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Protein

Oral cancer-overexpressed protein 1

Gene

ORAOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Oral cancer-overexpressed protein 1
Alternative name(s):
Tumor-amplified and overexpressed sequence 1
Gene namesi
Name:ORAOV1
Synonyms:TAOS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17589. ORAOV1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38242.

Polymorphism and mutation databases

BioMutaiORAOV1.
DMDMi85701377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 137136Oral cancer-overexpressed protein 1PRO_0000058075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei4 – 41Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WV07.
PaxDbiQ8WV07.
PRIDEiQ8WV07.

PTM databases

PhosphoSiteiQ8WV07.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8WV07.
CleanExiHS_ORAOV1.
ExpressionAtlasiQ8WV07. baseline and differential.
GenevisibleiQ8WV07. HS.

Interactioni

Protein-protein interaction databases

BioGridi128622. 5 interactions.
STRINGi9606.ENSP00000279147.

Structurei

3D structure databases

ProteinModelPortaliQ8WV07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORAOV1 family.Curated

Phylogenomic databases

eggNOGiNOG313934.
GeneTreeiENSGT00390000009426.
HOGENOMiHOG000242351.
HOVERGENiHBG053371.
InParanoidiQ8WV07.
OMAiAKFRQVC.
PhylomeDBiQ8WV07.
TreeFamiTF332075.

Family and domain databases

InterProiIPR019191. Essential_protein_Yae1_N.
[Graphical view]
PfamiPF09811. Yae1_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WV07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSQDIFDA IVMADERFHG EGYREGYEEG SSLGVMEGRQ HGTLHGAKIG
60 70 80 90 100
SEIGCYQGFA FAWKCLLHSC TTEKDSRKMK VLESLIGMIQ KFPYDDPTYD
110 120 130
KLHEDLDKIR GKFKQFCSLL NVQPDFKISA EGSGLSF
Length:137
Mass (Da):15,354
Last modified:March 1, 2004 - v2
Checksum:i7FD11DF1C08DD37A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31G → S.
Corresponds to variant rs56107468 [ dbSNP | Ensembl ].
VAR_062231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503940 mRNA. Translation: AAM97902.1.
AK311918 mRNA. Translation: BAG34859.1.
CH471076 Genomic DNA. Translation: EAW74749.1.
BC019024 mRNA. Translation: AAH19024.4.
BC065542 mRNA. Translation: AAH65542.1.
CCDSiCCDS8192.1.
RefSeqiNP_703152.1. NM_153451.2.
XP_006718533.1. XM_006718470.2.
UniGeneiHs.667996.

Genome annotation databases

EnsembliENST00000279147; ENSP00000279147; ENSG00000149716.
ENST00000535657; ENSP00000446129; ENSG00000149716.
GeneIDi220064.
KEGGihsa:220064.
UCSCiuc001opc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503940 mRNA. Translation: AAM97902.1.
AK311918 mRNA. Translation: BAG34859.1.
CH471076 Genomic DNA. Translation: EAW74749.1.
BC019024 mRNA. Translation: AAH19024.4.
BC065542 mRNA. Translation: AAH65542.1.
CCDSiCCDS8192.1.
RefSeqiNP_703152.1. NM_153451.2.
XP_006718533.1. XM_006718470.2.
UniGeneiHs.667996.

3D structure databases

ProteinModelPortaliQ8WV07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128622. 5 interactions.
STRINGi9606.ENSP00000279147.

PTM databases

PhosphoSiteiQ8WV07.

Polymorphism and mutation databases

BioMutaiORAOV1.
DMDMi85701377.

Proteomic databases

MaxQBiQ8WV07.
PaxDbiQ8WV07.
PRIDEiQ8WV07.

Protocols and materials databases

DNASUi220064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279147; ENSP00000279147; ENSG00000149716.
ENST00000535657; ENSP00000446129; ENSG00000149716.
GeneIDi220064.
KEGGihsa:220064.
UCSCiuc001opc.3. human.

Organism-specific databases

CTDi220064.
GeneCardsiGC11M069468.
HGNCiHGNC:17589. ORAOV1.
MIMi607224. gene.
neXtProtiNX_Q8WV07.
PharmGKBiPA38242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313934.
GeneTreeiENSGT00390000009426.
HOGENOMiHOG000242351.
HOVERGENiHBG053371.
InParanoidiQ8WV07.
OMAiAKFRQVC.
PhylomeDBiQ8WV07.
TreeFamiTF332075.

Miscellaneous databases

ChiTaRSiORAOV1. human.
GenomeRNAii220064.
NextBioi90965.
PROiQ8WV07.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WV07.
CleanExiHS_ORAOV1.
ExpressionAtlasiQ8WV07. baseline and differential.
GenevisibleiQ8WV07. HS.

Family and domain databases

InterProiIPR019191. Essential_protein_Yae1_N.
[Graphical view]
PfamiPF09811. Yae1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells."
    Huang X., Gollin S.M., Raja S., Godfrey T.E.
    Proc. Natl. Acad. Sci. U.S.A. 99:11369-11374(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma and Pancreatic carcinoma.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiORAV1_HUMAN
AccessioniPrimary (citable) accession number: Q8WV07
Secondary accession number(s): B2R4R2, Q8NFK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2004
Last modified: June 24, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Amplified and overexpressed in oral cancer cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.