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Protein

Oral cancer-overexpressed protein 1

Gene

ORAOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Amplified and overexpressed in oral cancer cells.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Oral cancer-overexpressed protein 1
Alternative name(s):
Tumor-amplified and overexpressed sequence 1
Gene namesi
Name:ORAOV1
Synonyms:TAOS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149716.12
HGNCiHGNC:17589 ORAOV1
MIMi607224 gene
neXtProtiNX_Q8WV07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi220064
OpenTargetsiENSG00000149716
PharmGKBiPA38242

Polymorphism and mutation databases

BioMutaiORAOV1
DMDMi85701377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000580752 – 137Oral cancer-overexpressed protein 1Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WV07
MaxQBiQ8WV07
PaxDbiQ8WV07
PeptideAtlasiQ8WV07
PRIDEiQ8WV07

PTM databases

iPTMnetiQ8WV07
PhosphoSitePlusiQ8WV07

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000149716
CleanExiHS_ORAOV1
ExpressionAtlasiQ8WV07 baseline and differential
GenevisibleiQ8WV07 HS

Organism-specific databases

HPAiHPA062696

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YAE1D1Q9NRH14EBI-12249832,EBI-712905

Protein-protein interaction databases

BioGridi128622, 10 interactors
IntActiQ8WV07, 1 interactor
STRINGi9606.ENSP00000279147

Structurei

3D structure databases

ProteinModelPortaliQ8WV07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORAOV1 family.Curated

Phylogenomic databases

eggNOGiKOG4595 Eukaryota
ENOG410XX62 LUCA
GeneTreeiENSGT00390000009426
HOGENOMiHOG000242351
HOVERGENiHBG053371
InParanoidiQ8WV07
OMAiKFRQVCS
PhylomeDBiQ8WV07
TreeFamiTF332075

Family and domain databases

InterProiView protein in InterPro
IPR019191 Essential_protein_Yae1_N
PfamiView protein in Pfam
PF09811 Yae1_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WV07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSQDIFDA IVMADERFHG EGYREGYEEG SSLGVMEGRQ HGTLHGAKIG
60 70 80 90 100
SEIGCYQGFA FAWKCLLHSC TTEKDSRKMK VLESLIGMIQ KFPYDDPTYD
110 120 130
KLHEDLDKIR GKFKQFCSLL NVQPDFKISA EGSGLSF
Length:137
Mass (Da):15,354
Last modified:March 1, 2004 - v2
Checksum:i7FD11DF1C08DD37A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0622313G → S. Corresponds to variant dbSNP:rs56107468Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503940 mRNA Translation: AAM97902.1
AK311918 mRNA Translation: BAG34859.1
CH471076 Genomic DNA Translation: EAW74749.1
BC019024 mRNA Translation: AAH19024.4
BC065542 mRNA Translation: AAH65542.1
CCDSiCCDS8192.1
RefSeqiNP_703152.1, NM_153451.2
XP_006718533.1, XM_006718470.2
UniGeneiHs.667996

Genome annotation databases

EnsembliENST00000279147; ENSP00000279147; ENSG00000149716
ENST00000535657; ENSP00000446129; ENSG00000149716
GeneIDi220064
KEGGihsa:220064
UCSCiuc001opc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiORAV1_HUMAN
AccessioniPrimary (citable) accession number: Q8WV07
Secondary accession number(s): B2R4R2, Q8NFK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2004
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health