Q8WV41 (SNX33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin-33

Alternative name(s):
SH3 and PX domain-containing protein 3

Gene names

Name:	SNX33
Synonyms:	SH3PX3, SH3PXD3C, SNX30

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with ADAM15. Interacts with FASLG. Ref.1 Ref.6 Ref.7
Sequence similarities	Belongs to the sorting nexin family. Contains 1 BAR domain. Contains 1 PX (phox homology) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Domain	SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FASLG	P48023	2	EBI-2481535,EBI-495538

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 574

574

Sorting nexin-33

PRO_0000311948

Regions

Domain

1 – 61

61

SH3

Domain

230 – 340

111

PX

Domain

371 – 574

204

BAR

Compositional bias

112 – 122

11

Poly-Asp

Amino acid modifications

Modified residue

77

1

Phosphoserine Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

574

Helix Strand Turn

Details...

Beta strand

213 – 215

3

Beta strand

220 – 223

4

Beta strand

232 – 235

4

Beta strand

252 – 256

5

Beta strand

259 – 261

3

Beta strand

263 – 265

3

Helix

267 – 280

14

Beta strand

282 – 284

3

Turn

302 – 304

3

Helix

305 – 318

14

Helix

323 – 325

3

Helix

327 – 333

7

Helix

339 – 349

11

Helix

355 – 360

6

Helix

371 – 407

37

Helix

409 – 427

19

Helix

432 – 434

3

Helix

437 – 459

23

Helix

460 – 462

3

Helix

465 – 504

40

Helix

510 – 568

59

Helix

569 – 571

3

Sequences

	Sequence		Length	Mass (Da)
	Q8WV41 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7CE51C0F35DDBC3C	FASTA	574	65,265
	10 20 30 40 50 60 MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL FPASYVEIVR 70 80 90 100 110 120 SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS GFLSNQGSFE EDDDDDWDDW 130 140 150 160 170 180 DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA YPSQHMAFRP KPPLERQDSL ASAKRGSVVG 190 200 210 220 230 240 RNLNRFSCFV RSGVEAFILG DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ 250 260 270 280 290 300 TKFKGIKSYI SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE 310 320 330 340 350 360 DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK DEMVGASFLL 370 380 390 400 410 420 TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS ELVRKHVGGF RKEFQKLGSA 430 440 450 460 470 480 FQAISHSFQM DPPFCSEALN SAISHTGRTY EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS 490 500 510 520 530 540 NFPDIIHLQK GAFAKVKESQ RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL 550 560 570 DFKHMMQNYL RQQILFYQRV GQQLEKTLRM YDNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome." Kaerkkaeinen S., Hiipakka M., Wang J.-H., Kleino I., Vaehae-Jaakkola M., Renkema G.H., Liss M., Wagner R., Saksela K. EMBO Rep. 7:186-191(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ADAM15.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Stomach.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
[7]	"Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins." Kleino I., Ortiz R.M., Yritys M., Huovila A.P., Saksela K. J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ADAM15.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EF219141 mRNA. Translation: ABN09670.1.
AL833039 mRNA. Translation: CAH56299.1.
CH471136 Genomic DNA. Translation: EAW99243.1.
BC018775 mRNA. Translation: AAH18775.1.

IPI

IPI00103013.

RefSeq

NP_695003.1. NM_153271.1.

UniGene

Hs.8705.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AKV	X-ray	2.65	A/B	212-574	[»]

ProteinModelPortal

Q8WV41.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WV41. 1 interaction.

MINT

MINT-2792452.

STRING

9606.ENSP00000311427.

PTM databases

PhosphoSite

Q8WV41.

Polymorphism databases

DMDM

74751538.

Proteomic databases

PaxDb

Q8WV41.

PRIDE

Q8WV41.

Protocols and materials databases

DNASU

257364.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000308527; ENSP00000311427; ENSG00000173548.

GeneID

257364.

KEGG

hsa:257364.

UCSC

uc002bau.3. human.

Organism-specific databases

CTD

257364.

GeneCards

GC15P075940.

H-InvDB

HIX0012446.

HGNC

HGNC:28468. SNX33.

HPA

HPA040988.

neXtProt

NX_Q8WV41.

PharmGKB

PA162404345.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5391.

HOGENOM

HOG000261633.

HOVERGEN

HBG009996.

InParanoid

Q8WV41.

OMA

QKLGSAF.

OrthoDB

EOG43FGWP.

PhylomeDB

Q8WV41.

Gene expression databases

ArrayExpress

Q8WV41.

Bgee

Q8WV41.

CleanEx

HS_SNX30.
HS_SNX33.

Genevestigator

Q8WV41.

Family and domain databases

Gene3D

3.30.1520.10. 1 hit.

InterPro

IPR001683. Phox.
IPR001452. SH3_domain.
IPR014536. Snx9.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]

Pfam

PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

PIRSF

PIRSF027744. Snx9. 1 hit.

SMART

SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF64268. PX. 1 hit.
SSF50044. SH3. 1 hit.

PROSITE

PS51021. BAR. False negative.
PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

257364.

NextBio

92998.

Entry information

Entry name

SNX33_HUMAN

Accession

Primary (citable) accession number: Q8WV41

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.