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Protein

Pleckstrin homology-like domain family A member 1

Gene

PHLDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 1
Alternative name(s):
Apoptosis-associated nuclear protein
Proline- and glutamine-rich protein
Short name:
PQ-rich protein
Short name:
PQR protein
Proline- and histidine-rich protein
T-cell death-associated gene 51 protein
Gene namesi
Name:PHLDA1
Synonyms:PHRIP, TDAG51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:8933. PHLDA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33274.

Polymorphism and mutation databases

BioMutaiPHLDA1.
DMDMi229463035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Pleckstrin homology-like domain family A member 1PRO_0000053897Add
BLAST

Proteomic databases

EPDiQ8WV24.
MaxQBiQ8WV24.
PaxDbiQ8WV24.
PRIDEiQ8WV24.

PTM databases

iPTMnetiQ8WV24.
PhosphoSiteiQ8WV24.

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).2 Publications

Inductioni

Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.1 Publication

Gene expression databases

BgeeiQ8WV24.
CleanExiHS_PHLDA1.
ExpressionAtlasiQ8WV24. baseline and differential.
GenevisibleiQ8WV24. HS.

Organism-specific databases

HPAiCAB016160.
HPA019000.

Interactioni

Subunit structurei

Interacts with RPL14, EIF3S7 and PABPC4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3DO153712EBI-738731,EBI-353818
MDFIQ997503EBI-738731,EBI-724076
PABPC4Q133102EBI-738731,EBI-372844
RPL14P509142EBI-738731,EBI-356746

Protein-protein interaction databases

BioGridi116498. 12 interactions.
IntActiQ8WV24. 9 interactions.
MINTiMINT-1477754.
STRINGi9606.ENSP00000266671.

Structurei

3D structure databases

ProteinModelPortaliQ8WV24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 283133PHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 3463615 X 2 AA repeats of P-QAdd
BLAST
Regioni352 – 3893814 X 2 AA repeats of P-HAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 20418Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXHQ. Eukaryota.
ENOG4111IXF. LUCA.
GeneTreeiENSGT00440000039564.
HOVERGENiHBG108249.
InParanoidiQ8WV24.
OMAiGRQEPPF.
OrthoDBiEOG7NKKM7.
PhylomeDBiQ8WV24.
TreeFamiTF332320.

Family and domain databases

InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8WV24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAPAAERL LELGFPPRCG RQEPPFPLGV TRGWGRWPIQ KRREGARPVP
60 70 80 90 100
FSERSQEDGR GPAARSSGTL WRIRTRLSLC RDPEPPPPLC LLRVSLLCAL
110 120 130 140 150
RAGGRGSRWG EDGARLLLLP PARAAGNGEA EPSGGPSYAG RMLESSGCKA
160 170 180 190 200
LKEGVLEKRS DGLLQLWKKK CCILTEEGLL LIPPKQLQHQ QQQQQQQQQQ
210 220 230 240 250
QQQQPGQGPA EPSQPSGPAV ASLEPPVKLK ELHFSNMKTV DCVERKGKYM
260 270 280 290 300
YFTVVMAEGK EIDFRCPQDQ GWNAEITLQM VQYKNRQAIL AVKSTRQKQQ
310 320 330 340 350
HLVQQQPPSQ PQPQPQLQPQ PQPQPQPQPQ PQSQPQPQPQ PKPQPQQLHP
360 370 380 390 400
YPHPHPHPHS HPHSHPHPHP HPHPHQIPHP HPQPHSQPHG HRLLRSTSNS

A
Length:401
Mass (Da):45,016
Last modified:May 5, 2009 - v4
Checksum:i1E01E7F75116A517
GO

Sequence cautioni

The sequence AAH18929.3 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI10821.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI26426.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041Missing in AAF64165 (PubMed:10894922).Curated
Sequence conflicti204 – 2041Missing in CAA90576 (Ref. 2) Curated
Sequence conflicti204 – 2041Missing (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239986 Genomic DNA. Translation: AAF64165.1.
Z50194 mRNA. Translation: CAA90576.1.
BC018929 mRNA. Translation: AAH18929.3. Different initiation.
BC110820 mRNA. Translation: AAI10821.1. Different initiation.
BC126425 mRNA. Translation: AAI26426.2. Different initiation.
AF220656 mRNA. Translation: AAF36387.1.
CCDSiCCDS31861.1.
PIRiS58222.
RefSeqiNP_031376.3. NM_007350.3.
UniGeneiHs.602085.

Genome annotation databases

EnsembliENST00000266671; ENSP00000266671; ENSG00000139289.
ENST00000619060; ENSP00000480767; ENSG00000139289.
GeneIDi22822.
KEGGihsa:22822.
UCSCiuc001sxu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239986 Genomic DNA. Translation: AAF64165.1.
Z50194 mRNA. Translation: CAA90576.1.
BC018929 mRNA. Translation: AAH18929.3. Different initiation.
BC110820 mRNA. Translation: AAI10821.1. Different initiation.
BC126425 mRNA. Translation: AAI26426.2. Different initiation.
AF220656 mRNA. Translation: AAF36387.1.
CCDSiCCDS31861.1.
PIRiS58222.
RefSeqiNP_031376.3. NM_007350.3.
UniGeneiHs.602085.

3D structure databases

ProteinModelPortaliQ8WV24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116498. 12 interactions.
IntActiQ8WV24. 9 interactions.
MINTiMINT-1477754.
STRINGi9606.ENSP00000266671.

PTM databases

iPTMnetiQ8WV24.
PhosphoSiteiQ8WV24.

Polymorphism and mutation databases

BioMutaiPHLDA1.
DMDMi229463035.

Proteomic databases

EPDiQ8WV24.
MaxQBiQ8WV24.
PaxDbiQ8WV24.
PRIDEiQ8WV24.

Protocols and materials databases

DNASUi22822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266671; ENSP00000266671; ENSG00000139289.
ENST00000619060; ENSP00000480767; ENSG00000139289.
GeneIDi22822.
KEGGihsa:22822.
UCSCiuc001sxu.3. human.

Organism-specific databases

CTDi22822.
GeneCardsiPHLDA1.
H-InvDBHIX0010830.
HGNCiHGNC:8933. PHLDA1.
HPAiCAB016160.
HPA019000.
MIMi605335. gene.
neXtProtiNX_Q8WV24.
PharmGKBiPA33274.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXHQ. Eukaryota.
ENOG4111IXF. LUCA.
GeneTreeiENSGT00440000039564.
HOVERGENiHBG108249.
InParanoidiQ8WV24.
OMAiGRQEPPF.
OrthoDBiEOG7NKKM7.
PhylomeDBiQ8WV24.
TreeFamiTF332320.

Miscellaneous databases

ChiTaRSiPHLDA1. human.
GeneWikiiPHLDA1.
GenomeRNAii22822.
NextBioi43220.
PROiQ8WV24.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WV24.
CleanExiHS_PHLDA1.
ExpressionAtlasiQ8WV24. baseline and differential.
GenevisibleiQ8WV24. HS.

Family and domain databases

InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping."
    Kuske M.D., Johnson J.P.
    Cytogenet. Cell Genet. 89:1-1(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A cDNA, which predicts a protein with PQ-rich repeats, isolated from a phage library of human fetal liver tissue."
    Wagner F.F., Flegel W.A.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-401.
    Tissue: Brain and Uterus.
  4. "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation."
    Neef R., Kuske M.A., Proels E., Johnson J.P.
    Cancer Res. 62:5920-5929(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-401, TISSUE SPECIFICITY.
  5. "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product."
    Hinz T., Flindt S., Marx A., Janssen O., Kabelitz D.
    Cell. Signal. 13:345-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPL14; EIF3S7 AND PABPC4.
  6. "TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia."
    Hossain G.S., van Thienen J.V., Werstuck G.H., Zhou J., Sood S.K., Dickhout J.G., de Koning A.B., Tang D., Wu D., Falk E., Poddar R., Jacobsen D.W., Zhang K., Kaufman R.J., Austin R.C.
    J. Biol. Chem. 278:30317-30327(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPHLA1_HUMAN
AccessioniPrimary (citable) accession number: Q8WV24
Secondary accession number(s): A1A4G9
, Q15184, Q2TAN2, Q9NZ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 5, 2009
Last modified: March 16, 2016
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.