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Protein

DEP domain-containing protein 1B

Gene

DEPDC1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. positive regulation of Wnt signaling pathway Source: UniProtKB
  3. regulation of small GTPase mediated signal transduction Source: Reactome
  4. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1B
Alternative name(s):
HBV X-transactivated gene 8 protein
HBV XAg-transactivated protein 8
Gene namesi
Name:DEPDC1B
Synonyms:XTP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24902. DEPDC1B.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529DEP domain-containing protein 1BPRO_0000284790Add
BLAST

Proteomic databases

MaxQBiQ8WUY9.
PaxDbiQ8WUY9.
PRIDEiQ8WUY9.

PTM databases

PhosphoSiteiQ8WUY9.

Expressioni

Gene expression databases

BgeeiQ8WUY9.
CleanExiHS_DEPDC1B.
ExpressionAtlasiQ8WUY9. baseline and differential.
GenevestigatoriQ8WUY9.

Organism-specific databases

HPAiHPA038255.

Interactioni

Protein-protein interaction databases

BioGridi120903. 4 interactions.
IntActiQ8WUY9. 1 interaction.
STRINGi9606.ENSP00000265036.

Structurei

3D structure databases

SMRiQ8WUY9. Positions 7-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10885DEPPROSITE-ProRule annotationAdd
BLAST
Domaini201 – 393193Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi468 – 4758Poly-Lys

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG148822.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000013064.
HOVERGENiHBG059792.
InParanoidiQ8WUY9.
OMAiFSHCILC.
OrthoDBiEOG74FF08.
PhylomeDBiQ8WUY9.
TreeFamiTF328365.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV
60 70 80 90 100
DWLHELLRCS QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN
110 120 130 140 150
RHLYRFPPSS PLKPYPKKPP NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM
160 170 180 190 200
NSEMWYKRHS IAIGEVPACR LVHRRQLTEA NVEEIWKSMT LSYLQKILGL
210 220 230 240 250
DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP HWVLSAMKCL
260 270 280 290 300
ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
310 320 330 340 350
LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF
360 370 380 390 400
GTRTLMVQTF SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ
410 420 430 440 450
TSIEERVAHL RRVQIKYPGA DMDITLSAPS FCRQISPEEF EYQRSYGSQE
460 470 480 490 500
PLAALLEEVI TDAKLSNKEK KKKLKQFQKS YPEVYQERFP TPESAALLFP
510 520
EKPKPKPQLL MWALKKPFQP FQRTRSFRM
Length:529
Mass (Da):61,771
Last modified:April 16, 2007 - v2
Checksum:iE640F8034BD308C6
GO
Isoform 2 (identifier: Q8WUY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-475: Missing.

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):54,726
Checksum:iC549F29AF83121F8
GO

Sequence cautioni

The sequence AAH10904.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91529.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721F → C in AAN31126 (Ref. 1) Curated
Sequence conflicti272 – 2721F → C in BAA92089 (PubMed:14702039).Curated
Sequence conflicti380 – 3801R → K in AAN31126 (Ref. 1) Curated
Sequence conflicti402 – 4021S → P in BAA92089 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321R → M.2 Publications
Corresponds to variant rs17856590 [ dbSNP | Ensembl ].
VAR_031819
Natural varianti395 – 3951V → L.2 Publications
Corresponds to variant rs17851707 [ dbSNP | Ensembl ].
VAR_031820

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei414 – 47562Missing in isoform 2. 1 PublicationVSP_042922Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
CCDSiCCDS3977.1. [Q8WUY9-1]
CCDS47214.1. [Q8WUY9-2]
RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
NP_060839.2. NM_018369.2. [Q8WUY9-1]
UniGeneiHs.482233.

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneIDi55789.
KEGGihsa:55789.
UCSCiuc003jsh.3. human. [Q8WUY9-1]
uc011cqm.2. human. [Q8WUY9-2]

Polymorphism databases

DMDMi145558895.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
CCDSiCCDS3977.1. [Q8WUY9-1]
CCDS47214.1. [Q8WUY9-2]
RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
NP_060839.2. NM_018369.2. [Q8WUY9-1]
UniGeneiHs.482233.

3D structure databases

SMRiQ8WUY9. Positions 7-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120903. 4 interactions.
IntActiQ8WUY9. 1 interaction.
STRINGi9606.ENSP00000265036.

PTM databases

PhosphoSiteiQ8WUY9.

Polymorphism databases

DMDMi145558895.

Proteomic databases

MaxQBiQ8WUY9.
PaxDbiQ8WUY9.
PRIDEiQ8WUY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneIDi55789.
KEGGihsa:55789.
UCSCiuc003jsh.3. human. [Q8WUY9-1]
uc011cqm.2. human. [Q8WUY9-2]

Organism-specific databases

CTDi55789.
GeneCardsiGC05M059892.
HGNCiHGNC:24902. DEPDC1B.
HPAiHPA038255.
MIMi616066. gene.
neXtProtiNX_Q8WUY9.
PharmGKBiPA134941087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148822.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000013064.
HOVERGENiHBG059792.
InParanoidiQ8WUY9.
OMAiFSHCILC.
OrthoDBiEOG74FF08.
PhylomeDBiQ8WUY9.
TreeFamiTF328365.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiDEPDC1B. human.
GenomeRNAii55789.
NextBioi60896.
PROiQ8WUY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUY9.
CleanExiHS_DEPDC1B.
ExpressionAtlasiQ8WUY9. baseline and differential.
GenevestigatoriQ8WUY9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcript in human breast cancer cells."
    Gokhale P.C., Kumar D., Monia B.P., Rahman A., Dritschilo A., Kasid U.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary cancer.
  2. "Cloning and identification of human gene 8 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
    Tissue: Pancreas.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiDEP1B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY9
Secondary accession number(s): A8K3R9
, B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2007
Last sequence update: April 16, 2007
Last modified: March 31, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.