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Protein

Sorting nexin-33

Gene

SNX33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.6 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol binding Source: InterPro

GO - Biological processi

  • cleavage furrow formation Source: UniProtKB
  • endocytosis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • endosome organization Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • macropinocytosis Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • negative regulation of endocytosis Source: UniProtKB
  • negative regulation of protein localization to cell surface Source: UniProtKB
  • plasma membrane tubulation Source: UniProtKB
  • positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB
  • protein import Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-33
Alternative name(s):
SH3 and PX domain-containing protein 3
Gene namesi
Name:SNX33
Synonyms:SH3PX3, SH3PXD3C, SNX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28468. SNX33.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • extrinsic component of membrane Source: UniProtKB
  • membrane Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173548.
PharmGKBiPA162404345.

Polymorphism and mutation databases

BioMutaiSNX33.
DMDMi74751538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119481 – 574Sorting nexin-33Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WV41.
MaxQBiQ8WV41.
PaxDbiQ8WV41.
PeptideAtlasiQ8WV41.
PRIDEiQ8WV41.

PTM databases

iPTMnetiQ8WV41.
PhosphoSitePlusiQ8WV41.

Expressioni

Tissue specificityi

Detected in heart and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000173548.
CleanExiHS_SNX30.
HS_SNX33.
ExpressionAtlasiQ8WV41. baseline and differential.
GenevisibleiQ8WV41. HS.

Organism-specific databases

HPAiHPA040988.

Interactioni

Subunit structurei

Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi129214. 16 interactors.
IntActiQ8WV41. 17 interactors.
MINTiMINT-2792452.
STRINGi9606.ENSP00000311427.

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi213 – 215Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi232 – 235Combined sources4
Beta strandi252 – 256Combined sources5
Beta strandi259 – 261Combined sources3
Beta strandi263 – 265Combined sources3
Helixi267 – 280Combined sources14
Beta strandi282 – 284Combined sources3
Turni302 – 304Combined sources3
Helixi305 – 318Combined sources14
Helixi323 – 325Combined sources3
Helixi327 – 333Combined sources7
Helixi339 – 349Combined sources11
Helixi355 – 360Combined sources6
Helixi371 – 407Combined sources37
Helixi409 – 427Combined sources19
Helixi432 – 434Combined sources3
Helixi437 – 459Combined sources23
Helixi460 – 462Combined sources3
Helixi465 – 504Combined sources40
Helixi510 – 568Combined sources59
Helixi569 – 571Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AKVX-ray2.65A/B212-574[»]
ProteinModelPortaliQ8WV41.
SMRiQ8WV41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini230 – 340PXPROSITE-ProRule annotationAdd BLAST111
Domaini371 – 574BARAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 122Poly-AspAdd BLAST11

Domaini

The PX and BAR domains mediate association with membranes and are required for membrane tubulation.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2528. Eukaryota.
ENOG410XPHZ. LUCA.
GeneTreeiENSGT00510000046469.
HOGENOMiHOG000261633.
HOVERGENiHBG009996.
InParanoidiQ8WV41.
KOiK17923.
OMAiGSMVGRN.
OrthoDBiEOG091G07IM.
PhylomeDBiQ8WV41.
TreeFamiTF314082.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR001683. Phox.
IPR001452. SH3_domain.
IPR028642. SNX33.
IPR014536. Snx9_fam.
IPR019497. Sorting_nexin_WASP-bd-dom.
PANTHERiPTHR10555:SF175. PTHR10555:SF175. 1 hit.
PfamiView protein in Pfam
PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
PIRSFiPIRSF027744. Snx9. 1 hit.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WV41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL
60 70 80 90 100
FPASYVEIVR SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS
110 120 130 140 150
GFLSNQGSFE EDDDDDWDDW DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA
160 170 180 190 200
YPSQHMAFRP KPPLERQDSL ASAKRGSVVG RNLNRFSCFV RSGVEAFILG
210 220 230 240 250
DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ TKFKGIKSYI
260 270 280 290 300
SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE
310 320 330 340 350
DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK
360 370 380 390 400
DEMVGASFLL TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS
410 420 430 440 450
ELVRKHVGGF RKEFQKLGSA FQAISHSFQM DPPFCSEALN SAISHTGRTY
460 470 480 490 500
EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS NFPDIIHLQK GAFAKVKESQ
510 520 530 540 550
RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL DFKHMMQNYL
560 570
RQQILFYQRV GQQLEKTLRM YDNL
Length:574
Mass (Da):65,265
Last modified:March 1, 2002 - v1
Checksum:i7CE51C0F35DDBC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF219141 mRNA. Translation: ABN09670.1.
EF653821 mRNA. Translation: ABV26009.1.
AL833039 mRNA. Translation: CAH56299.1.
CH471136 Genomic DNA. Translation: EAW99243.1.
BC018775 mRNA. Translation: AAH18775.1.
CCDSiCCDS10283.1.
RefSeqiNP_001305075.1. NM_001318146.1.
NP_695003.1. NM_153271.1.
UniGeneiHs.8705.

Genome annotation databases

EnsembliENST00000308527; ENSP00000311427; ENSG00000173548.
GeneIDi257364.
KEGGihsa:257364.
UCSCiuc002bau.4. human.

Similar proteinsi

Entry informationi

Entry nameiSNX33_HUMAN
AccessioniPrimary (citable) accession number: Q8WV41
Secondary accession number(s): B1NM17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families