ID   KCTD4_HUMAN             Reviewed;         259 AA.
AC   Q8WVF5; Q5W0P9;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   27-MAR-2024, entry version 147.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD4;
GN   Name=KCTD4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8WVF5; Q9UER7: DAXX; NbExp=3; IntAct=EBI-741463, EBI-77321;
CC       Q8WVF5; Q5JVL4: EFHC1; NbExp=6; IntAct=EBI-741463, EBI-743105;
CC       Q8WVF5; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-741463, EBI-741158;
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DR   EMBL; AK290675; BAF83364.1; -; mRNA.
DR   EMBL; AL138693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471075; EAX08730.1; -; Genomic_DNA.
DR   EMBL; BC018063; AAH18063.1; -; mRNA.
DR   CCDS; CCDS9396.1; -.
DR   RefSeq; NP_940686.2; NM_198404.2.
DR   AlphaFoldDB; Q8WVF5; -.
DR   SMR; Q8WVF5; -.
DR   BioGRID; 132114; 15.
DR   IntAct; Q8WVF5; 6.
DR   STRING; 9606.ENSP00000368402; -.
DR   iPTMnet; Q8WVF5; -.
DR   PhosphoSitePlus; Q8WVF5; -.
DR   BioMuta; KCTD4; -.
DR   DMDM; 206729877; -.
DR   MassIVE; Q8WVF5; -.
DR   MaxQB; Q8WVF5; -.
DR   PaxDb; 9606-ENSP00000368402; -.
DR   PeptideAtlas; Q8WVF5; -.
DR   ProteomicsDB; 74792; -.
DR   Antibodypedia; 23595; 187 antibodies from 22 providers.
DR   DNASU; 386618; -.
DR   Ensembl; ENST00000379108.2; ENSP00000368402.1; ENSG00000180332.7.
DR   GeneID; 386618; -.
DR   KEGG; hsa:386618; -.
DR   MANE-Select; ENST00000379108.2; ENSP00000368402.1; NM_198404.3; NP_940686.2.
DR   UCSC; uc058wts.1; human.
DR   AGR; HGNC:23227; -.
DR   CTD; 386618; -.
DR   GeneCards; KCTD4; -.
DR   HGNC; HGNC:23227; KCTD4.
DR   HPA; ENSG00000180332; Tissue enriched (brain).
DR   MIM; 620638; gene.
DR   neXtProt; NX_Q8WVF5; -.
DR   OpenTargets; ENSG00000180332; -.
DR   PharmGKB; PA134880839; -.
DR   VEuPathDB; HostDB:ENSG00000180332; -.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000159552; -.
DR   HOGENOM; CLU_1081647_0_0_1; -.
DR   InParanoid; Q8WVF5; -.
DR   OMA; GKKPVQH; -.
DR   OrthoDB; 2912088at2759; -.
DR   PhylomeDB; Q8WVF5; -.
DR   TreeFam; TF315332; -.
DR   PathwayCommons; Q8WVF5; -.
DR   SignaLink; Q8WVF5; -.
DR   BioGRID-ORCS; 386618; 10 hits in 1146 CRISPR screens.
DR   GenomeRNAi; 386618; -.
DR   Pharos; Q8WVF5; Tdark.
DR   PRO; PR:Q8WVF5; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q8WVF5; Protein.
DR   Bgee; ENSG00000180332; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 105 other cell types or tissues.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18364; BTB_POZ_KCTD4; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045740; KCTD4_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14499:SF9; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD4; 1.
DR   PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF19323; KCTD4_C; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   Genevisible; Q8WVF5; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..259
FT                   /note="BTB/POZ domain-containing protein KCTD4"
FT                   /id="PRO_0000191289"
FT   DOMAIN          33..134
FT                   /note="BTB"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        195
FT                   /note="Q -> R (in Ref. 4; AAH18063)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   259 AA;  29967 MW;  9630F610E0466741 CRC64;
     MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE
     GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK
     GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL
     DGFPEEFSIS SNIIQFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT
     SLDCSKGSIV HSDALHFIK
//