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Q8WV07

- ORAV1_HUMAN

UniProt

Q8WV07 - ORAV1_HUMAN

Protein

Oral cancer-overexpressed protein 1

Gene

ORAOV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oral cancer-overexpressed protein 1
    Alternative name(s):
    Tumor-amplified and overexpressed sequence 1
    Gene namesi
    Name:ORAOV1
    Synonyms:TAOS1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:17589. ORAOV1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38242.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 137136Oral cancer-overexpressed protein 1PRO_0000058075Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei4 – 41Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WV07.
    PaxDbiQ8WV07.
    PRIDEiQ8WV07.

    PTM databases

    PhosphoSiteiQ8WV07.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ8WV07.
    BgeeiQ8WV07.
    CleanExiHS_ORAOV1.
    GenevestigatoriQ8WV07.

    Interactioni

    Protein-protein interaction databases

    BioGridi128622. 6 interactions.
    STRINGi9606.ENSP00000279147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WV07.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORAOV1 family.Curated

    Phylogenomic databases

    eggNOGiNOG313934.
    HOGENOMiHOG000242351.
    HOVERGENiHBG053371.
    InParanoidiQ8WV07.
    PhylomeDBiQ8WV07.
    TreeFamiTF332075.

    Family and domain databases

    InterProiIPR019191. Essential_protein_Yae1_N.
    [Graphical view]
    PfamiPF09811. Yae1_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WV07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSQDIFDA IVMADERFHG EGYREGYEEG SSLGVMEGRQ HGTLHGAKIG    50
    SEIGCYQGFA FAWKCLLHSC TTEKDSRKMK VLESLIGMIQ KFPYDDPTYD 100
    KLHEDLDKIR GKFKQFCSLL NVQPDFKISA EGSGLSF 137
    Length:137
    Mass (Da):15,354
    Last modified:March 1, 2004 - v2
    Checksum:i7FD11DF1C08DD37A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31G → S.
    Corresponds to variant rs56107468 [ dbSNP | Ensembl ].
    VAR_062231

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503940 mRNA. Translation: AAM97902.1.
    AK311918 mRNA. Translation: BAG34859.1.
    CH471076 Genomic DNA. Translation: EAW74749.1.
    BC019024 mRNA. Translation: AAH19024.4.
    BC065542 mRNA. Translation: AAH65542.1.
    CCDSiCCDS8192.1.
    RefSeqiNP_703152.1. NM_153451.2.
    XP_006718533.1. XM_006718470.1.
    UniGeneiHs.667996.

    Genome annotation databases

    EnsembliENST00000279147; ENSP00000279147; ENSG00000149716.
    ENST00000535657; ENSP00000446129; ENSG00000149716.
    GeneIDi220064.
    KEGGihsa:220064.
    UCSCiuc001opc.3. human.

    Polymorphism databases

    DMDMi85701377.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503940 mRNA. Translation: AAM97902.1 .
    AK311918 mRNA. Translation: BAG34859.1 .
    CH471076 Genomic DNA. Translation: EAW74749.1 .
    BC019024 mRNA. Translation: AAH19024.4 .
    BC065542 mRNA. Translation: AAH65542.1 .
    CCDSi CCDS8192.1.
    RefSeqi NP_703152.1. NM_153451.2.
    XP_006718533.1. XM_006718470.1.
    UniGenei Hs.667996.

    3D structure databases

    ProteinModelPortali Q8WV07.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128622. 6 interactions.
    STRINGi 9606.ENSP00000279147.

    PTM databases

    PhosphoSitei Q8WV07.

    Polymorphism databases

    DMDMi 85701377.

    Proteomic databases

    MaxQBi Q8WV07.
    PaxDbi Q8WV07.
    PRIDEi Q8WV07.

    Protocols and materials databases

    DNASUi 220064.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279147 ; ENSP00000279147 ; ENSG00000149716 .
    ENST00000535657 ; ENSP00000446129 ; ENSG00000149716 .
    GeneIDi 220064.
    KEGGi hsa:220064.
    UCSCi uc001opc.3. human.

    Organism-specific databases

    CTDi 220064.
    GeneCardsi GC11M069468.
    HGNCi HGNC:17589. ORAOV1.
    MIMi 607224. gene.
    neXtProti NX_Q8WV07.
    PharmGKBi PA38242.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313934.
    HOGENOMi HOG000242351.
    HOVERGENi HBG053371.
    InParanoidi Q8WV07.
    PhylomeDBi Q8WV07.
    TreeFami TF332075.

    Miscellaneous databases

    ChiTaRSi ORAOV1. human.
    GenomeRNAii 220064.
    NextBioi 90965.
    PROi Q8WV07.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WV07.
    Bgeei Q8WV07.
    CleanExi HS_ORAOV1.
    Genevestigatori Q8WV07.

    Family and domain databases

    InterProi IPR019191. Essential_protein_Yae1_N.
    [Graphical view ]
    Pfami PF09811. Yae1_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells."
      Huang X., Gollin S.M., Raja S., Godfrey T.E.
      Proc. Natl. Acad. Sci. U.S.A. 99:11369-11374(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Melanoma and Pancreatic carcinoma.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiORAV1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WV07
    Secondary accession number(s): B2R4R2, Q8NFK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Amplified and overexpressed in oral cancer cells.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3