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Protein

Transmembrane protein 170A

Gene

TMEM170A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).1 Publication

GO - Biological processi

  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • nuclear envelope organization Source: UniProtKB
  • nuclear pore complex assembly Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi8.A.70.1.1. the endomembrane morphogenesis tmem170a (tmem170a) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 170A
Gene namesi
Name:TMEM170A
Synonyms:TMEM170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29577. TMEM170A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Lumenal1 PublicationAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Topological domaini72 – 8514Cytoplasmic1 PublicationAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 11610Lumenal1 Publication
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 1447Cytoplasmic1 Publication

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nuclear envelope Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405922.

Polymorphism and mutation databases

BioMutaiTMEM170A.
DMDMi74730840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Transmembrane protein 170APRO_0000291759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WVE7.
PRIDEiQ8WVE7.

PTM databases

iPTMnetiQ8WVE7.
PhosphoSiteiQ8WVE7.

Expressioni

Gene expression databases

BgeeiQ8WVE7.
CleanExiHS_TMEM170A.
ExpressionAtlasiQ8WVE7. baseline and differential.
GenevisibleiQ8WVE7. HS.

Organism-specific databases

HPAiHPA055071.

Interactioni

Subunit structurei

Interacts with RTN4 (PubMed:26906412).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000454404.

Structurei

3D structure databases

ProteinModelPortaliQ8WVE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM170 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4349. Eukaryota.
ENOG4111MVH. LUCA.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ8WVE7.
OMAiSEMWYGV.
OrthoDBiEOG7HXCSS.
PhylomeDBiQ8WVE7.
TreeFamiTF314615.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEREGSGGSG GSAGLLQQIL SLKVVPRVGN GTLCPNSTSL CSFPEMWYGV
60 70 80 90 100
FLWALVSSLF FHVPAGLLAL FTLRHHKYGR FMSVSILLMG IVGPITAGIL
110 120 130 140
TSAAIAGVYR AAGKEMIPFE ALTLGTGQTF CVLVVSFLRI LATL
Length:144
Mass (Da):15,250
Last modified:March 1, 2002 - v1
Checksum:iC4ABBC85305CDCF0
GO
Isoform 2 (identifier: Q8WVE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-102: Missing.

Show »
Length:121
Mass (Da):12,891
Checksum:i936130107393A2B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 10223Missing in isoform 2. 3 PublicationsVSP_026229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302139 mRNA. Translation: AAP57631.1.
AK298475 mRNA. Translation: BAG60686.1.
AK311919 mRNA. Translation: BAG34860.1.
BX648484 mRNA. No translation available.
AC009163 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95643.1.
CH471114 Genomic DNA. Translation: EAW95644.1.
BC018082 mRNA. Translation: AAH18082.1.
CCDSiCCDS10917.1. [Q8WVE7-1]
CCDS76901.1. [Q8WVE7-2]
RefSeqiNP_001291925.1. NM_001304996.1. [Q8WVE7-2]
NP_660297.1. NM_145254.2. [Q8WVE7-1]
UniGeneiHs.487510.

Genome annotation databases

EnsembliENST00000357613; ENSP00000350230; ENSG00000166822. [Q8WVE7-2]
ENST00000561878; ENSP00000454404; ENSG00000166822. [Q8WVE7-1]
ENST00000568559; ENSP00000454552; ENSG00000166822. [Q8WVE7-2]
GeneIDi124491.
KEGGihsa:124491.
UCSCiuc002fec.4. human. [Q8WVE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302139 mRNA. Translation: AAP57631.1.
AK298475 mRNA. Translation: BAG60686.1.
AK311919 mRNA. Translation: BAG34860.1.
BX648484 mRNA. No translation available.
AC009163 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95643.1.
CH471114 Genomic DNA. Translation: EAW95644.1.
BC018082 mRNA. Translation: AAH18082.1.
CCDSiCCDS10917.1. [Q8WVE7-1]
CCDS76901.1. [Q8WVE7-2]
RefSeqiNP_001291925.1. NM_001304996.1. [Q8WVE7-2]
NP_660297.1. NM_145254.2. [Q8WVE7-1]
UniGeneiHs.487510.

3D structure databases

ProteinModelPortaliQ8WVE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000454404.

Protein family/group databases

TCDBi8.A.70.1.1. the endomembrane morphogenesis tmem170a (tmem170a) family.

PTM databases

iPTMnetiQ8WVE7.
PhosphoSiteiQ8WVE7.

Polymorphism and mutation databases

BioMutaiTMEM170A.
DMDMi74730840.

Proteomic databases

PaxDbiQ8WVE7.
PRIDEiQ8WVE7.

Protocols and materials databases

DNASUi124491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357613; ENSP00000350230; ENSG00000166822. [Q8WVE7-2]
ENST00000561878; ENSP00000454404; ENSG00000166822. [Q8WVE7-1]
ENST00000568559; ENSP00000454552; ENSG00000166822. [Q8WVE7-2]
GeneIDi124491.
KEGGihsa:124491.
UCSCiuc002fec.4. human. [Q8WVE7-1]

Organism-specific databases

CTDi124491.
GeneCardsiTMEM170A.
H-InvDBHIX0017750.
HGNCiHGNC:29577. TMEM170A.
HPAiHPA055071.
neXtProtiNX_Q8WVE7.
PharmGKBiPA162405922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4349. Eukaryota.
ENOG4111MVH. LUCA.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ8WVE7.
OMAiSEMWYGV.
OrthoDBiEOG7HXCSS.
PhylomeDBiQ8WVE7.
TreeFamiTF314615.

Miscellaneous databases

ChiTaRSiTMEM170A. human.
GenomeRNAii124491.
NextBioi81290.
PROiQ8WVE7.

Gene expression databases

BgeeiQ8WVE7.
CleanExiHS_TMEM170A.
ExpressionAtlasiQ8WVE7. baseline and differential.
GenevisibleiQ8WVE7. HS.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhou G., Yu R., Li H., Shen C., Zhong G., Lin L., Yang S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Transmembrane protein TMEM170A is a novel regulator of ER and NE morphogenesis in human cells."
    Christodoulou A., Santarella-Mellwig R., Santama N., Mattaj I.W.
    J. Cell Sci. 0:0-0(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH RTN4.

Entry informationi

Entry nameiT170A_HUMAN
AccessioniPrimary (citable) accession number: Q8WVE7
Secondary accession number(s): B2R4R3
, B4DPS4, D3DUK2, Q7Z6F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.