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Protein

Nucleoside diphosphate-linked moiety X motif 8

Gene

NUDT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Magnesium or manganeseBy similarity
Metal bindingi89 – 891Magnesium or manganeseBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 8 (EC:3.6.1.-)
Short name:
Nudix motif 8
Gene namesi
Name:NUDT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8055. NUDT8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31841.

Polymorphism and mutation databases

BioMutaiNUDT8.
DMDMi68565920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Nucleoside diphosphate-linked moiety X motif 8PRO_0000019948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-succinyllysineBy similarity

Proteomic databases

EPDiQ8WV74.
MaxQBiQ8WV74.
PaxDbiQ8WV74.
PRIDEiQ8WV74.

PTM databases

iPTMnetiQ8WV74.

Expressioni

Gene expression databases

BgeeiQ8WV74.
CleanExiHS_NUDT8.

Organism-specific databases

HPAiHPA041252.
HPA041466.

Interactioni

Protein-protein interaction databases

BioGridi129040. 6 interactions.
STRINGi9606.ENSP00000301490.

Structurei

3D structure databases

ProteinModelPortaliQ8WV74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 172148Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 9122Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3069. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00530000063767.
HOGENOMiHOG000250455.
HOVERGENiHBG082068.
InParanoidiQ8WV74.
KOiK18665.
OMAiNEYRIWG.
OrthoDBiEOG77HDFZ.
PhylomeDBiQ8WV74.
TreeFamiTF106350.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT
60 70 80 90 100
LRSSRLTGRH KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW
110 120 130 140 150
GLLRPVYDPQ KATVVPVLAG VGPLDPQSLR PNSEEVDEVF ALPLAHLLQT
160 170 180 190 200
QNQGYTHFCR GGHFRYTLPV FLHGPHRVWG LTAVITEFAL QLLAPGTYQP
210 220 230
RLAGLTCSGA EGLARPKQPL ASPCQASSTP GLNKGL
Length:236
Mass (Da):25,370
Last modified:July 5, 2005 - v2
Checksum:i7DDD2A56010B4D9F
GO
Isoform 2 (identifier: Q8WV74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-140: DEVF → SWGI
     141-236: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,052
Checksum:iCE854912E843E501
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei137 – 1404DEVF → SWGI in isoform 2. 1 PublicationVSP_014282
Alternative sequencei141 – 23696Missing in isoform 2. 1 PublicationVSP_014283Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123561 mRNA. Translation: BAC85646.1.
BC018644 mRNA. Translation: AAH18644.1.
CCDSiCCDS58151.1. [Q8WV74-1]
CCDS8174.1. [Q8WV74-2]
RefSeqiNP_001230679.1. NM_001243750.1. [Q8WV74-1]
NP_862826.1. NM_181843.2. [Q8WV74-2]
UniGeneiHs.433329.

Genome annotation databases

EnsembliENST00000301490; ENSP00000301490; ENSG00000167799. [Q8WV74-2]
ENST00000376693; ENSP00000365883; ENSG00000167799. [Q8WV74-1]
GeneIDi254552.
KEGGihsa:254552.
UCSCiuc001omn.4. human. [Q8WV74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123561 mRNA. Translation: BAC85646.1.
BC018644 mRNA. Translation: AAH18644.1.
CCDSiCCDS58151.1. [Q8WV74-1]
CCDS8174.1. [Q8WV74-2]
RefSeqiNP_001230679.1. NM_001243750.1. [Q8WV74-1]
NP_862826.1. NM_181843.2. [Q8WV74-2]
UniGeneiHs.433329.

3D structure databases

ProteinModelPortaliQ8WV74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129040. 6 interactions.
STRINGi9606.ENSP00000301490.

PTM databases

iPTMnetiQ8WV74.

Polymorphism and mutation databases

BioMutaiNUDT8.
DMDMi68565920.

Proteomic databases

EPDiQ8WV74.
MaxQBiQ8WV74.
PaxDbiQ8WV74.
PRIDEiQ8WV74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301490; ENSP00000301490; ENSG00000167799. [Q8WV74-2]
ENST00000376693; ENSP00000365883; ENSG00000167799. [Q8WV74-1]
GeneIDi254552.
KEGGihsa:254552.
UCSCiuc001omn.4. human. [Q8WV74-1]

Organism-specific databases

CTDi254552.
GeneCardsiNUDT8.
HGNCiHGNC:8055. NUDT8.
HPAiHPA041252.
HPA041466.
neXtProtiNX_Q8WV74.
PharmGKBiPA31841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3069. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00530000063767.
HOGENOMiHOG000250455.
HOVERGENiHBG082068.
InParanoidiQ8WV74.
KOiK18665.
OMAiNEYRIWG.
OrthoDBiEOG77HDFZ.
PhylomeDBiQ8WV74.
TreeFamiTF106350.

Miscellaneous databases

ChiTaRSiNUDT8. human.
GenomeRNAii254552.
PROiQ8WV74.

Gene expression databases

BgeeiQ8WV74.
CleanExiHS_NUDT8.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUDT8_HUMAN
AccessioniPrimary (citable) accession number: Q8WV74
Secondary accession number(s): Q6ZW59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.