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Q8WV93 (LACE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lactation elevated protein 1
Gene names
Name:LACE1
Synonyms:AFG1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AFG1 ATPase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Lactation elevated protein 1
PRO_0000279521

Regions

Nucleotide binding136 – 1438ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8WV93 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 5B612E3B657DCA12

FASTA48154,845
        10         20         30         40         50         60 
MAASWSLLVT LRPLAQSPLR GRCVGCGAWA AALAPLATAP GKPFWKAYTV QTSESMTPTA 

        70         80         90        100        110        120 
TSETYLKALA VCHGPLDHYD FLIKAHELKD DEHQRRVIQC LQKLHEDLKG YNIEAEGLFS 

       130        140        150        160        170        180 
KLFSRSKPPR GLYVYGDVGT GKTMVMDMFY AYVEMKRKKR VHFHGFMLDV HKRIHRLKQS 

       190        200        210        220        230        240 
LPKRKPGFMA KSYDPIAPIA EEISEEACLL CFDEFQVTDI ADAMILKQLF ENLFKNGVVV 

       250        260        270        280        290        300 
VATSNRPPED LYKNGLQRAN FVPFIAVLKE YCNTVQLDSG IDYRKRELPA AGKLYYLTSE 

       310        320        330        340        350        360 
ADVEAVMDKL FDELAQKQND LTRPRILKVQ GRELRLNKAC GTVADCTFEE LCERPLGASD 

       370        380        390        400        410        420 
YLELSKNFDT IFLRNIPQFT LANRTQGRRF ITLIDNFYDL KVRIICSAST PISSLFLHQH 

       430        440        450        460        470        480 
HDSELEQSRI LMDDLGLSQD SAEGLSMFTG EEEIFAFQRT ISRLTEMQTE QYWNEGDRTK 


K

« Hide

References

« Hide 'large scale' references
[1]"Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci."
Abrahams B.S., Mak G.M., Berry M.L., Palmquist D.L., Saionz J.R., Tay A., Tan Y.H., Brenner S., Simpson E.M., Venkatesh B.
Genomics 80:45-53(2002) [PubMed: 12079282] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retinoblastoma.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF520418 mRNA. Translation: AAM74228.1.
AL356121 expand/collapse EMBL AC list , Z98742, AL139106, AL353706 Genomic DNA. Translation: CAI95324.1.
Z98742 expand/collapse EMBL AC list , AL139106, AL353706, AL356121 Genomic DNA. Translation: CAI95645.1.
AL353706 expand/collapse EMBL AC list , Z98742, AL139106, AL356121 Genomic DNA. Translation: CAI95698.1.
AL139106 expand/collapse EMBL AC list , Z98742, AL353706, AL356121 Genomic DNA. Translation: CAI95701.1.
BC018445 mRNA. Translation: AAH18445.2.
IPIIPI00166976.
RefSeqNP_660358.2. NM_145315.3.
UniGeneHs.259666.

3D structure databases

ProteinModelPortalQ8WV93.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8WV93. 1 interaction.
STRINGQ8WV93.

Polymorphism databases

DMDM74762631.

Proteomic databases

PRIDEQ8WV93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368977; ENSP00000357973; ENSG00000135537.
GeneID246269.
KEGGhsa:246269.
UCSCuc003psj.1. human.

Organism-specific databases

CTD246269.
GeneCardsGC06P108616.
H-InvDBHIX0022241.
HGNCHGNC:16411. LACE1.
HPAHPA030154.
HPA030155.
HPA030659.
neXtProtNX_Q8WV93.
PharmGKBPA38404.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11371.
GeneTreeENSGT00390000013227.
HOGENOMHBG664131.
HOVERGENHBG081885.
InParanoidQ8WV93.
OMAEFYDRNV.
OrthoDBEOG4QNMW1.
PhylomeDBQ8WV93.

Gene expression databases

ArrayExpressQ8WV93.
BgeeQ8WV93.
CleanExHS_LACE1.
GenevestigatorQ8WV93.

Family and domain databases

InterProIPR005654. ATPase_AFG1-like.
[Graphical view]
PANTHERPTHR12169. AFG1_ATPase. 1 hit.
PfamPF03969. AFG1_ATPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio91902.

Entry information

Entry nameLACE1_HUMAN
AccessionPrimary (citable) accession number: Q8WV93
Secondary accession number(s): Q8N6A3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2004
Last modified: January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents