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Protein

Coiled-coil domain-containing protein 107

Gene

CCDC107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 107
Gene namesi
Name:CCDC107
ORF Names:PSEC0222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28465. CCDC107.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008668.

Polymorphism and mutation databases

BioMutaiCCDC107.
DMDMi143955294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 283259Coiled-coil domain-containing protein 107PRO_0000282407Add
BLAST

Proteomic databases

PaxDbiQ8WV48.
PRIDEiQ8WV48.

PTM databases

iPTMnetiQ8WV48.

Expressioni

Gene expression databases

BgeeiQ8WV48.
CleanExiHS_CCDC107.
ExpressionAtlasiQ8WV48. baseline and differential.
GenevisibleiQ8WV48. HS.

Organism-specific databases

HPAiHPA016857.
HPA050442.

Interactioni

Protein-protein interaction databases

BioGridi128462. 19 interactions.
IntActiQ8WV48. 3 interactions.
MINTiMINT-2879137.
STRINGi9606.ENSP00000414964.

Structurei

3D structure databases

ProteinModelPortaliQ8WV48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 13431Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW9E. Eukaryota.
ENOG41118NC. LUCA.
GeneTreeiENSGT00390000018608.
HOGENOMiHOG000111377.
HOVERGENiHBG099537.
InParanoidiQ8WV48.
OMAiWEVEQGL.
OrthoDBiEOG7P2XTQ.
PhylomeDBiQ8WV48.
TreeFamiTF333319.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAVSLLGV VGLLLVSALS GVLGDRANPD LRAHPGNAAH PGSGATEPRR
60 70 80 90 100
RPPLKDQRER TRAGSLPLGA LYTAAVAAFV LYKCLQGKDE TAVLHEEASK
110 120 130 140 150
QQPLQSEQQL AQLTQQLAQT EQHLNNLMAQ LDPLFERVTT LAGAQQELLN
160 170 180 190 200
MKLWTIHELL QDSKPDKDME ASEPGEGSGG ESAGGGDKVS ETGTFLISPH
210 220 230 240 250
TEASRPLPED FCLKEDEEEI GDSQAWEEPT NWSTETWNLA TSWEVGRGLR
260 270 280
RRCSQAVAKG PSHSLGWEGG TTAEGRLKQS LFS
Length:283
Mass (Da):30,509
Last modified:April 3, 2007 - v2
Checksum:iA2EBDBBFA49F978D
GO
Isoform 2 (identifier: Q8WV48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-155: VTTLAGAQQELLNMKLWT → PAGASEHEAMDHPRAAAR
     156-283: Missing.

Show »
Length:155
Mass (Da):16,522
Checksum:i7494C271760EAC28
GO
Isoform 3 (identifier: Q8WV48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-139: VT → SF
     140-283: Missing.

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):14,900
Checksum:i44538CF48B218405
GO
Isoform 4 (identifier: Q8WV48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-119: EQQLAQLTQQLAQ → GGFSRSLCWVGGV
     120-283: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:119
Mass (Da):12,340
Checksum:i43D644A35800565A
GO
Isoform 5 (identifier: Q8WV48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-201: Missing.

Show »
Length:256
Mass (Da):27,992
Checksum:i18029DD52F28AB8A
GO

Sequence cautioni

The sequence CAI13448.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901S → F.
Corresponds to variant rs2275420 [ dbSNP | Ensembl ].
VAR_031406
Natural varianti220 – 2201I → V.3 Publications
Corresponds to variant rs1339374 [ dbSNP | Ensembl ].
VAR_031407
Natural varianti242 – 2421S → C.
Corresponds to variant rs10441685 [ dbSNP | Ensembl ].
VAR_031408

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 11913EQQLA…QQLAQ → GGFSRSLCWVGGV in isoform 4. CuratedVSP_024128Add
BLAST
Alternative sequencei120 – 283164Missing in isoform 4. CuratedVSP_024129Add
BLAST
Alternative sequencei138 – 15518VTTLA…MKLWT → PAGASEHEAMDHPRAAAR in isoform 2. 1 PublicationVSP_024130Add
BLAST
Alternative sequencei138 – 1392VT → SF in isoform 3. 1 PublicationVSP_024131
Alternative sequencei140 – 283144Missing in isoform 3. 1 PublicationVSP_024132Add
BLAST
Alternative sequencei156 – 283128Missing in isoform 2. 1 PublicationVSP_024133Add
BLAST
Alternative sequencei175 – 20127Missing in isoform 5. 1 PublicationVSP_042165Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ884403 mRNA. Translation: ABI63370.1.
AK075523 mRNA. Translation: BAC11669.1.
AL357874 Genomic DNA. Translation: CAI13447.1.
AL357874 Genomic DNA. Translation: CAI13448.1. Sequence problems.
AL357874 Genomic DNA. Translation: CAI13449.1.
AL357874 Genomic DNA. Translation: CAI13450.1.
AL357874 Genomic DNA. Translation: CAI13451.1.
CH471071 Genomic DNA. Translation: EAW58369.1.
BC018758 mRNA. Translation: AAH18758.1.
BC051285 mRNA. Translation: AAH51285.1.
CCDSiCCDS56573.1. [Q8WV48-5]
CCDS56574.1. [Q8WV48-2]
CCDS56575.1. [Q8WV48-3]
CCDS6583.1. [Q8WV48-1]
RefSeqiNP_001182129.1. NM_001195200.1. [Q8WV48-5]
NP_001182130.1. NM_001195201.1. [Q8WV48-2]
NP_001182146.1. NM_001195217.1. [Q8WV48-3]
NP_777583.2. NM_174923.2. [Q8WV48-1]
UniGeneiHs.745107.

Genome annotation databases

EnsembliENST00000327351; ENSP00000330327; ENSG00000159884. [Q8WV48-2]
ENST00000378407; ENSP00000367662; ENSG00000159884. [Q8WV48-3]
ENST00000378409; ENSP00000367665; ENSG00000159884. [Q8WV48-5]
ENST00000421582; ENSP00000413003; ENSG00000159884. [Q8WV48-4]
ENST00000426546; ENSP00000414964; ENSG00000159884. [Q8WV48-1]
GeneIDi203260.
KEGGihsa:203260.
UCSCiuc003zxj.4. human. [Q8WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ884403 mRNA. Translation: ABI63370.1.
AK075523 mRNA. Translation: BAC11669.1.
AL357874 Genomic DNA. Translation: CAI13447.1.
AL357874 Genomic DNA. Translation: CAI13448.1. Sequence problems.
AL357874 Genomic DNA. Translation: CAI13449.1.
AL357874 Genomic DNA. Translation: CAI13450.1.
AL357874 Genomic DNA. Translation: CAI13451.1.
CH471071 Genomic DNA. Translation: EAW58369.1.
BC018758 mRNA. Translation: AAH18758.1.
BC051285 mRNA. Translation: AAH51285.1.
CCDSiCCDS56573.1. [Q8WV48-5]
CCDS56574.1. [Q8WV48-2]
CCDS56575.1. [Q8WV48-3]
CCDS6583.1. [Q8WV48-1]
RefSeqiNP_001182129.1. NM_001195200.1. [Q8WV48-5]
NP_001182130.1. NM_001195201.1. [Q8WV48-2]
NP_001182146.1. NM_001195217.1. [Q8WV48-3]
NP_777583.2. NM_174923.2. [Q8WV48-1]
UniGeneiHs.745107.

3D structure databases

ProteinModelPortaliQ8WV48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128462. 19 interactions.
IntActiQ8WV48. 3 interactions.
MINTiMINT-2879137.
STRINGi9606.ENSP00000414964.

PTM databases

iPTMnetiQ8WV48.

Polymorphism and mutation databases

BioMutaiCCDC107.
DMDMi143955294.

Proteomic databases

PaxDbiQ8WV48.
PRIDEiQ8WV48.

Protocols and materials databases

DNASUi203260.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327351; ENSP00000330327; ENSG00000159884. [Q8WV48-2]
ENST00000378407; ENSP00000367662; ENSG00000159884. [Q8WV48-3]
ENST00000378409; ENSP00000367665; ENSG00000159884. [Q8WV48-5]
ENST00000421582; ENSP00000413003; ENSG00000159884. [Q8WV48-4]
ENST00000426546; ENSP00000414964; ENSG00000159884. [Q8WV48-1]
GeneIDi203260.
KEGGihsa:203260.
UCSCiuc003zxj.4. human. [Q8WV48-1]

Organism-specific databases

CTDi203260.
GeneCardsiCCDC107.
HGNCiHGNC:28465. CCDC107.
HPAiHPA016857.
HPA050442.
neXtProtiNX_Q8WV48.
PharmGKBiPA145008668.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW9E. Eukaryota.
ENOG41118NC. LUCA.
GeneTreeiENSGT00390000018608.
HOGENOMiHOG000111377.
HOVERGENiHBG099537.
InParanoidiQ8WV48.
OMAiWEVEQGL.
OrthoDBiEOG7P2XTQ.
PhylomeDBiQ8WV48.
TreeFamiTF333319.

Miscellaneous databases

GenomeRNAii203260.
PROiQ8WV48.

Gene expression databases

BgeeiQ8WV48.
CleanExiHS_CCDC107.
ExpressionAtlasiQ8WV48. baseline and differential.
GenevisibleiQ8WV48. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A computer system platform used to predict novel genes."
    Yu Z., Zheng Z., Tang T., Fu Y.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANT VAL-220.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryo.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-220.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-220.
    Tissue: Mammary gland and Pancreas.

Entry informationi

Entry nameiCC107_HUMAN
AccessioniPrimary (citable) accession number: Q8WV48
Secondary accession number(s): A6XND6
, Q5T4R5, Q5T4R8, Q5T4R9, Q86VB6, Q8N2E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.