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Protein

B-cell CLL/lymphoma 7 protein family member C

Gene

BCL7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an anti-apoptotic role.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member C
Gene namesi
Name:BCL7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000099385.11
HGNCiHGNC:1006 BCL7C
MIMi605847 gene
neXtProtiNX_Q8WUZ0

Pathology & Biotechi

Organism-specific databases

DisGeNETi9274
OpenTargetsiENSG00000099385
PharmGKBiPA25316

Polymorphism and mutation databases

BioMutaiBCL7C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398331 – 217B-cell CLL/lymphoma 7 protein family member CAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphoserineBy similarity1
Modified residuei111PhosphothreonineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUZ0
MaxQBiQ8WUZ0
PaxDbiQ8WUZ0
PeptideAtlasiQ8WUZ0
PRIDEiQ8WUZ0
ProteomicsDBi74730
74731 [Q8WUZ0-2]

PTM databases

iPTMnetiQ8WUZ0
PhosphoSitePlusiQ8WUZ0

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000099385
CleanExiHS_BCL7C
ExpressionAtlasiQ8WUZ0 baseline and differential
GenevisibleiQ8WUZ0 HS

Organism-specific databases

HPAiHPA018676
HPA052654

Interactioni

Protein-protein interaction databases

BioGridi114691, 65 interactors
ComplexPortaliCPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
IntActiQ8WUZ0, 10 interactors
MINTiQ8WUZ0
STRINGi9606.ENSP00000215115

Structurei

3D structure databases

ProteinModelPortaliQ8WUZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 217Pro-richAdd BLAST110

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095 Eukaryota
ENOG4111TES LUCA
GeneTreeiENSGT00390000002172
HOGENOMiHOG000232196
HOVERGENiHBG008481
InParanoidiQ8WUZ0
OMAiPVVDPHE
PhylomeDBiQ8WUZ0
TreeFamiTF317441

Family and domain databases

InterProiView protein in InterPro
IPR006804 BCL7
PANTHERiPTHR12767 PTHR12767, 1 hit
PfamiView protein in Pfam
PF04714 BCL_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRTVRAET RSRAKDDIKK VMATIEKVRR WEKRWVTVGD TSLRIFKWVP
60 70 80 90 100
VVDPQEEERR RAGGGAERSR GRERRGRGAS PRGGGPLILL DLNDENSNQS
110 120 130 140 150
FHSEGSLQKG TEPSPGGTPQ PSRPVSPAGP PEGVPEEAQP PRLGQERDPG
160 170 180 190 200
GITAGSTDEP PMLTKEEPVP ELLEAEAPEA YPVFEPVPPV PEAAQGDTED
210
SEGAPPLKRI CPNAPDP
Length:217
Mass (Da):23,468
Last modified:May 18, 2010 - v3
Checksum:i379CDFFF250195A5
GO
Isoform 2 (identifier: Q8WUZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-217: APEAYPVFEP...KRICPNAPDP → DSGVRMTRRA...PRTIPQGKGR

Show »
Length:242
Mass (Da):26,422
Checksum:iE817AA957541D705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → P in CAA11754 (PubMed:9931421).Curated1
Sequence conflicti202E → G in CAA11754 (PubMed:9931421).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019282177 – 217APEAY…NAPDP → DSGVRMTRRALHEKGLKTEP LRRLLPRRGLRTNVRPSSMA VPDTRAPGGGSKAPRAPRTI PQGKGR in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223980 mRNA Translation: CAA11754.1
AC135048 Genomic DNA No translation available.
BC019071 mRNA Translation: AAH19071.1
BC058863 mRNA Translation: AAH58863.1
CCDSiCCDS10693.1 [Q8WUZ0-1]
CCDS67012.1 [Q8WUZ0-2]
RefSeqiNP_001273455.1, NM_001286526.1 [Q8WUZ0-2]
NP_004756.2, NM_004765.3 [Q8WUZ0-1]
UniGeneiHs.658547

Genome annotation databases

EnsembliENST00000215115; ENSP00000215115; ENSG00000099385 [Q8WUZ0-1]
ENST00000380317; ENSP00000369674; ENSG00000099385 [Q8WUZ0-2]
GeneIDi9274
KEGGihsa:9274
UCSCiuc002dzv.5 human [Q8WUZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBCL7C_HUMAN
AccessioniPrimary (citable) accession number: Q8WUZ0
Secondary accession number(s): O43770, Q6PD89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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