Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pentatricopeptide repeat-containing protein 2, mitochondrial

Gene

PTCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049883-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat-containing protein 2, mitochondrial
Gene namesi
Name:PTCD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25734. PTCD2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000049883.
PharmGKBiPA134909110.

Polymorphism and mutation databases

DMDMi215274210.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440501 – 388Pentatricopeptide repeat-containing protein 2, mitochondrialAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WV60.
MaxQBiQ8WV60.
PaxDbiQ8WV60.
PeptideAtlasiQ8WV60.
PRIDEiQ8WV60.

PTM databases

iPTMnetiQ8WV60.
PhosphoSitePlusiQ8WV60.

Expressioni

Gene expression databases

BgeeiENSG00000049883.
CleanExiHS_PTCD2.
ExpressionAtlasiQ8WV60. baseline and differential.
GenevisibleiQ8WV60. HS.

Organism-specific databases

HPAiHPA043686.

Interactioni

Protein-protein interaction databases

BioGridi122905. 16 interactors.
IntActiQ8WV60. 3 interactors.
STRINGi9606.ENSP00000308948.

Structurei

3D structure databases

ProteinModelPortaliQ8WV60.
SMRiQ8WV60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati166 – 200PPRAdd BLAST35

Sequence similaritiesi

Belongs to the PTCD2 family.Curated
Contains 1 PPR (pentatricopeptide) repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIEH. Eukaryota.
ENOG4111GFQ. LUCA.
GeneTreeiENSGT00390000009329.
HOGENOMiHOG000115757.
HOVERGENiHBG106362.
InParanoidiQ8WV60.
KOiK17711.
OMAiGTKETYF.
OrthoDBiEOG091G0AUZ.
PhylomeDBiQ8WV60.
TreeFamiTF324851.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
IPR019266. Ribosomal_S27_mit.
[Graphical view]
PfamiPF10037. MRP-S27. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD
60 70 80 90 100
NVVKLKEFQQ KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH
110 120 130 140 150
LCESRDHVEL AKNVIYRYHA ENKNFTLGEY KFGPLFVRLC YELDLEESAV
160 170 180 190 200
ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK YKSALQVLIE MKNQDVKFTK
210 220 230 240 250
DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA SCFAVALALN
260 270 280 290 300
QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN
310 320 330 340 350
LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL
360 370 380
DAVLCHTPRD RKSHTLLLNK RMVSRRTFQP LSQSLLAE
Length:388
Mass (Da):43,968
Last modified:November 25, 2008 - v3
Checksum:i344BD840EBB80597
GO
Isoform 2 (identifier: Q8WV60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MVRDSMAAAFR → MWNWLKMSFTG
     12-183: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,460
Checksum:i957D458B4E677A61
GO
Isoform 3 (identifier: Q8WV60-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-183: KETYFRNLKK...MLFIKGKYKS → KG

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):30,970
Checksum:i53EF65B7D727F013
GO

Sequence cautioni

The sequence AAH18720 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW95706 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → P in BAH12866 (PubMed:14702039).Curated1
Sequence conflicti194Q → L in BAB14162 (PubMed:14702039).Curated1
Sequence conflicti388E → D in CAG33571 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552571 – 11MVRDSMAAAFR → MWNWLKMSFTG in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05525812 – 183Missing in isoform 2. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_05568073 – 183KETYF…GKYKS → KG in isoform 3. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022660 mRNA. Translation: BAB14162.1. Different initiation.
AK298750 mRNA. Translation: BAH12866.1.
AK303639 mRNA. Translation: BAH14003.1.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95706.1. Sequence problems.
BC018720 mRNA. Translation: AAH18720.1. Different initiation.
CR457290 mRNA. Translation: CAG33571.1.
CCDSiCCDS4014.2. [Q8WV60-1]
CCDS68891.1. [Q8WV60-3]
CCDS68892.1. [Q8WV60-2]
RefSeqiNP_001271332.1. NM_001284403.1. [Q8WV60-3]
NP_001271333.1. NM_001284404.1. [Q8WV60-2]
NP_079030.3. NM_024754.4. [Q8WV60-1]
XP_005248660.1. XM_005248603.2.
UniGeneiHs.126906.

Genome annotation databases

EnsembliENST00000308077; ENSP00000308948; ENSG00000049883. [Q8WV60-1]
ENST00000380639; ENSP00000370013; ENSG00000049883. [Q8WV60-1]
ENST00000503868; ENSP00000427349; ENSG00000049883. [Q8WV60-3]
ENST00000536805; ENSP00000444772; ENSG00000049883. [Q8WV60-2]
GeneIDi79810.
KEGGihsa:79810.
UCSCiuc003kcb.5. human. [Q8WV60-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022660 mRNA. Translation: BAB14162.1. Different initiation.
AK298750 mRNA. Translation: BAH12866.1.
AK303639 mRNA. Translation: BAH14003.1.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95706.1. Sequence problems.
BC018720 mRNA. Translation: AAH18720.1. Different initiation.
CR457290 mRNA. Translation: CAG33571.1.
CCDSiCCDS4014.2. [Q8WV60-1]
CCDS68891.1. [Q8WV60-3]
CCDS68892.1. [Q8WV60-2]
RefSeqiNP_001271332.1. NM_001284403.1. [Q8WV60-3]
NP_001271333.1. NM_001284404.1. [Q8WV60-2]
NP_079030.3. NM_024754.4. [Q8WV60-1]
XP_005248660.1. XM_005248603.2.
UniGeneiHs.126906.

3D structure databases

ProteinModelPortaliQ8WV60.
SMRiQ8WV60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122905. 16 interactors.
IntActiQ8WV60. 3 interactors.
STRINGi9606.ENSP00000308948.

PTM databases

iPTMnetiQ8WV60.
PhosphoSitePlusiQ8WV60.

Polymorphism and mutation databases

DMDMi215274210.

Proteomic databases

EPDiQ8WV60.
MaxQBiQ8WV60.
PaxDbiQ8WV60.
PeptideAtlasiQ8WV60.
PRIDEiQ8WV60.

Protocols and materials databases

DNASUi79810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308077; ENSP00000308948; ENSG00000049883. [Q8WV60-1]
ENST00000380639; ENSP00000370013; ENSG00000049883. [Q8WV60-1]
ENST00000503868; ENSP00000427349; ENSG00000049883. [Q8WV60-3]
ENST00000536805; ENSP00000444772; ENSG00000049883. [Q8WV60-2]
GeneIDi79810.
KEGGihsa:79810.
UCSCiuc003kcb.5. human. [Q8WV60-1]

Organism-specific databases

CTDi79810.
GeneCardsiPTCD2.
HGNCiHGNC:25734. PTCD2.
HPAiHPA043686.
MIMi615484. gene.
neXtProtiNX_Q8WV60.
OpenTargetsiENSG00000049883.
PharmGKBiPA134909110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEH. Eukaryota.
ENOG4111GFQ. LUCA.
GeneTreeiENSGT00390000009329.
HOGENOMiHOG000115757.
HOVERGENiHBG106362.
InParanoidiQ8WV60.
KOiK17711.
OMAiGTKETYF.
OrthoDBiEOG091G0AUZ.
PhylomeDBiQ8WV60.
TreeFamiTF324851.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049883-MONOMER.

Miscellaneous databases

GenomeRNAii79810.
PROiQ8WV60.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049883.
CleanExiHS_PTCD2.
ExpressionAtlasiQ8WV60. baseline and differential.
GenevisibleiQ8WV60. HS.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
IPR019266. Ribosomal_S27_mit.
[Graphical view]
PfamiPF10037. MRP-S27. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTCD2_HUMAN
AccessioniPrimary (citable) accession number: Q8WV60
Secondary accession number(s): B7Z5D0
, B7Z8L7, E9PFV7, Q6IA65, Q9H9R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.