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Protein

RING finger protein 141

Gene

RNF141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 19238RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • ubiquitin-protein transferase activity Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein autoubiquitination Source: FlyBase
  • regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 141
Alternative name(s):
Zinc finger protein 230
Gene namesi
Name:RNF141
Synonyms:ZNF230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:21159. RNF141.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981805.

Polymorphism and mutation databases

BioMutaiRNF141.
DMDMi74751546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 230229RING finger protein 141PRO_0000056101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine2 Publications

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ8WVD5.
MaxQBiQ8WVD5.
PaxDbiQ8WVD5.
PeptideAtlasiQ8WVD5.
PRIDEiQ8WVD5.

PTM databases

iPTMnetiQ8WVD5.
PhosphoSiteiQ8WVD5.

Expressioni

Tissue specificityi

Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients.1 Publication

Gene expression databases

BgeeiENSG00000110315.
CleanExiHS_RNF141.
HS_ZNF230.
ExpressionAtlasiQ8WVD5. baseline and differential.
GenevisibleiQ8WVD5. HS.

Organism-specific databases

HPAiHPA018133.

Interactioni

Protein-protein interaction databases

BioGridi119162. 5 interactions.
IntActiQ8WVD5. 4 interactions.
STRINGi9606.ENSP00000265981.

Structurei

Secondary structure

1
230
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi156 – 1583Combined sources
Beta strandi164 – 1674Combined sources
Turni168 – 1703Combined sources
Beta strandi171 – 1733Combined sources
Helixi175 – 1806Combined sources
Helixi189 – 1935Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ECNNMR-A145-201[»]
ProteinModelPortaliQ8WVD5.
SMRiQ8WVD5. Positions 144-201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WVD5.

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 19238RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1039. Eukaryota.
ENOG410XRM0. LUCA.
GeneTreeiENSGT00390000003145.
HOGENOMiHOG000247058.
HOVERGENiHBG055763.
InParanoidiQ8WVD5.
OMAiVAVRVVC.
OrthoDBiEOG091G0MC1.
PhylomeDBiQ8WVD5.
TreeFamiTF323284.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVD5-1) [UniParc]FASTAAdd to basket
Also known as: Short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQQISDQTQ LVINKLPEKV AKHVTLVRES GSLTYEEFLG RVAELNDVTA
60 70 80 90 100
KVASGQEKHL LFEVQPGSDS SAFWKVVVRV VCTKINKSSG IVEASRIMNL
110 120 130 140 150
YQFIQLYKDI TSQAAGVLAQ SSTSEEPDEN SSSVTSCQAS LWMGRVKQLT
160 170 180 190 200
DEEECCICMD GRADLILPCA HSFCQKCIDK WSDRHRNCPI CRLQMTGANE
210 220 230
SWVVSDAPTE DDMANYILNM ADEAGQPHRP
Length:230
Mass (Da):25,535
Last modified:March 1, 2002 - v1
Checksum:i730950F8A6E47129
GO
Isoform 2 (identifier: Q8WVD5-2)
Also known as: Long
Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181L → S in AAF30180 (PubMed:11672448).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214680 mRNA. Translation: AAF30180.1.
AK289764 mRNA. Translation: BAF82453.1.
CH471064 Genomic DNA. Translation: EAW68566.1.
BC018104 mRNA. Translation: AAH18104.1.
BT006662 mRNA. Translation: AAP35308.1.
CCDSiCCDS7803.1. [Q8WVD5-1]
RefSeqiNP_057506.2. NM_016422.3. [Q8WVD5-1]
UniGeneiHs.44685.
Hs.712894.

Genome annotation databases

EnsembliENST00000265981; ENSP00000265981; ENSG00000110315. [Q8WVD5-1]
GeneIDi50862.
KEGGihsa:50862.
UCSCiuc001mis.2. human. [Q8WVD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214680 mRNA. Translation: AAF30180.1.
AK289764 mRNA. Translation: BAF82453.1.
CH471064 Genomic DNA. Translation: EAW68566.1.
BC018104 mRNA. Translation: AAH18104.1.
BT006662 mRNA. Translation: AAP35308.1.
CCDSiCCDS7803.1. [Q8WVD5-1]
RefSeqiNP_057506.2. NM_016422.3. [Q8WVD5-1]
UniGeneiHs.44685.
Hs.712894.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ECNNMR-A145-201[»]
ProteinModelPortaliQ8WVD5.
SMRiQ8WVD5. Positions 144-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119162. 5 interactions.
IntActiQ8WVD5. 4 interactions.
STRINGi9606.ENSP00000265981.

PTM databases

iPTMnetiQ8WVD5.
PhosphoSiteiQ8WVD5.

Polymorphism and mutation databases

BioMutaiRNF141.
DMDMi74751546.

Proteomic databases

EPDiQ8WVD5.
MaxQBiQ8WVD5.
PaxDbiQ8WVD5.
PeptideAtlasiQ8WVD5.
PRIDEiQ8WVD5.

Protocols and materials databases

DNASUi50862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265981; ENSP00000265981; ENSG00000110315. [Q8WVD5-1]
GeneIDi50862.
KEGGihsa:50862.
UCSCiuc001mis.2. human. [Q8WVD5-1]

Organism-specific databases

CTDi50862.
GeneCardsiRNF141.
HGNCiHGNC:21159. RNF141.
HPAiHPA018133.
MIMi616641. gene.
neXtProtiNX_Q8WVD5.
PharmGKBiPA134981805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1039. Eukaryota.
ENOG410XRM0. LUCA.
GeneTreeiENSGT00390000003145.
HOGENOMiHOG000247058.
HOVERGENiHBG055763.
InParanoidiQ8WVD5.
OMAiVAVRVVC.
OrthoDBiEOG091G0MC1.
PhylomeDBiQ8WVD5.
TreeFamiTF323284.

Miscellaneous databases

ChiTaRSiRNF141. human.
EvolutionaryTraceiQ8WVD5.
GenomeRNAii50862.
PROiQ8WVD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110315.
CleanExiHS_RNF141.
HS_ZNF230.
ExpressionAtlasiQ8WVD5. baseline and differential.
GenevisibleiQ8WVD5. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN141_HUMAN
AccessioniPrimary (citable) accession number: Q8WVD5
Secondary accession number(s): A8K149, Q9NZB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.