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Protein

AN1-type zinc finger protein 2B

Gene

ZFAND2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5246AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 14549AN1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 2B
Alternative name(s):
Arsenite-inducible RNA-associated protein-like protein
Short name:
AIRAP-like protein
Gene namesi
Name:ZFAND2B
Synonyms:AIRAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25206. ZFAND2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670527.

Polymorphism and mutation databases

DMDMi74730823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257AN1-type zinc finger protein 2BPRO_0000232876Add
BLAST

Proteomic databases

EPDiQ8WV99.
MaxQBiQ8WV99.
PaxDbiQ8WV99.
PRIDEiQ8WV99.

PTM databases

iPTMnetiQ8WV99.
PhosphoSiteiQ8WV99.

Expressioni

Gene expression databases

BgeeiQ8WV99.
CleanExiHS_ZFAND2B.
ExpressionAtlasiQ8WV99. baseline and differential.
GenevisibleiQ8WV99. HS.

Organism-specific databases

HPAiHPA035159.
HPA035160.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150386EBI-747823,EBI-724310
TARDBPG3V1623EBI-747823,EBI-10177881
UBQLN1Q9UMX0-23EBI-747823,EBI-10173939

Protein-protein interaction databases

BioGridi126246. 24 interactions.
IntActiQ8WV99. 4 interactions.
MINTiMINT-1448171.
STRINGi9606.ENSP00000289528.

Structurei

Secondary structure

1
257
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi116 – 1183Combined sources
Helixi124 – 1274Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4VNMR-A93-142[»]
ProteinModelPortaliQ8WV99.
SMRiQ8WV99. Positions 5-44, 93-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WV99.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 21620UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 24020UIM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 15111VCP/p97-interacting motif (VIM)1 PublicationAdd
BLAST

Sequence similaritiesi

Contains 2 AN1-type zinc fingers.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5246AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 14549AN1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000110968.
HOGENOMiHOG000243115.
HOVERGENiHBG061194.
InParanoidiQ8WV99.
PhylomeDBiQ8WV99.
TreeFamiTF314219.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR003903. UIM_dom.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS51039. ZF_AN1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA QHHCGSAYQK
60 70 80 90 100
DIQVPVCPLC NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC
110 120 130 140 150
ERAGCRQREM MKLTCERCSR NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS
160 170 180 190 200
RAQAVASTST VPSPSQTMPS CTSPSRATTR SPSWTAPPVI ALQNGLSEDE
210 220 230 240 250
ALQRALEMSL AETKPQVPSC QEEEDLALAQ ALSASEAEYQ RQQAQSRSSK

PSNCSLC
Length:257
Mass (Da):28,023
Last modified:March 1, 2002 - v1
Checksum:iE87D47744157F48C
GO
Isoform 2 (identifier: Q8WV99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-257: Missing.

Show »
Length:176
Mass (Da):19,306
Checksum:iF656E1B2AE47E8EA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei177 – 25781Missing in isoform 2. 1 PublicationVSP_018001Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091345 mRNA. Translation: BAC03642.1.
BC018415 mRNA. Translation: AAH18415.1.
CCDSiCCDS2435.1. [Q8WV99-1]
RefSeqiNP_001257927.1. NM_001270998.1. [Q8WV99-1]
NP_001257928.1. NM_001270999.1.
NP_620157.1. NM_138802.2. [Q8WV99-1]
UniGeneiHs.534540.

Genome annotation databases

EnsembliENST00000289528; ENSP00000289528; ENSG00000158552. [Q8WV99-1]
ENST00000409206; ENSP00000386824; ENSG00000158552. [Q8WV99-2]
ENST00000409336; ENSP00000386898; ENSG00000158552. [Q8WV99-1]
ENST00000409594; ENSP00000386399; ENSG00000158552. [Q8WV99-2]
ENST00000444522; ENSP00000411334; ENSG00000158552. [Q8WV99-1]
GeneIDi130617.
KEGGihsa:130617.
UCSCiuc002vjz.3. human. [Q8WV99-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091345 mRNA. Translation: BAC03642.1.
BC018415 mRNA. Translation: AAH18415.1.
CCDSiCCDS2435.1. [Q8WV99-1]
RefSeqiNP_001257927.1. NM_001270998.1. [Q8WV99-1]
NP_001257928.1. NM_001270999.1.
NP_620157.1. NM_138802.2. [Q8WV99-1]
UniGeneiHs.534540.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4VNMR-A93-142[»]
ProteinModelPortaliQ8WV99.
SMRiQ8WV99. Positions 5-44, 93-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126246. 24 interactions.
IntActiQ8WV99. 4 interactions.
MINTiMINT-1448171.
STRINGi9606.ENSP00000289528.

PTM databases

iPTMnetiQ8WV99.
PhosphoSiteiQ8WV99.

Polymorphism and mutation databases

DMDMi74730823.

Proteomic databases

EPDiQ8WV99.
MaxQBiQ8WV99.
PaxDbiQ8WV99.
PRIDEiQ8WV99.

Protocols and materials databases

DNASUi130617.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289528; ENSP00000289528; ENSG00000158552. [Q8WV99-1]
ENST00000409206; ENSP00000386824; ENSG00000158552. [Q8WV99-2]
ENST00000409336; ENSP00000386898; ENSG00000158552. [Q8WV99-1]
ENST00000409594; ENSP00000386399; ENSG00000158552. [Q8WV99-2]
ENST00000444522; ENSP00000411334; ENSG00000158552. [Q8WV99-1]
GeneIDi130617.
KEGGihsa:130617.
UCSCiuc002vjz.3. human. [Q8WV99-1]

Organism-specific databases

CTDi130617.
GeneCardsiZFAND2B.
HGNCiHGNC:25206. ZFAND2B.
HPAiHPA035159.
HPA035160.
MIMi613474. gene.
neXtProtiNX_Q8WV99.
PharmGKBiPA142670527.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000110968.
HOGENOMiHOG000243115.
HOVERGENiHBG061194.
InParanoidiQ8WV99.
PhylomeDBiQ8WV99.
TreeFamiTF314219.

Miscellaneous databases

ChiTaRSiZFAND2B. human.
EvolutionaryTraceiQ8WV99.
GenomeRNAii130617.
NextBioi82790.
PROiQ8WV99.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WV99.
CleanExiHS_ZFAND2B.
ExpressionAtlasiQ8WV99. baseline and differential.
GenevisibleiQ8WV99. HS.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR003903. UIM_dom.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS50330. UIM. 2 hits.
PS51039. ZF_AN1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors."
    Stapf C., Cartwright E., Bycroft M., Hofmann K., Buchberger A.
    J. Biol. Chem. 286:38670-38678(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VCP, VIM MOTIF.
  5. "Solution structure of the ZF-AN1 domain from human hypothetical protein LOC130617."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 93-142 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiZFN2B_HUMAN
AccessioniPrimary (citable) accession number: Q8WV99
Secondary accession number(s): Q8NB98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.