HGNC:27652. CPLX3.
    MIMi 609585. gene.
    neXtProti NX_Q8WVH0.
    PharmGKBi PA142672081.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38928.
    HOGENOMi HOG000111927.
    HOVERGENi HBG060856.
    InParanoidi Q8WVH0.
    KOi K15295.
    OMAi TENCSLM.
    OrthoDBi EOG70CR8H.
    PhylomeDBi Q8WVH0.
    TreeFami TF331867.

    Miscellaneous databases

    NextBioi 112775.
    PROi Q8WVH0.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CPLX3.
    Genevestigatori Q8WVH0.

    Family and domain databases

    InterProi IPR008849. Synaphin.
    [Graphical view ]
    PANTHERi PTHR16705. PTHR16705. 1 hit.
    Pfami PF05835. Synaphin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structurally and functionally unique complexins at retinal ribbon synapses."
      Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
      J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neuroblastoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCPLX3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVH0
    Secondary accession number(s): D3DW66, Q8TEM6, Q9H818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3