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Q8WUY9

- DEP1B_HUMAN

UniProt

Q8WUY9 - DEP1B_HUMAN

Protein

DEP domain-containing protein 1B

Gene

DEPDC1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: Reactome
    2. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DEP domain-containing protein 1B
    Alternative name(s):
    HBV X-transactivated gene 8 protein
    HBV XAg-transactivated protein 8
    Gene namesi
    Name:DEPDC1B
    Synonyms:XTP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24902. DEPDC1B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941087.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529DEP domain-containing protein 1BPRO_0000284790Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei436 – 4361Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WUY9.
    PaxDbiQ8WUY9.
    PRIDEiQ8WUY9.

    PTM databases

    PhosphoSiteiQ8WUY9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WUY9.
    BgeeiQ8WUY9.
    CleanExiHS_DEPDC1B.
    GenevestigatoriQ8WUY9.

    Organism-specific databases

    HPAiHPA038255.

    Interactioni

    Protein-protein interaction databases

    BioGridi120903. 3 interactions.
    IntActiQ8WUY9. 1 interaction.
    STRINGi9606.ENSP00000265036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUY9.
    SMRiQ8WUY9. Positions 7-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10885DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini201 – 393193Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi468 – 4758Poly-Lys

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG148822.
    HOGENOMiHOG000013064.
    HOVERGENiHBG059792.
    InParanoidiQ8WUY9.
    OMAiPSFCHQI.
    OrthoDBiEOG74FF08.
    PhylomeDBiQ8WUY9.
    TreeFamiTF328365.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.555.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00049. DEP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUY9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV    50
    DWLHELLRCS QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN 100
    RHLYRFPPSS PLKPYPKKPP NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM 150
    NSEMWYKRHS IAIGEVPACR LVHRRQLTEA NVEEIWKSMT LSYLQKILGL 200
    DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP HWVLSAMKCL 250
    ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG 300
    LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF 350
    GTRTLMVQTF SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ 400
    TSIEERVAHL RRVQIKYPGA DMDITLSAPS FCRQISPEEF EYQRSYGSQE 450
    PLAALLEEVI TDAKLSNKEK KKKLKQFQKS YPEVYQERFP TPESAALLFP 500
    EKPKPKPQLL MWALKKPFQP FQRTRSFRM 529
    Length:529
    Mass (Da):61,771
    Last modified:April 17, 2007 - v2
    Checksum:iE640F8034BD308C6
    GO
    Isoform 2 (identifier: Q8WUY9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         414-475: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:467
    Mass (Da):54,726
    Checksum:iC549F29AF83121F8
    GO

    Sequence cautioni

    The sequence AAH10904.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91529.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721F → C in AAN31126. 1 PublicationCurated
    Sequence conflicti272 – 2721F → C in BAA92089. (PubMed:14702039)Curated
    Sequence conflicti380 – 3801R → K in AAN31126. 1 PublicationCurated
    Sequence conflicti402 – 4021S → P in BAA92089. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti332 – 3321R → M.2 Publications
    Corresponds to variant rs17856590 [ dbSNP | Ensembl ].
    VAR_031819
    Natural varianti395 – 3951V → L.2 Publications
    Corresponds to variant rs17851707 [ dbSNP | Ensembl ].
    VAR_031820

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei414 – 47562Missing in isoform 2. 1 PublicationVSP_042922Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303178 mRNA. Translation: AAN31126.1.
    AF488828 mRNA. Translation: AAO49477.1.
    AF490257 mRNA. Translation: AAO85465.1.
    AK001166 mRNA. Translation: BAA91529.1. Different initiation.
    AK002114 mRNA. Translation: BAA92089.1.
    AK290684 mRNA. Translation: BAF83373.1.
    AK300782 mRNA. Translation: BAG62446.1.
    AC016591 Genomic DNA. No translation available.
    AC109133 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54998.1.
    BC010904 mRNA. Translation: AAH10904.1. Different initiation.
    BC019075 mRNA. Translation: AAH19075.1.
    CCDSiCCDS3977.1. [Q8WUY9-1]
    CCDS47214.1. [Q8WUY9-2]
    RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
    NP_060839.2. NM_018369.2. [Q8WUY9-1]
    UniGeneiHs.482233.

    Genome annotation databases

    EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
    ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
    GeneIDi55789.
    KEGGihsa:55789.
    UCSCiuc003jsh.3. human. [Q8WUY9-1]
    uc011cqm.2. human. [Q8WUY9-2]

    Polymorphism databases

    DMDMi145558895.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303178 mRNA. Translation: AAN31126.1 .
    AF488828 mRNA. Translation: AAO49477.1 .
    AF490257 mRNA. Translation: AAO85465.1 .
    AK001166 mRNA. Translation: BAA91529.1 . Different initiation.
    AK002114 mRNA. Translation: BAA92089.1 .
    AK290684 mRNA. Translation: BAF83373.1 .
    AK300782 mRNA. Translation: BAG62446.1 .
    AC016591 Genomic DNA. No translation available.
    AC109133 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54998.1 .
    BC010904 mRNA. Translation: AAH10904.1 . Different initiation.
    BC019075 mRNA. Translation: AAH19075.1 .
    CCDSi CCDS3977.1. [Q8WUY9-1 ]
    CCDS47214.1. [Q8WUY9-2 ]
    RefSeqi NP_001138680.1. NM_001145208.1. [Q8WUY9-2 ]
    NP_060839.2. NM_018369.2. [Q8WUY9-1 ]
    UniGenei Hs.482233.

    3D structure databases

    ProteinModelPortali Q8WUY9.
    SMRi Q8WUY9. Positions 7-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120903. 3 interactions.
    IntActi Q8WUY9. 1 interaction.
    STRINGi 9606.ENSP00000265036.

    PTM databases

    PhosphoSitei Q8WUY9.

    Polymorphism databases

    DMDMi 145558895.

    Proteomic databases

    MaxQBi Q8WUY9.
    PaxDbi Q8WUY9.
    PRIDEi Q8WUY9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265036 ; ENSP00000265036 ; ENSG00000035499 . [Q8WUY9-1 ]
    ENST00000453022 ; ENSP00000389101 ; ENSG00000035499 . [Q8WUY9-2 ]
    GeneIDi 55789.
    KEGGi hsa:55789.
    UCSCi uc003jsh.3. human. [Q8WUY9-1 ]
    uc011cqm.2. human. [Q8WUY9-2 ]

    Organism-specific databases

    CTDi 55789.
    GeneCardsi GC05M059928.
    HGNCi HGNC:24902. DEPDC1B.
    HPAi HPA038255.
    neXtProti NX_Q8WUY9.
    PharmGKBi PA134941087.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148822.
    HOGENOMi HOG000013064.
    HOVERGENi HBG059792.
    InParanoidi Q8WUY9.
    OMAi PSFCHQI.
    OrthoDBi EOG74FF08.
    PhylomeDBi Q8WUY9.
    TreeFami TF328365.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    GenomeRNAii 55789.
    NextBioi 60896.
    PROi Q8WUY9.

    Gene expression databases

    ArrayExpressi Q8WUY9.
    Bgeei Q8WUY9.
    CleanExi HS_DEPDC1B.
    Genevestigatori Q8WUY9.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.555.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00049. DEP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel transcript in human breast cancer cells."
      Gokhale P.C., Kumar D., Monia B.P., Rahman A., Dritschilo A., Kasid U.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary cancer.
    2. "Cloning and identification of human gene 8 transactivated by hepatitis B virus X antigen."
      Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
      Tissue: Pancreas.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDEP1B_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUY9
    Secondary accession number(s): A8K3R9
    , B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3