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Protein

Unique cartilage matrix-associated protein

Gene

UCMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Unique cartilage matrix-associated protein
Cleaved into the following chain:
Alternative name(s):
Gla-rich protein
Short name:
GRP
Gene namesi
Name:UCMA
Synonyms:C10orf49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25205. UCMA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi221044.
OpenTargetsiENSG00000165623.
PharmGKBiPA164727494.

Polymorphism and mutation databases

BioMutaiUCMA.
DMDMi68565241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001954927 – 138Unique cartilage matrix-associated proteinAdd BLAST112
PropeptideiPRO_000034706328 – 64Ucma-NAdd BLAST37
ChainiPRO_000034706465 – 138Unique cartilage matrix-associated protein C-terminal fragmentAdd BLAST74

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.By similarity
Sulfated on tyrosine residues.By similarity

Keywords - PTMi

Sulfation

Proteomic databases

EPDiQ8WVF2.
PaxDbiQ8WVF2.
PeptideAtlasiQ8WVF2.
PRIDEiQ8WVF2.

Miscellaneous databases

PMAP-CutDBQ8WVF2.

Expressioni

Tissue specificityi

Predominantly expressed in resting chondrocytes.1 Publication

Gene expression databases

BgeeiENSG00000165623.
CleanExiHS_C10orf49.
ExpressionAtlasiQ8WVF2. baseline and differential.
GenevisibleiQ8WVF2. HS.

Organism-specific databases

HPAiHPA046718.

Interactioni

Protein-protein interaction databases

BioGridi128678. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8WVF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 122Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the UCMA family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IY09. Eukaryota.
ENOG4111U8I. LUCA.
GeneTreeiENSGT00390000011492.
HOGENOMiHOG000253965.
HOVERGENiHBG098812.
InParanoidiQ8WVF2.
OMAiYLYNRHH.
OrthoDBiEOG091G10F8.
PhylomeDBiQ8WVF2.
TreeFamiTF332568.

Family and domain databases

InterProiIPR031386. UCMA.
[Graphical view]
PfamiPF17085. UCMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ
60 70 80 90 100
ESDASNFLKR RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF
110 120 130
VEEQNDEQEE RSREAVEQWR QWHYDGLHPS YLYNRHHT
Length:138
Mass (Da):16,563
Last modified:October 11, 2004 - v2
Checksum:iDFCF8D3DA9B36F23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138764 Genomic DNA. Translation: CAI12909.1.
BC018068 mRNA. Translation: AAH18068.2.
CCDSiCCDS31147.1.
RefSeqiNP_001290047.1. NM_001303118.1.
NP_001290048.1. NM_001303119.1.
NP_660357.2. NM_145314.2.
UniGeneiHs.112998.

Genome annotation databases

EnsembliENST00000378681; ENSP00000367952; ENSG00000165623.
GeneIDi221044.
KEGGihsa:221044.
UCSCiuc001imd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138764 Genomic DNA. Translation: CAI12909.1.
BC018068 mRNA. Translation: AAH18068.2.
CCDSiCCDS31147.1.
RefSeqiNP_001290047.1. NM_001303118.1.
NP_001290048.1. NM_001303119.1.
NP_660357.2. NM_145314.2.
UniGeneiHs.112998.

3D structure databases

ProteinModelPortaliQ8WVF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128678. 1 interactor.

Polymorphism and mutation databases

BioMutaiUCMA.
DMDMi68565241.

Proteomic databases

EPDiQ8WVF2.
PaxDbiQ8WVF2.
PeptideAtlasiQ8WVF2.
PRIDEiQ8WVF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378681; ENSP00000367952; ENSG00000165623.
GeneIDi221044.
KEGGihsa:221044.
UCSCiuc001imd.4. human.

Organism-specific databases

CTDi221044.
DisGeNETi221044.
GeneCardsiUCMA.
HGNCiHGNC:25205. UCMA.
HPAiHPA046718.
neXtProtiNX_Q8WVF2.
OpenTargetsiENSG00000165623.
PharmGKBiPA164727494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY09. Eukaryota.
ENOG4111U8I. LUCA.
GeneTreeiENSGT00390000011492.
HOGENOMiHOG000253965.
HOVERGENiHBG098812.
InParanoidiQ8WVF2.
OMAiYLYNRHH.
OrthoDBiEOG091G10F8.
PhylomeDBiQ8WVF2.
TreeFamiTF332568.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165623-MONOMER.

Miscellaneous databases

GenomeRNAii221044.
PMAP-CutDBQ8WVF2.
PROiQ8WVF2.

Gene expression databases

BgeeiENSG00000165623.
CleanExiHS_C10orf49.
ExpressionAtlasiQ8WVF2. baseline and differential.
GenevisibleiQ8WVF2. HS.

Family and domain databases

InterProiIPR031386. UCMA.
[Graphical view]
PfamiPF17085. UCMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCMA_HUMAN
AccessioniPrimary (citable) accession number: Q8WVF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.