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Protein

Solute carrier family 35 member F5

Gene

SLC35F5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative solute transporter.Curated

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.24.6 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F5
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 3
Short name:
HCV NS5A-transactivated protein 3
Gene namesi
Name:SLC35F5
Synonyms:NS5ATP3
ORF Names:UNQ2545/PRO6097
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115084.12
HGNCiHGNC:23617 SLC35F5
neXtProtiNX_Q8WV83

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115084
PharmGKBiPA134953009

Polymorphism and mutation databases

DMDMi74730818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119561 – 523Solute carrier family 35 member F5Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WV83
PaxDbiQ8WV83
PeptideAtlasiQ8WV83
PRIDEiQ8WV83

PTM databases

iPTMnetiQ8WV83
PhosphoSitePlusiQ8WV83

Expressioni

Tissue specificityi

Expressed in colorectal cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000115084
CleanExiHS_SLC35F5
ExpressionAtlasiQ8WV83 baseline and differential
GenevisibleiQ8WV83 HS

Organism-specific databases

HPAiHPA034828
HPA049229

Interactioni

Protein-protein interaction databases

BioGridi123201, 11 interactors
IntActiQ8WV83, 2 interactors
MINTiQ8WV83
STRINGi9606.ENSP00000245680

Structurei

3D structure databases

ProteinModelPortaliQ8WV83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 316EamAAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 374Poly-Leu4

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2765 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00390000005949
HOGENOMiHOG000045636
HOVERGENiHBG057096
InParanoidiQ8WV83
KOiK15289
OMAiCVFIMNR
OrthoDBiEOG091G09Y5
PhylomeDBiQ8WV83
TreeFamiTF314261

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
PfamiView protein in Pfam
PF00892 EamA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPPRRHRGA GRPGVLSSSP PFRLRSAKFS GIALEDLRRA LKTRLQMVCV
60 70 80 90 100
FVMNRMNSQN SGFTQRRRMA LGIVILLLVD VIWVASSELT SYVFTQYNKP
110 120 130 140 150
FFSTFAKTSM FVLYLLGFII WKPWRQQCTR GLRGKHAAFF ADAEGYFAAC
160 170 180 190 200
TTDTTMNSSL SEPLYVPVKF HDLPSEKPES TNIDTEKTPK KSRVRFSNIM
210 220 230 240 250
EIRQLPSSHA LEAKLSRMSY PVKEQESILK TVGKLTATQV AKISFFFCFV
260 270 280 290 300
WFLANLSYQE ALSDTQVAIV NILSSTSGLF TLILAAVFPS NSGDRFTLSK
310 320 330 340 350
LLAVILSIGG VVLVNLAGSE KPAGRDTVGS IWSLAGAMLY AVYIVMIKRK
360 370 380 390 400
VDREDKLDIP MFFGFVGLFN LLLLWPGFFL LHYTGFEDFE FPNKVVLMCI
410 420 430 440 450
IINGLIGTVL SEFLWLWGCF LTSSLIGTLA LSLTIPLSII ADMCMQKVQF
460 470 480 490 500
SWLFFAGAIP VFFSFFIVTL LCHYNNWDPV MVGIRRIFAF ICRKHRIQRV
510 520
PEDSEQCESL ISMHSVSQED GAS
Length:523
Mass (Da):58,887
Last modified:March 1, 2002 - v1
Checksum:i1B8CEDF0F1F33179
GO
Isoform 2 (identifier: Q8WV83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     7-13: HRGAGRP → MDSSGWR
     248-250: CFV → ALW
     251-523: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):27,826
Checksum:iC533AEB78A6C1CAA
GO

Sequence cautioni

The sequence BAB14954 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320E → G in BAB14954 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296651 – 6Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_0296667 – 13HRGAGRP → MDSSGWR in isoform 2. 1 Publication7
Alternative sequenceiVSP_029667248 – 250CFV → ALW in isoform 2. 1 Publication3
Alternative sequenceiVSP_029668251 – 523Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529364 mRNA Translation: AAQ09598.1
AY358620 mRNA Translation: AAQ88983.1
AK024666 mRNA Translation: BAB14954.1 Different initiation.
AK025657 mRNA Translation: BAB15206.1
AC017074 Genomic DNA Translation: AAY14808.1
CH471103 Genomic DNA Translation: EAW95176.1
BC018537 mRNA Translation: AAH18537.1
CCDSiCCDS2119.1 [Q8WV83-1]
RefSeqiNP_001317246.1, NM_001330317.1
NP_079457.2, NM_025181.4 [Q8WV83-1]
UniGeneiHs.355655
Hs.608286
Hs.632527

Genome annotation databases

EnsembliENST00000245680; ENSP00000245680; ENSG00000115084 [Q8WV83-1]
GeneIDi80255
KEGGihsa:80255
UCSCiuc002tku.2 human [Q8WV83-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35F5_HUMAN
AccessioniPrimary (citable) accession number: Q8WV83
Secondary accession number(s): Q9H6P8, Q9H7D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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