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Q8WVD3

- RN138_HUMAN

UniProt

Q8WVD3 - RN138_HUMAN

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Protein

E3 ubiquitin-protein ligase RNF138

Gene
RNF138, NARF, HSD-4, HSD4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein kinase binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
  2. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF138 (EC:6.3.2.-)
Alternative name(s):
Nemo-like kinase-associated RING finger protein
Short name:
NLK-associated RING finger protein
Short name:
hNARF
RING finger protein 138
Gene namesi
Name:RNF138
Synonyms:NARF
ORF Names:HSD-4, HSD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:17765. RNF138.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 245244E3 ubiquitin-protein ligase RNF138PRO_0000261607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Post-translational modificationi

Auto-ubiquitinated.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ8WVD3.
PaxDbiQ8WVD3.
PRIDEiQ8WVD3.

PTM databases

PhosphoSiteiQ8WVD3.

Expressioni

Gene expression databases

ArrayExpressiQ8WVD3.
BgeeiQ8WVD3.
CleanExiHS_NARF.
HS_RNF138.
GenevestigatoriQ8WVD3.

Organism-specific databases

HPAiHPA041101.
HPA041373.

Interactioni

Subunit structurei

Interacts with NLK.1 Publication

Protein-protein interaction databases

BioGridi119545. 15 interactions.
IntActiQ8WVD3. 12 interactions.
MINTiMINT-1479614.
STRINGi9606.ENSP00000261593.

Structurei

3D structure databases

ProteinModelPortaliQ8WVD3.
SMRiQ8WVD3. Positions 18-107.

Family & Domainsi

Domaini

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG44750.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ8WVD3.
KOiK10668.
OMAiEANFTRQ.
OrthoDBiEOG73NG41.
PhylomeDBiQ8WVD3.
TreeFamiTF331012.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding.
IPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
PF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WVD3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES    50
GAHCPLCRGN VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH 100
HYKSCKKYQD EYGVSSIIPN FQISQDSVGN SNRSETSTSD NTETYQENTS 150
SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH LFQIVPVTCP ICVSLPWGDP 200
SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES FQVNI 245
Length:245
Mass (Da):28,193
Last modified:March 1, 2002 - v1
Checksum:i807EE4500BE0919C
GO
Isoform 2 (identifier: Q8WVD3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-131: Missing.

Note: No experimental confirmation available.

Show »
Length:151
Mass (Da):17,262
Checksum:i4FDCD6069E17B2BB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811K → R.
Corresponds to variant rs7229690 [ dbSNP | Ensembl ].
VAR_052109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 13194Missing in isoform 2. VSP_021732Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181I → V in AAD46623. 1 Publication
Sequence conflicti215 – 2151H → R in AAD46623. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162680 mRNA. Translation: AAD46623.2.
AK023579 mRNA. Translation: BAB14614.1.
AK315761 mRNA. Translation: BAG38114.1.
BT006878 mRNA. Translation: AAP35524.1.
CR457150 mRNA. Translation: CAG33431.1.
CH471088 Genomic DNA. Translation: EAX01280.1.
BC018107 mRNA. Translation: AAH18107.1.
AL133557 mRNA. Translation: CAB63712.1.
CCDSiCCDS11903.1. [Q8WVD3-1]
CCDS11904.1. [Q8WVD3-2]
PIRiT43439.
RefSeqiNP_001178253.2. NM_001191324.1. [Q8WVD3-1]
NP_057355.2. NM_016271.4. [Q8WVD3-1]
NP_937761.1. NM_198128.2. [Q8WVD3-2]
XP_005258343.1. XM_005258286.1. [Q8WVD3-2]
UniGeneiHs.302408.

Genome annotation databases

EnsembliENST00000257190; ENSP00000257190; ENSG00000134758. [Q8WVD3-2]
ENST00000261593; ENSP00000261593; ENSG00000134758. [Q8WVD3-1]
GeneIDi51444.
KEGGihsa:51444.
UCSCiuc002kxg.3. human. [Q8WVD3-1]
uc002kxh.3. human. [Q8WVD3-2]

Polymorphism databases

DMDMi74762632.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162680 mRNA. Translation: AAD46623.2 .
AK023579 mRNA. Translation: BAB14614.1 .
AK315761 mRNA. Translation: BAG38114.1 .
BT006878 mRNA. Translation: AAP35524.1 .
CR457150 mRNA. Translation: CAG33431.1 .
CH471088 Genomic DNA. Translation: EAX01280.1 .
BC018107 mRNA. Translation: AAH18107.1 .
AL133557 mRNA. Translation: CAB63712.1 .
CCDSi CCDS11903.1. [Q8WVD3-1 ]
CCDS11904.1. [Q8WVD3-2 ]
PIRi T43439.
RefSeqi NP_001178253.2. NM_001191324.1. [Q8WVD3-1 ]
NP_057355.2. NM_016271.4. [Q8WVD3-1 ]
NP_937761.1. NM_198128.2. [Q8WVD3-2 ]
XP_005258343.1. XM_005258286.1. [Q8WVD3-2 ]
UniGenei Hs.302408.

3D structure databases

ProteinModelPortali Q8WVD3.
SMRi Q8WVD3. Positions 18-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119545. 15 interactions.
IntActi Q8WVD3. 12 interactions.
MINTi MINT-1479614.
STRINGi 9606.ENSP00000261593.

PTM databases

PhosphoSitei Q8WVD3.

Polymorphism databases

DMDMi 74762632.

Proteomic databases

MaxQBi Q8WVD3.
PaxDbi Q8WVD3.
PRIDEi Q8WVD3.

Protocols and materials databases

DNASUi 51444.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257190 ; ENSP00000257190 ; ENSG00000134758 . [Q8WVD3-2 ]
ENST00000261593 ; ENSP00000261593 ; ENSG00000134758 . [Q8WVD3-1 ]
GeneIDi 51444.
KEGGi hsa:51444.
UCSCi uc002kxg.3. human. [Q8WVD3-1 ]
uc002kxh.3. human. [Q8WVD3-2 ]

Organism-specific databases

CTDi 51444.
GeneCardsi GC18P029671.
HGNCi HGNC:17765. RNF138.
HPAi HPA041101.
HPA041373.
neXtProti NX_Q8WVD3.
PharmGKBi PA134952071.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44750.
HOGENOMi HOG000230946.
HOVERGENi HBG074331.
InParanoidi Q8WVD3.
KOi K10668.
OMAi EANFTRQ.
OrthoDBi EOG73NG41.
PhylomeDBi Q8WVD3.
TreeFami TF331012.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii 51444.
NextBioi 55035.
PROi Q8WVD3.

Gene expression databases

ArrayExpressi Q8WVD3.
Bgeei Q8WVD3.
CleanExi HS_NARF.
HS_RNF138.
Genevestigatori Q8WVD3.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR008598. Di19_Zn_binding.
IPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00097. zf-C3HC4. 1 hit.
PF05605. zf-Di19. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new spermatogenesis-related gene."
    Wang L., Miao S., Yang J., Zhang X., Li M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Trachea.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-245 (ISOFORM 1).
    Tissue: Testis.
  8. "NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)."
    Yamada M., Ohnishi J., Ohkawara B., Iemura S., Satoh K., Hyodo-Miura J., Kawachi K., Natsume T., Shibuya H.
    J. Biol. Chem. 281:20749-20760(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NLK.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRN138_HUMAN
AccessioniPrimary (citable) accession number: Q8WVD3
Secondary accession number(s): B2RE17
, Q9H8K2, Q9UF87, Q9UKI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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