Q8WVF1 (OSCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein OSCP1
Short name=hOSCP1

Alternative name(s):
Organic solute transport protein 1
Oxidored-nitro domain-containing protein 1

Gene names

Name:	OSCP1
Synonyms:	C1orf102, NOR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in drug clearance in the placenta. Ref.2
Subcellular location	Basal cell membrane. Note: Syncytiotrophoblast in placenta.
Tissue specificity	Expressed predominantly in testis, also found in placenta and to a lesser extent in thymus and small intestine; abundantly expressed in tumor-derived cell lines (Ref.2). Ubiquitously expressed (Ref.1). Ref.1 Ref.2
Miscellaneous	May be involved in the development and/or progression of nosopharyngeal carcinoma.
Caution	The polymorphism 'Glu58Gly' (described in Ref.1) is in fact an error, the G to A change described representing a synonymous mutation that does not induce any amino acid change in Gly-32.
Biophysicochemical properties	Kinetic parameters: In Xenopus laevis oocytes, in a sodium-independent manner. KM=35.0 µM for p-aminohippurate (PAH) Ref.2 KM=62.3 µM for tetraethylammonium
Sequence caution	The sequence AAL89738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	basal plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WVF1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WVF1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     329-378: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8WVF1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     38-47: Missing.

Isoform 4 (identifier: Q8WVF1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     38-47: Missing.
     183-231: VSMFLKDKVQ...KGEEVKRIEF → RECFWKHMQE...ENFEFCTWAK
     232-389: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Protein OSCP1		PRO_0000251965
Natural variations
	Alternative sequence	38 – 47	10	Missing in isoform 3 and isoform 4.		VSP_039475
	Alternative sequence	183 – 231	49	VSMFL…KRIEF → RECFWKHMQETVHSAQCCLP GVGNYMEDRRRRLTFHYVYP FENFEFCTWAK in isoform 4.		VSP_039476
	Alternative sequence	232 – 389	158	Missing in isoform 4.		VSP_039477
	Alternative sequence	329 – 378	50	Missing in isoform 2.		VSP_020826
	Natural variant	31	1	P → R. Ref.1 Ref.6 Corresponds to variant rs11547025 [ dbSNP | Ensembl ].		VAR_027741
	Natural variant	141	1	T → A. Ref.2 Corresponds to variant rs34409118 [ dbSNP | Ensembl ].		VAR_056958
	Natural variant	242	1	K → E. Corresponds to variant rs2359016 [ dbSNP | Ensembl ].		VAR_027742
Experimental info
	Sequence conflict	51	1	D → G in BAC05326. Ref.3
	Sequence conflict	317	1	G → R in BAE16984. Ref.2
	Sequence conflict	377	1	S → G in AAL89738. Ref.1
	Sequence conflict	377	1	S → G in AAH18069. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 4. Checksum: 8EA5C1EF2D9973F4	FASTA	389	44,586
	10 20 30 40 50 60 MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN DIISTMFNRK 70 80 90 100 110 120 FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD 130 140 150 160 170 180 VLLVTFNHLD TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH 190 200 210 220 230 240 IRVSMFLKDK VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA 250 260 270 280 290 300 PKEGSFELYG DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA 310 320 330 340 350 360 RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA 370 380 RIMGEFEITE QPRLSTSKGD DLLAMMDEL
	Isoform 2 [UniParc]. Checksum: A275B77A753D79D1	FASTA	339	38,810
	10 20 30 40 50 60 MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN DIISTMFNRK 70 80 90 100 110 120 FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD 130 140 150 160 170 180 VLLVTFNHLD TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH 190 200 210 220 230 240 IRVSMFLKDK VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA 250 260 270 280 290 300 PKEGSFELYG DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA 310 320 330 RLMGGMEIKK PSGPEPGFRL NLFTTDEEGD DLLAMMDEL
	Isoform 3 [UniParc]. Checksum: B233ECE9C1E46F08	FASTA	379	43,271
	10 20 30 40 50 60 MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKVLN DIISTMFNRK FMEELFKPQE 70 80 90 100 110 120 LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD 130 140 150 160 170 180 TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRVSMFLKDK 190 200 210 220 230 240 VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA PKEGSFELYG 250 260 270 280 290 300 DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA RLMGGMEIKK 310 320 330 340 350 360 PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA RIMGEFEITE 370 QPRLSTSKGD DLLAMMDEL
	Isoform 4 [UniParc]. Checksum: 769226B3771F756D	FASTA	223	26,431
	10 20 30 40 50 60 MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKVLN DIISTMFNRK FMEELFKPQE 70 80 90 100 110 120 LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD 130 140 150 160 170 180 TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRRECFWKHM 190 200 210 220 QETVHSAQCC LPGVGNYMED RRRRLTFHYV YPFENFEFCT WAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line." Nie X., Zhang B., Li X., Xiang J., Xiao B., Ma J., Zhou M., Zhu S., Lu H., Gui R., Shen S., Li G. J. Cancer Res. Clin. Oncol. 129:410-414(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ARG-31.
[2]	"Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1." Kobayashi Y., Shibusawa A., Saito H., Ohshiro N., Ohbayashi M., Kohyama N., Yamamoto T. J. Biol. Chem. 280:32332-32339(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, VARIANT ALA-141. Tissue: Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-31. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF462348 mRNA. Translation: AAL89738.1. Different initiation. AB079075 mRNA. Translation: BAE16984.1. AK098541 mRNA. Translation: BAC05326.1. AC119675 Genomic DNA. No translation available. CH471059 Genomic DNA. Translation: EAX07365.1. BC018069 mRNA. Translation: AAH18069.2.
IPI	IPI00154774. IPI00335636. IPI00409599. IPI00969199.
RefSeq	NP_659484.4. NM_145047.4. NP_996668.1. NM_206837.2.
UniGene	Hs.202207.
3D structure databases
ProteinModelPortal	Q8WVF1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000349052.
Protein family/group databases
TCDB	9.B.68.1.1. putative na-independent organic solute carrier protein (OSCP1) family.
PTM databases
PhosphoSite	Q8WVF1.
Polymorphism databases
DMDM	300669715.
Proteomic databases
PaxDb	Q8WVF1.
PRIDE	Q8WVF1.
Protocols and materials databases
DNASU	127700.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000235532; ENSP00000235532; ENSG00000116885. ENST00000315643; ENSP00000314541; ENSG00000116885. ENST00000354267; ENSP00000346216; ENSG00000116885. ENST00000356637; ENSP00000349052; ENSG00000116885.
GeneID	127700.
KEGG	hsa:127700.
UCSC	uc001caq.3. human. uc001car.3. human. uc021olk.1. human.
Organism-specific databases
CTD	127700.
GeneCards	GC01M036881.
HGNC	HGNC:29971. OSCP1.
HPA	HPA028436.
MIM	608854. gene.
neXtProt	NX_Q8WVF1.
PharmGKB	PA165752125.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307804.
HOVERGEN	HBG055313.
OMA	GTNMYSV.
Gene expression databases
ArrayExpress	Q8WVF1.
Bgee	Q8WVF1.
CleanEx	HS_C1orf102.
Genevestigator	Q8WVF1.
GermOnline	ENSG00000116885. Homo sapiens.
Family and domain databases
InterPro	IPR019332. OSCP1. [Graphical view]
Pfam	PF10188. Oscp1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OSCP1. human.
GenomeRNAi	127700.
NextBio	82166.
SOURCE	Search...

Entry information

Entry name

OSCP1_HUMAN

Accession

Primary (citable) accession number: Q8WVF1
Secondary accession number(s): A6NHM5 , A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 74 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.