Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WV44 (TRI41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase TRIM41

EC=6.3.2.-
Alternative name(s):
RING finger-interacting protein with C kinase
Short name=RINCK
Tripartite motif-containing protein 41
Gene names
Name:TRIM41
Synonyms:RINCK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Ref.8

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with PRKCA. Ref.8

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Expressed in multiple tissues with the highest levels in heart and skeletal muscle. Ref.8

Post-translational modification

Auto-ubiquitinated.

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMPhosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from direct assay. Source: HPA

   Molecular_functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PrkcbP68403-23EBI-726015,EBI-397092From a different organism.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WV44-1)

Also known as: TRIM41a; TRIM41alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WV44-2)

Also known as: TRIM41b; TRIM41beta; RINCK1;

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.
Isoform 3 (identifier: Q8WV44-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.
Isoform 4 (identifier: Q8WV44-4)

Also known as: RINCK2;

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630E3 ubiquitin-protein ligase TRIM41
PRO_0000056262

Regions

Domain413 – 630218B30.2/SPRY
Zinc finger20 – 6142RING-type
Zinc finger222 – 26342B box-type
Coiled coil264 – 373110 Potential
Compositional bias51 – 163113Glu-rich

Amino acid modifications

Modified residue4471Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 420420Missing in isoform 3.
VSP_012515
Alternative sequence3811D → V in isoform 4.
VSP_012516
Alternative sequence382 – 630249Missing in isoform 4.
VSP_012517
Alternative sequence490 – 51829VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2.
VSP_010395
Alternative sequence519 – 630112Missing in isoform 2.
VSP_010396
Natural variant781A → T.
Corresponds to variant rs6601178 [ dbSNP | Ensembl ].
VAR_027914
Natural variant4381D → G.
Corresponds to variant rs2241371 [ dbSNP | Ensembl ].
VAR_027915

Experimental info

Mutagenesis201C → A: Abolishes E3 ligase activity. Ref.8
Sequence conflict2761G → E in BAD07472. Ref.1
Sequence conflict2761G → E in BAD07473. Ref.1
Sequence conflict2761G → E in BAB70617. Ref.5

Secondary structure

........... 630
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (TRIM41a) (TRIM41alpha) [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 8E704CBEAB928BF5

FASTA63071,670
        10         20         30         40         50         60 
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD 

        70         80         90        100        110        120 
REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM 

       130        140        150        160        170        180 
DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC 

       190        200        210        220        230        240 
FTCPQCRKSF PRRSFRPNLQ LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV 

       250        260        270        280        290        300 
DEEAICVVCR ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT 

       310        320        330        340        350        360 
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA SRLAEQAAQL 

       370        380        390        400        410        420 
SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW SPDPCQPHSH DFLTDAIVRK 

       430        440        450        460        470        480 
MSRMFCQAAR VDLTLDPDTA HPALMLSPDR RGVRLAERRQ EVADHPKRFS ADCCVLGAQG 

       490        500        510        520        530        540 
FRSGRHYWEV EVGGRRGWAV GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP 

       550        560        570        580        590        600 
QQPLLQREVW CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH 

       610        620        630 
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP 

« Hide

Isoform 2 (TRIM41b) (TRIM41beta) (RINCK1) [UniParc].

Checksum: 88078577B9A3C98E
Show »

FASTA51859,302
Isoform 3 [UniParc].

Checksum: 6354BEB70AFB1C7C
Show »

FASTA21023,608
Isoform 4 (RINCK2) [UniParc].

Checksum: 2716AF100B4CA18B
Show »

FASTA38143,491

References

« Hide 'large scale' references
[1]"Intracellular localization and domain organization of human TRIM41 proteins."
Tanaka M., Fukuda Y., Mashima K., Hanai R.
Mol. Biol. Rep. 32:87-93(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
[2]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-630 (ISOFORM 4).
Tissue: Lung, Pancreas and Uterus.
[7]"M phase-specific association of human topoisomerase IIIbeta with chromosomes."
Kobayashi M., Hanai R.
Biochem. Biophys. Res. Commun. 287:282-287(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-630 (ISOFORM 2).
[8]"Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase."
Chen D., Gould C., Garza R., Gao T., Hampton R.Y., Newton A.C.
J. Biol. Chem. 282:33776-33787(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH PRKCA, MUTAGENESIS OF CYS-20.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Solution structure of the ZF-b_box domain from human tripartite motif protein 41."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 214-263.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB100366 mRNA. Translation: BAD07472.1.
AB100367 mRNA. Translation: BAD07473.1.
AF258579 mRNA. Translation: AAG23782.1.
CR457349 mRNA. Translation: CAG33630.1.
AK027601 mRNA. Translation: BAG51358.1.
CH471165 Genomic DNA. Translation: EAW53712.1.
CH471165 Genomic DNA. Translation: EAW53708.1.
CH471165 Genomic DNA. Translation: EAW53709.1.
BC004956 mRNA. Translation: AAH04956.1.
BC009762 mRNA. Translation: AAH09762.2.
BC018765 mRNA. Translation: AAH18765.2.
BC071887 mRNA. Translation: AAH71887.1.
BC090953 mRNA. Translation: AAH90953.1.
AB063180 mRNA. Translation: BAB70617.1.
RefSeqNP_291027.3. NM_033549.4.
NP_963921.1. NM_201627.2.
UniGeneHs.441488.
Hs.700303.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortalQ8WV44.
SMRQ8WV44. Positions 11-47, 220-263, 431-617.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124780. 26 interactions.
IntActQ8WV44. 26 interactions.
MINTMINT-1377793.
STRING9606.ENSP00000320869.

PTM databases

PhosphoSiteQ8WV44.

Polymorphism databases

DMDM116242826.

Proteomic databases

PaxDbQ8WV44.
PRIDEQ8WV44.

Protocols and materials databases

DNASU90933.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315073; ENSP00000320869; ENSG00000146063. [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063. [Q8WV44-2]
GeneID90933.
KEGGhsa:90933.
UCSCuc003mnc.2. human. [Q8WV44-4]
uc003mnd.2. human. [Q8WV44-2]
uc003mne.2. human. [Q8WV44-1]
uc003mng.1. human. [Q8WV44-3]

Organism-specific databases

CTD90933.
GeneCardsGC05P180649.
H-InvDBHIX0121034.
HGNCHGNC:19013. TRIM41.
HPAHPA021194.
HPA024204.
MIM610530. gene.
neXtProtNX_Q8WV44.
PharmGKBPA134918519.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325772.
HOVERGENHBG001357.
InParanoidQ8WV44.
KOK12017.
OMAWTSGMGG.
OrthoDBEOG71G9TJ.
PhylomeDBQ8WV44.
TreeFamTF342569.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8WV44.
BgeeQ8WV44.
CleanExHS_TRIM41.
GenevestigatorQ8WV44.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM41. human.
EvolutionaryTraceQ8WV44.
GeneWikiTRIM41.
GenomeRNAi90933.
NextBio77034.
PROQ8WV44.
SOURCESearch...

Entry information

Entry nameTRI41_HUMAN
AccessionPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6 expand/collapse secondary AC list , D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM