Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD4

Gene

KCTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD4
Gene namesi
Name:KCTD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:23227. KCTD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880839.

Polymorphism and mutation databases

BioMutaiKCTD4.
DMDMi206729877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259BTB/POZ domain-containing protein KCTD4PRO_0000191289Add
BLAST

Proteomic databases

MaxQBiQ8WVF5.
PaxDbiQ8WVF5.
PRIDEiQ8WVF5.

PTM databases

PhosphoSiteiQ8WVF5.

Expressioni

Gene expression databases

BgeeiQ8WVF5.
CleanExiHS_KCTD4.
GenevisibleiQ8WVF5. HS.

Organism-specific databases

HPAiHPA040734.

Interactioni

Protein-protein interaction databases

BioGridi132114. 2 interactions.
IntActiQ8WVF5. 3 interactions.
MINTiMINT-1438597.
STRINGi9606.ENSP00000368402.

Structurei

3D structure databases

ProteinModelPortaliQ8WVF5.
SMRiQ8WVF5. Positions 34-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 134102BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG241047.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000113213.
HOVERGENiHBG052242.
InParanoidiQ8WVF5.
OMAiTDSHERS.
OrthoDBiEOG7C2R1X.
PhylomeDBiQ8WVF5.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WVF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT
60 70 80 90 100
LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL
110 120 130 140 150
PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD
160 170 180 190 200
RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIQFKYFI
210 220 230 240 250
KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV

HSDALHFIK
Length:259
Mass (Da):29,967
Last modified:September 23, 2008 - v2
Checksum:i9630F610E0466741
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951Q → R in AAH18063 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290675 mRNA. Translation: BAF83364.1.
AL138693 Genomic DNA. Translation: CAH72460.1.
CH471075 Genomic DNA. Translation: EAX08730.1.
BC018063 mRNA. Translation: AAH18063.1.
CCDSiCCDS9396.1.
RefSeqiNP_940686.2. NM_198404.2.
UniGeneiHs.23406.
Hs.693242.

Genome annotation databases

EnsembliENST00000379108; ENSP00000368402; ENSG00000180332.
GeneIDi386618.
KEGGihsa:386618.
UCSCiuc001uzx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290675 mRNA. Translation: BAF83364.1.
AL138693 Genomic DNA. Translation: CAH72460.1.
CH471075 Genomic DNA. Translation: EAX08730.1.
BC018063 mRNA. Translation: AAH18063.1.
CCDSiCCDS9396.1.
RefSeqiNP_940686.2. NM_198404.2.
UniGeneiHs.23406.
Hs.693242.

3D structure databases

ProteinModelPortaliQ8WVF5.
SMRiQ8WVF5. Positions 34-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132114. 2 interactions.
IntActiQ8WVF5. 3 interactions.
MINTiMINT-1438597.
STRINGi9606.ENSP00000368402.

PTM databases

PhosphoSiteiQ8WVF5.

Polymorphism and mutation databases

BioMutaiKCTD4.
DMDMi206729877.

Proteomic databases

MaxQBiQ8WVF5.
PaxDbiQ8WVF5.
PRIDEiQ8WVF5.

Protocols and materials databases

DNASUi386618.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379108; ENSP00000368402; ENSG00000180332.
GeneIDi386618.
KEGGihsa:386618.
UCSCiuc001uzx.4. human.

Organism-specific databases

CTDi386618.
GeneCardsiGC13M045766.
HGNCiHGNC:23227. KCTD4.
HPAiHPA040734.
neXtProtiNX_Q8WVF5.
PharmGKBiPA134880839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241047.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000113213.
HOVERGENiHBG052242.
InParanoidiQ8WVF5.
OMAiTDSHERS.
OrthoDBiEOG7C2R1X.
PhylomeDBiQ8WVF5.
TreeFamiTF315332.

Miscellaneous databases

GenomeRNAii386618.
NextBioi100949.
PROiQ8WVF5.

Gene expression databases

BgeeiQ8WVF5.
CleanExiHS_KCTD4.
GenevisibleiQ8WVF5. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCTD4_HUMAN
AccessioniPrimary (citable) accession number: Q8WVF5
Secondary accession number(s): Q5W0P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 23, 2008
Last modified: June 24, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.