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Q8WVF5

- KCTD4_HUMAN

UniProt

Q8WVF5 - KCTD4_HUMAN

Protein

BTB/POZ domain-containing protein KCTD4

Gene

KCTD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD4
    Gene namesi
    Name:KCTD4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:23227. KCTD4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259BTB/POZ domain-containing protein KCTD4PRO_0000191289Add
    BLAST

    Proteomic databases

    MaxQBiQ8WVF5.
    PaxDbiQ8WVF5.
    PRIDEiQ8WVF5.

    PTM databases

    PhosphoSiteiQ8WVF5.

    Expressioni

    Gene expression databases

    BgeeiQ8WVF5.
    CleanExiHS_KCTD4.
    GenevestigatoriQ8WVF5.

    Organism-specific databases

    HPAiHPA040734.

    Interactioni

    Protein-protein interaction databases

    BioGridi132114. 2 interactions.
    IntActiQ8WVF5. 1 interaction.
    MINTiMINT-1438597.
    STRINGi9606.ENSP00000368402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVF5.
    SMRiQ8WVF5. Positions 34-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 134102BTBAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG241047.
    HOGENOMiHOG000113213.
    HOVERGENiHBG052242.
    InParanoidiQ8WVF5.
    OMAiTDSHERS.
    OrthoDBiEOG7C2R1X.
    PhylomeDBiQ8WVF5.
    TreeFamiTF315332.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8WVF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT    50
    LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL 100
    PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD 150
    RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIQFKYFI 200
    KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV 250
    HSDALHFIK 259
    Length:259
    Mass (Da):29,967
    Last modified:September 23, 2008 - v2
    Checksum:i9630F610E0466741
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951Q → R in AAH18063. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290675 mRNA. Translation: BAF83364.1.
    AL138693 Genomic DNA. Translation: CAH72460.1.
    CH471075 Genomic DNA. Translation: EAX08730.1.
    BC018063 mRNA. Translation: AAH18063.1.
    CCDSiCCDS9396.1.
    RefSeqiNP_940686.2. NM_198404.2.
    UniGeneiHs.23406.
    Hs.693242.

    Genome annotation databases

    EnsembliENST00000379108; ENSP00000368402; ENSG00000180332.
    GeneIDi386618.
    KEGGihsa:386618.
    UCSCiuc001uzx.4. human.

    Polymorphism databases

    DMDMi206729877.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290675 mRNA. Translation: BAF83364.1 .
    AL138693 Genomic DNA. Translation: CAH72460.1 .
    CH471075 Genomic DNA. Translation: EAX08730.1 .
    BC018063 mRNA. Translation: AAH18063.1 .
    CCDSi CCDS9396.1.
    RefSeqi NP_940686.2. NM_198404.2.
    UniGenei Hs.23406.
    Hs.693242.

    3D structure databases

    ProteinModelPortali Q8WVF5.
    SMRi Q8WVF5. Positions 34-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132114. 2 interactions.
    IntActi Q8WVF5. 1 interaction.
    MINTi MINT-1438597.
    STRINGi 9606.ENSP00000368402.

    PTM databases

    PhosphoSitei Q8WVF5.

    Polymorphism databases

    DMDMi 206729877.

    Proteomic databases

    MaxQBi Q8WVF5.
    PaxDbi Q8WVF5.
    PRIDEi Q8WVF5.

    Protocols and materials databases

    DNASUi 386618.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379108 ; ENSP00000368402 ; ENSG00000180332 .
    GeneIDi 386618.
    KEGGi hsa:386618.
    UCSCi uc001uzx.4. human.

    Organism-specific databases

    CTDi 386618.
    GeneCardsi GC13M045766.
    HGNCi HGNC:23227. KCTD4.
    HPAi HPA040734.
    neXtProti NX_Q8WVF5.
    PharmGKBi PA134880839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241047.
    HOGENOMi HOG000113213.
    HOVERGENi HBG052242.
    InParanoidi Q8WVF5.
    OMAi TDSHERS.
    OrthoDBi EOG7C2R1X.
    PhylomeDBi Q8WVF5.
    TreeFami TF315332.

    Miscellaneous databases

    GenomeRNAii 386618.
    NextBioi 100949.
    PROi Q8WVF5.

    Gene expression databases

    Bgeei Q8WVF5.
    CleanExi HS_KCTD4.
    Genevestigatori Q8WVF5.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCTD4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVF5
    Secondary accession number(s): Q5W0P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3