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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6142RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:6.3.2.-)
Alternative name(s):
RING finger-interacting protein with C kinase
Short name:
RINCK
Tripartite motif-containing protein 41
Gene namesi
Name:TRIM41
Synonyms:RINCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19013. TRIM41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi20 – 201C → A: Abolishes E3 ligase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134918519.

Polymorphism and mutation databases

BioMutaiTRIM41.
DMDMi116242826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630E3 ubiquitin-protein ligase TRIM41PRO_0000056262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Phosphothreonine1 Publication
Modified residuei447 – 4471Phosphoserine1 Publication

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8WV44.
PaxDbiQ8WV44.
PRIDEiQ8WV44.

PTM databases

PhosphoSiteiQ8WV44.

Expressioni

Tissue specificityi

Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8WV44.
CleanExiHS_TRIM41.
ExpressionAtlasiQ8WV44. baseline and differential.
GenevisibleiQ8WV44. HS.

Organism-specific databases

HPAiHPA021194.
HPA024204.

Interactioni

Subunit structurei

Interacts with PRKCA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6F03EBI-725997,EBI-10307481
AENQ8WTP83EBI-725997,EBI-8637627
AESQ081173EBI-725997,EBI-717810
C10orf4D3DR403EBI-725997,EBI-10176576
CEP44Q9C0F13EBI-725997,EBI-744115
CHD2O146474EBI-725997,EBI-1210503
CSNK2A2P197843EBI-725997,EBI-347451
EHHADHQ084263EBI-725997,EBI-2339219
FAM124AQ86V423EBI-725997,EBI-744506
GPATCH2LQ9NWQ43EBI-725997,EBI-5666657
KIFC3Q9BVG83EBI-725997,EBI-2125614
KRTAP10-9P604115EBI-725997,EBI-10172052
MAGEH1Q9H2133EBI-725997,EBI-473834
MEOX2A4D1273EBI-725997,EBI-10172134
MORF4L1Q9UBU83EBI-725997,EBI-399246
NCK2O436393EBI-725997,EBI-713635
PHC2Q8IXK03EBI-725997,EBI-713786
PrkcbP68403-23EBI-726015,EBI-397092From a different organism.
PUS7LQ9H0K63EBI-725997,EBI-5464419
RNPS1D3DU923EBI-725997,EBI-10176640
SORBS3O605043EBI-725997,EBI-741237
TOP3BO959853EBI-725997,EBI-373403
ZBTB24O431673EBI-725997,EBI-744471
ZFP2Q6ZN573EBI-725997,EBI-7236323
ZFP64Q9NPA53EBI-725997,EBI-711679
ZFP64Q9NTW73EBI-725997,EBI-745730
ZNF138P52744-23EBI-725997,EBI-10213071
ZNF250P15622-33EBI-725997,EBI-10177272
ZNF26P170313EBI-725997,EBI-2841331
ZNF264Q14C613EBI-725997,EBI-2826570
ZNF266Q145846EBI-725997,EBI-7115319
ZNF329Q86UD43EBI-725997,EBI-7233259
ZNF417Q8TAU33EBI-725997,EBI-740727
ZNF490Q9ULM23EBI-725997,EBI-1105370
ZNF564Q8TBZ83EBI-725997,EBI-10273713
ZNF587Q96SQ53EBI-725997,EBI-6427977
ZNF670Q9BS343EBI-725997,EBI-745276
ZSCAN21Q9Y5A63EBI-725997,EBI-10281938
ZSCAN26Q166703EBI-725997,EBI-3920053

Protein-protein interaction databases

BioGridi124780. 71 interactions.
IntActiQ8WV44. 63 interactions.
MINTiMINT-1377793.
STRINGi9606.ENSP00000320869.

Structurei

Secondary structure

1
630
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni228 – 2303Combined sources
Beta strandi236 – 2383Combined sources
Turni239 – 2424Combined sources
Beta strandi243 – 2453Combined sources
Helixi247 – 2515Combined sources
Helixi253 – 2564Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44.
SMRiQ8WV44. Positions 11-47, 220-394, 431-617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WV44.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini413 – 630218B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili264 – 373110Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 163113Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6142RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG325772.
GeneTreeiENSGT00760000118838.
HOVERGENiHBG001357.
InParanoidiQ8WV44.
KOiK12017.
OMAiWTSGMGG.
OrthoDBiEOG71G9TJ.
PhylomeDBiQ8WV44.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to basket

Also known as: TRIM41a, TRIM41alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE
110 120 130 140 150
EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE
160 170 180 190 200
EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR
460 470 480 490 500
RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW
560 570 580 590 600
CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,670
Last modified:October 17, 2006 - v3
Checksum:i8E704CBEAB928BF5
GO
Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to basket

Also known as: TRIM41b, TRIM41beta, RINCK1

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.

Show »
Length:518
Mass (Da):59,302
Checksum:i88078577B9A3C98E
GO
Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:210
Mass (Da):23,608
Checksum:i6354BEB70AFB1C7C
GO
Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to basket

Also known as: RINCK2

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Show »
Length:381
Mass (Da):43,491
Checksum:i2716AF100B4CA18B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti276 – 2761G → E in BAD07472 (PubMed:16022281).Curated
Sequence conflicti276 – 2761G → E in BAD07473 (PubMed:16022281).Curated
Sequence conflicti276 – 2761G → E in BAB70617 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781A → T.
Corresponds to variant rs6601178 [ dbSNP | Ensembl ].
VAR_027914
Natural varianti438 – 4381D → G.
Corresponds to variant rs2241371 [ dbSNP | Ensembl ].
VAR_027915

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 420420Missing in isoform 3. 2 PublicationsVSP_012515Add
BLAST
Alternative sequencei381 – 3811D → V in isoform 4. 1 PublicationVSP_012516
Alternative sequencei382 – 630249Missing in isoform 4. 1 PublicationVSP_012517Add
BLAST
Alternative sequencei490 – 51829VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsVSP_010395Add
BLAST
Alternative sequencei519 – 630112Missing in isoform 2. 3 PublicationsVSP_010396Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA. Translation: BAD07472.1.
AB100367 mRNA. Translation: BAD07473.1.
AF258579 mRNA. Translation: AAG23782.1.
CR457349 mRNA. Translation: CAG33630.1.
AK027601 mRNA. Translation: BAG51358.1.
CH471165 Genomic DNA. Translation: EAW53712.1.
CH471165 Genomic DNA. Translation: EAW53708.1.
CH471165 Genomic DNA. Translation: EAW53709.1.
BC004956 mRNA. Translation: AAH04956.1.
BC009762 mRNA. Translation: AAH09762.2.
BC018765 mRNA. Translation: AAH18765.2.
BC071887 mRNA. Translation: AAH71887.1.
BC090953 mRNA. Translation: AAH90953.1.
AB063180 mRNA. Translation: BAB70617.1.
CCDSiCCDS4465.1. [Q8WV44-2]
CCDS4466.1. [Q8WV44-1]
RefSeqiNP_291027.3. NM_033549.4. [Q8WV44-1]
NP_963921.1. NM_201627.2. [Q8WV44-2]
UniGeneiHs.441488.
Hs.700303.

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
GeneIDi90933.
KEGGihsa:90933.
UCSCiuc003mnc.2. human. [Q8WV44-4]
uc003mnd.2. human. [Q8WV44-2]
uc003mne.2. human. [Q8WV44-1]
uc003mng.1. human. [Q8WV44-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA. Translation: BAD07472.1.
AB100367 mRNA. Translation: BAD07473.1.
AF258579 mRNA. Translation: AAG23782.1.
CR457349 mRNA. Translation: CAG33630.1.
AK027601 mRNA. Translation: BAG51358.1.
CH471165 Genomic DNA. Translation: EAW53712.1.
CH471165 Genomic DNA. Translation: EAW53708.1.
CH471165 Genomic DNA. Translation: EAW53709.1.
BC004956 mRNA. Translation: AAH04956.1.
BC009762 mRNA. Translation: AAH09762.2.
BC018765 mRNA. Translation: AAH18765.2.
BC071887 mRNA. Translation: AAH71887.1.
BC090953 mRNA. Translation: AAH90953.1.
AB063180 mRNA. Translation: BAB70617.1.
CCDSiCCDS4465.1. [Q8WV44-2]
CCDS4466.1. [Q8WV44-1]
RefSeqiNP_291027.3. NM_033549.4. [Q8WV44-1]
NP_963921.1. NM_201627.2. [Q8WV44-2]
UniGeneiHs.441488.
Hs.700303.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44.
SMRiQ8WV44. Positions 11-47, 220-394, 431-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124780. 71 interactions.
IntActiQ8WV44. 63 interactions.
MINTiMINT-1377793.
STRINGi9606.ENSP00000320869.

PTM databases

PhosphoSiteiQ8WV44.

Polymorphism and mutation databases

BioMutaiTRIM41.
DMDMi116242826.

Proteomic databases

MaxQBiQ8WV44.
PaxDbiQ8WV44.
PRIDEiQ8WV44.

Protocols and materials databases

DNASUi90933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
GeneIDi90933.
KEGGihsa:90933.
UCSCiuc003mnc.2. human. [Q8WV44-4]
uc003mnd.2. human. [Q8WV44-2]
uc003mne.2. human. [Q8WV44-1]
uc003mng.1. human. [Q8WV44-3]

Organism-specific databases

CTDi90933.
GeneCardsiGC05P180649.
H-InvDBHIX0121034.
HGNCiHGNC:19013. TRIM41.
HPAiHPA021194.
HPA024204.
MIMi610530. gene.
neXtProtiNX_Q8WV44.
PharmGKBiPA134918519.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325772.
GeneTreeiENSGT00760000118838.
HOVERGENiHBG001357.
InParanoidiQ8WV44.
KOiK12017.
OMAiWTSGMGG.
OrthoDBiEOG71G9TJ.
PhylomeDBiQ8WV44.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiTRIM41. human.
EvolutionaryTraceiQ8WV44.
GeneWikiiTRIM41.
GenomeRNAii90933.
NextBioi77034.
PROiQ8WV44.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WV44.
CleanExiHS_TRIM41.
ExpressionAtlasiQ8WV44. baseline and differential.
GenevisibleiQ8WV44. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intracellular localization and domain organization of human TRIM41 proteins."
    Tanaka M., Fukuda Y., Mashima K., Hanai R.
    Mol. Biol. Rep. 32:87-93(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-630 (ISOFORM 4).
    Tissue: Lung, Pancreas and Uterus.
  7. "M phase-specific association of human topoisomerase IIIbeta with chromosomes."
    Kobayashi M., Hanai R.
    Biochem. Biophys. Res. Commun. 287:282-287(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-630 (ISOFORM 2).
  8. "Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase."
    Chen D., Gould C., Garza R., Gao T., Hampton R.Y., Newton A.C.
    J. Biol. Chem. 282:33776-33787(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH PRKCA, MUTAGENESIS OF CYS-20.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Solution structure of the ZF-b_box domain from human tripartite motif protein 41."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 214-263.

Entry informationi

Entry nameiTRI41_HUMAN
AccessioniPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6
, D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.