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Protein

Vesicle transport protein SFT2A

Gene

SFT2D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SFT2A
Alternative name(s):
SFT2 domain-containing protein 1
pRGR1
Gene namesi
Name:SFT2D1Imported
Synonyms:C6orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21102. SFT2D1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 625LumenalSequence analysis
Transmembranei63 – 8321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 9714CytoplasmicSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 1224LumenalSequence analysis
Transmembranei123 – 14321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini144 – 15916CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962126.

Polymorphism and mutation databases

BioMutaiSFT2D1.
DMDMi74751535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Vesicle transport protein SFT2APRO_0000238607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WV19.
MaxQBiQ8WV19.
PaxDbiQ8WV19.
PeptideAtlasiQ8WV19.
PRIDEiQ8WV19.

PTM databases

iPTMnetiQ8WV19.
PhosphoSiteiQ8WV19.
SwissPalmiQ8WV19.

Expressioni

Gene expression databases

BgeeiQ8WV19.
CleanExiHS_SFT2D1.
GenevisibleiQ8WV19. HS.

Organism-specific databases

HPAiHPA014677.

Interactioni

Protein-protein interaction databases

IntActiQ8WV19. 1 interaction.
STRINGi9606.ENSP00000354590.

Structurei

3D structure databases

ProteinModelPortaliQ8WV19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SFT2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2887. Eukaryota.
COG5102. LUCA.
GeneTreeiENSGT00390000018525.
HOGENOMiHOG000017959.
HOVERGENiHBG053306.
InParanoidiQ8WV19.
OMAiALWWRKK.
OrthoDBiEOG71CFP3.
PhylomeDBiQ8WV19.
TreeFamiTF315157.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
IPR011691. Vesicle_transpt_SFT2.
[Graphical view]
PANTHERiPTHR23137. PTHR23137. 1 hit.
PfamiPF04178. Got1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WV19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL
60 70 80 90 100
GTGLLWLPGG IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA
110 120 130 140 150
TIVMLLCFIF TLCAALWWHK KGLAVLFCIL QFLSMTWYSL SYIPYARDAV

IKCCSSLLS
Length:159
Mass (Da):17,804
Last modified:March 1, 2002 - v1
Checksum:i0EC8A9CED7EF27E0
GO

Sequence cautioni

The sequence AAF18564.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931F → C in AAF18564 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091I → V.
Corresponds to variant rs11551053 [ dbSNP | Ensembl ].
VAR_034492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041429 mRNA. Translation: AAF18564.1. Different initiation.
AL022069, AL121956 Genomic DNA. Translation: CAI19656.2.
AL121956, AL022069 Genomic DNA. Translation: CAI22197.2.
BC018969 mRNA. Translation: AAH18969.1.
CCDSiCCDS5292.1.
RefSeqiNP_660152.1. NM_145169.2.
UniGeneiHs.487143.

Genome annotation databases

EnsembliENST00000361731; ENSP00000354590; ENSG00000198818.
GeneIDi113402.
KEGGihsa:113402.
UCSCiuc003qux.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041429 mRNA. Translation: AAF18564.1. Different initiation.
AL022069, AL121956 Genomic DNA. Translation: CAI19656.2.
AL121956, AL022069 Genomic DNA. Translation: CAI22197.2.
BC018969 mRNA. Translation: AAH18969.1.
CCDSiCCDS5292.1.
RefSeqiNP_660152.1. NM_145169.2.
UniGeneiHs.487143.

3D structure databases

ProteinModelPortaliQ8WV19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8WV19. 1 interaction.
STRINGi9606.ENSP00000354590.

PTM databases

iPTMnetiQ8WV19.
PhosphoSiteiQ8WV19.
SwissPalmiQ8WV19.

Polymorphism and mutation databases

BioMutaiSFT2D1.
DMDMi74751535.

Proteomic databases

EPDiQ8WV19.
MaxQBiQ8WV19.
PaxDbiQ8WV19.
PeptideAtlasiQ8WV19.
PRIDEiQ8WV19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361731; ENSP00000354590; ENSG00000198818.
GeneIDi113402.
KEGGihsa:113402.
UCSCiuc003qux.4. human.

Organism-specific databases

CTDi113402.
GeneCardsiSFT2D1.
H-InvDBHIX0200841.
HGNCiHGNC:21102. SFT2D1.
HPAiHPA014677.
neXtProtiNX_Q8WV19.
PharmGKBiPA134962126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2887. Eukaryota.
COG5102. LUCA.
GeneTreeiENSGT00390000018525.
HOGENOMiHOG000017959.
HOVERGENiHBG053306.
InParanoidiQ8WV19.
OMAiALWWRKK.
OrthoDBiEOG71CFP3.
PhylomeDBiQ8WV19.
TreeFamiTF315157.

Miscellaneous databases

ChiTaRSiSFT2D1. human.
GenomeRNAii113402.
PROiQ8WV19.

Gene expression databases

BgeeiQ8WV19.
CleanExiHS_SFT2D1.
GenevisibleiQ8WV19. HS.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
IPR011691. Vesicle_transpt_SFT2.
[Graphical view]
PANTHERiPTHR23137. PTHR23137. 1 hit.
PfamiPF04178. Got1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hu Y.F., Mao X.H., Zhuang M., Lu C.D.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Choriocarcinoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSFT2A_HUMAN
AccessioniPrimary (citable) accession number: Q8WV19
Secondary accession number(s): Q5TI64, Q9UIC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.