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Q8WV44

- TRI41_HUMAN

UniProt

Q8WV44 - TRI41_HUMAN

Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 6142RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM41 (EC:6.3.2.-)
    Alternative name(s):
    RING finger-interacting protein with C kinase
    Short name:
    RINCK
    Tripartite motif-containing protein 41
    Gene namesi
    Name:TRIM41
    Synonyms:RINCK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:19013. TRIM41.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi20 – 201C → A: Abolishes E3 ligase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134918519.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630E3 ubiquitin-protein ligase TRIM41PRO_0000056262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei447 – 4471Phosphoserine1 Publication

    Post-translational modificationi

    Auto-ubiquitinated.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8WV44.
    PaxDbiQ8WV44.
    PRIDEiQ8WV44.

    PTM databases

    PhosphoSiteiQ8WV44.

    Expressioni

    Tissue specificityi

    Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ8WV44.
    BgeeiQ8WV44.
    CleanExiHS_TRIM41.
    GenevestigatoriQ8WV44.

    Organism-specific databases

    HPAiHPA021194.
    HPA024204.

    Interactioni

    Subunit structurei

    Interacts with PRKCA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PrkcbP68403-23EBI-726015,EBI-397092From a different organism.

    Protein-protein interaction databases

    BioGridi124780. 27 interactions.
    IntActiQ8WV44. 26 interactions.
    MINTiMINT-1377793.
    STRINGi9606.ENSP00000320869.

    Structurei

    Secondary structure

    1
    630
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni228 – 2303
    Beta strandi236 – 2383
    Turni239 – 2424
    Beta strandi243 – 2453
    Helixi247 – 2515
    Helixi253 – 2564

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EGMNMR-A214-263[»]
    ProteinModelPortaliQ8WV44.
    SMRiQ8WV44. Positions 11-47, 220-263, 431-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WV44.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini413 – 630218B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili264 – 373110Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi51 – 163113Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 6142RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG325772.
    HOVERGENiHBG001357.
    InParanoidiQ8WV44.
    KOiK12017.
    OMAiWTSGMGG.
    OrthoDBiEOG71G9TJ.
    PhylomeDBiQ8WV44.
    TreeFamiTF342569.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to Basket

    Also known as: TRIM41a, TRIM41alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG    50
    EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE 100
    EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE 150
    EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ 200
    LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR 250
    ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT 300
    ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA 350
    SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW 400
    SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR 450
    RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV 500
    GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW 550
    CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH 600
    VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP 630
    Length:630
    Mass (Da):71,670
    Last modified:October 17, 2006 - v3
    Checksum:i8E704CBEAB928BF5
    GO
    Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to Basket

    Also known as: TRIM41b, TRIM41beta, RINCK1

    The sequence of this isoform differs from the canonical sequence as follows:
         490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
         519-630: Missing.

    Show »
    Length:518
    Mass (Da):59,302
    Checksum:i88078577B9A3C98E
    GO
    Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-420: Missing.

    Show »
    Length:210
    Mass (Da):23,608
    Checksum:i6354BEB70AFB1C7C
    GO
    Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to Basket

    Also known as: RINCK2

    The sequence of this isoform differs from the canonical sequence as follows:
         381-381: D → V
         382-630: Missing.

    Show »
    Length:381
    Mass (Da):43,491
    Checksum:i2716AF100B4CA18B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti276 – 2761G → E in BAD07472. (PubMed:16022281)Curated
    Sequence conflicti276 – 2761G → E in BAD07473. (PubMed:16022281)Curated
    Sequence conflicti276 – 2761G → E in BAB70617. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781A → T.
    Corresponds to variant rs6601178 [ dbSNP | Ensembl ].
    VAR_027914
    Natural varianti438 – 4381D → G.
    Corresponds to variant rs2241371 [ dbSNP | Ensembl ].
    VAR_027915

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 420420Missing in isoform 3. 2 PublicationsVSP_012515Add
    BLAST
    Alternative sequencei381 – 3811D → V in isoform 4. 1 PublicationVSP_012516
    Alternative sequencei382 – 630249Missing in isoform 4. 1 PublicationVSP_012517Add
    BLAST
    Alternative sequencei490 – 51829VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsVSP_010395Add
    BLAST
    Alternative sequencei519 – 630112Missing in isoform 2. 3 PublicationsVSP_010396Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100366 mRNA. Translation: BAD07472.1.
    AB100367 mRNA. Translation: BAD07473.1.
    AF258579 mRNA. Translation: AAG23782.1.
    CR457349 mRNA. Translation: CAG33630.1.
    AK027601 mRNA. Translation: BAG51358.1.
    CH471165 Genomic DNA. Translation: EAW53712.1.
    CH471165 Genomic DNA. Translation: EAW53708.1.
    CH471165 Genomic DNA. Translation: EAW53709.1.
    BC004956 mRNA. Translation: AAH04956.1.
    BC009762 mRNA. Translation: AAH09762.2.
    BC018765 mRNA. Translation: AAH18765.2.
    BC071887 mRNA. Translation: AAH71887.1.
    BC090953 mRNA. Translation: AAH90953.1.
    AB063180 mRNA. Translation: BAB70617.1.
    CCDSiCCDS4465.1. [Q8WV44-2]
    CCDS4466.1. [Q8WV44-1]
    RefSeqiNP_291027.3. NM_033549.4. [Q8WV44-1]
    NP_963921.1. NM_201627.2. [Q8WV44-2]
    UniGeneiHs.441488.
    Hs.700303.

    Genome annotation databases

    EnsembliENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
    ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
    GeneIDi90933.
    KEGGihsa:90933.
    UCSCiuc003mnc.2. human. [Q8WV44-4]
    uc003mnd.2. human. [Q8WV44-2]
    uc003mne.2. human. [Q8WV44-1]
    uc003mng.1. human. [Q8WV44-3]

    Polymorphism databases

    DMDMi116242826.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100366 mRNA. Translation: BAD07472.1 .
    AB100367 mRNA. Translation: BAD07473.1 .
    AF258579 mRNA. Translation: AAG23782.1 .
    CR457349 mRNA. Translation: CAG33630.1 .
    AK027601 mRNA. Translation: BAG51358.1 .
    CH471165 Genomic DNA. Translation: EAW53712.1 .
    CH471165 Genomic DNA. Translation: EAW53708.1 .
    CH471165 Genomic DNA. Translation: EAW53709.1 .
    BC004956 mRNA. Translation: AAH04956.1 .
    BC009762 mRNA. Translation: AAH09762.2 .
    BC018765 mRNA. Translation: AAH18765.2 .
    BC071887 mRNA. Translation: AAH71887.1 .
    BC090953 mRNA. Translation: AAH90953.1 .
    AB063180 mRNA. Translation: BAB70617.1 .
    CCDSi CCDS4465.1. [Q8WV44-2 ]
    CCDS4466.1. [Q8WV44-1 ]
    RefSeqi NP_291027.3. NM_033549.4. [Q8WV44-1 ]
    NP_963921.1. NM_201627.2. [Q8WV44-2 ]
    UniGenei Hs.441488.
    Hs.700303.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EGM NMR - A 214-263 [» ]
    ProteinModelPortali Q8WV44.
    SMRi Q8WV44. Positions 11-47, 220-263, 431-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124780. 27 interactions.
    IntActi Q8WV44. 26 interactions.
    MINTi MINT-1377793.
    STRINGi 9606.ENSP00000320869.

    PTM databases

    PhosphoSitei Q8WV44.

    Polymorphism databases

    DMDMi 116242826.

    Proteomic databases

    MaxQBi Q8WV44.
    PaxDbi Q8WV44.
    PRIDEi Q8WV44.

    Protocols and materials databases

    DNASUi 90933.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315073 ; ENSP00000320869 ; ENSG00000146063 . [Q8WV44-1 ]
    ENST00000351937 ; ENSP00000336749 ; ENSG00000146063 . [Q8WV44-2 ]
    GeneIDi 90933.
    KEGGi hsa:90933.
    UCSCi uc003mnc.2. human. [Q8WV44-4 ]
    uc003mnd.2. human. [Q8WV44-2 ]
    uc003mne.2. human. [Q8WV44-1 ]
    uc003mng.1. human. [Q8WV44-3 ]

    Organism-specific databases

    CTDi 90933.
    GeneCardsi GC05P180649.
    H-InvDB HIX0121034.
    HGNCi HGNC:19013. TRIM41.
    HPAi HPA021194.
    HPA024204.
    MIMi 610530. gene.
    neXtProti NX_Q8WV44.
    PharmGKBi PA134918519.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325772.
    HOVERGENi HBG001357.
    InParanoidi Q8WV44.
    KOi K12017.
    OMAi WTSGMGG.
    OrthoDBi EOG71G9TJ.
    PhylomeDBi Q8WV44.
    TreeFami TF342569.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi TRIM41. human.
    EvolutionaryTracei Q8WV44.
    GeneWikii TRIM41.
    GenomeRNAii 90933.
    NextBioi 77034.
    PROi Q8WV44.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WV44.
    Bgeei Q8WV44.
    CleanExi HS_TRIM41.
    Genevestigatori Q8WV44.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intracellular localization and domain organization of human TRIM41 proteins."
      Tanaka M., Fukuda Y., Mashima K., Hanai R.
      Mol. Biol. Rep. 32:87-93(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-630 (ISOFORM 4).
      Tissue: Lung, Pancreas and Uterus.
    7. "M phase-specific association of human topoisomerase IIIbeta with chromosomes."
      Kobayashi M., Hanai R.
      Biochem. Biophys. Res. Commun. 287:282-287(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-630 (ISOFORM 2).
    8. "Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase."
      Chen D., Gould C., Garza R., Gao T., Hampton R.Y., Newton A.C.
      J. Biol. Chem. 282:33776-33787(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH PRKCA, MUTAGENESIS OF CYS-20.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Solution structure of the ZF-b_box domain from human tripartite motif protein 41."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 214-263.

    Entry informationi

    Entry nameiTRI41_HUMAN
    AccessioniPrimary (citable) accession number: Q8WV44
    Secondary accession number(s): B3KNJ6
    , D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3