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Q8WUY9

- DEP1B_HUMAN

UniProt

Q8WUY9 - DEP1B_HUMAN

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Protein
DEP domain-containing protein 1B
Gene
DEPDC1B, XTP8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: Reactome
  2. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1B
Alternative name(s):
HBV X-transactivated gene 8 protein
HBV XAg-transactivated protein 8
Gene namesi
Name:DEPDC1B
Synonyms:XTP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24902. DEPDC1B.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529DEP domain-containing protein 1B
PRO_0000284790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei436 – 4361Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WUY9.
PaxDbiQ8WUY9.
PRIDEiQ8WUY9.

PTM databases

PhosphoSiteiQ8WUY9.

Expressioni

Gene expression databases

ArrayExpressiQ8WUY9.
BgeeiQ8WUY9.
CleanExiHS_DEPDC1B.
GenevestigatoriQ8WUY9.

Organism-specific databases

HPAiHPA038255.

Interactioni

Protein-protein interaction databases

BioGridi120903. 3 interactions.
IntActiQ8WUY9. 1 interaction.
STRINGi9606.ENSP00000265036.

Structurei

3D structure databases

ProteinModelPortaliQ8WUY9.
SMRiQ8WUY9. Positions 7-107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10885DEP
Add
BLAST
Domaini201 – 393193Rho-GAP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi468 – 4758Poly-Lys

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 Rho-GAP domain.

Phylogenomic databases

eggNOGiNOG148822.
HOGENOMiHOG000013064.
HOVERGENiHBG059792.
InParanoidiQ8WUY9.
OMAiPSFCHQI.
OrthoDBiEOG74FF08.
PhylomeDBiQ8WUY9.
TreeFamiTF328365.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WUY9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV    50
DWLHELLRCS QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN 100
RHLYRFPPSS PLKPYPKKPP NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM 150
NSEMWYKRHS IAIGEVPACR LVHRRQLTEA NVEEIWKSMT LSYLQKILGL 200
DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP HWVLSAMKCL 250
ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG 300
LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF 350
GTRTLMVQTF SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ 400
TSIEERVAHL RRVQIKYPGA DMDITLSAPS FCRQISPEEF EYQRSYGSQE 450
PLAALLEEVI TDAKLSNKEK KKKLKQFQKS YPEVYQERFP TPESAALLFP 500
EKPKPKPQLL MWALKKPFQP FQRTRSFRM 529
Length:529
Mass (Da):61,771
Last modified:April 17, 2007 - v2
Checksum:iE640F8034BD308C6
GO
Isoform 2 (identifier: Q8WUY9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-475: Missing.

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):54,726
Checksum:iC549F29AF83121F8
GO

Sequence cautioni

The sequence AAH10904.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91529.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321R → M.2 Publications
Corresponds to variant rs17856590 [ dbSNP | Ensembl ].
VAR_031819
Natural varianti395 – 3951V → L.2 Publications
Corresponds to variant rs17851707 [ dbSNP | Ensembl ].
VAR_031820

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei414 – 47562Missing in isoform 2.
VSP_042922Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721F → C in AAN31126. 1 Publication
Sequence conflicti272 – 2721F → C in BAA92089. 1 Publication
Sequence conflicti380 – 3801R → K in AAN31126. 1 Publication
Sequence conflicti402 – 4021S → P in BAA92089. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303178 mRNA. Translation: AAN31126.1.
AF488828 mRNA. Translation: AAO49477.1.
AF490257 mRNA. Translation: AAO85465.1.
AK001166 mRNA. Translation: BAA91529.1. Different initiation.
AK002114 mRNA. Translation: BAA92089.1.
AK290684 mRNA. Translation: BAF83373.1.
AK300782 mRNA. Translation: BAG62446.1.
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1.
BC010904 mRNA. Translation: AAH10904.1. Different initiation.
BC019075 mRNA. Translation: AAH19075.1.
CCDSiCCDS3977.1. [Q8WUY9-1]
CCDS47214.1. [Q8WUY9-2]
RefSeqiNP_001138680.1. NM_001145208.1. [Q8WUY9-2]
NP_060839.2. NM_018369.2. [Q8WUY9-1]
UniGeneiHs.482233.

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499. [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499. [Q8WUY9-2]
GeneIDi55789.
KEGGihsa:55789.
UCSCiuc003jsh.3. human. [Q8WUY9-1]
uc011cqm.2. human. [Q8WUY9-2]

Polymorphism databases

DMDMi145558895.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303178 mRNA. Translation: AAN31126.1 .
AF488828 mRNA. Translation: AAO49477.1 .
AF490257 mRNA. Translation: AAO85465.1 .
AK001166 mRNA. Translation: BAA91529.1 . Different initiation.
AK002114 mRNA. Translation: BAA92089.1 .
AK290684 mRNA. Translation: BAF83373.1 .
AK300782 mRNA. Translation: BAG62446.1 .
AC016591 Genomic DNA. No translation available.
AC109133 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54998.1 .
BC010904 mRNA. Translation: AAH10904.1 . Different initiation.
BC019075 mRNA. Translation: AAH19075.1 .
CCDSi CCDS3977.1. [Q8WUY9-1 ]
CCDS47214.1. [Q8WUY9-2 ]
RefSeqi NP_001138680.1. NM_001145208.1. [Q8WUY9-2 ]
NP_060839.2. NM_018369.2. [Q8WUY9-1 ]
UniGenei Hs.482233.

3D structure databases

ProteinModelPortali Q8WUY9.
SMRi Q8WUY9. Positions 7-107.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120903. 3 interactions.
IntActi Q8WUY9. 1 interaction.
STRINGi 9606.ENSP00000265036.

PTM databases

PhosphoSitei Q8WUY9.

Polymorphism databases

DMDMi 145558895.

Proteomic databases

MaxQBi Q8WUY9.
PaxDbi Q8WUY9.
PRIDEi Q8WUY9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265036 ; ENSP00000265036 ; ENSG00000035499 . [Q8WUY9-1 ]
ENST00000453022 ; ENSP00000389101 ; ENSG00000035499 . [Q8WUY9-2 ]
GeneIDi 55789.
KEGGi hsa:55789.
UCSCi uc003jsh.3. human. [Q8WUY9-1 ]
uc011cqm.2. human. [Q8WUY9-2 ]

Organism-specific databases

CTDi 55789.
GeneCardsi GC05M059928.
HGNCi HGNC:24902. DEPDC1B.
HPAi HPA038255.
neXtProti NX_Q8WUY9.
PharmGKBi PA134941087.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148822.
HOGENOMi HOG000013064.
HOVERGENi HBG059792.
InParanoidi Q8WUY9.
OMAi PSFCHQI.
OrthoDBi EOG74FF08.
PhylomeDBi Q8WUY9.
TreeFami TF328365.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii 55789.
NextBioi 60896.
PROi Q8WUY9.

Gene expression databases

ArrayExpressi Q8WUY9.
Bgeei Q8WUY9.
CleanExi HS_DEPDC1B.
Genevestigatori Q8WUY9.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.555.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00049. DEP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcript in human breast cancer cells."
    Gokhale P.C., Kumar D., Monia B.P., Rahman A., Dritschilo A., Kasid U.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary cancer.
  2. "Cloning and identification of human gene 8 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-332 AND LEU-395.
    Tissue: Pancreas.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDEP1B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY9
Secondary accession number(s): A8K3R9
, B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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