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Protein

Protein-lysine N-methyltransferase N6AMT2

Gene

N6AMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine N-methyltransferase N6AMT2UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Gene namesi
Name:N6AMT2UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:27351. N6AMT2.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150456.
PharmGKBiPA162396671.

Polymorphism and mutation databases

BioMutaiN6AMT2.
DMDMi74751547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003112942 – 214Protein-lysine N-methyltransferase N6AMT2Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WVE0.
MaxQBiQ8WVE0.
PaxDbiQ8WVE0.
PeptideAtlasiQ8WVE0.
PRIDEiQ8WVE0.

PTM databases

iPTMnetiQ8WVE0.
PhosphoSitePlusiQ8WVE0.

Expressioni

Gene expression databases

BgeeiENSG00000150456.
CleanExiHS_N6AMT2.
ExpressionAtlasiQ8WVE0. baseline and differential.
GenevisibleiQ8WVE0. HS.

Organism-specific databases

HPAiHPA040417.
HPA042543.

Interactioni

Protein-protein interaction databases

BioGridi128690. 6 interactors.
STRINGi9606.ENSP00000372202.

Structurei

3D structure databases

ProteinModelPortaliQ8WVE0.
SMRiQ8WVE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350. Eukaryota.
ENOG4111GGY. LUCA.
GeneTreeiENSGT00390000016366.
HOGENOMiHOG000240418.
HOVERGENiHBG059901.
InParanoidiQ8WVE0.
OMAiFEEDWQL.
OrthoDBiEOG091G0GA7.
PhylomeDBiQ8WVE0.
TreeFamiTF106153.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03187. Methyltr_EFM5. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. Efm5.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10237. N6-adenineMlase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL
60 70 80 90 100
SQFWYSQETA LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY
110 120 130 140 150
IFEYDKRFAM YGEEFIFYDY NNPLDLPERI AAHSFDIVIA DPPYLSEECL
160 170 180 190 200
RKTSETVKYL TRGKILLCTG AIMEEQAAEL LGVKMCTFVP RHTRNLANEF
210
RCYVNYDSGL DCGI
Length:214
Mass (Da):24,506
Last modified:March 1, 2002 - v1
Checksum:i6E16B4052B696552
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037216193T → N.Corresponds to variant rs11549810dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823637 mRNA. Translation: ABK41021.1.
AL512652 Genomic DNA. Translation: CAH71794.1.
CH471075 Genomic DNA. Translation: EAX08277.1.
BC018091 mRNA. Translation: AAH18091.1.
CCDSiCCDS9293.1.
RefSeqiNP_001305868.1. NM_001318939.1.
NP_777588.1. NM_174928.2.
XP_016875921.1. XM_017020432.1.
UniGeneiHs.26674.

Genome annotation databases

EnsembliENST00000382754; ENSP00000372202; ENSG00000150456.
ENST00000382758; ENSP00000372206; ENSG00000150456.
GeneIDi221143.
KEGGihsa:221143.
UCSCiuc001uno.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823637 mRNA. Translation: ABK41021.1.
AL512652 Genomic DNA. Translation: CAH71794.1.
CH471075 Genomic DNA. Translation: EAX08277.1.
BC018091 mRNA. Translation: AAH18091.1.
CCDSiCCDS9293.1.
RefSeqiNP_001305868.1. NM_001318939.1.
NP_777588.1. NM_174928.2.
XP_016875921.1. XM_017020432.1.
UniGeneiHs.26674.

3D structure databases

ProteinModelPortaliQ8WVE0.
SMRiQ8WVE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128690. 6 interactors.
STRINGi9606.ENSP00000372202.

PTM databases

iPTMnetiQ8WVE0.
PhosphoSitePlusiQ8WVE0.

Polymorphism and mutation databases

BioMutaiN6AMT2.
DMDMi74751547.

Proteomic databases

EPDiQ8WVE0.
MaxQBiQ8WVE0.
PaxDbiQ8WVE0.
PeptideAtlasiQ8WVE0.
PRIDEiQ8WVE0.

Protocols and materials databases

DNASUi221143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382754; ENSP00000372202; ENSG00000150456.
ENST00000382758; ENSP00000372206; ENSG00000150456.
GeneIDi221143.
KEGGihsa:221143.
UCSCiuc001uno.2. human.

Organism-specific databases

CTDi221143.
GeneCardsiN6AMT2.
H-InvDBHIX0011161.
HGNCiHGNC:27351. N6AMT2.
HPAiHPA040417.
HPA042543.
neXtProtiNX_Q8WVE0.
OpenTargetsiENSG00000150456.
PharmGKBiPA162396671.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3350. Eukaryota.
ENOG4111GGY. LUCA.
GeneTreeiENSGT00390000016366.
HOGENOMiHOG000240418.
HOVERGENiHBG059901.
InParanoidiQ8WVE0.
OMAiFEEDWQL.
OrthoDBiEOG091G0GA7.
PhylomeDBiQ8WVE0.
TreeFamiTF106153.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150456-MONOMER.

Miscellaneous databases

GenomeRNAii221143.
PROiQ8WVE0.

Gene expression databases

BgeeiENSG00000150456.
CleanExiHS_N6AMT2.
ExpressionAtlasiQ8WVE0. baseline and differential.
GenevisibleiQ8WVE0. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03187. Methyltr_EFM5. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. Efm5.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10237. N6-adenineMlase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiN6MT2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVE0
Secondary accession number(s): B5G4V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.