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Q8WVF5

- KCTD4_HUMAN

UniProt

Q8WVF5 - KCTD4_HUMAN

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Protein

BTB/POZ domain-containing protein KCTD4

Gene

KCTD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD4
Gene namesi
Name:KCTD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:23227. KCTD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259BTB/POZ domain-containing protein KCTD4PRO_0000191289Add
BLAST

Proteomic databases

MaxQBiQ8WVF5.
PaxDbiQ8WVF5.
PRIDEiQ8WVF5.

PTM databases

PhosphoSiteiQ8WVF5.

Expressioni

Gene expression databases

BgeeiQ8WVF5.
CleanExiHS_KCTD4.
GenevestigatoriQ8WVF5.

Organism-specific databases

HPAiHPA040734.

Interactioni

Protein-protein interaction databases

BioGridi132114. 2 interactions.
IntActiQ8WVF5. 1 interaction.
MINTiMINT-1438597.
STRINGi9606.ENSP00000368402.

Structurei

3D structure databases

ProteinModelPortaliQ8WVF5.
SMRiQ8WVF5. Positions 34-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 134102BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG241047.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000113213.
HOVERGENiHBG052242.
InParanoidiQ8WVF5.
OMAiTDSHERS.
OrthoDBiEOG7C2R1X.
PhylomeDBiQ8WVF5.
TreeFamiTF315332.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WVF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT
60 70 80 90 100
LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL
110 120 130 140 150
PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD
160 170 180 190 200
RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIQFKYFI
210 220 230 240 250
KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV

HSDALHFIK
Length:259
Mass (Da):29,967
Last modified:September 23, 2008 - v2
Checksum:i9630F610E0466741
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951Q → R in AAH18063. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290675 mRNA. Translation: BAF83364.1.
AL138693 Genomic DNA. Translation: CAH72460.1.
CH471075 Genomic DNA. Translation: EAX08730.1.
BC018063 mRNA. Translation: AAH18063.1.
CCDSiCCDS9396.1.
RefSeqiNP_940686.2. NM_198404.2.
UniGeneiHs.23406.
Hs.693242.

Genome annotation databases

EnsembliENST00000379108; ENSP00000368402; ENSG00000180332.
GeneIDi386618.
KEGGihsa:386618.
UCSCiuc001uzx.4. human.

Polymorphism databases

DMDMi206729877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290675 mRNA. Translation: BAF83364.1 .
AL138693 Genomic DNA. Translation: CAH72460.1 .
CH471075 Genomic DNA. Translation: EAX08730.1 .
BC018063 mRNA. Translation: AAH18063.1 .
CCDSi CCDS9396.1.
RefSeqi NP_940686.2. NM_198404.2.
UniGenei Hs.23406.
Hs.693242.

3D structure databases

ProteinModelPortali Q8WVF5.
SMRi Q8WVF5. Positions 34-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132114. 2 interactions.
IntActi Q8WVF5. 1 interaction.
MINTi MINT-1438597.
STRINGi 9606.ENSP00000368402.

PTM databases

PhosphoSitei Q8WVF5.

Polymorphism databases

DMDMi 206729877.

Proteomic databases

MaxQBi Q8WVF5.
PaxDbi Q8WVF5.
PRIDEi Q8WVF5.

Protocols and materials databases

DNASUi 386618.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379108 ; ENSP00000368402 ; ENSG00000180332 .
GeneIDi 386618.
KEGGi hsa:386618.
UCSCi uc001uzx.4. human.

Organism-specific databases

CTDi 386618.
GeneCardsi GC13M045766.
HGNCi HGNC:23227. KCTD4.
HPAi HPA040734.
neXtProti NX_Q8WVF5.
PharmGKBi PA134880839.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241047.
GeneTreei ENSGT00760000119013.
HOGENOMi HOG000113213.
HOVERGENi HBG052242.
InParanoidi Q8WVF5.
OMAi TDSHERS.
OrthoDBi EOG7C2R1X.
PhylomeDBi Q8WVF5.
TreeFami TF315332.

Miscellaneous databases

GenomeRNAii 386618.
NextBioi 100949.
PROi Q8WVF5.

Gene expression databases

Bgeei Q8WVF5.
CleanExi HS_KCTD4.
Genevestigatori Q8WVF5.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCTD4_HUMAN
AccessioniPrimary (citable) accession number: Q8WVF5
Secondary accession number(s): Q5W0P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3