Q8WV74 (NUDT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate-linked moiety X motif 8, mitochondrial
Short name=Nudix motif 8
EC=3.6.1.-

Gene names

Name:

NUDT8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives By similarity.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WV74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WV74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-140: DEVF → SWGI
     141-236: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 236		Nucleoside diphosphate-linked moiety X motif 8, mitochondrial		PRO_0000019948
Regions
	Domain	25 – 172	148	Nudix hydrolase
	Motif	70 – 91	22	Nudix box
Sites
	Metal binding	85	1	Magnesium or manganese By similarity
	Metal binding	89	1	Magnesium or manganese By similarity
Natural variations
	Alternative sequence	137 – 140	4	DEVF → SWGI in isoform 2.		VSP_014282
	Alternative sequence	141 – 236	96	Missing in isoform 2.		VSP_014283

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 7DDD2A56010B4D9F	FASTA	236	25,370
	10 20 30 40 50 60 MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT LRSSRLTGRH 70 80 90 100 110 120 KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW GLLRPVYDPQ KATVVPVLAG 130 140 150 160 170 180 VGPLDPQSLR PNSEEVDEVF ALPLAHLLQT QNQGYTHFCR GGHFRYTLPV FLHGPHRVWG 190 200 210 220 230 LTAVITEFAL QLLAPGTYQP RLAGLTCSGA EGLARPKQPL ASPCQASSTP GLNKGL
	Isoform 2 [UniParc]. Checksum: CE854912E843E501	FASTA	140	15,052
	10 20 30 40 50 60 MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT LRSSRLTGRH 70 80 90 100 110 120 KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW GLLRPVYDPQ KATVVPVLAG 130 140 VGPLDPQSLR PNSEEVSWGI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Tongue.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123561 mRNA. Translation: BAC85646.1. BC018644 mRNA. Translation: AAH18644.1.
IPI	IPI00291313. IPI00607555.
RefSeq	NP_001230679.1. NM_001243750.1. NP_862826.1. NM_181843.2.
UniGene	Hs.433329.
3D structure databases
ProteinModelPortal	Q8WV74.
SMR	Q8WV74. Positions 30-191.
ModBase	Search...
Polymorphism databases
DMDM	68565920.
Proteomic databases
PRIDE	Q8WV74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376693; ENSP00000365883; ENSG00000167799.
GeneID	254552.
KEGG	hsa:254552.
UCSC	uc001omn.1. human. uc001omo.1. human.
Organism-specific databases
CTD	254552.
GeneCards	GC11M067395.
HGNC	HGNC:8055. NUDT8.
HPA	HPA041252. HPA041466.
neXtProt	NX_Q8WV74.
PharmGKB	PA31841.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10785.
GeneTree	ENSGT00530000063767.
HOGENOM	HBG729456.
HOVERGEN	HBG082068.
InParanoid	Q8WV74.
OMA	PAHETVT.
OrthoDB	EOG49S67C.
PhylomeDB	Q8WV74.
Gene expression databases
ArrayExpress	Q8WV74.
Bgee	Q8WV74.
CleanEx	HS_NUDT8.
Genevestigator	Q8WV74.
Family and domain databases
InterPro	IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KO	K01529.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	92368.

Entry information

Entry name

NUDT8_HUMAN

Accession

Primary (citable) accession number: Q8WV74
Secondary accession number(s): Q6ZW59

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.