Reviewed, UniProtKB/Swiss-Prot Q8WV99 (ZFN2B_HUMAN)

Names and origin

Protein names

Recommended name:
    AN1-type zinc finger protein 2B

Gene names

Name:

ZFAND2B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 2 AN1-type zinc fingers. Contains 2 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DAZAP2	Q15038	2	EBI-747823,EBI-724310

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WV99-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WV99-2)

The sequence of this isoform differs from the canonical sequence as follows:
     177-257: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 257

257

AN1-type zinc finger protein 2B

PRO_0000232876

Regions

Repeat

197 – 216

20

UIM 1

Repeat

221 – 240

20

UIM 2

Zinc finger

7 – 52

46

AN1-type 1

Zinc finger

97 – 145

49

AN1-type 2

Natural variations

Alternative sequence

177 – 257

81

Missing in isoform 2.

VSP_018001

Secondary structure

1

.

.

.

.

.

257

Helix Strand Turn

Details...

Beta strand

116 – 118

3

Helix

124 – 127

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E87D47744157F48C	FASTA	257	28,023
	10 20 30 40 50 60 MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA QHHCGSAYQK DIQVPVCPLC 70 80 90 100 110 120 NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC ERAGCRQREM MKLTCERCSR 130 140 150 160 170 180 NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS RAQAVASTST VPSPSQTMPS CTSPSRATTR 190 200 210 220 230 240 SPSWTAPPVI ALQNGLSEDE ALQRALEMSL AETKPQVPSC QEEEDLALAQ ALSASEAEYQ 250 RQQAQSRSSK PSNCSLC
	Isoform 2. Checksum: F656E1B2AE47E8EA	FASTA	176	19,306
	10 20 30 40 50 60 MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA QHHCGSAYQK DIQVPVCPLC 70 80 90 100 110 120 NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC ERAGCRQREM MKLTCERCSR 130 140 150 160 170 NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS RAQAVASTST VPSPSQTMPS CTSPSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Ovary.
[3]	"Solution structure of the ZF-AN1 domain from human hypothetical protein LOC130617." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 93-142 IN COMPLEX WITH ZINC IONS.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AK091345 mRNA. Translation: BAC03642.1.
BC018415 mRNA. Translation: AAH18415.1.

IPI

IPI00103075.
IPI00743841.

RefSeq

NP_620157.1.

UniGene

Hs.534540

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X4V	NMR	-	A	93-142	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WV99. 1 interaction.

PTM databases

PhosphoSite

Q8WV99.

Proteomic databases

PRIDE

Q8WV99.

Genome annotation databases

Ensembl

ENST00000289528; ENSP00000289528; ENSG00000158552; Homo sapiens. [Genome view]
ENST00000409336; ENSP00000386898; ENSG00000158552; Homo sapiens. [Genome view]

GeneID

130617.

KEGG

hsa:130617.

UCSC

uc002vjy.1. human.
uc002vka.1. human.

Organism-specific databases

CTD

130617.

GeneCards

GC02P219780.

HGNC

HGNC:25206. ZFAND2B.

PharmGKB

PA142670527.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q8WV99.

HOVERGEN

Q8WV99.

Gene expression databases

ArrayExpress

Q8WV99.

Bgee

Q8WV99.

CleanEx

HS_ZFAND2B.

Genevestigator

Q8WV99.

GermOnline

ENSG00000158552. Homo sapiens.

Family and domain databases

InterPro

IPR003903. Ubiquitin-int_motif.
IPR000058. Znf_AN1.
[Graphical view]

Gene3D

G3DSA:4.10.1110.10. Znf_AN1. 2 hits.

Pfam

PF02809. UIM. 2 hits.
PF01428. zf-AN1. 2 hits.
[Graphical view]

SMART

SM00726. UIM. 2 hits.
SM00154. ZnF_AN1. 2 hits.
[Graphical view]

PROSITE

PS50330. UIM. 2 hits.
PS51039. ZF_AN1. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

82790.

Entry information

Entry name

ZFN2B_HUMAN

Accession

Primary (citable) accession number: Q8WV99
Secondary accession number(s): Q8NB98

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	March 1, 2002
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.