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Protein

DEP domain-containing protein 1B

Gene

DEPDC1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1B
Alternative name(s):
HBV X-transactivated gene 8 protein
HBV XAg-transactivated protein 8
Gene namesi
Name:DEPDC1B
Synonyms:XTP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24902. DEPDC1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55789.
OpenTargetsiENSG00000035499.
PharmGKBiPA134941087.

Polymorphism and mutation databases

BioMutaiDEPDC1B.
DMDMi145558895.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847901 – 529DEP domain-containing protein 1BAdd BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUY9.
MaxQBiQ8WUY9.
PaxDbiQ8WUY9.
PeptideAtlasiQ8WUY9.
PRIDEiQ8WUY9.

PTM databases

iPTMnetiQ8WUY9.
PhosphoSitePlusiQ8WUY9.

Expressioni

Gene expression databases

BgeeiENSG00000035499.
CleanExiHS_DEPDC1B.
ExpressionAtlasiQ8WUY9. baseline and differential.
GenevisibleiQ8WUY9. HS.

Organism-specific databases

HPAiHPA038255.

Interactioni

Protein-protein interaction databases

BioGridi120903. 7 interactors.
IntActiQ8WUY9. 5 interactors.
STRINGi9606.ENSP00000265036.

Structurei

3D structure databases

ProteinModelPortaliQ8WUY9.
SMRiQ8WUY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 108DEPPROSITE-ProRule annotationAdd BLAST85
Domaini201 – 393Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 475Poly-Lys8

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEI5. Eukaryota.
ENOG410YMM7. LUCA.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000013064.
HOVERGENiHBG059792.
InParanoidiQ8WUY9.
OMAiECKLIRR.
OrthoDBiEOG091G04WW.
PhylomeDBiQ8WUY9.
TreeFamiTF328365.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV
60 70 80 90 100
DWLHELLRCS QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN
110 120 130 140 150
RHLYRFPPSS PLKPYPKKPP NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM
160 170 180 190 200
NSEMWYKRHS IAIGEVPACR LVHRRQLTEA NVEEIWKSMT LSYLQKILGL
210 220 230 240 250
DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP HWVLSAMKCL
260 270 280 290 300
ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
310 320 330 340 350
LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF
360 370 380 390 400
GTRTLMVQTF SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ
410 420 430 440 450
TSIEERVAHL RRVQIKYPGA DMDITLSAPS FCRQISPEEF EYQRSYGSQE
460 470 480 490 500
PLAALLEEVI TDAKLSNKEK KKKLKQFQKS YPEVYQERFP TPESAALLFP
510 520
EKPKPKPQLL MWALKKPFQP FQRTRSFRM
Length:529
Mass (Da):61,771
Last modified:April 17, 2007 - v2
Checksum:iE640F8034BD308C6
GO
Isoform 2 (identifier: Q8WUY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-475: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):54,726
Checksum:iC549F29AF83121F8
GO

Sequence cautioni

The sequence AAH10904 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91529 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272F → C in AAN31126 (Ref. 1) Curated1
Sequence conflicti272F → C in BAA92089 (PubMed:14702039).Curated1
Sequence conflicti380R → K in AAN31126 (Ref. 1) Curated1
Sequence conflicti402S → P in BAA92089 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031819332R → M.2 PublicationsCorresponds to variant rs17856590dbSNPEnsembl.1
Natural variantiVAR_031820395V → L.2 PublicationsCorresponds to variant rs17851707dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042922414 – 475Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
CCDSiCCDS3977.1. [Q8WUY9-1]
CCDS47214.1. [Q8WUY9-2]
RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
NP_060839.2. NM_018369.2. [Q8WUY9-1]
UniGeneiHs.482233.

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneIDi55789.
KEGGihsa:55789.
UCSCiuc003jsh.4. human. [Q8WUY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
CCDSiCCDS3977.1. [Q8WUY9-1]
CCDS47214.1. [Q8WUY9-2]
RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
NP_060839.2. NM_018369.2. [Q8WUY9-1]
UniGeneiHs.482233.

3D structure databases

ProteinModelPortaliQ8WUY9.
SMRiQ8WUY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120903. 7 interactors.
IntActiQ8WUY9. 5 interactors.
STRINGi9606.ENSP00000265036.

PTM databases

iPTMnetiQ8WUY9.
PhosphoSitePlusiQ8WUY9.

Polymorphism and mutation databases

BioMutaiDEPDC1B.
DMDMi145558895.

Proteomic databases

EPDiQ8WUY9.
MaxQBiQ8WUY9.
PaxDbiQ8WUY9.
PeptideAtlasiQ8WUY9.
PRIDEiQ8WUY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneIDi55789.
KEGGihsa:55789.
UCSCiuc003jsh.4. human. [Q8WUY9-1]

Organism-specific databases

CTDi55789.
DisGeNETi55789.
GeneCardsiDEPDC1B.
HGNCiHGNC:24902. DEPDC1B.
HPAiHPA038255.
MIMi616066. gene.
neXtProtiNX_Q8WUY9.
OpenTargetsiENSG00000035499.
PharmGKBiPA134941087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI5. Eukaryota.
ENOG410YMM7. LUCA.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000013064.
HOVERGENiHBG059792.
InParanoidiQ8WUY9.
OMAiECKLIRR.
OrthoDBiEOG091G04WW.
PhylomeDBiQ8WUY9.
TreeFamiTF328365.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiDEPDC1B. human.
GenomeRNAii55789.
PROiQ8WUY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000035499.
CleanExiHS_DEPDC1B.
ExpressionAtlasiQ8WUY9. baseline and differential.
GenevisibleiQ8WUY9. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEP1B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY9
Secondary accession number(s): A8K3R9
, B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.