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Protein

Protein OSCP1

Gene

OSCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in drug clearance in the placenta.1 Publication

Kineticsi

In Xenopus laevis oocytes, in a sodium-independent manner.

  1. KM=35.0 µM for p-aminohippurate (PAH)1 Publication
  2. KM=62.3 µM for tetraethylammonium1 Publication

    GO - Biological processi

    • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
    • transport Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi9.B.68.1.1. the putative na-independent organic solute carrier protein (oscp1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OSCP1
    Short name:
    hOSCP1
    Alternative name(s):
    Organic solute transport protein 1
    Oxidored-nitro domain-containing protein 1
    Gene namesi
    Name:OSCP1
    Synonyms:C1orf102, NOR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29971. OSCP1.

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165752125.

    Polymorphism and mutation databases

    BioMutaiOSCP1.
    DMDMi300669715.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Protein OSCP1PRO_0000251965Add
    BLAST

    Proteomic databases

    EPDiQ8WVF1.
    MaxQBiQ8WVF1.
    PaxDbiQ8WVF1.
    PeptideAtlasiQ8WVF1.
    PRIDEiQ8WVF1.

    PTM databases

    iPTMnetiQ8WVF1.
    PhosphoSiteiQ8WVF1.

    Expressioni

    Tissue specificityi

    Expressed predominantly in testis, also found in placenta and to a lesser extent in thymus and small intestine; abundantly expressed in tumor-derived cell lines (PubMed:16006562). Ubiquitously expressed (PubMed:12819961).2 Publications

    Gene expression databases

    BgeeiENSG00000116885.
    CleanExiHS_C1orf102.
    ExpressionAtlasiQ8WVF1. baseline and differential.
    GenevisibleiQ8WVF1. HS.

    Organism-specific databases

    HPAiHPA028436.
    HPA052655.

    Interactioni

    Protein-protein interaction databases

    BioGridi126078. 5 interactions.
    IntActiQ8WVF1. 1 interaction.
    STRINGi9606.ENSP00000235532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiKOG4033. Eukaryota.
    ENOG41107FG. LUCA.
    GeneTreeiENSGT00390000004808.
    HOVERGENiHBG055313.
    InParanoidiQ8WVF1.
    OMAiTNMYSVN.
    OrthoDBiEOG091G0N0U.
    PhylomeDBiQ8WVF1.
    TreeFamiTF105789.

    Family and domain databases

    InterProiIPR019332. OSCP1.
    [Graphical view]
    PfamiPF10188. Oscp1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8WVF1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN
    60 70 80 90 100
    DIISTMFNRK FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL
    110 120 130 140 150
    YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD TIKGFIRDSP TILQQVDETL
    160 170 180 190 200
    RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRVSMFLKDK VQNNNGRFVL
    210 220 230 240 250
    PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA PKEGSFELYG
    260 270 280 290 300
    DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA
    310 320 330 340 350
    RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT
    360 370 380
    QDQQRSEELA RIMGEFEITE QPRLSTSKGD DLLAMMDEL
    Length:389
    Mass (Da):44,586
    Last modified:July 13, 2010 - v4
    Checksum:i8EA5C1EF2D9973F4
    GO
    Isoform 2 (identifier: Q8WVF1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         329-378: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:339
    Mass (Da):38,810
    Checksum:iA275B77A753D79D1
    GO
    Isoform 3 (identifier: Q8WVF1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-47: Missing.

    Show »
    Length:379
    Mass (Da):43,271
    Checksum:iB233ECE9C1E46F08
    GO
    Isoform 4 (identifier: Q8WVF1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-47: Missing.
         183-231: VSMFLKDKVQ...KGEEVKRIEF → RECFWKHMQE...ENFEFCTWAK
         232-389: Missing.

    Show »
    Length:223
    Mass (Da):26,431
    Checksum:i769226B3771F756D
    GO

    Sequence cautioni

    The sequence AAL89738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511D → G in BAC05326 (PubMed:14702039).Curated
    Sequence conflicti317 – 3171G → R in BAE16984 (PubMed:16006562).Curated
    Sequence conflicti377 – 3771S → G in AAL89738 (PubMed:12819961).Curated
    Sequence conflicti377 – 3771S → G in AAH18069 (Ref. 5) Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311P → R.2 Publications
    Corresponds to variant rs11547025 [ dbSNP | Ensembl ].
    VAR_027741
    Natural varianti141 – 1411T → A.1 Publication
    Corresponds to variant rs34409118 [ dbSNP | Ensembl ].
    VAR_056958
    Natural varianti242 – 2421K → E.
    Corresponds to variant rs2359016 [ dbSNP | Ensembl ].
    VAR_027742

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei38 – 4710Missing in isoform 3 and isoform 4. 3 PublicationsVSP_039475
    Alternative sequencei183 – 23149VSMFL…KRIEF → RECFWKHMQETVHSAQCCLP GVGNYMEDRRRRLTFHYVYP FENFEFCTWAK in isoform 4. CuratedVSP_039476Add
    BLAST
    Alternative sequencei232 – 389158Missing in isoform 4. CuratedVSP_039477Add
    BLAST
    Alternative sequencei329 – 37850Missing in isoform 2. 1 PublicationVSP_020826Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF462348 mRNA. Translation: AAL89738.1. Different initiation.
    AB079075 mRNA. Translation: BAE16984.1.
    AK098541 mRNA. Translation: BAC05326.1.
    AC119675 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07365.1.
    BC018069 mRNA. Translation: AAH18069.2.
    CCDSiCCDS409.2. [Q8WVF1-3]
    CCDS410.1. [Q8WVF1-4]
    RefSeqiNP_659484.4. NM_145047.4. [Q8WVF1-3]
    NP_996668.1. NM_206837.2. [Q8WVF1-4]
    XP_005270518.1. XM_005270461.1. [Q8WVF1-1]
    UniGeneiHs.202207.

    Genome annotation databases

    EnsembliENST00000235532; ENSP00000235532; ENSG00000116885. [Q8WVF1-3]
    ENST00000354267; ENSP00000346216; ENSG00000116885. [Q8WVF1-4]
    ENST00000356637; ENSP00000349052; ENSG00000116885. [Q8WVF1-1]
    GeneIDi127700.
    KEGGihsa:127700.
    UCSCiuc001caq.4. human. [Q8WVF1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF462348 mRNA. Translation: AAL89738.1. Different initiation.
    AB079075 mRNA. Translation: BAE16984.1.
    AK098541 mRNA. Translation: BAC05326.1.
    AC119675 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07365.1.
    BC018069 mRNA. Translation: AAH18069.2.
    CCDSiCCDS409.2. [Q8WVF1-3]
    CCDS410.1. [Q8WVF1-4]
    RefSeqiNP_659484.4. NM_145047.4. [Q8WVF1-3]
    NP_996668.1. NM_206837.2. [Q8WVF1-4]
    XP_005270518.1. XM_005270461.1. [Q8WVF1-1]
    UniGeneiHs.202207.

    3D structure databases

    ProteinModelPortaliQ8WVF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi126078. 5 interactions.
    IntActiQ8WVF1. 1 interaction.
    STRINGi9606.ENSP00000235532.

    Protein family/group databases

    TCDBi9.B.68.1.1. the putative na-independent organic solute carrier protein (oscp1) family.

    PTM databases

    iPTMnetiQ8WVF1.
    PhosphoSiteiQ8WVF1.

    Polymorphism and mutation databases

    BioMutaiOSCP1.
    DMDMi300669715.

    Proteomic databases

    EPDiQ8WVF1.
    MaxQBiQ8WVF1.
    PaxDbiQ8WVF1.
    PeptideAtlasiQ8WVF1.
    PRIDEiQ8WVF1.

    Protocols and materials databases

    DNASUi127700.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000235532; ENSP00000235532; ENSG00000116885. [Q8WVF1-3]
    ENST00000354267; ENSP00000346216; ENSG00000116885. [Q8WVF1-4]
    ENST00000356637; ENSP00000349052; ENSG00000116885. [Q8WVF1-1]
    GeneIDi127700.
    KEGGihsa:127700.
    UCSCiuc001caq.4. human. [Q8WVF1-1]

    Organism-specific databases

    CTDi127700.
    GeneCardsiOSCP1.
    HGNCiHGNC:29971. OSCP1.
    HPAiHPA028436.
    HPA052655.
    MIMi608854. gene.
    neXtProtiNX_Q8WVF1.
    PharmGKBiPA165752125.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG4033. Eukaryota.
    ENOG41107FG. LUCA.
    GeneTreeiENSGT00390000004808.
    HOVERGENiHBG055313.
    InParanoidiQ8WVF1.
    OMAiTNMYSVN.
    OrthoDBiEOG091G0N0U.
    PhylomeDBiQ8WVF1.
    TreeFamiTF105789.

    Miscellaneous databases

    ChiTaRSiOSCP1. human.
    GenomeRNAii127700.
    PROiQ8WVF1.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000116885.
    CleanExiHS_C1orf102.
    ExpressionAtlasiQ8WVF1. baseline and differential.
    GenevisibleiQ8WVF1. HS.

    Family and domain databases

    InterProiIPR019332. OSCP1.
    [Graphical view]
    PfamiPF10188. Oscp1. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiOSCP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVF1
    Secondary accession number(s): A6NHM5
    , A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 13, 2010
    Last modified: September 7, 2016
    This is version 100 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    May be involved in the development and/or progression of nosopharyngeal carcinoma.

    Caution

    The polymorphism 'Glu58Gly' (described in PubMed:12819961) is in fact an error, the G to A change described representing a synonymous mutation that does not induce any amino acid change in Gly-32.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.