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Protein

Protein OSCP1

Gene

OSCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in drug clearance in the placenta.1 Publication

Miscellaneous

May be involved in the development and/or progression of nosopharyngeal carcinoma.

Caution

The polymorphism 'Glu58Gly' (described in PubMed:12819961) is in fact an error, the G to A change described representing a synonymous mutation that does not induce any amino acid change in Gly-32.Curated

Kineticsi

In Xenopus laevis oocytes, in a sodium-independent manner.
  1. KM=35.0 µM for p-aminohippurate (PAH)1 Publication
  2. KM=62.3 µM for tetraethylammonium1 Publication

    Keywordsi

    Biological processTransport

    Protein family/group databases

    TCDBi9.B.68.1.1 the putative na-independent organic solute carrier protein (oscp1) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OSCP1
    Short name:
    hOSCP1
    Alternative name(s):
    Organic solute transport protein 1
    Oxidored-nitro domain-containing protein 1
    Gene namesi
    Name:OSCP1
    Synonyms:C1orf102, NOR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000116885.18
    HGNCiHGNC:29971 OSCP1
    MIMi608854 gene
    neXtProtiNX_Q8WVF1

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi127700
    OpenTargetsiENSG00000116885
    PharmGKBiPA165752125

    Polymorphism and mutation databases

    BioMutaiOSCP1
    DMDMi300669715

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002519651 – 389Protein OSCP1Add BLAST389

    Proteomic databases

    EPDiQ8WVF1
    MaxQBiQ8WVF1
    PaxDbiQ8WVF1
    PeptideAtlasiQ8WVF1
    PRIDEiQ8WVF1

    PTM databases

    iPTMnetiQ8WVF1
    PhosphoSitePlusiQ8WVF1

    Expressioni

    Tissue specificityi

    Expressed predominantly in testis, also found in placenta and to a lesser extent in thymus and small intestine; abundantly expressed in tumor-derived cell lines (PubMed:16006562). Ubiquitously expressed (PubMed:12819961).2 Publications

    Gene expression databases

    BgeeiENSG00000116885
    CleanExiHS_C1orf102
    ExpressionAtlasiQ8WVF1 baseline and differential
    GenevisibleiQ8WVF1 HS

    Organism-specific databases

    HPAiHPA028436
    HPA052655

    Interactioni

    Protein-protein interaction databases

    BioGridi126078, 5 interactors
    IntActiQ8WVF1, 1 interactor
    STRINGi9606.ENSP00000235532

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVF1
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiKOG4033 Eukaryota
    ENOG41107FG LUCA
    GeneTreeiENSGT00390000004808
    HOVERGENiHBG055313
    InParanoidiQ8WVF1
    OMAiGTNMYSV
    OrthoDBiEOG091G0N0U
    PhylomeDBiQ8WVF1
    TreeFamiTF105789

    Family and domain databases

    InterProiView protein in InterPro
    IPR019332 OSCP1
    PfamiView protein in Pfam
    PF10188 Oscp1, 1 hit

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8WVF1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN
    60 70 80 90 100
    DIISTMFNRK FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL
    110 120 130 140 150
    YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD TIKGFIRDSP TILQQVDETL
    160 170 180 190 200
    RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRVSMFLKDK VQNNNGRFVL
    210 220 230 240 250
    PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA PKEGSFELYG
    260 270 280 290 300
    DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA
    310 320 330 340 350
    RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT
    360 370 380
    QDQQRSEELA RIMGEFEITE QPRLSTSKGD DLLAMMDEL
    Length:389
    Mass (Da):44,586
    Last modified:July 13, 2010 - v4
    Checksum:i8EA5C1EF2D9973F4
    GO
    Isoform 2 (identifier: Q8WVF1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         329-378: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:339
    Mass (Da):38,810
    Checksum:iA275B77A753D79D1
    GO
    Isoform 3 (identifier: Q8WVF1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-47: Missing.

    Show »
    Length:379
    Mass (Da):43,271
    Checksum:iB233ECE9C1E46F08
    GO
    Isoform 4 (identifier: Q8WVF1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-47: Missing.
         183-231: VSMFLKDKVQ...KGEEVKRIEF → RECFWKHMQE...ENFEFCTWAK
         232-389: Missing.

    Show »
    Length:223
    Mass (Da):26,431
    Checksum:i769226B3771F756D
    GO

    Sequence cautioni

    The sequence AAL89738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti51D → G in BAC05326 (PubMed:14702039).Curated1
    Sequence conflicti317G → R in BAE16984 (PubMed:16006562).Curated1
    Sequence conflicti377S → G in AAL89738 (PubMed:12819961).Curated1
    Sequence conflicti377S → G in AAH18069 (Ref. 5) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02774131P → R2 PublicationsCorresponds to variant dbSNP:rs11547025Ensembl.1
    Natural variantiVAR_056958141T → A1 PublicationCorresponds to variant dbSNP:rs34409118Ensembl.1
    Natural variantiVAR_027742242K → E. Corresponds to variant dbSNP:rs2359016Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_03947538 – 47Missing in isoform 3 and isoform 4. 3 Publications10
    Alternative sequenceiVSP_039476183 – 231VSMFL…KRIEF → RECFWKHMQETVHSAQCCLP GVGNYMEDRRRRLTFHYVYP FENFEFCTWAK in isoform 4. CuratedAdd BLAST49
    Alternative sequenceiVSP_039477232 – 389Missing in isoform 4. CuratedAdd BLAST158
    Alternative sequenceiVSP_020826329 – 378Missing in isoform 2. 1 PublicationAdd BLAST50

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF462348 mRNA Translation: AAL89738.1 Different initiation.
    AB079075 mRNA Translation: BAE16984.1
    AK098541 mRNA Translation: BAC05326.1
    AC119675 Genomic DNA No translation available.
    CH471059 Genomic DNA Translation: EAX07365.1
    BC018069 mRNA Translation: AAH18069.2
    CCDSiCCDS409.2 [Q8WVF1-3]
    CCDS410.1 [Q8WVF1-4]
    CCDS81301.1 [Q8WVF1-1]
    RefSeqiNP_001317422.1, NM_001330493.1 [Q8WVF1-1]
    NP_659484.4, NM_145047.4 [Q8WVF1-3]
    NP_996668.1, NM_206837.2 [Q8WVF1-4]
    UniGeneiHs.202207

    Genome annotation databases

    EnsembliENST00000235532; ENSP00000235532; ENSG00000116885 [Q8WVF1-3]
    ENST00000354267; ENSP00000346216; ENSG00000116885 [Q8WVF1-4]
    ENST00000356637; ENSP00000349052; ENSG00000116885 [Q8WVF1-1]
    GeneIDi127700
    KEGGihsa:127700
    UCSCiuc001caq.4 human [Q8WVF1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiOSCP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVF1
    Secondary accession number(s): A6NHM5
    , A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 13, 2010
    Last modified: May 23, 2018
    This is version 110 of the entry and version 4 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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