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Q8WUY9 (DEP1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DEP domain-containing protein 1B
Alternative name(s):
HBV X-transactivated gene 8 protein
HBV XAg-transactivated protein 8
Gene names
Name:DEPDC1B
Synonyms:XTP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 DEP domain.

Contains 1 Rho-GAP domain.

Sequence caution

The sequence AAH10904.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA91529.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WUY9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WUY9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     414-475: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529DEP domain-containing protein 1B
PRO_0000284790

Regions

Domain24 – 10885DEP
Domain201 – 393193Rho-GAP
Compositional bias468 – 4758Poly-Lys

Amino acid modifications

Modified residue4361Phosphoserine Ref.8

Natural variations

Alternative sequence414 – 47562Missing in isoform 2.
VSP_042922
Natural variant3321R → M. Ref.2 Ref.6
Corresponds to variant rs17856590 [ dbSNP | Ensembl ].
VAR_031819
Natural variant3951V → L. Ref.2 Ref.6
Corresponds to variant rs17851707 [ dbSNP | Ensembl ].
VAR_031820

Experimental info

Sequence conflict2721F → C in AAN31126. Ref.1
Sequence conflict2721F → C in BAA92089. Ref.3
Sequence conflict3801R → K in AAN31126. Ref.1
Sequence conflict4021S → P in BAA92089. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: E640F8034BD308C6

FASTA52961,771
        10         20         30         40         50         60 
MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV DWLHELLRCS 

        70         80         90        100        110        120 
QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN RHLYRFPPSS PLKPYPKKPP 

       130        140        150        160        170        180 
NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM NSEMWYKRHS IAIGEVPACR LVHRRQLTEA 

       190        200        210        220        230        240 
NVEEIWKSMT LSYLQKILGL DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP 

       250        260        270        280        290        300 
HWVLSAMKCL ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG 

       310        320        330        340        350        360 
LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF GTRTLMVQTF 

       370        380        390        400        410        420 
SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ TSIEERVAHL RRVQIKYPGA 

       430        440        450        460        470        480 
DMDITLSAPS FCRQISPEEF EYQRSYGSQE PLAALLEEVI TDAKLSNKEK KKKLKQFQKS 

       490        500        510        520 
YPEVYQERFP TPESAALLFP EKPKPKPQLL MWALKKPFQP FQRTRSFRM 

« Hide

Isoform 2 [UniParc].

Checksum: C549F29AF83121F8
Show »

FASTA46754,726

References

« Hide 'large scale' references
[1]"Novel transcript in human breast cancer cells."
Gokhale P.C., Kumar D., Monia B.P., Rahman A., Dritschilo A., Kasid U.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Mammary cancer.
[2]"Cloning and identification of human gene 8 transactivated by hepatitis B virus X antigen."
Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
Tissue: Pancreas.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
RefSeqNP_001138680.1. NM_001145208.1.
NP_060839.2. NM_018369.2.
UniGeneHs.482233.

3D structure databases

ProteinModelPortalQ8WUY9.
SMRQ8WUY9. Positions 7-107, 269-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120903. 3 interactions.
IntActQ8WUY9. 1 interaction.
STRING9606.ENSP00000265036.

PTM databases

PhosphoSiteQ8WUY9.

Polymorphism databases

DMDM145558895.

Proteomic databases

PaxDbQ8WUY9.
PRIDEQ8WUY9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneID55789.
KEGGhsa:55789.
UCSCuc003jsh.3. human. [Q8WUY9-1]
uc011cqm.2. human. [Q8WUY9-2]

Organism-specific databases

CTD55789.
GeneCardsGC05M059928.
HGNCHGNC:24902. DEPDC1B.
HPAHPA038255.
neXtProtNX_Q8WUY9.
PharmGKBPA134941087.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148822.
HOGENOMHOG000013064.
HOVERGENHBG059792.
InParanoidQ8WUY9.
OMAFSHCILC.
OrthoDBEOG74FF08.
PhylomeDBQ8WUY9.
TreeFamTF328365.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ8WUY9.
BgeeQ8WUY9.
CleanExHS_DEPDC1B.
GenevestigatorQ8WUY9.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55789.
NextBio60896.
PROQ8WUY9.

Entry information

Entry nameDEP1B_HUMAN
AccessionPrimary (citable) accession number: Q8WUY9
Secondary accession number(s): A8K3R9 expand/collapse secondary AC list , B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM