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Protein

Coiled-coil domain-containing protein 107

Gene

CCDC107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 107
Gene namesi
Name:CCDC107
ORF Names:PSEC0222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000159884.11
HGNCiHGNC:28465 CCDC107
neXtProtiNX_Q8WV48

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159884
PharmGKBiPA145008668

Polymorphism and mutation databases

BioMutaiCCDC107
DMDMi143955294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000028240725 – 283Coiled-coil domain-containing protein 107Add BLAST259

Proteomic databases

PaxDbiQ8WV48
PeptideAtlasiQ8WV48
PRIDEiQ8WV48

PTM databases

iPTMnetiQ8WV48
PhosphoSitePlusiQ8WV48

Expressioni

Gene expression databases

BgeeiENSG00000159884
CleanExiHS_CCDC107
ExpressionAtlasiQ8WV48 baseline and differential
GenevisibleiQ8WV48 HS

Organism-specific databases

HPAiHPA016857
HPA050442

Interactioni

Protein-protein interaction databases

BioGridi12846224 interactors.
IntActiQ8WV48 3 interactors.
MINTiQ8WV48

Structurei

3D structure databases

ProteinModelPortaliQ8WV48
SMRiQ8WV48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 134Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW9E Eukaryota
ENOG41118NC LUCA
GeneTreeiENSGT00390000018608
HOGENOMiHOG000111377
HOVERGENiHBG099537
InParanoidiQ8WV48
OMAiWEVEQGL
OrthoDBiEOG091G0NZ8
PhylomeDBiQ8WV48
TreeFamiTF333319

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAVSLLGV VGLLLVSALS GVLGDRANPD LRAHPGNAAH PGSGATEPRR
60 70 80 90 100
RPPLKDQRER TRAGSLPLGA LYTAAVAAFV LYKCLQGKDE TAVLHEEASK
110 120 130 140 150
QQPLQSEQQL AQLTQQLAQT EQHLNNLMAQ LDPLFERVTT LAGAQQELLN
160 170 180 190 200
MKLWTIHELL QDSKPDKDME ASEPGEGSGG ESAGGGDKVS ETGTFLISPH
210 220 230 240 250
TEASRPLPED FCLKEDEEEI GDSQAWEEPT NWSTETWNLA TSWEVGRGLR
260 270 280
RRCSQAVAKG PSHSLGWEGG TTAEGRLKQS LFS
Length:283
Mass (Da):30,509
Last modified:April 3, 2007 - v2
Checksum:iA2EBDBBFA49F978D
GO
Isoform 2 (identifier: Q8WV48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-155: VTTLAGAQQELLNMKLWT → PAGASEHEAMDHPRAAAR
     156-283: Missing.

Show »
Length:155
Mass (Da):16,522
Checksum:i7494C271760EAC28
GO
Isoform 3 (identifier: Q8WV48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-139: VT → SF
     140-283: Missing.

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):14,900
Checksum:i44538CF48B218405
GO
Isoform 4 (identifier: Q8WV48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-119: EQQLAQLTQQLAQ → GGFSRSLCWVGGV
     120-283: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:119
Mass (Da):12,340
Checksum:i43D644A35800565A
GO
Isoform 5 (identifier: Q8WV48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-201: Missing.

Show »
Length:256
Mass (Da):27,992
Checksum:i18029DD52F28AB8A
GO

Sequence cautioni

The sequence CAI13448 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031406190S → F. Corresponds to variant dbSNP:rs2275420Ensembl.1
Natural variantiVAR_031407220I → V3 PublicationsCorresponds to variant dbSNP:rs1339374Ensembl.1
Natural variantiVAR_031408242S → C. Corresponds to variant dbSNP:rs10441685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024128107 – 119EQQLA…QQLAQ → GGFSRSLCWVGGV in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_024129120 – 283Missing in isoform 4. CuratedAdd BLAST164
Alternative sequenceiVSP_024130138 – 155VTTLA…MKLWT → PAGASEHEAMDHPRAAAR in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_024131138 – 139VT → SF in isoform 3. 1 Publication2
Alternative sequenceiVSP_024132140 – 283Missing in isoform 3. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_024133156 – 283Missing in isoform 2. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_042165175 – 201Missing in isoform 5. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ884403 mRNA Translation: ABI63370.1
AK075523 mRNA Translation: BAC11669.1
AL357874 Genomic DNA Translation: CAI13447.1
AL357874 Genomic DNA Translation: CAI13448.1 Sequence problems.
AL357874 Genomic DNA Translation: CAI13449.1
AL357874 Genomic DNA Translation: CAI13450.1
AL357874 Genomic DNA Translation: CAI13451.1
CH471071 Genomic DNA Translation: EAW58369.1
BC018758 mRNA Translation: AAH18758.1
BC051285 mRNA Translation: AAH51285.1
CCDSiCCDS56573.1 [Q8WV48-5]
CCDS56574.1 [Q8WV48-2]
CCDS56575.1 [Q8WV48-3]
CCDS6583.1 [Q8WV48-1]
RefSeqiNP_001182129.1, NM_001195200.1 [Q8WV48-5]
NP_001182130.1, NM_001195201.1 [Q8WV48-2]
NP_001182146.1, NM_001195217.1 [Q8WV48-3]
NP_777583.2, NM_174923.2 [Q8WV48-1]
UniGeneiHs.745107

Genome annotation databases

EnsembliENST00000327351; ENSP00000330327; ENSG00000159884 [Q8WV48-2]
ENST00000378407; ENSP00000367662; ENSG00000159884 [Q8WV48-3]
ENST00000378409; ENSP00000367665; ENSG00000159884 [Q8WV48-5]
ENST00000421582; ENSP00000413003; ENSG00000159884 [Q8WV48-4]
ENST00000426546; ENSP00000414964; ENSG00000159884 [Q8WV48-1]
GeneIDi203260
KEGGihsa:203260
UCSCiuc003zxj.4 human [Q8WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC107_HUMAN
AccessioniPrimary (citable) accession number: Q8WV48
Secondary accession number(s): A6XND6
, Q5T4R5, Q5T4R8, Q5T4R9, Q86VB6, Q8N2E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome