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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transferase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Protein family/group databases

MoonDBiQ8WV44 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:2.3.2.27)
Alternative name(s):
RING finger-interacting protein with C kinase
Short name:
RINCK
RING-type E3 ubiquitin transferase TRIM41Curated
Tripartite motif-containing protein 41
Gene namesi
Name:TRIM41
Synonyms:RINCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146063.18
HGNCiHGNC:19013 TRIM41
MIMi610530 gene
neXtProtiNX_Q8WV44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20C → A: Abolishes E3 ligase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000146063
PharmGKBiPA134918519

Polymorphism and mutation databases

BioMutaiTRIM41
DMDMi116242826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562621 – 630E3 ubiquitin-protein ligase TRIM41Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphothreonineCombined sources1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei447PhosphoserineCombined sources1

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WV44
MaxQBiQ8WV44
PaxDbiQ8WV44
PeptideAtlasiQ8WV44
PRIDEiQ8WV44
ProteomicsDBi74747
74748 [Q8WV44-2]
74749 [Q8WV44-3]
74750 [Q8WV44-4]

PTM databases

iPTMnetiQ8WV44
PhosphoSitePlusiQ8WV44

Expressioni

Tissue specificityi

Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000146063
CleanExiHS_TRIM41
ExpressionAtlasiQ8WV44 baseline and differential
GenevisibleiQ8WV44 HS

Organism-specific databases

HPAiHPA024204

Interactioni

Subunit structurei

Interacts with PRKCA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-725997,EBI-725997
Q9H6F03EBI-725997,EBI-10307481
AENQ8WTP83EBI-725997,EBI-8637627
AESQ081173EBI-725997,EBI-717810
C10orf4D3DR403EBI-725997,EBI-10176576
CEP44Q9C0F13EBI-725997,EBI-744115
CHD2O146474EBI-725997,EBI-1210503
CSNK2A2P197845EBI-725997,EBI-347451
EHHADHQ084265EBI-725997,EBI-2339219
FAM124AQ86V423EBI-725997,EBI-744506
GPATCH2LQ9NWQ43EBI-725997,EBI-5666657
KIFC3Q9BVG83EBI-725997,EBI-2125614
KRTAP10-9P604115EBI-725997,EBI-10172052
MAGEH1Q9H2133EBI-725997,EBI-473834
MEOX2P502227EBI-725997,EBI-748397
MORF4L1Q9UBU83EBI-725997,EBI-399246
NCK2O436395EBI-725997,EBI-713635
NPC5E5223EBI-725997,EBI-12583355From Influenza A virus (A/New York/1682/2009(H1N1)).
NPP034665EBI-725997,EBI-2547640From Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
NPQ1K9H23EBI-725997,EBI-6050688From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).
NPQ5EP283EBI-725997,EBI-12582202From Influenza A virus (A/Viet Nam/1203/2004(H5N1)).
PHC2Q8IXK03EBI-725997,EBI-713786
PrkcbP68403-23EBI-726015,EBI-397092From a different organism.
PRPF31Q8WWY33EBI-725997,EBI-1567797
PUS7LQ9H0K63EBI-725997,EBI-5464419
RNPS1D3DU923EBI-725997,EBI-10176640
SORBS3O605043EBI-725997,EBI-741237
TOP3BO959853EBI-725997,EBI-373403
TRIM17Q9Y5775EBI-725997,EBI-743894
ZBTB24O431675EBI-725997,EBI-744471
ZBTB48P100743EBI-725997,EBI-744864
ZBTB8AQ96BR93EBI-725997,EBI-742740
ZFP2Q6ZN575EBI-725997,EBI-7236323
ZFP64Q9NPA53EBI-725997,EBI-711679
ZFP64Q9NTW73EBI-725997,EBI-745730
ZNF138P527444EBI-725997,EBI-10746567
ZNF138P52744-23EBI-725997,EBI-10213071
ZNF250P15622-35EBI-725997,EBI-10177272
ZNF26P170313EBI-725997,EBI-2841331
ZNF263O149783EBI-725997,EBI-744493
ZNF264Q14C613EBI-725997,EBI-2826570
ZNF266Q145846EBI-725997,EBI-7115319
ZNF329Q86UD43EBI-725997,EBI-7233259
ZNF408Q9H9D46EBI-725997,EBI-347633
ZNF417Q8TAU35EBI-725997,EBI-740727
ZNF473Q8WTR73EBI-725997,EBI-751409
ZNF490Q9ULM27EBI-725997,EBI-1105370
ZNF564Q8TBZ83EBI-725997,EBI-10273713
ZNF587Q96SQ55EBI-725997,EBI-6427977
ZNF670Q9BS345EBI-725997,EBI-745276
ZNF71Q9NQZ84EBI-725997,EBI-7138235
ZSCAN21Q9Y5A63EBI-725997,EBI-10281938
ZSCAN26Q166703EBI-725997,EBI-3920053

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi124780, 105 interactors
IntActiQ8WV44, 138 interactors
MINTiQ8WV44
STRINGi9606.ENSP00000320869

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni228 – 230Combined sources3
Beta strandi236 – 238Combined sources3
Turni239 – 242Combined sources4
Beta strandi243 – 245Combined sources3
Helixi247 – 251Combined sources5
Helixi253 – 256Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44
SMRiQ8WV44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WV44

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 630B30.2/SPRYPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili264 – 373Sequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 163Glu-richAdd BLAST113

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOVERGENiHBG001357
InParanoidiQ8WV44
KOiK12017
OMAiWTSGMGG
OrthoDBiEOG091G04RX
PhylomeDBiQ8WV44
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to basket
Also known as: TRIM41a, TRIM41alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE
110 120 130 140 150
EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE
160 170 180 190 200
EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR
460 470 480 490 500
RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW
560 570 580 590 600
CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,670
Last modified:October 17, 2006 - v3
Checksum:i8E704CBEAB928BF5
GO
Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to basket
Also known as: TRIM41b, TRIM41beta, RINCK1

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.

Show »
Length:518
Mass (Da):59,302
Checksum:i88078577B9A3C98E
GO
Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:210
Mass (Da):23,608
Checksum:i6354BEB70AFB1C7C
GO
Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to basket
Also known as: RINCK2

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Show »
Length:381
Mass (Da):43,491
Checksum:i2716AF100B4CA18B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276G → E in BAD07472 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAD07473 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAB70617 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02791478A → T. Corresponds to variant dbSNP:rs6601178Ensembl.1
Natural variantiVAR_027915438D → G. Corresponds to variant dbSNP:rs2241371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0125151 – 420Missing in isoform 3. 2 PublicationsAdd BLAST420
Alternative sequenceiVSP_012516381D → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_012517382 – 630Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_010395490 – 518VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_010396519 – 630Missing in isoform 2. 3 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA Translation: BAD07472.1
AB100367 mRNA Translation: BAD07473.1
AF258579 mRNA Translation: AAG23782.1
CR457349 mRNA Translation: CAG33630.1
AK027601 mRNA Translation: BAG51358.1
CH471165 Genomic DNA Translation: EAW53712.1
CH471165 Genomic DNA Translation: EAW53708.1
CH471165 Genomic DNA Translation: EAW53709.1
BC004956 mRNA Translation: AAH04956.1
BC009762 mRNA Translation: AAH09762.2
BC018765 mRNA Translation: AAH18765.2
BC071887 mRNA Translation: AAH71887.1
BC090953 mRNA Translation: AAH90953.1
AB063180 mRNA Translation: BAB70617.1
CCDSiCCDS4465.1 [Q8WV44-2]
CCDS4466.1 [Q8WV44-1]
RefSeqiNP_291027.3, NM_033549.4 [Q8WV44-1]
NP_963921.1, NM_201627.2 [Q8WV44-2]
UniGeneiHs.441488
Hs.700303

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063 [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063 [Q8WV44-2]
GeneIDi90933
KEGGihsa:90933
UCSCiuc003mnd.3 human [Q8WV44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI41_HUMAN
AccessioniPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6
, D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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