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Q8WV28

- BLNK_HUMAN

UniProt

Q8WV28 - BLNK_HUMAN

Protein

B-cell linker protein

Gene

BLNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.4 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. SH3/SH2 adaptor activity Source: UniProtKB
    3. transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. humoral immune response Source: ProtInc
    3. inflammatory response Source: ProtInc
    4. intracellular signal transduction Source: UniProtKB
    5. positive regulation of signal transduction Source: GOC
    6. transmembrane receptor protein tyrosine kinase signaling pathway Source: GOC

    Keywords - Biological processi

    B-cell activation

    Enzyme and pathway databases

    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_23787. Regulation of signaling by CBL.
    SignaLinkiQ8WV28.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell linker protein
    Alternative name(s):
    B-cell adapter containing a SH2 domain protein
    B-cell adapter containing a Src homology 2 domain protein
    Cytoplasmic adapter protein
    Src homology 2 domain-containing leukocyte protein of 65 kDa
    Short name:
    SLP-65
    Gene namesi
    Name:BLNK
    Synonyms:BASH, SLP65
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14211. BLNK.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication
    Note: BCR activation results in the translocation to membrane fraction.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. intracellular Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi72 – 721Y → F: Significant phosphorylation reduction; when associated with F-84; F-96 and F-178. 2 Publications
    Mutagenesisi84 – 841Y → F: Significant phosphorylation reduction; when associated with F-72; F-96 and F-178. 2 Publications
    Mutagenesisi96 – 961Y → F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-178. 2 Publications
    Mutagenesisi178 – 1781Y → F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-96. 1 Publication

    Organism-specific databases

    MIMi613502. phenotype.
    Orphaneti33110. Autosomal agammaglobulinemia.
    PharmGKBiPA25371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456B-cell linker proteinPRO_0000064940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Phosphotyrosine; by SYK2 Publications
    Modified residuei84 – 841Phosphotyrosine; by SYK2 Publications
    Modified residuei96 – 961Phosphotyrosine; by SYK2 Publications
    Modified residuei178 – 1781Phosphotyrosine; by SYK2 Publications
    Modified residuei189 – 1891Phosphotyrosine; by SYK2 Publications

    Post-translational modificationi

    Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca2+ and MAPK signaling pathways.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WV28.
    PaxDbiQ8WV28.
    PRIDEiQ8WV28.

    PTM databases

    PhosphoSiteiQ8WV28.

    Expressioni

    Tissue specificityi

    Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.

    Gene expression databases

    ArrayExpressiQ8WV28.
    BgeeiQ8WV28.
    CleanExiHS_BLNK.
    GenevestigatoriQ8WV28.

    Organism-specific databases

    HPAiCAB009333.
    CAB016291.
    HPA038309.
    HPA038310.

    Interactioni

    Subunit structurei

    Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A. Interacts (via SH2 domain) with SYK; phosphorylated and activated by SYK. Interacts with SCIMP.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARP102752EBI-2623522,EBI-608057
    BTKQ061872EBI-2623522,EBI-624835
    CD2APQ9Y5K62EBI-2623522,EBI-298152
    GRB2P629934EBI-2623522,EBI-401755
    KITP107212EBI-2623522,EBI-1379503
    SH3KBP1Q5ZMQ73EBI-2623522,EBI-7061433From a different organism.

    Protein-protein interaction databases

    BioGridi118894. 33 interactions.
    IntActiQ8WV28. 22 interactions.
    MINTiMINT-110179.
    STRINGi9606.ENSP00000224337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WV28.
    SMRiQ8WV28. Positions 331-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini346 – 453108SH2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi98 – 260163Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG44661.
    HOGENOMiHOG000088646.
    HOVERGENiHBG053147.
    InParanoidiQ8WV28.
    KOiK07371.
    OMAiHRQENMQ.
    PhylomeDBiQ8WV28.
    TreeFamiTF326567.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WV28-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR    50
    DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP 100
    VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT 150
    STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP 200
    EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA APSPLPRAGK 250
    KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ 300
    KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA 350
    CDRKSAEEAL HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF 400
    IEATKQYALG RKKNGEEYFG SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK 450
    YAVKVS 456
    Length:456
    Mass (Da):50,466
    Last modified:November 22, 2005 - v2
    Checksum:i95F1D5485D03D397
    GO
    Isoform 2 (identifier: Q8WV28-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-225: Missing.

    Show »
    Length:433
    Mass (Da):48,229
    Checksum:i0B36FE9FCF5DC7DC
    GO
    Isoform 3 (identifier: Q8WV28-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-417: Missing.

    Show »
    Length:404
    Mass (Da):44,451
    Checksum:i2288B35E399683F4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621E → Q in AAH18906. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei203 – 22523Missing in isoform 2. 1 PublicationVSP_016178Add
    BLAST
    Alternative sequencei366 – 41752Missing in isoform 3. 1 PublicationVSP_045324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068180 mRNA. Translation: AAC39936.1.
    AF068181 mRNA. Translation: AAC39937.1.
    AF180756
    , AF180740, AF180741, AF180742, AF180743, AF180744, AF180745, AF180746, AF180747, AF180748, AF180749, AF180750, AF180751, AF180752, AF180753, AF180754, AF180755 Genomic DNA. Translation: AAF20382.1.
    AF180756
    , AF180740, AF180741, AF180742, AF180743, AF180744, AF180745, AF180746, AF180748, AF180749, AF180750, AF180751, AF180752, AF180753, AF180754, AF180755 Genomic DNA. Translation: AAF20383.1.
    AM180337 mRNA. Translation: CAJ55331.1.
    AC021037 Genomic DNA. No translation available.
    BC018906 mRNA. Translation: AAH18906.1.
    CCDSiCCDS44464.1. [Q8WV28-2]
    CCDS58091.1. [Q8WV28-3]
    CCDS7446.1. [Q8WV28-1]
    RefSeqiNP_001107566.1. NM_001114094.1. [Q8WV28-2]
    NP_001245369.1. NM_001258440.1. [Q8WV28-3]
    NP_037446.1. NM_013314.3. [Q8WV28-1]
    UniGeneiHs.665244.

    Genome annotation databases

    EnsembliENST00000224337; ENSP00000224337; ENSG00000095585. [Q8WV28-1]
    ENST00000371176; ENSP00000360218; ENSG00000095585. [Q8WV28-2]
    ENST00000413476; ENSP00000397487; ENSG00000095585. [Q8WV28-3]
    GeneIDi29760.
    KEGGihsa:29760.
    UCSCiuc001kls.4. human. [Q8WV28-1]
    uc001klt.4. human. [Q8WV28-2]
    uc001klu.4. human.

    Polymorphism databases

    DMDMi82592659.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    BLNKbase

    BLNK mutation db

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068180 mRNA. Translation: AAC39936.1 .
    AF068181 mRNA. Translation: AAC39937.1 .
    AF180756
    , AF180740 , AF180741 , AF180742 , AF180743 , AF180744 , AF180745 , AF180746 , AF180747 , AF180748 , AF180749 , AF180750 , AF180751 , AF180752 , AF180753 , AF180754 , AF180755 Genomic DNA. Translation: AAF20382.1 .
    AF180756
    , AF180740 , AF180741 , AF180742 , AF180743 , AF180744 , AF180745 , AF180746 , AF180748 , AF180749 , AF180750 , AF180751 , AF180752 , AF180753 , AF180754 , AF180755 Genomic DNA. Translation: AAF20383.1 .
    AM180337 mRNA. Translation: CAJ55331.1 .
    AC021037 Genomic DNA. No translation available.
    BC018906 mRNA. Translation: AAH18906.1 .
    CCDSi CCDS44464.1. [Q8WV28-2 ]
    CCDS58091.1. [Q8WV28-3 ]
    CCDS7446.1. [Q8WV28-1 ]
    RefSeqi NP_001107566.1. NM_001114094.1. [Q8WV28-2 ]
    NP_001245369.1. NM_001258440.1. [Q8WV28-3 ]
    NP_037446.1. NM_013314.3. [Q8WV28-1 ]
    UniGenei Hs.665244.

    3D structure databases

    ProteinModelPortali Q8WV28.
    SMRi Q8WV28. Positions 331-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118894. 33 interactions.
    IntActi Q8WV28. 22 interactions.
    MINTi MINT-110179.
    STRINGi 9606.ENSP00000224337.

    PTM databases

    PhosphoSitei Q8WV28.

    Polymorphism databases

    DMDMi 82592659.

    Proteomic databases

    MaxQBi Q8WV28.
    PaxDbi Q8WV28.
    PRIDEi Q8WV28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000224337 ; ENSP00000224337 ; ENSG00000095585 . [Q8WV28-1 ]
    ENST00000371176 ; ENSP00000360218 ; ENSG00000095585 . [Q8WV28-2 ]
    ENST00000413476 ; ENSP00000397487 ; ENSG00000095585 . [Q8WV28-3 ]
    GeneIDi 29760.
    KEGGi hsa:29760.
    UCSCi uc001kls.4. human. [Q8WV28-1 ]
    uc001klt.4. human. [Q8WV28-2 ]
    uc001klu.4. human.

    Organism-specific databases

    CTDi 29760.
    GeneCardsi GC10M097941.
    HGNCi HGNC:14211. BLNK.
    HPAi CAB009333.
    CAB016291.
    HPA038309.
    HPA038310.
    MIMi 604515. gene.
    613502. phenotype.
    neXtProti NX_Q8WV28.
    Orphaneti 33110. Autosomal agammaglobulinemia.
    PharmGKBi PA25371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44661.
    HOGENOMi HOG000088646.
    HOVERGENi HBG053147.
    InParanoidi Q8WV28.
    KOi K07371.
    OMAi HRQENMQ.
    PhylomeDBi Q8WV28.
    TreeFami TF326567.

    Enzyme and pathway databases

    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_23787. Regulation of signaling by CBL.
    SignaLinki Q8WV28.

    Miscellaneous databases

    GeneWikii B-cell_linker.
    GenomeRNAii 29760.
    NextBioi 52250.
    PROi Q8WV28.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WV28.
    Bgeei Q8WV28.
    CleanExi HS_BLNK.
    Genevestigatori Q8WV28.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BLNK: a central linker protein in B cell activation."
      Fu C., Turck C.W., Kurosaki T., Chan A.C.
      Immunity 9:93-103(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 7-20; 140-146; 237-248; 250-257; 366-373 AND 392-405, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLCG1; VAV1; GRB2 AND NCK1, ALTERNATIVE SPLICING, PHOSPHORYLATION, MUTAGENESIS OF TYR-72; TYR-84; TYR-96 AND TYR-178.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), FUNCTION IN B-CELL DEVELOPMENT, INVOLVEMENT IN AGM4.
    3. "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."
      Sprangers M., Feldhahn N., Liedtke S., Jumaa H., Siebert R., Muschen M.
      Oncogene 25:5180-5186(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    6. "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation."
      Fu C., Chan A.C.
      J. Biol. Chem. 272:27362-27368(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLCG1; VAV1; GRB2 AND NCK1.
    7. "BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins."
      Chiu C.W., Dalton M., Ishiai M., Kurosaki T., Chan A.C.
      EMBO J. 21:6461-6472(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-72; TYR-84; TYR-96; TYR-178 AND TYR-189 BY SYK, MUTAGENESIS OF TYR-72; TYR-84 AND TYR-96.
    8. "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells."
      Taguchi T., Kiyokawa N., Takenouch H., Matsui J., Tang W.-R., Nakajima H., Suzuki K., Shiozawa Y., Saito M., Katagiri Y.U., Takahashi T., Karasuyama H., Matsuo Y., Okita H., Fujimoto J.
      Immunology 112:575-582(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PLCG1 ACTIVATION AND CALCIUM MOBILIZATION.
    9. "Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes."
      Grabbe A., Wienands J.
      Blood 108:3761-3768(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GRB2.
    10. "The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development."
      Kulathu Y., Hobeika E., Turchinovich G., Reth M.
      EMBO J. 27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYK.
    11. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
      Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.
      Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCIMP.

    Entry informationi

    Entry nameiBLNK_HUMAN
    AccessioniPrimary (citable) accession number: Q8WV28
    Secondary accession number(s): O75498, O75499, Q2MD49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3