Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromosome transmission fidelity protein 18 homolog

Gene

CHTF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi374 – 3818ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 18 homolog
Short name:
hCTF18
Alternative name(s):
CHL12
Gene namesi
Name:CHTF18
Synonyms:C16orf41, CTF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18435. CHTF18.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associates with chromatin during S phase.

GO - Cellular componenti

  • Ctf18 RFC-like complex Source: UniProtKB
  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908713.

Polymorphism and mutation databases

BioMutaiCHTF18.
DMDMi74751544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Chromosome transmission fidelity protein 18 homologPRO_0000340081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511PhosphothreonineCombined sources
Modified residuei64 – 641PhosphoserineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei871 – 8711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVB6.
MaxQBiQ8WVB6.
PaxDbiQ8WVB6.
PeptideAtlasiQ8WVB6.
PRIDEiQ8WVB6.

PTM databases

iPTMnetiQ8WVB6.

Expressioni

Gene expression databases

BgeeiQ8WVB6.
CleanExiHS_CHTF18.
ExpressionAtlasiQ8WVB6. baseline and differential.
GenevisibleiQ8WVB6. HS.

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21.3 Publications

Protein-protein interaction databases

BioGridi121991. 26 interactions.
IntActiQ8WVB6. 6 interactions.
STRINGi9606.ENSP00000262315.

Structurei

3D structure databases

ProteinModelPortaliQ8WVB6.
SMRiQ8WVB6. Positions 369-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1969. Eukaryota.
ENOG410XP8M. LUCA.
GeneTreeiENSGT00550000075029.
HOVERGENiHBG062099.
InParanoidiQ8WVB6.
KOiK11269.
OrthoDBiEOG7V1FQG.
PhylomeDBiQ8WVB6.
TreeFamiTF314392.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR
60 70 80 90 100
TFEEALARGD AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHAPRIK
110 120 130 140 150
RPRLQVVKRL NFRSEEMEEP PPPDSSPTDI TPPPSPEDLA ELWGHGVSEA
160 170 180 190 200
AADVGLTRAS PAARNPVLRR PPILEDYVHV TSTEGVRAYL VLRADPMAPG
210 220 230 240 250
VQGSLLHVPW RGGGQLDLLG VSLASLKKQV DGERRERLLQ EAQKLSDTLH
260 270 280 290 300
SLRSGEEEAA QPLGAPEEEP TDGQDASSHC LWVDEFAPRH YTELLSDDFT
310 320 330 340 350
NRCLLKWLKL WDLVVFGHER PSRKPRPSVE PARVSKEATA PGKWKSHEQV
360 370 380 390 400
LEEMLEAGLD PSQRPKQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA
410 420 430 440 450
SDDRSPEVFR TRIEAATQME SVLGAGGKPN CLVIDEIDGA PVAAINVLLS
460 470 480 490 500
ILNRKGPQEV GPQGPAVPSG GGRRRRAEGG LLMRPIICIC NDQFAPSLRQ
510 520 530 540 550
LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA LCEKTDNDIR
560 570 580 590 600
ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ
610 620 630 640 650
RRRVGQDPAL PADTLLLGDG DAGSLTSASQ RFYRVLHAAA SAGEHEKVVQ
660 670 680 690 700
GLFDNFLRLR LRDSSLGAVC VALDWLAFDD LLAGAAHHSQ SFQLLRYPPF
710 720 730 740 750
LPVAFHVLFA SSHTPRITFP SSQQEAQNRM SQMRNLIQTL VSGIAPATRS
760 770 780 790 800
RATPQALLLD ALCLLLDILA PKLRPVSTQL YSTREKQQLA SLVGTMLAYS
810 820 830 840 850
LTYRQERTPD GQYIYRLEPN VEELCRFPEL PARKPLTYQT KQLIAREIEV
860 870 880 890 900
EKMRRAEASA RVENSPQVDG SPPGLEGLLG GIGEKGVHRP APRNHEQRLE
910 920 930 940 950
HIMRRAAREE QPEKDFFGRV VVRSTAVPSA GDTAPEQDSV ERRMGTAVGR
960 970
SEVWFRFNEG VSNAVRRSLY IRDLL
Length:975
Mass (Da):107,383
Last modified:March 1, 2002 - v1
Checksum:i1C71B8D71DA916CB
GO
Isoform 2 (identifier: Q8WVB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: H → HGRLAALPQGLRSGREAEEASGSLHVSPP

Show »
Length:1,003
Mass (Da):110,208
Checksum:i667E07BD080C1DA8
GO
Isoform 3 (identifier: Q8WVB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-418: Missing.

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):61,869
Checksum:i8544B6372474219B
GO

Sequence cautioni

The sequence AAH06437.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15766.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631S → F.
Corresponds to variant rs2277902 [ dbSNP | Ensembl ].
VAR_043990
Natural varianti82 – 821Q → P.1 Publication
Corresponds to variant rs2277901 [ dbSNP | Ensembl ].
VAR_043991
Natural varianti244 – 2441K → R.1 Publication
Corresponds to variant rs3765263 [ dbSNP | Ensembl ].
VAR_043992
Natural varianti466 – 4661A → S.
Corresponds to variant rs34595992 [ dbSNP | Ensembl ].
VAR_043993
Natural varianti928 – 9281P → L.1 Publication
Corresponds to variant rs2294451 [ dbSNP | Ensembl ].
VAR_043994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 418418Missing in isoform 3. 1 PublicationVSP_034179Add
BLAST
Alternative sequencei95 – 951H → HGRLAALPQGLRSGREAEEA SGSLHVSPP in isoform 2. 1 PublicationVSP_034180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA. Translation: BAB15766.1. Different initiation.
AL031033 Genomic DNA. Translation: CAB53058.2.
AL031033 Genomic DNA. Translation: CAX15074.1.
CH471112 Genomic DNA. Translation: EAW85706.1.
CH471112 Genomic DNA. Translation: EAW85707.1.
CH471112 Genomic DNA. Translation: EAW85711.1.
BC006278 mRNA. Translation: AAH06278.2.
BC006437 mRNA. Translation: AAH06437.1. Different initiation.
BC018184 mRNA. Translation: AAH18184.1.
CCDSiCCDS45371.1. [Q8WVB6-1]
RefSeqiNP_071375.1. NM_022092.2. [Q8WVB6-1]
XP_005255528.1. XM_005255471.2. [Q8WVB6-2]
XP_005255529.1. XM_005255472.1. [Q8WVB6-3]
XP_011520875.1. XM_011522573.1. [Q8WVB6-3]
UniGeneiHs.153850.

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586. [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586. [Q8WVB6-2]
GeneIDi63922.
KEGGihsa:63922.
UCSCiuc002cke.4. human. [Q8WVB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA. Translation: BAB15766.1. Different initiation.
AL031033 Genomic DNA. Translation: CAB53058.2.
AL031033 Genomic DNA. Translation: CAX15074.1.
CH471112 Genomic DNA. Translation: EAW85706.1.
CH471112 Genomic DNA. Translation: EAW85707.1.
CH471112 Genomic DNA. Translation: EAW85711.1.
BC006278 mRNA. Translation: AAH06278.2.
BC006437 mRNA. Translation: AAH06437.1. Different initiation.
BC018184 mRNA. Translation: AAH18184.1.
CCDSiCCDS45371.1. [Q8WVB6-1]
RefSeqiNP_071375.1. NM_022092.2. [Q8WVB6-1]
XP_005255528.1. XM_005255471.2. [Q8WVB6-2]
XP_005255529.1. XM_005255472.1. [Q8WVB6-3]
XP_011520875.1. XM_011522573.1. [Q8WVB6-3]
UniGeneiHs.153850.

3D structure databases

ProteinModelPortaliQ8WVB6.
SMRiQ8WVB6. Positions 369-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121991. 26 interactions.
IntActiQ8WVB6. 6 interactions.
STRINGi9606.ENSP00000262315.

PTM databases

iPTMnetiQ8WVB6.

Polymorphism and mutation databases

BioMutaiCHTF18.
DMDMi74751544.

Proteomic databases

EPDiQ8WVB6.
MaxQBiQ8WVB6.
PaxDbiQ8WVB6.
PeptideAtlasiQ8WVB6.
PRIDEiQ8WVB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586. [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586. [Q8WVB6-2]
GeneIDi63922.
KEGGihsa:63922.
UCSCiuc002cke.4. human. [Q8WVB6-1]

Organism-specific databases

CTDi63922.
GeneCardsiCHTF18.
HGNCiHGNC:18435. CHTF18.
MIMi613201. gene.
neXtProtiNX_Q8WVB6.
PharmGKBiPA134908713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1969. Eukaryota.
ENOG410XP8M. LUCA.
GeneTreeiENSGT00550000075029.
HOVERGENiHBG062099.
InParanoidiQ8WVB6.
KOiK11269.
OrthoDBiEOG7V1FQG.
PhylomeDBiQ8WVB6.
TreeFamiTF314392.

Miscellaneous databases

GeneWikiiCHTF18.
GenomeRNAii63922.
PROiQ8WVB6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WVB6.
CleanExiHS_CHTF18.
ExpressionAtlasiQ8WVB6. baseline and differential.
GenevisibleiQ8WVB6. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-82; ARG-244 AND LEU-928.
    Tissue: Spleen.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Lung and Placenta.
  5. "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment."
    Merkle C.J., Karnitz L.M., Henry-Sanchez J.T., Chen J.
    J. Biol. Chem. 278:30051-30056(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE CTF18-RFC COMPLEX, INTERACTION WITH PCNA, SUBCELLULAR LOCATION.
  6. "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA."
    Bermudez V.P., Maniwa Y., Tappin I., Ozato K., Yokomori K., Hurwitz J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10237-10242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE CTF18-RFC COMPLEX, INTERACTION WITH SMC1A AND RAD21, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity."
    Shiomi Y., Masutani C., Hanaoka F., Kimura H., Tsurimoto T.
    J. Biol. Chem. 282:20906-20914(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POLH.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; SER-64; SER-225 AND SER-871, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiCTF18_HUMAN
AccessioniPrimary (citable) accession number: Q8WVB6
Secondary accession number(s): B7ZBA2
, D3DU68, Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.