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Q8WV28

- BLNK_HUMAN

UniProt

Q8WV28 - BLNK_HUMAN

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Protein

B-cell linker protein

Gene

BLNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.4 Publications

GO - Molecular functioni

  1. SH3/SH2 adaptor activity Source: UniProtKB
  2. transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. humoral immune response Source: ProtInc
  3. inflammatory response Source: ProtInc
  4. intracellular signal transduction Source: UniProtKB
  5. positive regulation of signal transduction Source: GOC
  6. transmembrane receptor protein tyrosine kinase signaling pathway Source: GOC
Complete GO annotation...

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_23787. Regulation of signaling by CBL.
SignaLinkiQ8WV28.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell linker protein
Alternative name(s):
B-cell adapter containing a SH2 domain protein
B-cell adapter containing a Src homology 2 domain protein
Cytoplasmic adapter protein
Src homology 2 domain-containing leukocyte protein of 65 kDa
Short name:
SLP-65
Gene namesi
Name:BLNK
Synonyms:BASH, SLP65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14211. BLNK.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication
Note: BCR activation results in the translocation to membrane fraction.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. intracellular Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi72 – 721Y → F: Significant phosphorylation reduction; when associated with F-84; F-96 and F-178. 2 Publications
Mutagenesisi84 – 841Y → F: Significant phosphorylation reduction; when associated with F-72; F-96 and F-178. 2 Publications
Mutagenesisi96 – 961Y → F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-178. 2 Publications
Mutagenesisi178 – 1781Y → F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-96. 1 Publication

Organism-specific databases

MIMi613502. phenotype.
Orphaneti33110. Autosomal agammaglobulinemia.
PharmGKBiPA25371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456B-cell linker proteinPRO_0000064940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Phosphotyrosine; by SYK1 Publication
Modified residuei84 – 841Phosphotyrosine; by SYK1 Publication
Modified residuei96 – 961Phosphotyrosine; by SYK1 Publication
Modified residuei178 – 1781Phosphotyrosine; by SYK1 Publication
Modified residuei189 – 1891Phosphotyrosine; by SYK1 Publication

Post-translational modificationi

Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca2+ and MAPK signaling pathways.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WV28.
PaxDbiQ8WV28.
PRIDEiQ8WV28.

PTM databases

PhosphoSiteiQ8WV28.

Expressioni

Tissue specificityi

Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.

Gene expression databases

BgeeiQ8WV28.
CleanExiHS_BLNK.
ExpressionAtlasiQ8WV28. baseline and differential.
GenevestigatoriQ8WV28.

Organism-specific databases

HPAiCAB009333.
CAB016291.
HPA038309.
HPA038310.

Interactioni

Subunit structurei

Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A. Interacts (via SH2 domain) with SYK; phosphorylated and activated by SYK. Interacts with SCIMP.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-2623522,EBI-608057
BTKQ061872EBI-2623522,EBI-624835
CD2APQ9Y5K62EBI-2623522,EBI-298152
GRB2P629934EBI-2623522,EBI-401755
KITP107212EBI-2623522,EBI-1379503
SH3KBP1Q5ZMQ73EBI-2623522,EBI-7061433From a different organism.

Protein-protein interaction databases

BioGridi118894. 33 interactions.
IntActiQ8WV28. 22 interactions.
MINTiMINT-110179.
STRINGi9606.ENSP00000224337.

Structurei

3D structure databases

ProteinModelPortaliQ8WV28.
SMRiQ8WV28. Positions 331-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini346 – 453108SH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 260163Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG44661.
GeneTreeiENSGT00530000063094.
HOGENOMiHOG000088646.
HOVERGENiHBG053147.
InParanoidiQ8WV28.
KOiK07371.
OMAiHRQENMQ.
PhylomeDBiQ8WV28.
TreeFamiTF326567.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WV28-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR
60 70 80 90 100
DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP
110 120 130 140 150
VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT
160 170 180 190 200
STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP
210 220 230 240 250
EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA APSPLPRAGK
260 270 280 290 300
KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ
310 320 330 340 350
KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA
360 370 380 390 400
CDRKSAEEAL HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF
410 420 430 440 450
IEATKQYALG RKKNGEEYFG SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK

YAVKVS
Length:456
Mass (Da):50,466
Last modified:November 22, 2005 - v2
Checksum:i95F1D5485D03D397
GO
Isoform 2 (identifier: Q8WV28-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-225: Missing.

Show »
Length:433
Mass (Da):48,229
Checksum:i0B36FE9FCF5DC7DC
GO
Isoform 3 (identifier: Q8WV28-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-417: Missing.

Show »
Length:404
Mass (Da):44,451
Checksum:i2288B35E399683F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621E → Q in AAH18906. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei203 – 22523Missing in isoform 2. 1 PublicationVSP_016178Add
BLAST
Alternative sequencei366 – 41752Missing in isoform 3. 1 PublicationVSP_045324Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068180 mRNA. Translation: AAC39936.1.
AF068181 mRNA. Translation: AAC39937.1.
AF180756
, AF180740, AF180741, AF180742, AF180743, AF180744, AF180745, AF180746, AF180747, AF180748, AF180749, AF180750, AF180751, AF180752, AF180753, AF180754, AF180755 Genomic DNA. Translation: AAF20382.1.
AF180756
, AF180740, AF180741, AF180742, AF180743, AF180744, AF180745, AF180746, AF180748, AF180749, AF180750, AF180751, AF180752, AF180753, AF180754, AF180755 Genomic DNA. Translation: AAF20383.1.
AM180337 mRNA. Translation: CAJ55331.1.
AC021037 Genomic DNA. No translation available.
BC018906 mRNA. Translation: AAH18906.1.
CCDSiCCDS44464.1. [Q8WV28-2]
CCDS58091.1. [Q8WV28-3]
CCDS7446.1. [Q8WV28-1]
RefSeqiNP_001107566.1. NM_001114094.1. [Q8WV28-2]
NP_001245369.1. NM_001258440.1. [Q8WV28-3]
NP_037446.1. NM_013314.3. [Q8WV28-1]
UniGeneiHs.665244.

Genome annotation databases

EnsembliENST00000224337; ENSP00000224337; ENSG00000095585. [Q8WV28-1]
ENST00000371176; ENSP00000360218; ENSG00000095585. [Q8WV28-2]
ENST00000413476; ENSP00000397487; ENSG00000095585. [Q8WV28-3]
GeneIDi29760.
KEGGihsa:29760.
UCSCiuc001kls.4. human. [Q8WV28-1]
uc001klt.4. human. [Q8WV28-2]
uc001klu.4. human.

Polymorphism databases

DMDMi82592659.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

BLNKbase

BLNK mutation db

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068180 mRNA. Translation: AAC39936.1 .
AF068181 mRNA. Translation: AAC39937.1 .
AF180756
, AF180740 , AF180741 , AF180742 , AF180743 , AF180744 , AF180745 , AF180746 , AF180747 , AF180748 , AF180749 , AF180750 , AF180751 , AF180752 , AF180753 , AF180754 , AF180755 Genomic DNA. Translation: AAF20382.1 .
AF180756
, AF180740 , AF180741 , AF180742 , AF180743 , AF180744 , AF180745 , AF180746 , AF180748 , AF180749 , AF180750 , AF180751 , AF180752 , AF180753 , AF180754 , AF180755 Genomic DNA. Translation: AAF20383.1 .
AM180337 mRNA. Translation: CAJ55331.1 .
AC021037 Genomic DNA. No translation available.
BC018906 mRNA. Translation: AAH18906.1 .
CCDSi CCDS44464.1. [Q8WV28-2 ]
CCDS58091.1. [Q8WV28-3 ]
CCDS7446.1. [Q8WV28-1 ]
RefSeqi NP_001107566.1. NM_001114094.1. [Q8WV28-2 ]
NP_001245369.1. NM_001258440.1. [Q8WV28-3 ]
NP_037446.1. NM_013314.3. [Q8WV28-1 ]
UniGenei Hs.665244.

3D structure databases

ProteinModelPortali Q8WV28.
SMRi Q8WV28. Positions 331-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118894. 33 interactions.
IntActi Q8WV28. 22 interactions.
MINTi MINT-110179.
STRINGi 9606.ENSP00000224337.

PTM databases

PhosphoSitei Q8WV28.

Polymorphism databases

DMDMi 82592659.

Proteomic databases

MaxQBi Q8WV28.
PaxDbi Q8WV28.
PRIDEi Q8WV28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000224337 ; ENSP00000224337 ; ENSG00000095585 . [Q8WV28-1 ]
ENST00000371176 ; ENSP00000360218 ; ENSG00000095585 . [Q8WV28-2 ]
ENST00000413476 ; ENSP00000397487 ; ENSG00000095585 . [Q8WV28-3 ]
GeneIDi 29760.
KEGGi hsa:29760.
UCSCi uc001kls.4. human. [Q8WV28-1 ]
uc001klt.4. human. [Q8WV28-2 ]
uc001klu.4. human.

Organism-specific databases

CTDi 29760.
GeneCardsi GC10M097941.
HGNCi HGNC:14211. BLNK.
HPAi CAB009333.
CAB016291.
HPA038309.
HPA038310.
MIMi 604515. gene.
613502. phenotype.
neXtProti NX_Q8WV28.
Orphaneti 33110. Autosomal agammaglobulinemia.
PharmGKBi PA25371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44661.
GeneTreei ENSGT00530000063094.
HOGENOMi HOG000088646.
HOVERGENi HBG053147.
InParanoidi Q8WV28.
KOi K07371.
OMAi HRQENMQ.
PhylomeDBi Q8WV28.
TreeFami TF326567.

Enzyme and pathway databases

Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_23787. Regulation of signaling by CBL.
SignaLinki Q8WV28.

Miscellaneous databases

GeneWikii B-cell_linker.
GenomeRNAii 29760.
NextBioi 52250.
PROi Q8WV28.
SOURCEi Search...

Gene expression databases

Bgeei Q8WV28.
CleanExi HS_BLNK.
ExpressionAtlasi Q8WV28. baseline and differential.
Genevestigatori Q8WV28.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BLNK: a central linker protein in B cell activation."
    Fu C., Turck C.W., Kurosaki T., Chan A.C.
    Immunity 9:93-103(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 7-20; 140-146; 237-248; 250-257; 366-373 AND 392-405, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLCG1; VAV1; GRB2 AND NCK1, ALTERNATIVE SPLICING, PHOSPHORYLATION, MUTAGENESIS OF TYR-72; TYR-84; TYR-96 AND TYR-178.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), FUNCTION IN B-CELL DEVELOPMENT, INVOLVEMENT IN AGM4.
  3. "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."
    Sprangers M., Feldhahn N., Liedtke S., Jumaa H., Siebert R., Muschen M.
    Oncogene 25:5180-5186(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  6. "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation."
    Fu C., Chan A.C.
    J. Biol. Chem. 272:27362-27368(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLCG1; VAV1; GRB2 AND NCK1.
  7. "BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins."
    Chiu C.W., Dalton M., Ishiai M., Kurosaki T., Chan A.C.
    EMBO J. 21:6461-6472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-72; TYR-84; TYR-96; TYR-178 AND TYR-189 BY SYK, MUTAGENESIS OF TYR-72; TYR-84 AND TYR-96.
  8. "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells."
    Taguchi T., Kiyokawa N., Takenouch H., Matsui J., Tang W.-R., Nakajima H., Suzuki K., Shiozawa Y., Saito M., Katagiri Y.U., Takahashi T., Karasuyama H., Matsuo Y., Okita H., Fujimoto J.
    Immunology 112:575-582(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PLCG1 ACTIVATION AND CALCIUM MOBILIZATION.
  9. "Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes."
    Grabbe A., Wienands J.
    Blood 108:3761-3768(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GRB2.
  10. "The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development."
    Kulathu Y., Hobeika E., Turchinovich G., Reth M.
    EMBO J. 27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYK.
  11. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
    Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.
    Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCIMP.

Entry informationi

Entry nameiBLNK_HUMAN
AccessioniPrimary (citable) accession number: Q8WV28
Secondary accession number(s): O75498, O75499, Q2MD49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3