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Protein

Solute carrier family 35 member F5

Gene

SLC35F5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative solute transporter.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F5
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 3
Short name:
HCV NS5A-transactivated protein 3
Gene namesi
Name:SLC35F5
Synonyms:NS5ATP3
ORF Names:UNQ2545/PRO6097
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23617. SLC35F5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence analysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953009.

Polymorphism and mutation databases

DMDMi74730818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Solute carrier family 35 member F5PRO_0000311956Add
BLAST

Proteomic databases

MaxQBiQ8WV83.
PaxDbiQ8WV83.
PRIDEiQ8WV83.

Expressioni

Tissue specificityi

Expressed in colorectal cancer cells.1 Publication

Gene expression databases

BgeeiQ8WV83.
CleanExiHS_SLC35F5.
ExpressionAtlasiQ8WV83. baseline and differential.
GenevisibleiQ8WV83. HS.

Organism-specific databases

HPAiHPA034828.
HPA049229.

Interactioni

Protein-protein interaction databases

BioGridi123201. 7 interactions.
IntActiQ8WV83. 1 interaction.
STRINGi9606.ENSP00000245680.

Structurei

3D structure databases

ProteinModelPortaliQ8WV83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini252 – 31665EamAAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi371 – 3744Poly-Leu

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated
Contains 1 EamA domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2765. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000005949.
HOGENOMiHOG000045636.
HOVERGENiHBG057096.
InParanoidiQ8WV83.
KOiK15289.
OMAiRMSYPAV.
OrthoDBiEOG7BCND9.
PhylomeDBiQ8WV83.
TreeFamiTF314261.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPPRRHRGA GRPGVLSSSP PFRLRSAKFS GIALEDLRRA LKTRLQMVCV
60 70 80 90 100
FVMNRMNSQN SGFTQRRRMA LGIVILLLVD VIWVASSELT SYVFTQYNKP
110 120 130 140 150
FFSTFAKTSM FVLYLLGFII WKPWRQQCTR GLRGKHAAFF ADAEGYFAAC
160 170 180 190 200
TTDTTMNSSL SEPLYVPVKF HDLPSEKPES TNIDTEKTPK KSRVRFSNIM
210 220 230 240 250
EIRQLPSSHA LEAKLSRMSY PVKEQESILK TVGKLTATQV AKISFFFCFV
260 270 280 290 300
WFLANLSYQE ALSDTQVAIV NILSSTSGLF TLILAAVFPS NSGDRFTLSK
310 320 330 340 350
LLAVILSIGG VVLVNLAGSE KPAGRDTVGS IWSLAGAMLY AVYIVMIKRK
360 370 380 390 400
VDREDKLDIP MFFGFVGLFN LLLLWPGFFL LHYTGFEDFE FPNKVVLMCI
410 420 430 440 450
IINGLIGTVL SEFLWLWGCF LTSSLIGTLA LSLTIPLSII ADMCMQKVQF
460 470 480 490 500
SWLFFAGAIP VFFSFFIVTL LCHYNNWDPV MVGIRRIFAF ICRKHRIQRV
510 520
PEDSEQCESL ISMHSVSQED GAS
Length:523
Mass (Da):58,887
Last modified:March 1, 2002 - v1
Checksum:i1B8CEDF0F1F33179
GO
Isoform 2 (identifier: Q8WV83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     7-13: HRGAGRP → MDSSGWR
     248-250: CFV → ALW
     251-523: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):27,826
Checksum:iC533AEB78A6C1CAA
GO

Sequence cautioni

The sequence BAB14954.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti320 – 3201E → G in BAB14954 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66Missing in isoform 2. 1 PublicationVSP_029665
Alternative sequencei7 – 137HRGAGRP → MDSSGWR in isoform 2. 1 PublicationVSP_029666
Alternative sequencei248 – 2503CFV → ALW in isoform 2. 1 PublicationVSP_029667
Alternative sequencei251 – 523273Missing in isoform 2. 1 PublicationVSP_029668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529364 mRNA. Translation: AAQ09598.1.
AY358620 mRNA. Translation: AAQ88983.1.
AK024666 mRNA. Translation: BAB14954.1. Different initiation.
AK025657 mRNA. Translation: BAB15206.1.
AC017074 Genomic DNA. Translation: AAY14808.1.
CH471103 Genomic DNA. Translation: EAW95176.1.
BC018537 mRNA. Translation: AAH18537.1.
CCDSiCCDS2119.1. [Q8WV83-1]
RefSeqiNP_079457.2. NM_025181.3. [Q8WV83-1]
UniGeneiHs.608286.
Hs.632527.

Genome annotation databases

EnsembliENST00000245680; ENSP00000245680; ENSG00000115084. [Q8WV83-1]
GeneIDi80255.
KEGGihsa:80255.
UCSCiuc002tku.2. human. [Q8WV83-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529364 mRNA. Translation: AAQ09598.1.
AY358620 mRNA. Translation: AAQ88983.1.
AK024666 mRNA. Translation: BAB14954.1. Different initiation.
AK025657 mRNA. Translation: BAB15206.1.
AC017074 Genomic DNA. Translation: AAY14808.1.
CH471103 Genomic DNA. Translation: EAW95176.1.
BC018537 mRNA. Translation: AAH18537.1.
CCDSiCCDS2119.1. [Q8WV83-1]
RefSeqiNP_079457.2. NM_025181.3. [Q8WV83-1]
UniGeneiHs.608286.
Hs.632527.

3D structure databases

ProteinModelPortaliQ8WV83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123201. 7 interactions.
IntActiQ8WV83. 1 interaction.
STRINGi9606.ENSP00000245680.

Protein family/group databases

TCDBi2.A.7.24.6. the drug/metabolite transporter (dmt) superfamily.

Polymorphism and mutation databases

DMDMi74730818.

Proteomic databases

MaxQBiQ8WV83.
PaxDbiQ8WV83.
PRIDEiQ8WV83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245680; ENSP00000245680; ENSG00000115084. [Q8WV83-1]
GeneIDi80255.
KEGGihsa:80255.
UCSCiuc002tku.2. human. [Q8WV83-1]

Organism-specific databases

CTDi80255.
GeneCardsiSLC35F5.
H-InvDBHIX0002398.
HGNCiHGNC:23617. SLC35F5.
HPAiHPA034828.
HPA049229.
neXtProtiNX_Q8WV83.
PharmGKBiPA134953009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2765. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000005949.
HOGENOMiHOG000045636.
HOVERGENiHBG057096.
InParanoidiQ8WV83.
KOiK15289.
OMAiRMSYPAV.
OrthoDBiEOG7BCND9.
PhylomeDBiQ8WV83.
TreeFamiTF314261.

Miscellaneous databases

ChiTaRSiSLC35F5. human.
GenomeRNAii80255.
NextBioi70705.
PROiQ8WV83.

Gene expression databases

BgeeiQ8WV83.
CleanExiHS_SLC35F5.
ExpressionAtlasiQ8WV83. baseline and differential.
GenevisibleiQ8WV83. HS.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of human gene 3 transactivated by hepatitis C virus NS5A protein."
    Liu Y., Cheng J., Wang G., Duan H., Zhang L., Chen J., Li L.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-523 (ISOFORM 1).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  7. "Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response."
    Matsuyama R., Togo S., Shimizu D., Momiyama N., Ishikawa T., Ichikawa Y., Endo I., Kunisaki C., Suzuki H., Hayasizaki Y., Shimada H.
    Int. J. Cancer 119:406-413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS35F5_HUMAN
AccessioniPrimary (citable) accession number: Q8WV83
Secondary accession number(s): Q9H6P8, Q9H7D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.