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Protein

Dephospho-CoA kinase domain-containing protein

Gene

DCAKD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase domain-containing protein
Gene namesi
Name:DCAKD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26238. DCAKD.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672013.

Polymorphism and mutation databases

BioMutaiDCAKD.
DMDMi74730834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Dephospho-CoA kinase domain-containing proteinPRO_0000316849Add
BLAST

Proteomic databases

EPDiQ8WVC6.
MaxQBiQ8WVC6.
PaxDbiQ8WVC6.
PeptideAtlasiQ8WVC6.
PRIDEiQ8WVC6.

PTM databases

iPTMnetiQ8WVC6.
PhosphoSiteiQ8WVC6.

Expressioni

Gene expression databases

BgeeiQ8WVC6.
CleanExiHS_DCAKD.
ExpressionAtlasiQ8WVC6. baseline and differential.
GenevisibleiQ8WVC6. HS.

Organism-specific databases

HPAiHPA060997.

Interactioni

Protein-protein interaction databases

BioGridi122965. 16 interactions.
IntActiQ8WVC6. 1 interaction.
STRINGi9606.ENSP00000341504.

Structurei

3D structure databases

ProteinModelPortaliQ8WVC6.
SMRiQ8WVC6. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 207205DPCKAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiKOG3220. Eukaryota.
COG0237. LUCA.
GeneTreeiENSGT00550000075038.
HOGENOMiHOG000020768.
HOVERGENiHBG061063.
InParanoidiQ8WVC6.
OMAiTVENTKM.
OrthoDBiEOG7353XT.
PhylomeDBiQ8WVC6.
TreeFamiTF314815.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV
60 70 80 90 100
EVFGTEVLLE NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF
110 120 130 140 150
KYFLRGYRYV ILDIPLLFET KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL
160 170 180 190 200
NRKDAEARIN AQLPLTDKAR MARHVLDNSG EWSVTKRQVI LLHTELERSL
210 220 230
EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A
Length:231
Mass (Da):26,550
Last modified:March 1, 2002 - v1
Checksum:iE3AE93E8E3962544
GO
Isoform 2 (identifier: Q8WVC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-132: GYRYVILDIPLLFETKKLLKYMKHTVV → EPRTSPRGKKHVPSALKEADSLMRRDT
     133-231: Missing.

Show »
Length:132
Mass (Da):14,927
Checksum:i33228A5A74EDA3AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181S → N in BAF83444 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841N → I.1 Publication
Corresponds to variant rs17850104 [ dbSNP | Ensembl ].
VAR_038406

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 13227GYRYV…KHTVV → EPRTSPRGKKHVPSALKEAD SLMRRDT in isoform 2. 1 PublicationVSP_030810Add
BLAST
Alternative sequencei133 – 23199Missing in isoform 2. 1 PublicationVSP_030811Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026608 mRNA. Translation: BAB15508.1.
AK290755 mRNA. Translation: BAF83444.1.
CH471178 Genomic DNA. Translation: EAW51558.1.
CH471178 Genomic DNA. Translation: EAW51559.1.
CH471178 Genomic DNA. Translation: EAW51560.1.
CH471178 Genomic DNA. Translation: EAW51561.1.
CH471178 Genomic DNA. Translation: EAW51562.1.
BC006472 mRNA. Translation: AAH06472.1.
BC006546 mRNA. Translation: AAH06546.1.
BC018132 mRNA. Translation: AAH18132.1.
BC033299 mRNA. Translation: AAH33299.1.
CCDSiCCDS11493.1. [Q8WVC6-1]
RefSeqiNP_001122103.1. NM_001128631.2. [Q8WVC6-1]
NP_001275583.1. NM_001288654.2. [Q8WVC6-1]
NP_001275584.1. NM_001288655.1. [Q8WVC6-1]
NP_001308255.1. NM_001321326.1. [Q8WVC6-1]
NP_079095.3. NM_024819.6. [Q8WVC6-1]
XP_005257745.1. XM_005257688.2. [Q8WVC6-2]
XP_011523564.1. XM_011525262.1. [Q8WVC6-1]
XP_011523565.1. XM_011525263.1. [Q8WVC6-2]
XP_011523566.1. XM_011525264.1. [Q8WVC6-2]
UniGeneiHs.463148.

Genome annotation databases

EnsembliENST00000310604; ENSP00000308515; ENSG00000172992. [Q8WVC6-1]
ENST00000342350; ENSP00000341504; ENSG00000172992. [Q8WVC6-1]
ENST00000452796; ENSP00000413483; ENSG00000172992. [Q8WVC6-1]
ENST00000588499; ENSP00000467913; ENSG00000172992. [Q8WVC6-1]
ENST00000614054; ENSP00000478909; ENSG00000172992. [Q8WVC6-1]
GeneIDi79877.
KEGGihsa:79877.
UCSCiuc002ihx.3. human. [Q8WVC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026608 mRNA. Translation: BAB15508.1.
AK290755 mRNA. Translation: BAF83444.1.
CH471178 Genomic DNA. Translation: EAW51558.1.
CH471178 Genomic DNA. Translation: EAW51559.1.
CH471178 Genomic DNA. Translation: EAW51560.1.
CH471178 Genomic DNA. Translation: EAW51561.1.
CH471178 Genomic DNA. Translation: EAW51562.1.
BC006472 mRNA. Translation: AAH06472.1.
BC006546 mRNA. Translation: AAH06546.1.
BC018132 mRNA. Translation: AAH18132.1.
BC033299 mRNA. Translation: AAH33299.1.
CCDSiCCDS11493.1. [Q8WVC6-1]
RefSeqiNP_001122103.1. NM_001128631.2. [Q8WVC6-1]
NP_001275583.1. NM_001288654.2. [Q8WVC6-1]
NP_001275584.1. NM_001288655.1. [Q8WVC6-1]
NP_001308255.1. NM_001321326.1. [Q8WVC6-1]
NP_079095.3. NM_024819.6. [Q8WVC6-1]
XP_005257745.1. XM_005257688.2. [Q8WVC6-2]
XP_011523564.1. XM_011525262.1. [Q8WVC6-1]
XP_011523565.1. XM_011525263.1. [Q8WVC6-2]
XP_011523566.1. XM_011525264.1. [Q8WVC6-2]
UniGeneiHs.463148.

3D structure databases

ProteinModelPortaliQ8WVC6.
SMRiQ8WVC6. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122965. 16 interactions.
IntActiQ8WVC6. 1 interaction.
STRINGi9606.ENSP00000341504.

PTM databases

iPTMnetiQ8WVC6.
PhosphoSiteiQ8WVC6.

Polymorphism and mutation databases

BioMutaiDCAKD.
DMDMi74730834.

Proteomic databases

EPDiQ8WVC6.
MaxQBiQ8WVC6.
PaxDbiQ8WVC6.
PeptideAtlasiQ8WVC6.
PRIDEiQ8WVC6.

Protocols and materials databases

DNASUi79877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310604; ENSP00000308515; ENSG00000172992. [Q8WVC6-1]
ENST00000342350; ENSP00000341504; ENSG00000172992. [Q8WVC6-1]
ENST00000452796; ENSP00000413483; ENSG00000172992. [Q8WVC6-1]
ENST00000588499; ENSP00000467913; ENSG00000172992. [Q8WVC6-1]
ENST00000614054; ENSP00000478909; ENSG00000172992. [Q8WVC6-1]
GeneIDi79877.
KEGGihsa:79877.
UCSCiuc002ihx.3. human. [Q8WVC6-1]

Organism-specific databases

CTDi79877.
GeneCardsiDCAKD.
H-InvDBHIX0020552.
HGNCiHGNC:26238. DCAKD.
HPAiHPA060997.
neXtProtiNX_Q8WVC6.
PharmGKBiPA142672013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3220. Eukaryota.
COG0237. LUCA.
GeneTreeiENSGT00550000075038.
HOGENOMiHOG000020768.
HOVERGENiHBG061063.
InParanoidiQ8WVC6.
OMAiTVENTKM.
OrthoDBiEOG7353XT.
PhylomeDBiQ8WVC6.
TreeFamiTF314815.

Miscellaneous databases

ChiTaRSiDCAKD. human.
GenomeRNAii79877.
PROiQ8WVC6.

Gene expression databases

BgeeiQ8WVC6.
CleanExiHS_DCAKD.
ExpressionAtlasiQ8WVC6. baseline and differential.
GenevisibleiQ8WVC6. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-84.
    Tissue: Brain, Lung and Pancreas.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCAKD_HUMAN
AccessioniPrimary (citable) accession number: Q8WVC6
Secondary accession number(s): A8K3Z0
, D3DX60, D3DX62, Q9BR71, Q9H5W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.