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Protein

Leucine-rich repeat-containing protein 29

Gene

LRRC29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 29
Alternative name(s):
F-box and leucine-rich repeat protein 9
F-box protein FBL9
F-box/LRR-repeat protein 9
Gene namesi
Name:LRRC29
Synonyms:FBL9, FBXL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13605. LRRC29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28029.

Polymorphism and mutation databases

BioMutaiLRRC29.
DMDMi38257689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Leucine-rich repeat-containing protein 29PRO_0000119852Add
BLAST

Proteomic databases

PaxDbiQ8WV35.
PRIDEiQ8WV35.

Expressioni

Tissue specificityi

Expressed in heart, kidney, liver, lung and pancreas.1 Publication

Gene expression databases

BgeeiQ8WV35.
CleanExiHS_LRRC29.
ExpressionAtlasiQ8WV35. baseline and differential.
GenevisibleiQ8WV35. HS.

Organism-specific databases

HPAiHPA034998.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-10276755,EBI-10174421
ADAMTSL4Q6UY14-33EBI-10276755,EBI-10173507

Protein-protein interaction databases

BioGridi117622. 5 interactions.
IntActiQ8WV35. 2 interactions.
STRINGi9606.ENSP00000344364.

Structurei

3D structure databases

ProteinModelPortaliQ8WV35.
SMRiQ8WV35. Positions 74-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 4822LRR 1Add
BLAST
Repeati56 – 8429LRR 2Add
BLAST
Repeati85 – 10925LRR 3Add
BLAST
Repeati110 – 13526LRR 4Add
BLAST
Domaini134 – 18148F-boxAdd
BLAST
Repeati136 – 16126LRR 5Add
BLAST
Repeati162 – 18726LRR 6Add
BLAST
Repeati188 – 21326LRR 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000059669.
HOVERGENiHBG081926.
InParanoidiQ8WV35.
KOiK10275.
OMAiATCPGIN.
OrthoDBiEOG7HHWTQ.
PhylomeDBiQ8WV35.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSSGWPAGA AEPRHGRGRE LAQALGCMHG APSQLASLSL AHCSSLKSRP
60 70 80 90 100
ELEHQASGTK DACPEPQGPS LLTLRALQEL DLTACSKLTD ASLAKVLQFL
110 120 130 140 150
QLRQLSLSLL PELTDNGLVA VARGCPSLEH LALSHCSRLS DKGWAQAASS
160 170 180 190 200
WPRLQHLNLS SCSQLIEQTL DAIGQACRQL RVLDVATCPG INMAAVRRFQ
210 220
AQLPQVSCVQ SRFVGGADLT LTL
Length:223
Mass (Da):23,797
Last modified:March 1, 2002 - v1
Checksum:iADFBA9EC878BE46D
GO

Sequence cautioni

The sequence AAF03701.1 differs from that shown. Reason: Frameshift at position 13. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751R → Q.
Corresponds to variant rs3743728 [ dbSNP | Ensembl ].
VAR_049031
Natural varianti117 – 1171G → S.
Corresponds to variant rs34595673 [ dbSNP | Ensembl ].
VAR_049032

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176701 mRNA. Translation: AAF03701.1. Frameshift.
AK316602 mRNA. Translation: BAG38189.1.
CH471092 Genomic DNA. Translation: EAW83099.1.
BC018785 mRNA. Translation: AAH18785.1.
CCDSiCCDS32465.1.
RefSeqiNP_001004055.1. NM_001004055.1.
NP_036295.1. NM_012163.2.
XP_011521300.1. XM_011522998.1.
UniGeneiHs.461000.

Genome annotation databases

EnsembliENST00000393992; ENSP00000377561; ENSG00000125122.
ENST00000409037; ENSP00000387318; ENSG00000125122.
ENST00000409509; ENSP00000386622; ENSG00000125122.
ENST00000629962; ENSP00000486223; ENSG00000125122.
GeneIDi26231.
KEGGihsa:26231.
UCSCiuc002esd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176701 mRNA. Translation: AAF03701.1. Frameshift.
AK316602 mRNA. Translation: BAG38189.1.
CH471092 Genomic DNA. Translation: EAW83099.1.
BC018785 mRNA. Translation: AAH18785.1.
CCDSiCCDS32465.1.
RefSeqiNP_001004055.1. NM_001004055.1.
NP_036295.1. NM_012163.2.
XP_011521300.1. XM_011522998.1.
UniGeneiHs.461000.

3D structure databases

ProteinModelPortaliQ8WV35.
SMRiQ8WV35. Positions 74-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117622. 5 interactions.
IntActiQ8WV35. 2 interactions.
STRINGi9606.ENSP00000344364.

Polymorphism and mutation databases

BioMutaiLRRC29.
DMDMi38257689.

Proteomic databases

PaxDbiQ8WV35.
PRIDEiQ8WV35.

Protocols and materials databases

DNASUi26231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393992; ENSP00000377561; ENSG00000125122.
ENST00000409037; ENSP00000387318; ENSG00000125122.
ENST00000409509; ENSP00000386622; ENSG00000125122.
ENST00000629962; ENSP00000486223; ENSG00000125122.
GeneIDi26231.
KEGGihsa:26231.
UCSCiuc002esd.4. human.

Organism-specific databases

CTDi26231.
GeneCardsiLRRC29.
HGNCiHGNC:13605. LRRC29.
HPAiHPA034998.
neXtProtiNX_Q8WV35.
PharmGKBiPA28029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000059669.
HOVERGENiHBG081926.
InParanoidiQ8WV35.
KOiK10275.
OMAiATCPGIN.
OrthoDBiEOG7HHWTQ.
PhylomeDBiQ8WV35.

Miscellaneous databases

ChiTaRSiLRRC29. human.
GenomeRNAii26231.
NextBioi48401.
PROiQ8WV35.

Gene expression databases

BgeeiQ8WV35.
CleanExiHS_LRRC29.
ExpressionAtlasiQ8WV35. baseline and differential.
GenevisibleiQ8WV35. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiLRC29_HUMAN
AccessioniPrimary (citable) accession number: Q8WV35
Secondary accession number(s): B2RE92, Q9UKA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.