Q8WUY8 (NAT14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyltransferase 14
EC=2.3.1.-

Alternative name(s):
K562 cell-derived leucine-zipper-like protein 1

Gene names

Name:	NAT14
Synonyms:	KLP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. Ref.1
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in K562 cells, HeLa cells and brain. Ref.1
Sequence similarities	Belongs to the camello family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	DNA-binding
Molecular function	Activator Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB transcription initiation, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	N-acetyltransferase 14		PRO_0000307786
Regions
	Transmembrane	57 – 77	21	Helical; Potential
	Domain	6 – 206	201	N-acetyltransferase
Experimental info
	Sequence conflict	21 – 24	4	Missing in BAB85857. Ref.2
	Sequence conflict	187	1	A → V in BAB03716. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WUY8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: EA8CF3AD64627970	FASTA	206	21,650
	10 20 30 40 50 60 MAPSHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA ASSGLRFVLA 70 80 90 100 110 120 SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA VRGSGDVCGV LALAPGTNAG 130 140 150 160 170 180 DGARVTRLSV SRWHRRRGVG RRLLAFAEAR ARAWAGGMGE PRARLVVPVA VAAWGVGGML 190 200 EGCGYQAEGG WGCLGYTLVR EFSKDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein." Takahashi S., Furuyama K., Kobayashi A., Taketani S., Harigae H., Yamamoto M., Igarashi K., Sasaki T., Hayashi N. Biochem. Biophys. Res. Commun. 273:596-602(2000) [PubMed: 10873651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DNA-BINDING, TISSUE SPECIFICITY.
[2]	"Genomic structure and regulation of a novel human gene, Klp1." Takahashi S., Harigae H., Yokoyama H., Kaku M., Sasaki T. Biochim. Biophys. Acta 1522:207-211(2001) [PubMed: 11779635] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB038651 mRNA. Translation: BAB03716.1. AB055059 Genomic DNA. Translation: BAB85857.1. BC019079 mRNA. Translation: AAH19079.1.
IPI	IPI00103059.
PIR	JC7320.
RefSeq	NP_065111.1. NM_020378.3.
UniGene	Hs.31854. Hs.728300.
3D structure databases
ProteinModelPortal	Q8WUY8.
SMR	Q8WUY8. Positions 91-189.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WUY8. 1 interaction.
STRING	Q8WUY8.
Polymorphism databases
DMDM	74730785.
Proteomic databases
PRIDE	Q8WUY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000205194; ENSP00000205194; ENSG00000090971.
GeneID	57106.
KEGG	hsa:57106.
UCSC	uc002qle.1. human.
Organism-specific databases
CTD	57106.
GeneCards	GC19P055996.
H-InvDB	HIX0015471.
HGNC	HGNC:28918. NAT14.
neXtProt	NX_Q8WUY8.
PharmGKB	PA162396977.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21022.
GeneTree	ENSGT00390000006838.
HOGENOM	HBG126937.
HOVERGEN	HBG098452.
InParanoid	Q8WUY8.
OMA	EGGWGCM.
OrthoDB	EOG4D26RD.
PhylomeDB	Q8WUY8.
Gene expression databases
ArrayExpress	Q8WUY8.
Bgee	Q8WUY8.
CleanEx	HS_NAT14.
Genevestigator	Q8WUY8.
Family and domain databases
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	62949.

Entry information

Entry name

NAT14_HUMAN

Accession

Primary (citable) accession number: Q8WUY8
Secondary accession number(s): Q8TDY7, Q9NS72

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.