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Protein

Lactation elevated protein 1

Gene

LACE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi136 – 1438ATPSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lactation elevated protein 1
Alternative name(s):
Protein AFG1 homolog
Gene namesi
Name:LACE1
Synonyms:AFG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16411. LACE1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38404.

Polymorphism and mutation databases

BioMutaiLACE1.
DMDMi74762631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Lactation elevated protein 1PRO_0000279521Add
BLAST

Proteomic databases

EPDiQ8WV93.
MaxQBiQ8WV93.
PaxDbiQ8WV93.
PeptideAtlasiQ8WV93.
PRIDEiQ8WV93.

PTM databases

iPTMnetiQ8WV93.
PhosphoSiteiQ8WV93.

Expressioni

Gene expression databases

BgeeiQ8WV93.
CleanExiHS_LACE1.
ExpressionAtlasiQ8WV93. baseline and differential.
GenevisibleiQ8WV93. HS.

Organism-specific databases

HPAiHPA030154.
HPA030155.
HPA030659.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-2865743,EBI-744695

Protein-protein interaction databases

BioGridi128885. 1 interaction.
IntActiQ8WV93. 2 interactions.
STRINGi9606.ENSP00000357973.

Structurei

3D structure databases

ProteinModelPortaliQ8WV93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AFG1 ATPase family.Curated

Phylogenomic databases

eggNOGiKOG2383. Eukaryota.
COG1485. LUCA.
GeneTreeiENSGT00390000013227.
HOGENOMiHOG000259600.
HOVERGENiHBG081885.
InParanoidiQ8WV93.
KOiK18798.
OMAiEQWAKHR.
OrthoDBiEOG7353X8.
PhylomeDBiQ8WV93.
TreeFamiTF314551.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005654. ATPase_AFG1-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12169. PTHR12169. 1 hit.
PfamiPF03969. AFG1_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WV93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASWSLLVT LRPLAQSPLR GRCVGCGAWA AALAPLATAP GKPFWKAYTV
60 70 80 90 100
QTSESMTPTA TSETYLKALA VCHGPLDHYD FLIKAHELKD DEHQRRVIQC
110 120 130 140 150
LQKLHEDLKG YNIEAEGLFS KLFSRSKPPR GLYVYGDVGT GKTMVMDMFY
160 170 180 190 200
AYVEMKRKKR VHFHGFMLDV HKRIHRLKQS LPKRKPGFMA KSYDPIAPIA
210 220 230 240 250
EEISEEACLL CFDEFQVTDI ADAMILKQLF ENLFKNGVVV VATSNRPPED
260 270 280 290 300
LYKNGLQRAN FVPFIAVLKE YCNTVQLDSG IDYRKRELPA AGKLYYLTSE
310 320 330 340 350
ADVEAVMDKL FDELAQKQND LTRPRILKVQ GRELRLNKAC GTVADCTFEE
360 370 380 390 400
LCERPLGASD YLELSKNFDT IFLRNIPQFT LANRTQGRRF ITLIDNFYDL
410 420 430 440 450
KVRIICSAST PISSLFLHQH HDSELEQSRI LMDDLGLSQD SAEGLSMFTG
460 470 480
EEEIFAFQRT ISRLTEMQTE QYWNEGDRTK K
Length:481
Mass (Da):54,845
Last modified:March 1, 2004 - v2
Checksum:i5B612E3B657DCA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520418 mRNA. Translation: AAM74228.1.
AL356121
, Z98742, AL139106, AL353706 Genomic DNA. Translation: CAI95324.1.
Z98742
, AL139106, AL353706, AL356121 Genomic DNA. Translation: CAI95645.1.
AL353706
, Z98742, AL139106, AL356121 Genomic DNA. Translation: CAI95698.1.
AL139106
, Z98742, AL353706, AL356121 Genomic DNA. Translation: CAI95701.1.
BC018445 mRNA. Translation: AAH18445.2.
CCDSiCCDS5067.1.
RefSeqiNP_001309934.1. NM_001323005.1.
NP_660358.2. NM_145315.4.
UniGeneiHs.259666.

Genome annotation databases

EnsembliENST00000368977; ENSP00000357973; ENSG00000135537.
GeneIDi246269.
KEGGihsa:246269.
UCSCiuc003psj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520418 mRNA. Translation: AAM74228.1.
AL356121
, Z98742, AL139106, AL353706 Genomic DNA. Translation: CAI95324.1.
Z98742
, AL139106, AL353706, AL356121 Genomic DNA. Translation: CAI95645.1.
AL353706
, Z98742, AL139106, AL356121 Genomic DNA. Translation: CAI95698.1.
AL139106
, Z98742, AL353706, AL356121 Genomic DNA. Translation: CAI95701.1.
BC018445 mRNA. Translation: AAH18445.2.
CCDSiCCDS5067.1.
RefSeqiNP_001309934.1. NM_001323005.1.
NP_660358.2. NM_145315.4.
UniGeneiHs.259666.

3D structure databases

ProteinModelPortaliQ8WV93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128885. 1 interaction.
IntActiQ8WV93. 2 interactions.
STRINGi9606.ENSP00000357973.

PTM databases

iPTMnetiQ8WV93.
PhosphoSiteiQ8WV93.

Polymorphism and mutation databases

BioMutaiLACE1.
DMDMi74762631.

Proteomic databases

EPDiQ8WV93.
MaxQBiQ8WV93.
PaxDbiQ8WV93.
PeptideAtlasiQ8WV93.
PRIDEiQ8WV93.

Protocols and materials databases

DNASUi246269.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368977; ENSP00000357973; ENSG00000135537.
GeneIDi246269.
KEGGihsa:246269.
UCSCiuc003psj.4. human.

Organism-specific databases

CTDi246269.
GeneCardsiLACE1.
HGNCiHGNC:16411. LACE1.
HPAiHPA030154.
HPA030155.
HPA030659.
neXtProtiNX_Q8WV93.
PharmGKBiPA38404.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2383. Eukaryota.
COG1485. LUCA.
GeneTreeiENSGT00390000013227.
HOGENOMiHOG000259600.
HOVERGENiHBG081885.
InParanoidiQ8WV93.
KOiK18798.
OMAiEQWAKHR.
OrthoDBiEOG7353X8.
PhylomeDBiQ8WV93.
TreeFamiTF314551.

Miscellaneous databases

GenomeRNAii246269.
PROiQ8WV93.

Gene expression databases

BgeeiQ8WV93.
CleanExiHS_LACE1.
ExpressionAtlasiQ8WV93. baseline and differential.
GenevisibleiQ8WV93. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005654. ATPase_AFG1-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12169. PTHR12169. 1 hit.
PfamiPF03969. AFG1_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci."
    Abrahams B.S., Mak G.M., Berry M.L., Palmquist D.L., Saionz J.R., Tay A., Tan Y.H., Brenner S., Simpson E.M., Venkatesh B.
    Genomics 80:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retinoblastoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiLACE1_HUMAN
AccessioniPrimary (citable) accession number: Q8WV93
Secondary accession number(s): Q8N6A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.