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Q8WVE0 (N6MT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N(6)-adenine-specific DNA methyltransferase 2

EC=2.1.1.-
Gene names
Name:N6AMT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative DNA methyltransferase By similarity.

Sequence similarities

Belongs to the methyltransferase superfamily. AML1 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionMethyltransferase
Transferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 214213N(6)-adenine-specific DNA methyltransferase 2
PRO_0000311294

Amino acid modifications

Modified residue21N-acetylserine Ref.5

Natural variations

Natural variant1931T → N.
Corresponds to variant rs11549810 [ dbSNP | Ensembl ].
VAR_037216

Sequences

Sequence LengthMass (Da)Tools
Q8WVE0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6E16B4052B696552

FASTA21424,506
        10         20         30         40         50         60 
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL SQFWYSQETA 

        70         80         90        100        110        120 
LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY IFEYDKRFAM YGEEFIFYDY 

       130        140        150        160        170        180 
NNPLDLPERI AAHSFDIVIA DPPYLSEECL RKTSETVKYL TRGKILLCTG AIMEEQAAEL 

       190        200        210 
LGVKMCTFVP RHTRNLANEF RCYVNYDSGL DCGI 

« Hide

References

[1]"Transcriptome analysis of a cDNA library from adult human epididymis."
Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Epididymis.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ823637 mRNA. Translation: ABK41021.1.
AL512652 Genomic DNA. Translation: CAH71794.1.
CH471075 Genomic DNA. Translation: EAX08277.1.
BC018091 mRNA. Translation: AAH18091.1.
RefSeqNP_777588.1. NM_174928.1.
XP_005266344.1. XM_005266287.2.
UniGeneHs.26674.

3D structure databases

ProteinModelPortalQ8WVE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128690. 1 interaction.
STRING9606.ENSP00000372202.

PTM databases

PhosphoSiteQ8WVE0.

Polymorphism databases

DMDM74751547.

Proteomic databases

PaxDbQ8WVE0.
PRIDEQ8WVE0.

Protocols and materials databases

DNASU221143.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382754; ENSP00000372202; ENSG00000150456.
ENST00000382758; ENSP00000372206; ENSG00000150456.
GeneID221143.
KEGGhsa:221143.
UCSCuc001uno.1. human.

Organism-specific databases

CTD221143.
GeneCardsGC13M021304.
H-InvDBHIX0011161.
HGNCHGNC:27351. N6AMT2.
HPAHPA040417.
HPA042543.
neXtProtNX_Q8WVE0.
PharmGKBPA162396671.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG127575.
HOGENOMHOG000240418.
HOVERGENHBG059901.
InParanoidQ8WVE0.
OMAGAIMEEQ.
OrthoDBEOG7C2R2J.
PhylomeDBQ8WVE0.
TreeFamTF106153.

Gene expression databases

ArrayExpressQ8WVE0.
BgeeQ8WVE0.
CleanExHS_N6AMT2.
GenevestigatorQ8WVE0.

Family and domain databases

InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
[Graphical view]
PfamPF10237. N6-adenineMlase. 1 hit.
[Graphical view]
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi221143.
NextBio91209.
PROQ8WVE0.

Entry information

Entry nameN6MT2_HUMAN
AccessionPrimary (citable) accession number: Q8WVE0
Secondary accession number(s): B5G4V1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM