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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ligase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:6.3.2.-)
Alternative name(s):
RING finger-interacting protein with C kinase
Short name:
RINCK
Tripartite motif-containing protein 41
Gene namesi
Name:TRIM41
Synonyms:RINCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19013. TRIM41.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20C → A: Abolishes E3 ligase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000146063.
PharmGKBiPA134918519.

Polymorphism and mutation databases

BioMutaiTRIM41.
DMDMi116242826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562621 – 630E3 ubiquitin-protein ligase TRIM41Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphothreonineCombined sources1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei447PhosphoserineCombined sources1

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WV44.
MaxQBiQ8WV44.
PaxDbiQ8WV44.
PeptideAtlasiQ8WV44.
PRIDEiQ8WV44.

PTM databases

iPTMnetiQ8WV44.
PhosphoSitePlusiQ8WV44.

Expressioni

Tissue specificityi

Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000146063.
CleanExiHS_TRIM41.
ExpressionAtlasiQ8WV44. baseline and differential.
GenevisibleiQ8WV44. HS.

Organism-specific databases

HPAiHPA021194.
HPA024204.

Interactioni

Subunit structurei

Interacts with PRKCA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi124780. 97 interactors.
IntActiQ8WV44. 113 interactors.
MINTiMINT-1377793.
STRINGi9606.ENSP00000320869.

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni228 – 230Combined sources3
Beta strandi236 – 238Combined sources3
Turni239 – 242Combined sources4
Beta strandi243 – 245Combined sources3
Helixi247 – 251Combined sources5
Helixi253 – 256Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44.
SMRiQ8WV44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WV44.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 630B30.2/SPRYPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili264 – 373Sequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 163Glu-richAdd BLAST113

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00860000133752.
HOVERGENiHBG001357.
InParanoidiQ8WV44.
KOiK12017.
OMAiWTSGMGG.
OrthoDBiEOG091G04RX.
PhylomeDBiQ8WV44.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to basket
Also known as: TRIM41a, TRIM41alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE
110 120 130 140 150
EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE
160 170 180 190 200
EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR
460 470 480 490 500
RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW
560 570 580 590 600
CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,670
Last modified:October 17, 2006 - v3
Checksum:i8E704CBEAB928BF5
GO
Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to basket
Also known as: TRIM41b, TRIM41beta, RINCK1

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.

Show »
Length:518
Mass (Da):59,302
Checksum:i88078577B9A3C98E
GO
Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:210
Mass (Da):23,608
Checksum:i6354BEB70AFB1C7C
GO
Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to basket
Also known as: RINCK2

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Show »
Length:381
Mass (Da):43,491
Checksum:i2716AF100B4CA18B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276G → E in BAD07472 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAD07473 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAB70617 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02791478A → T. Corresponds to variant dbSNP:rs6601178Ensembl.1
Natural variantiVAR_027915438D → G. Corresponds to variant dbSNP:rs2241371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0125151 – 420Missing in isoform 3. 2 PublicationsAdd BLAST420
Alternative sequenceiVSP_012516381D → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_012517382 – 630Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_010395490 – 518VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_010396519 – 630Missing in isoform 2. 3 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA. Translation: BAD07472.1.
AB100367 mRNA. Translation: BAD07473.1.
AF258579 mRNA. Translation: AAG23782.1.
CR457349 mRNA. Translation: CAG33630.1.
AK027601 mRNA. Translation: BAG51358.1.
CH471165 Genomic DNA. Translation: EAW53712.1.
CH471165 Genomic DNA. Translation: EAW53708.1.
CH471165 Genomic DNA. Translation: EAW53709.1.
BC004956 mRNA. Translation: AAH04956.1.
BC009762 mRNA. Translation: AAH09762.2.
BC018765 mRNA. Translation: AAH18765.2.
BC071887 mRNA. Translation: AAH71887.1.
BC090953 mRNA. Translation: AAH90953.1.
AB063180 mRNA. Translation: BAB70617.1.
CCDSiCCDS4465.1. [Q8WV44-2]
CCDS4466.1. [Q8WV44-1]
RefSeqiNP_291027.3. NM_033549.4. [Q8WV44-1]
NP_963921.1. NM_201627.2. [Q8WV44-2]
UniGeneiHs.441488.
Hs.700303.

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
GeneIDi90933.
KEGGihsa:90933.
UCSCiuc003mnd.3. human. [Q8WV44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA. Translation: BAD07472.1.
AB100367 mRNA. Translation: BAD07473.1.
AF258579 mRNA. Translation: AAG23782.1.
CR457349 mRNA. Translation: CAG33630.1.
AK027601 mRNA. Translation: BAG51358.1.
CH471165 Genomic DNA. Translation: EAW53712.1.
CH471165 Genomic DNA. Translation: EAW53708.1.
CH471165 Genomic DNA. Translation: EAW53709.1.
BC004956 mRNA. Translation: AAH04956.1.
BC009762 mRNA. Translation: AAH09762.2.
BC018765 mRNA. Translation: AAH18765.2.
BC071887 mRNA. Translation: AAH71887.1.
BC090953 mRNA. Translation: AAH90953.1.
AB063180 mRNA. Translation: BAB70617.1.
CCDSiCCDS4465.1. [Q8WV44-2]
CCDS4466.1. [Q8WV44-1]
RefSeqiNP_291027.3. NM_033549.4. [Q8WV44-1]
NP_963921.1. NM_201627.2. [Q8WV44-2]
UniGeneiHs.441488.
Hs.700303.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44.
SMRiQ8WV44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124780. 97 interactors.
IntActiQ8WV44. 113 interactors.
MINTiMINT-1377793.
STRINGi9606.ENSP00000320869.

PTM databases

iPTMnetiQ8WV44.
PhosphoSitePlusiQ8WV44.

Polymorphism and mutation databases

BioMutaiTRIM41.
DMDMi116242826.

Proteomic databases

EPDiQ8WV44.
MaxQBiQ8WV44.
PaxDbiQ8WV44.
PeptideAtlasiQ8WV44.
PRIDEiQ8WV44.

Protocols and materials databases

DNASUi90933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
GeneIDi90933.
KEGGihsa:90933.
UCSCiuc003mnd.3. human. [Q8WV44-1]

Organism-specific databases

CTDi90933.
GeneCardsiTRIM41.
H-InvDBHIX0121034.
HGNCiHGNC:19013. TRIM41.
HPAiHPA021194.
HPA024204.
MIMi610530. gene.
neXtProtiNX_Q8WV44.
OpenTargetsiENSG00000146063.
PharmGKBiPA134918519.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00860000133752.
HOVERGENiHBG001357.
InParanoidiQ8WV44.
KOiK12017.
OMAiWTSGMGG.
OrthoDBiEOG091G04RX.
PhylomeDBiQ8WV44.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiTRIM41. human.
EvolutionaryTraceiQ8WV44.
GeneWikiiTRIM41.
GenomeRNAii90933.
PROiQ8WV44.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146063.
CleanExiHS_TRIM41.
ExpressionAtlasiQ8WV44. baseline and differential.
GenevisibleiQ8WV44. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI41_HUMAN
AccessioniPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6
, D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: January 18, 2017
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.