Q8WVF2 (UCMA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unique cartilage matrix-associated protein

Cleaved into the following chain:

1. Unique cartilage matrix-associated protein C-terminal fragment
   Short name=Ucma-C
   Alternative name(s):
   Gla-rich protein
   Short name=GRP

Gene names

Name:	UCMA
Synonyms:	C10orf49

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Predominantly expressed in resting chondrocytes. Ref.3
Post-translational modification	Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation By similarity. Sulfated on tyrosine residues By similarity.
Sequence similarities	Belongs to the UCMA family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Coiled coil Signal
PTM	Gamma-carboxyglutamic acid Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 138	112	Unique cartilage matrix-associated protein		PRO_0000019549
	Propeptide	28 – 64	37	Ucma-N		PRO_0000347063
	Chain	65 – 138	74	Unique cartilage matrix-associated protein C-terminal fragment		PRO_0000347064
Regions
	Coiled coil	90 – 122	33	Potential
Amino acid modifications
	Modified residue	71	1	4-carboxyglutamate By similarity
	Modified residue	75	1	4-carboxyglutamate By similarity
	Modified residue	84	1	4-carboxyglutamate By similarity
	Modified residue	88	1	4-carboxyglutamate By similarity
	Modified residue	91	1	4-carboxyglutamate By similarity
	Modified residue	92	1	4-carboxyglutamate By similarity
	Modified residue	96	1	4-carboxyglutamate By similarity
	Modified residue	98	1	4-carboxyglutamate By similarity
	Modified residue	102	1	4-carboxyglutamate By similarity
	Modified residue	103	1	4-carboxyglutamate By similarity
	Modified residue	107	1	4-carboxyglutamate By similarity
	Modified residue	110	1	4-carboxyglutamate By similarity
	Modified residue	114	1	4-carboxyglutamate By similarity
	Modified residue	117	1	4-carboxyglutamate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WVF2 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: DFCF8D3DA9B36F23	FASTA	138	16,563
	10 20 30 40 50 60 MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR 70 80 90 100 110 120 RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR 130 QWHYDGLHPS YLYNRHHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[3]	"Expression profiling of human fetal growth plate cartilage by EST sequencing." Tagariello A., Schlaubitz S., Hankeln T., Mohrmann G., Stelzer C., Schweizer A., Hermanns P., Lee B., Schmidt E.R., Winterpacht A., Zabel B. Matrix Biol. 24:530-538(2005) [PubMed: 16176871] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL138764 Genomic DNA. Translation: CAI12909.1. BC018068 mRNA. Translation: AAH18068.2.
IPI	IPI00103115.
RefSeq	NP_660357.2. NM_145314.1.
UniGene	Hs.112998.
3D structure databases
ProteinModelPortal	Q8WVF2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WVF2.
Polymorphism databases
DMDM	68565241.
Proteomic databases
PRIDE	Q8WVF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378681; ENSP00000367952; ENSG00000165623.
GeneID	221044.
KEGG	hsa:221044.
UCSC	uc001imd.1. human.
Organism-specific databases
CTD	221044.
GeneCards	GC10M013263.
HGNC	HGNC:25205. UCMA.
neXtProt	NX_Q8WVF2.
PharmGKB	PA134974354. PA164727494.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21366.
GeneTree	ENSGT00390000011492.
HOGENOM	HBG446372.
HOVERGEN	HBG098812.
InParanoid	Q8WVF2.
OMA	PSYLYNR.
OrthoDB	EOG4T784K.
Gene expression databases
ArrayExpress	Q8WVF2.
Bgee	Q8WVF2.
CleanEx	HS_C10orf49.
Genevestigator	Q8WVF2.
GermOnline	ENSG00000165623. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	91167.
PMAP-CutDB	Q8WVF2.

Entry information

Entry name

UCMA_HUMAN

Accession

Primary (citable) accession number: Q8WVF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.