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Protein

Transmembrane protein 170A

Gene

TMEM170A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).1 Publication

GO - Biological processi

  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • nuclear envelope organization Source: UniProtKB
  • nuclear pore complex assembly Source: UniProtKB

Protein family/group databases

TCDBi8.A.70.1.1. the endomembrane morphogenesis tmem170a (tmem170a) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 170A
Gene namesi
Name:TMEM170A
Synonyms:TMEM170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166822.12.
HGNCiHGNC:29577. TMEM170A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50Lumenal1 PublicationAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85Cytoplasmic1 PublicationAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 116Lumenal1 Publication10
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 144Cytoplasmic1 Publication7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi124491.
OpenTargetsiENSG00000166822.
PharmGKBiPA162405922.

Polymorphism and mutation databases

BioMutaiTMEM170A.
DMDMi74730840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917591 – 144Transmembrane protein 170AAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WVE7.
PRIDEiQ8WVE7.

PTM databases

iPTMnetiQ8WVE7.
PhosphoSitePlusiQ8WVE7.

Expressioni

Gene expression databases

BgeeiENSG00000166822.
CleanExiHS_TMEM170A.
ExpressionAtlasiQ8WVE7. baseline and differential.
GenevisibleiQ8WVE7. HS.

Organism-specific databases

HPAiHPA055071.

Interactioni

Subunit structurei

Interacts with RTN4 (PubMed:26906412).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000454404.

Structurei

3D structure databases

ProteinModelPortaliQ8WVE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM170 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4349. Eukaryota.
ENOG4111MVH. LUCA.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ8WVE7.
OMAiSEMWYGV.
OrthoDBiEOG091G0V4L.
PhylomeDBiQ8WVE7.
TreeFamiTF314615.

Family and domain databases

InterProiView protein in InterPro
IPR019334. Transmembrane_pr_170.
PfamiView protein in Pfam
PF10190. Tmemb_170. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEREGSGGSG GSAGLLQQIL SLKVVPRVGN GTLCPNSTSL CSFPEMWYGV
60 70 80 90 100
FLWALVSSLF FHVPAGLLAL FTLRHHKYGR FMSVSILLMG IVGPITAGIL
110 120 130 140
TSAAIAGVYR AAGKEMIPFE ALTLGTGQTF CVLVVSFLRI LATL
Length:144
Mass (Da):15,250
Last modified:March 1, 2002 - v1
Checksum:iC4ABBC85305CDCF0
GO
Isoform 2 (identifier: Q8WVE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-102: Missing.

Show »
Length:121
Mass (Da):12,891
Checksum:i936130107393A2B2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02622980 – 102Missing in isoform 2. 3 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302139 mRNA. Translation: AAP57631.1.
AK298475 mRNA. Translation: BAG60686.1.
AK311919 mRNA. Translation: BAG34860.1.
BX648484 mRNA. No translation available.
AC009163 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95643.1.
CH471114 Genomic DNA. Translation: EAW95644.1.
BC018082 mRNA. Translation: AAH18082.1.
CCDSiCCDS10917.1. [Q8WVE7-1]
CCDS76901.1. [Q8WVE7-2]
RefSeqiNP_001291925.1. NM_001304996.1. [Q8WVE7-2]
NP_660297.1. NM_145254.2. [Q8WVE7-1]
UniGeneiHs.487510.

Genome annotation databases

EnsembliENST00000357613; ENSP00000350230; ENSG00000166822. [Q8WVE7-2]
ENST00000561878; ENSP00000454404; ENSG00000166822. [Q8WVE7-1]
ENST00000568559; ENSP00000454552; ENSG00000166822. [Q8WVE7-2]
GeneIDi124491.
KEGGihsa:124491.
UCSCiuc002fec.4. human. [Q8WVE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiT170A_HUMAN
AccessioniPrimary (citable) accession number: Q8WVE7
Secondary accession number(s): B2R4R3
, B4DPS4, D3DUK2, Q7Z6F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families