Q8WVE0 (N6MT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N(6)-adenine-specific DNA methyltransferase 2
EC=2.1.1.-

Gene names

Name:

N6AMT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative DNA methyltransferase By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. AML1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	N(6)-adenine-specific DNA methyltransferase 2		PRO_0000311294
Natural variations
	Natural variant	193	1	T → N. Corresponds to variant rs11549810 [ dbSNP | Ensembl ].		VAR_037216

Sequences

	Sequence		Length	Mass (Da)
	Q8WVE0 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6E16B4052B696552	FASTA	214	24,506
	10 20 30 40 50 60 MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL SQFWYSQETA 70 80 90 100 110 120 LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY IFEYDKRFAM YGEEFIFYDY 130 140 150 160 170 180 NNPLDLPERI AAHSFDIVIA DPPYLSEECL RKTSETVKYL TRGKILLCTG AIMEEQAAEL 190 200 210 LGVKMCTFVP RHTRNLANEF RCYVNYDSGL DCGI

References

[1]	"Transcriptome analysis of a cDNA library from adult human epididymis." Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L. DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Epididymis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ823637 mRNA. Translation: ABK41021.1. AL512652 Genomic DNA. Translation: CAH71794.1. CH471075 Genomic DNA. Translation: EAX08277.1. BC018091 mRNA. Translation: AAH18091.1.
IPI	IPI00103104.
RefSeq	NP_777588.1. NM_174928.1.
UniGene	Hs.26674.
3D structure databases
ProteinModelPortal	Q8WVE0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000372202.
PTM databases
PhosphoSite	Q8WVE0.
Polymorphism databases
DMDM	74751547.
Proteomic databases
PaxDb	Q8WVE0.
PRIDE	Q8WVE0.
Protocols and materials databases
DNASU	221143.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382754; ENSP00000372202; ENSG00000150456. ENST00000382758; ENSP00000372206; ENSG00000150456.
GeneID	221143.
KEGG	hsa:221143.
UCSC	uc001uno.1. human.
Organism-specific databases
CTD	221143.
GeneCards	GC13M021296.
H-InvDB	HIX0011161.
HGNC	HGNC:27351. N6AMT2.
HPA	HPA040417. HPA042543.
neXtProt	NX_Q8WVE0.
PharmGKB	PA162396671.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG127575.
HOGENOM	HOG000240418.
HOVERGEN	HBG059901.
InParanoid	Q8WVE0.
OMA	GAIMEEQ.
OrthoDB	EOG4VX26C.
PhylomeDB	Q8WVE0.
Gene expression databases
ArrayExpress	Q8WVE0.
Bgee	Q8WVE0.
CleanEx	HS_N6AMT2.
Genevestigator	Q8WVE0.
Family and domain databases
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR019369. N6_adenine_Mtase-rel_euk. [Graphical view]
Pfam	PF10237. N6-adenineMlase. 1 hit. [Graphical view]
PROSITE	PS00092. N6_MTASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221143.
NextBio	91209.

Entry information

Entry name

N6MT2_HUMAN

Accession

Primary (citable) accession number: Q8WVE0
Secondary accession number(s): B5G4V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.