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Protein

B-cell CLL/lymphoma 7 protein family member C

Gene

BCL7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play an anti-apoptotic role.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099385-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member C
Gene namesi
Name:BCL7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1006. BCL7C.

Pathology & Biotechi

Organism-specific databases

DisGeNETi9274.
OpenTargetsiENSG00000099385.
PharmGKBiPA25316.

Polymorphism and mutation databases

BioMutaiBCL7C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398331 – 217B-cell CLL/lymphoma 7 protein family member CAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphoserineBy similarity1
Modified residuei111PhosphothreonineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUZ0.
MaxQBiQ8WUZ0.
PaxDbiQ8WUZ0.
PeptideAtlasiQ8WUZ0.
PRIDEiQ8WUZ0.

PTM databases

iPTMnetiQ8WUZ0.
PhosphoSitePlusiQ8WUZ0.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000099385.
CleanExiHS_BCL7C.
ExpressionAtlasiQ8WUZ0. baseline and differential.
GenevisibleiQ8WUZ0. HS.

Organism-specific databases

HPAiHPA018676.
HPA052654.

Interactioni

Protein-protein interaction databases

BioGridi114691. 64 interactors.
IntActiQ8WUZ0. 9 interactors.
MINTiMINT-4535839.
STRINGi9606.ENSP00000215115.

Structurei

3D structure databases

ProteinModelPortaliQ8WUZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 217Pro-richAdd BLAST110

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ8WUZ0.
OMAiKRICPDA.
PhylomeDBiQ8WUZ0.
TreeFamiTF317441.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRTVRAET RSRAKDDIKK VMATIEKVRR WEKRWVTVGD TSLRIFKWVP
60 70 80 90 100
VVDPQEEERR RAGGGAERSR GRERRGRGAS PRGGGPLILL DLNDENSNQS
110 120 130 140 150
FHSEGSLQKG TEPSPGGTPQ PSRPVSPAGP PEGVPEEAQP PRLGQERDPG
160 170 180 190 200
GITAGSTDEP PMLTKEEPVP ELLEAEAPEA YPVFEPVPPV PEAAQGDTED
210
SEGAPPLKRI CPNAPDP
Length:217
Mass (Da):23,468
Last modified:May 18, 2010 - v3
Checksum:i379CDFFF250195A5
GO
Isoform 2 (identifier: Q8WUZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-217: APEAYPVFEP...KRICPNAPDP → DSGVRMTRRA...PRTIPQGKGR

Show »
Length:242
Mass (Da):26,422
Checksum:iE817AA957541D705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → P in CAA11754 (PubMed:9931421).Curated1
Sequence conflicti202E → G in CAA11754 (PubMed:9931421).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019282177 – 217APEAY…NAPDP → DSGVRMTRRALHEKGLKTEP LRRLLPRRGLRTNVRPSSMA VPDTRAPGGGSKAPRAPRTI PQGKGR in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223980 mRNA. Translation: CAA11754.1.
AC135048 Genomic DNA. No translation available.
BC019071 mRNA. Translation: AAH19071.1.
BC058863 mRNA. Translation: AAH58863.1.
CCDSiCCDS10693.1. [Q8WUZ0-1]
CCDS67012.1. [Q8WUZ0-2]
RefSeqiNP_001273455.1. NM_001286526.1. [Q8WUZ0-2]
NP_004756.2. NM_004765.3. [Q8WUZ0-1]
UniGeneiHs.658547.

Genome annotation databases

EnsembliENST00000215115; ENSP00000215115; ENSG00000099385. [Q8WUZ0-1]
ENST00000380317; ENSP00000369674; ENSG00000099385. [Q8WUZ0-2]
GeneIDi9274.
KEGGihsa:9274.
UCSCiuc002dzv.5. human. [Q8WUZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223980 mRNA. Translation: CAA11754.1.
AC135048 Genomic DNA. No translation available.
BC019071 mRNA. Translation: AAH19071.1.
BC058863 mRNA. Translation: AAH58863.1.
CCDSiCCDS10693.1. [Q8WUZ0-1]
CCDS67012.1. [Q8WUZ0-2]
RefSeqiNP_001273455.1. NM_001286526.1. [Q8WUZ0-2]
NP_004756.2. NM_004765.3. [Q8WUZ0-1]
UniGeneiHs.658547.

3D structure databases

ProteinModelPortaliQ8WUZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114691. 64 interactors.
IntActiQ8WUZ0. 9 interactors.
MINTiMINT-4535839.
STRINGi9606.ENSP00000215115.

PTM databases

iPTMnetiQ8WUZ0.
PhosphoSitePlusiQ8WUZ0.

Polymorphism and mutation databases

BioMutaiBCL7C.

Proteomic databases

EPDiQ8WUZ0.
MaxQBiQ8WUZ0.
PaxDbiQ8WUZ0.
PeptideAtlasiQ8WUZ0.
PRIDEiQ8WUZ0.

Protocols and materials databases

DNASUi9274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215115; ENSP00000215115; ENSG00000099385. [Q8WUZ0-1]
ENST00000380317; ENSP00000369674; ENSG00000099385. [Q8WUZ0-2]
GeneIDi9274.
KEGGihsa:9274.
UCSCiuc002dzv.5. human. [Q8WUZ0-1]

Organism-specific databases

CTDi9274.
DisGeNETi9274.
GeneCardsiBCL7C.
H-InvDBHIX0038875.
HGNCiHGNC:1006. BCL7C.
HPAiHPA018676.
HPA052654.
MIMi605847. gene.
neXtProtiNX_Q8WUZ0.
OpenTargetsiENSG00000099385.
PharmGKBiPA25316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ8WUZ0.
OMAiKRICPDA.
PhylomeDBiQ8WUZ0.
TreeFamiTF317441.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099385-MONOMER.

Miscellaneous databases

ChiTaRSiBCL7C. human.
GenomeRNAii9274.
PROiQ8WUZ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099385.
CleanExiHS_BCL7C.
ExpressionAtlasiQ8WUZ0. baseline and differential.
GenevisibleiQ8WUZ0. HS.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL7C_HUMAN
AccessioniPrimary (citable) accession number: Q8WUZ0
Secondary accession number(s): O43770, Q6PD89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.