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Protein

Vesicle transport protein SFT2A

Gene

SFT2D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SFT2A
Alternative name(s):
SFT2 domain-containing protein 1
pRGR1
Gene namesi
Name:SFT2D1Imported
Synonyms:C6orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198818.9.
HGNCiHGNC:21102. SFT2D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 62LumenalSequence analysis5
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 97CytoplasmicSequence analysisAdd BLAST14
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 122LumenalSequence analysis4
Transmembranei123 – 143Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini144 – 159CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198818.
PharmGKBiPA134962126.

Polymorphism and mutation databases

BioMutaiSFT2D1.
DMDMi74751535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386071 – 159Vesicle transport protein SFT2AAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WV19.
MaxQBiQ8WV19.
PaxDbiQ8WV19.
PeptideAtlasiQ8WV19.
PRIDEiQ8WV19.

PTM databases

iPTMnetiQ8WV19.
PhosphoSitePlusiQ8WV19.
SwissPalmiQ8WV19.

Expressioni

Gene expression databases

BgeeiENSG00000198818.
CleanExiHS_SFT2D1.
GenevisibleiQ8WV19. HS.

Organism-specific databases

HPAiHPA014677.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKHB2Q96CS74EBI-2854842,EBI-373552

Protein-protein interaction databases

BioGridi125243. 12 interactors.
IntActiQ8WV19. 3 interactors.
STRINGi9606.ENSP00000354590.

Structurei

3D structure databases

ProteinModelPortaliQ8WV19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SFT2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2887. Eukaryota.
COG5102. LUCA.
GeneTreeiENSGT00390000018525.
HOGENOMiHOG000017959.
HOVERGENiHBG053306.
InParanoidiQ8WV19.
OMAiAVIKCFT.
OrthoDBiEOG091G0UCR.
PhylomeDBiQ8WV19.
TreeFamiTF315157.

Family and domain databases

InterProiView protein in InterPro
IPR007305. Vesicle_transpt_Got1/SFT2.
IPR011691. Vesicle_transpt_SFT2.
PANTHERiPTHR23137. PTHR23137. 1 hit.
PfamiView protein in Pfam
PF04178. Got1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WV19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL
60 70 80 90 100
GTGLLWLPGG IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA
110 120 130 140 150
TIVMLLCFIF TLCAALWWHK KGLAVLFCIL QFLSMTWYSL SYIPYARDAV

IKCCSSLLS
Length:159
Mass (Da):17,804
Last modified:March 1, 2002 - v1
Checksum:i0EC8A9CED7EF27E0
GO

Sequence cautioni

The sequence AAF18564 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93F → C in AAF18564 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034492109I → V. Corresponds to variant dbSNP:rs11551053Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041429 mRNA. Translation: AAF18564.1. Different initiation.
AL022069 Genomic DNA. No translation available.
AL121956 Genomic DNA. No translation available.
BC018969 mRNA. Translation: AAH18969.1.
CCDSiCCDS5292.1.
RefSeqiNP_660152.1. NM_145169.2.
UniGeneiHs.487143.

Genome annotation databases

EnsembliENST00000361731; ENSP00000354590; ENSG00000198818.
GeneIDi113402.
KEGGihsa:113402.
UCSCiuc003qux.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSFT2A_HUMAN
AccessioniPrimary (citable) accession number: Q8WV19
Secondary accession number(s): Q5TI64, Q9UIC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families