Q8WVC6 (DCAKD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase domain-containing protein

Gene names

Name:

DCAKD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WVC6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WVC6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     106-132: GYRYVILDIPLLFETKKLLKYMKHTVV → EPRTSPRGKKHVPSALKEADSLMRRDT
     133-231: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Dephospho-CoA kinase domain-containing protein		PRO_0000316849
Regions
	Domain	3 – 207	205	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential
Natural variations
	Alternative sequence	106 – 132	27	GYRYV…KHTVV → EPRTSPRGKKHVPSALKEAD SLMRRDT in isoform 2.		VSP_030810
	Alternative sequence	133 – 231	99	Missing in isoform 2.		VSP_030811
	Natural variant	84	1	N → I. Ref.3 Corresponds to variant rs17850104 [ dbSNP | Ensembl ].		VAR_038406
Experimental info
	Sequence conflict	218	1	S → N in BAF83444. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E3AE93E8E3962544	FASTA	231	26,550
	10 20 30 40 50 60 MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV EVFGTEVLLE 70 80 90 100 110 120 NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF KYFLRGYRYV ILDIPLLFET 130 140 150 160 170 180 KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL NRKDAEARIN AQLPLTDKAR MARHVLDNSG 190 200 210 220 230 EWSVTKRQVI LLHTELERSL EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A
	Isoform 2 [UniParc]. Checksum: 33228A5A74EDA3AF	FASTA	132	14,927
	10 20 30 40 50 60 MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV EVFGTEVLLE 70 80 90 100 110 120 NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF KYFLREPRTS PRGKKHVPSA 130 LKEADSLMRR DT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-84. Tissue: Brain, Lung and Pancreas.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK026608 mRNA. Translation: BAB15508.1. AK290755 mRNA. Translation: BAF83444.1. CH471178 Genomic DNA. Translation: EAW51558.1. CH471178 Genomic DNA. Translation: EAW51559.1. CH471178 Genomic DNA. Translation: EAW51560.1. CH471178 Genomic DNA. Translation: EAW51561.1. CH471178 Genomic DNA. Translation: EAW51562.1. BC006472 mRNA. Translation: AAH06472.1. BC006546 mRNA. Translation: AAH06546.1. BC018132 mRNA. Translation: AAH18132.1. BC033299 mRNA. Translation: AAH33299.1.
IPI	IPI00015737. IPI00291417.
RefSeq	NP_001122103.1. NM_001128631.1. NP_079095.3. NM_024819.4.
UniGene	Hs.463148.
3D structure databases
HSSP	HSSP built from PDB template 1VHL based on UniProtKB P0A6I9.
ProteinModelPortal	Q8WVC6.
SMR	Q8WVC6. Positions 1-198.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WVC6.
Polymorphism databases
DMDM	74730834.
Proteomic databases
PRIDE	Q8WVC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342350; ENSP00000341504; ENSG00000172992. ENST00000452796; ENSP00000413483; ENSG00000172992.
GeneID	79877.
KEGG	hsa:79877.
NMPDR	fig|9606.3.peg.13896.
UCSC	uc002ihx.2. human. uc002ihy.2. human.
Organism-specific databases
CTD	79877.
GeneCards	GC17M043100.
HGNC	HGNC:26238. DCAKD.
neXtProt	NX_Q8WVC6.
PharmGKB	PA142672013.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14333.
GeneTree	ENSGT00550000075038.
HOGENOM	HBG650290.
HOVERGEN	HBG061063.
InParanoid	Q8WVC6.
OMA	VVVYCDP.
OrthoDB	EOG4GXFNQ.
PhylomeDB	Q8WVC6.
Gene expression databases
ArrayExpress	Q8WVC6.
Bgee	Q8WVC6.
CleanEx	HS_DCAKD.
Genevestigator	Q8WVC6.
Family and domain databases
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	69665.

Entry information

Entry name

DCAKD_HUMAN

Accession

Primary (citable) accession number: Q8WVC6
Secondary accession number(s): A8K3Z0 , D3DX60, D3DX62, Q9BR71, Q9H5W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.