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Q8WVE0

- N6MT2_HUMAN

UniProt

Q8WVE0 - N6MT2_HUMAN

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Protein

N(6)-adenine-specific DNA methyltransferase 2

Gene

N6AMT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Putative DNA methyltransferase.By similarity

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N(6)-adenine-specific DNA methyltransferase 2 (EC:2.1.1.-)
Gene namesi
Name:N6AMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:27351. N6AMT2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 214213N(6)-adenine-specific DNA methyltransferase 2PRO_0000311294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8WVE0.
PaxDbiQ8WVE0.
PRIDEiQ8WVE0.

PTM databases

PhosphoSiteiQ8WVE0.

Expressioni

Gene expression databases

BgeeiQ8WVE0.
CleanExiHS_N6AMT2.
ExpressionAtlasiQ8WVE0. baseline and differential.
GenevestigatoriQ8WVE0.

Organism-specific databases

HPAiHPA040417.
HPA042543.

Interactioni

Protein-protein interaction databases

BioGridi128690. 2 interactions.
STRINGi9606.ENSP00000372202.

Structurei

3D structure databases

ProteinModelPortaliQ8WVE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG127575.
GeneTreeiENSGT00390000016366.
HOGENOMiHOG000240418.
HOVERGENiHBG059901.
InParanoidiQ8WVE0.
OMAiVEPPATH.
OrthoDBiEOG7C2R2J.
PhylomeDBiQ8WVE0.
TreeFamiTF106153.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF10237. N6-adenineMlase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL
60 70 80 90 100
SQFWYSQETA LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY
110 120 130 140 150
IFEYDKRFAM YGEEFIFYDY NNPLDLPERI AAHSFDIVIA DPPYLSEECL
160 170 180 190 200
RKTSETVKYL TRGKILLCTG AIMEEQAAEL LGVKMCTFVP RHTRNLANEF
210
RCYVNYDSGL DCGI
Length:214
Mass (Da):24,506
Last modified:March 1, 2002 - v1
Checksum:i6E16B4052B696552
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931T → N.
Corresponds to variant rs11549810 [ dbSNP | Ensembl ].
VAR_037216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823637 mRNA. Translation: ABK41021.1.
AL512652 Genomic DNA. Translation: CAH71794.1.
CH471075 Genomic DNA. Translation: EAX08277.1.
BC018091 mRNA. Translation: AAH18091.1.
CCDSiCCDS9293.1.
RefSeqiNP_777588.1. NM_174928.1.
XP_005266344.1. XM_005266287.2.
UniGeneiHs.26674.

Genome annotation databases

EnsembliENST00000382754; ENSP00000372202; ENSG00000150456.
ENST00000382758; ENSP00000372206; ENSG00000150456.
GeneIDi221143.
KEGGihsa:221143.
UCSCiuc001uno.1. human.

Polymorphism databases

DMDMi74751547.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823637 mRNA. Translation: ABK41021.1 .
AL512652 Genomic DNA. Translation: CAH71794.1 .
CH471075 Genomic DNA. Translation: EAX08277.1 .
BC018091 mRNA. Translation: AAH18091.1 .
CCDSi CCDS9293.1.
RefSeqi NP_777588.1. NM_174928.1.
XP_005266344.1. XM_005266287.2.
UniGenei Hs.26674.

3D structure databases

ProteinModelPortali Q8WVE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128690. 2 interactions.
STRINGi 9606.ENSP00000372202.

PTM databases

PhosphoSitei Q8WVE0.

Polymorphism databases

DMDMi 74751547.

Proteomic databases

MaxQBi Q8WVE0.
PaxDbi Q8WVE0.
PRIDEi Q8WVE0.

Protocols and materials databases

DNASUi 221143.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382754 ; ENSP00000372202 ; ENSG00000150456 .
ENST00000382758 ; ENSP00000372206 ; ENSG00000150456 .
GeneIDi 221143.
KEGGi hsa:221143.
UCSCi uc001uno.1. human.

Organism-specific databases

CTDi 221143.
GeneCardsi GC13M021308.
H-InvDB HIX0011161.
HGNCi HGNC:27351. N6AMT2.
HPAi HPA040417.
HPA042543.
neXtProti NX_Q8WVE0.
PharmGKBi PA162396671.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG127575.
GeneTreei ENSGT00390000016366.
HOGENOMi HOG000240418.
HOVERGENi HBG059901.
InParanoidi Q8WVE0.
OMAi VEPPATH.
OrthoDBi EOG7C2R2J.
PhylomeDBi Q8WVE0.
TreeFami TF106153.

Miscellaneous databases

GenomeRNAii 221143.
NextBioi 91209.
PROi Q8WVE0.

Gene expression databases

Bgeei Q8WVE0.
CleanExi HS_N6AMT2.
ExpressionAtlasi Q8WVE0. baseline and differential.
Genevestigatori Q8WVE0.

Family and domain databases

InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF10237. N6-adenineMlase. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptome analysis of a cDNA library from adult human epididymis."
    Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
    DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Epididymis.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiN6MT2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVE0
Secondary accession number(s): B5G4V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3