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Protein

Chromosome transmission fidelity protein 18 homolog

Gene

CHTF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 381ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 18 homolog
Short name:
hCTF18
Alternative name(s):
CHL12
Gene namesi
Name:CHTF18
Synonyms:C16orf41, CTF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18435. CHTF18.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associates with chromatin during S phase.

GO - Cellular componenti

  • Ctf18 RFC-like complex Source: UniProtKB
  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127586.
PharmGKBiPA134908713.

Polymorphism and mutation databases

BioMutaiCHTF18.
DMDMi74751544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003400811 – 975Chromosome transmission fidelity protein 18 homologAdd BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphothreonineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVB6.
MaxQBiQ8WVB6.
PaxDbiQ8WVB6.
PeptideAtlasiQ8WVB6.
PRIDEiQ8WVB6.

PTM databases

iPTMnetiQ8WVB6.
PhosphoSitePlusiQ8WVB6.

Expressioni

Gene expression databases

BgeeiENSG00000127586.
CleanExiHS_CHTF18.
ExpressionAtlasiQ8WVB6. baseline and differential.
GenevisibleiQ8WVB6. HS.

Organism-specific databases

HPAiHPA040976.
HPA056209.

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5 (PubMed:12766176, PubMed:12930902). During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1 (PubMed:12766176, PubMed:12930902). The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH (PubMed:12766176, PubMed:17545166). The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex (PubMed:12766176). CTF18 interacts with SMC1A and RAD21 (PubMed:12930902). Interacts with DDX11 (PubMed:18499658).4 Publications

Protein-protein interaction databases

BioGridi121991. 26 interactors.
IntActiQ8WVB6. 6 interactors.
STRINGi9606.ENSP00000262315.

Structurei

3D structure databases

ProteinModelPortaliQ8WVB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1969. Eukaryota.
ENOG410XP8M. LUCA.
GeneTreeiENSGT00550000075029.
HOVERGENiHBG062099.
InParanoidiQ8WVB6.
KOiK11269.
PhylomeDBiQ8WVB6.
TreeFamiTF314392.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR
60 70 80 90 100
TFEEALARGD AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHAPRIK
110 120 130 140 150
RPRLQVVKRL NFRSEEMEEP PPPDSSPTDI TPPPSPEDLA ELWGHGVSEA
160 170 180 190 200
AADVGLTRAS PAARNPVLRR PPILEDYVHV TSTEGVRAYL VLRADPMAPG
210 220 230 240 250
VQGSLLHVPW RGGGQLDLLG VSLASLKKQV DGERRERLLQ EAQKLSDTLH
260 270 280 290 300
SLRSGEEEAA QPLGAPEEEP TDGQDASSHC LWVDEFAPRH YTELLSDDFT
310 320 330 340 350
NRCLLKWLKL WDLVVFGHER PSRKPRPSVE PARVSKEATA PGKWKSHEQV
360 370 380 390 400
LEEMLEAGLD PSQRPKQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA
410 420 430 440 450
SDDRSPEVFR TRIEAATQME SVLGAGGKPN CLVIDEIDGA PVAAINVLLS
460 470 480 490 500
ILNRKGPQEV GPQGPAVPSG GGRRRRAEGG LLMRPIICIC NDQFAPSLRQ
510 520 530 540 550
LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA LCEKTDNDIR
560 570 580 590 600
ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ
610 620 630 640 650
RRRVGQDPAL PADTLLLGDG DAGSLTSASQ RFYRVLHAAA SAGEHEKVVQ
660 670 680 690 700
GLFDNFLRLR LRDSSLGAVC VALDWLAFDD LLAGAAHHSQ SFQLLRYPPF
710 720 730 740 750
LPVAFHVLFA SSHTPRITFP SSQQEAQNRM SQMRNLIQTL VSGIAPATRS
760 770 780 790 800
RATPQALLLD ALCLLLDILA PKLRPVSTQL YSTREKQQLA SLVGTMLAYS
810 820 830 840 850
LTYRQERTPD GQYIYRLEPN VEELCRFPEL PARKPLTYQT KQLIAREIEV
860 870 880 890 900
EKMRRAEASA RVENSPQVDG SPPGLEGLLG GIGEKGVHRP APRNHEQRLE
910 920 930 940 950
HIMRRAAREE QPEKDFFGRV VVRSTAVPSA GDTAPEQDSV ERRMGTAVGR
960 970
SEVWFRFNEG VSNAVRRSLY IRDLL
Length:975
Mass (Da):107,383
Last modified:March 1, 2002 - v1
Checksum:i1C71B8D71DA916CB
GO
Isoform 2 (identifier: Q8WVB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: H → HGRLAALPQGLRSGREAEEASGSLHVSPP

Show »
Length:1,003
Mass (Da):110,208
Checksum:i667E07BD080C1DA8
GO
Isoform 3 (identifier: Q8WVB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-418: Missing.

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):61,869
Checksum:i8544B6372474219B
GO

Sequence cautioni

The sequence AAH06437 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15766 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04399063S → F.Corresponds to variant rs2277902dbSNPEnsembl.1
Natural variantiVAR_04399182Q → P.1 PublicationCorresponds to variant rs2277901dbSNPEnsembl.1
Natural variantiVAR_043992244K → R.1 PublicationCorresponds to variant rs3765263dbSNPEnsembl.1
Natural variantiVAR_043993466A → S.Corresponds to variant rs34595992dbSNPEnsembl.1
Natural variantiVAR_043994928P → L.1 PublicationCorresponds to variant rs2294451dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0341791 – 418Missing in isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_03418095H → HGRLAALPQGLRSGREAEEA SGSLHVSPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA. Translation: BAB15766.1. Different initiation.
AL031033 Genomic DNA. Translation: CAB53058.2.
AL031033 Genomic DNA. Translation: CAX15074.1.
CH471112 Genomic DNA. Translation: EAW85706.1.
CH471112 Genomic DNA. Translation: EAW85707.1.
CH471112 Genomic DNA. Translation: EAW85711.1.
BC006278 mRNA. Translation: AAH06278.2.
BC006437 mRNA. Translation: AAH06437.1. Different initiation.
BC018184 mRNA. Translation: AAH18184.1.
CCDSiCCDS45371.1. [Q8WVB6-1]
RefSeqiNP_071375.1. NM_022092.2. [Q8WVB6-1]
XP_005255528.1. XM_005255471.3. [Q8WVB6-2]
XP_011520875.1. XM_011522573.1. [Q8WVB6-3]
UniGeneiHs.153850.

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586. [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586. [Q8WVB6-2]
GeneIDi63922.
KEGGihsa:63922.
UCSCiuc002cke.4. human. [Q8WVB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA. Translation: BAB15766.1. Different initiation.
AL031033 Genomic DNA. Translation: CAB53058.2.
AL031033 Genomic DNA. Translation: CAX15074.1.
CH471112 Genomic DNA. Translation: EAW85706.1.
CH471112 Genomic DNA. Translation: EAW85707.1.
CH471112 Genomic DNA. Translation: EAW85711.1.
BC006278 mRNA. Translation: AAH06278.2.
BC006437 mRNA. Translation: AAH06437.1. Different initiation.
BC018184 mRNA. Translation: AAH18184.1.
CCDSiCCDS45371.1. [Q8WVB6-1]
RefSeqiNP_071375.1. NM_022092.2. [Q8WVB6-1]
XP_005255528.1. XM_005255471.3. [Q8WVB6-2]
XP_011520875.1. XM_011522573.1. [Q8WVB6-3]
UniGeneiHs.153850.

3D structure databases

ProteinModelPortaliQ8WVB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121991. 26 interactors.
IntActiQ8WVB6. 6 interactors.
STRINGi9606.ENSP00000262315.

PTM databases

iPTMnetiQ8WVB6.
PhosphoSitePlusiQ8WVB6.

Polymorphism and mutation databases

BioMutaiCHTF18.
DMDMi74751544.

Proteomic databases

EPDiQ8WVB6.
MaxQBiQ8WVB6.
PaxDbiQ8WVB6.
PeptideAtlasiQ8WVB6.
PRIDEiQ8WVB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586. [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586. [Q8WVB6-2]
GeneIDi63922.
KEGGihsa:63922.
UCSCiuc002cke.4. human. [Q8WVB6-1]

Organism-specific databases

CTDi63922.
GeneCardsiCHTF18.
HGNCiHGNC:18435. CHTF18.
HPAiHPA040976.
HPA056209.
MIMi613201. gene.
neXtProtiNX_Q8WVB6.
OpenTargetsiENSG00000127586.
PharmGKBiPA134908713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1969. Eukaryota.
ENOG410XP8M. LUCA.
GeneTreeiENSGT00550000075029.
HOVERGENiHBG062099.
InParanoidiQ8WVB6.
KOiK11269.
PhylomeDBiQ8WVB6.
TreeFamiTF314392.

Miscellaneous databases

GeneWikiiCHTF18.
GenomeRNAii63922.
PROiQ8WVB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127586.
CleanExiHS_CHTF18.
ExpressionAtlasiQ8WVB6. baseline and differential.
GenevisibleiQ8WVB6. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCTF18_HUMAN
AccessioniPrimary (citable) accession number: Q8WVB6
Secondary accession number(s): B7ZBA2
, D3DU68, Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.