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Q8WVE0

- N6MT2_HUMAN

UniProt

Q8WVE0 - N6MT2_HUMAN

Protein

N(6)-adenine-specific DNA methyltransferase 2

Gene

N6AMT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Putative DNA methyltransferase.By similarity

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N(6)-adenine-specific DNA methyltransferase 2 (EC:2.1.1.-)
    Gene namesi
    Name:N6AMT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:27351. N6AMT2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162396671.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 214213N(6)-adenine-specific DNA methyltransferase 2PRO_0000311294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8WVE0.
    PaxDbiQ8WVE0.
    PRIDEiQ8WVE0.

    PTM databases

    PhosphoSiteiQ8WVE0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WVE0.
    BgeeiQ8WVE0.
    CleanExiHS_N6AMT2.
    GenevestigatoriQ8WVE0.

    Organism-specific databases

    HPAiHPA040417.
    HPA042543.

    Interactioni

    Protein-protein interaction databases

    BioGridi128690. 1 interaction.
    STRINGi9606.ENSP00000372202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG127575.
    HOGENOMiHOG000240418.
    HOVERGENiHBG059901.
    InParanoidiQ8WVE0.
    OMAiVEPPATH.
    OrthoDBiEOG7C2R2J.
    PhylomeDBiQ8WVE0.
    TreeFamiTF106153.

    Family and domain databases

    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR019369. N6_adenine_Mtase-rel_euk.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF10237. N6-adenineMlase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WVE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL    50
    SQFWYSQETA LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY 100
    IFEYDKRFAM YGEEFIFYDY NNPLDLPERI AAHSFDIVIA DPPYLSEECL 150
    RKTSETVKYL TRGKILLCTG AIMEEQAAEL LGVKMCTFVP RHTRNLANEF 200
    RCYVNYDSGL DCGI 214
    Length:214
    Mass (Da):24,506
    Last modified:March 1, 2002 - v1
    Checksum:i6E16B4052B696552
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti193 – 1931T → N.
    Corresponds to variant rs11549810 [ dbSNP | Ensembl ].
    VAR_037216

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ823637 mRNA. Translation: ABK41021.1.
    AL512652 Genomic DNA. Translation: CAH71794.1.
    CH471075 Genomic DNA. Translation: EAX08277.1.
    BC018091 mRNA. Translation: AAH18091.1.
    CCDSiCCDS9293.1.
    RefSeqiNP_777588.1. NM_174928.1.
    XP_005266344.1. XM_005266287.2.
    UniGeneiHs.26674.

    Genome annotation databases

    EnsembliENST00000382754; ENSP00000372202; ENSG00000150456.
    ENST00000382758; ENSP00000372206; ENSG00000150456.
    GeneIDi221143.
    KEGGihsa:221143.
    UCSCiuc001uno.1. human.

    Polymorphism databases

    DMDMi74751547.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ823637 mRNA. Translation: ABK41021.1 .
    AL512652 Genomic DNA. Translation: CAH71794.1 .
    CH471075 Genomic DNA. Translation: EAX08277.1 .
    BC018091 mRNA. Translation: AAH18091.1 .
    CCDSi CCDS9293.1.
    RefSeqi NP_777588.1. NM_174928.1.
    XP_005266344.1. XM_005266287.2.
    UniGenei Hs.26674.

    3D structure databases

    ProteinModelPortali Q8WVE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128690. 1 interaction.
    STRINGi 9606.ENSP00000372202.

    PTM databases

    PhosphoSitei Q8WVE0.

    Polymorphism databases

    DMDMi 74751547.

    Proteomic databases

    MaxQBi Q8WVE0.
    PaxDbi Q8WVE0.
    PRIDEi Q8WVE0.

    Protocols and materials databases

    DNASUi 221143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382754 ; ENSP00000372202 ; ENSG00000150456 .
    ENST00000382758 ; ENSP00000372206 ; ENSG00000150456 .
    GeneIDi 221143.
    KEGGi hsa:221143.
    UCSCi uc001uno.1. human.

    Organism-specific databases

    CTDi 221143.
    GeneCardsi GC13M021304.
    H-InvDB HIX0011161.
    HGNCi HGNC:27351. N6AMT2.
    HPAi HPA040417.
    HPA042543.
    neXtProti NX_Q8WVE0.
    PharmGKBi PA162396671.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG127575.
    HOGENOMi HOG000240418.
    HOVERGENi HBG059901.
    InParanoidi Q8WVE0.
    OMAi VEPPATH.
    OrthoDBi EOG7C2R2J.
    PhylomeDBi Q8WVE0.
    TreeFami TF106153.

    Miscellaneous databases

    GenomeRNAii 221143.
    NextBioi 91209.
    PROi Q8WVE0.

    Gene expression databases

    ArrayExpressi Q8WVE0.
    Bgeei Q8WVE0.
    CleanExi HS_N6AMT2.
    Genevestigatori Q8WVE0.

    Family and domain databases

    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR019369. N6_adenine_Mtase-rel_euk.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF10237. N6-adenineMlase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptome analysis of a cDNA library from adult human epididymis."
      Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J., Jin S.H., Zhang Y.L.
      DNA Res. 15:115-122(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Epididymis.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiN6MT2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVE0
    Secondary accession number(s): B5G4V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3