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Protein

N-acetyltransferase 14

Gene

NAT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, initiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 14 (EC:2.3.1.-)
Alternative name(s):
K562 cell-derived leucine-zipper-like protein 1
Gene namesi
Name:NAT14
Synonyms:KLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28918. NAT14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396977.

Polymorphism and mutation databases

BioMutaiNAT14.
DMDMi74730785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206N-acetyltransferase 14PRO_0000307786Add
BLAST

Proteomic databases

EPDiQ8WUY8.
MaxQBiQ8WUY8.
PaxDbiQ8WUY8.
PeptideAtlasiQ8WUY8.
PRIDEiQ8WUY8.

PTM databases

SwissPalmiQ8WUY8.

Expressioni

Tissue specificityi

Expressed in K-562 and HeLa cell lines and in brain.1 Publication

Gene expression databases

BgeeiQ8WUY8.
CleanExiHS_NAT14.
ExpressionAtlasiQ8WUY8. baseline and differential.
GenevisibleiQ8WUY8. HS.

Interactioni

Protein-protein interaction databases

BioGridi121372. 20 interactions.
IntActiQ8WUY8. 3 interactions.
MINTiMINT-8247387.
STRINGi9606.ENSP00000205194.

Structurei

3D structure databases

ProteinModelPortaliQ8WUY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 206201N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the camello family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB7C. Eukaryota.
ENOG4112DCG. LUCA.
GeneTreeiENSGT00390000006838.
HOGENOMiHOG000113732.
HOVERGENiHBG098452.
InParanoidiQ8WUY8.
OMAiEACGYQA.
OrthoDBiEOG7S4X81.
PhylomeDBiQ8WUY8.
TreeFamiTF336981.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA
60 70 80 90 100
ASSGLRFVLA SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA
110 120 130 140 150
VRGSGDVCGV LALAPGTNAG DGARVTRLSV SRWHRRRGVG RRLLAFAEAR
160 170 180 190 200
ARAWAGGMGE PRARLVVPVA VAAWGVGGML EGCGYQAEGG WGCLGYTLVR

EFSKDL
Length:206
Mass (Da):21,650
Last modified:March 1, 2002 - v1
Checksum:iEA8CF3AD64627970
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 244Missing in BAB85857 (PubMed:11779635).Curated
Sequence conflicti187 – 1871A → V in BAB03716 (PubMed:10873651).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038651 mRNA. Translation: BAB03716.1.
AB055059 Genomic DNA. Translation: BAB85857.1.
BC019079 mRNA. Translation: AAH19079.1.
CCDSiCCDS12926.1.
PIRiJC7320.
RefSeqiNP_065111.1. NM_020378.3.
UniGeneiHs.31854.
Hs.745066.

Genome annotation databases

EnsembliENST00000205194; ENSP00000205194; ENSG00000090971.
GeneIDi57106.
KEGGihsa:57106.
UCSCiuc002qle.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038651 mRNA. Translation: BAB03716.1.
AB055059 Genomic DNA. Translation: BAB85857.1.
BC019079 mRNA. Translation: AAH19079.1.
CCDSiCCDS12926.1.
PIRiJC7320.
RefSeqiNP_065111.1. NM_020378.3.
UniGeneiHs.31854.
Hs.745066.

3D structure databases

ProteinModelPortaliQ8WUY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121372. 20 interactions.
IntActiQ8WUY8. 3 interactions.
MINTiMINT-8247387.
STRINGi9606.ENSP00000205194.

PTM databases

SwissPalmiQ8WUY8.

Polymorphism and mutation databases

BioMutaiNAT14.
DMDMi74730785.

Proteomic databases

EPDiQ8WUY8.
MaxQBiQ8WUY8.
PaxDbiQ8WUY8.
PeptideAtlasiQ8WUY8.
PRIDEiQ8WUY8.

Protocols and materials databases

DNASUi57106.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205194; ENSP00000205194; ENSG00000090971.
GeneIDi57106.
KEGGihsa:57106.
UCSCiuc002qle.3. human.

Organism-specific databases

CTDi57106.
GeneCardsiNAT14.
HGNCiHGNC:28918. NAT14.
neXtProtiNX_Q8WUY8.
PharmGKBiPA162396977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB7C. Eukaryota.
ENOG4112DCG. LUCA.
GeneTreeiENSGT00390000006838.
HOGENOMiHOG000113732.
HOVERGENiHBG098452.
InParanoidiQ8WUY8.
OMAiEACGYQA.
OrthoDBiEOG7S4X81.
PhylomeDBiQ8WUY8.
TreeFamiTF336981.

Miscellaneous databases

GenomeRNAii57106.
PROiQ8WUY8.

Gene expression databases

BgeeiQ8WUY8.
CleanExiHS_NAT14.
ExpressionAtlasiQ8WUY8. baseline and differential.
GenevisibleiQ8WUY8. HS.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DNA-BINDING, TISSUE SPECIFICITY.
  2. "Genomic structure and regulation of a novel human gene, Klp1."
    Takahashi S., Harigae H., Yokoyama H., Kaku M., Sasaki T.
    Biochim. Biophys. Acta 1522:207-211(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiNAT14_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY8
Secondary accession number(s): Q8TDY7, Q9NS72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.