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Protein

Protein prune homolog 2

Gene

PRUNE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein prune homolog 2
Alternative name(s):
BNIP2 motif-containing molecule at the C-terminal region 1
Gene namesi
Name:PRUNE2
Synonyms:BMCC1, BNIPXL, C9orf65, KIAA0367
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25209. PRUNE2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400198.

Polymorphism and mutation databases

BioMutaiPRUNE2.
DMDMi298286907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 30883088Protein prune homolog 2PRO_0000089701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WUY3.
MaxQBiQ8WUY3.
PaxDbiQ8WUY3.
PeptideAtlasiQ8WUY3.
PRIDEiQ8WUY3.

PTM databases

iPTMnetiQ8WUY3.
PhosphoSiteiQ8WUY3.

Expressioni

Tissue specificityi

A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.1 Publication

Developmental stagei

Induced during the G1 phase of the cell cycle.

Inductioni

Down-regulated after NGF-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis.1 Publication

Gene expression databases

BgeeiQ8WUY3.
CleanExiHS_PRUNE2.
ExpressionAtlasiQ8WUY3. baseline and differential.
GenevisibleiQ8WUY3. HS.

Organism-specific databases

HPAiHPA022470.
HPA031079.

Interactioni

Protein-protein interaction databases

BioGridi127687. 16 interactions.
IntActiQ8WUY3. 2 interactions.
MINTiMINT-1483115.
STRINGi9606.ENSP00000365908.

Structurei

3D structure databases

ProteinModelPortaliQ8WUY3.
SMRiQ8WUY3. Positions 3-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2895 – 3056162CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1113DHH motifBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi550 – 5534Poly-Ser

Sequence similaritiesi

Belongs to the PPase class C family. Prune subfamily.Curated
Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFIP. Eukaryota.
ENOG410ZS9Z. LUCA.
GeneTreeiENSGT00420000029688.
HOVERGENiHBG054692.
InParanoidiQ8WUY3.
KOiK18449.
OMAiQNPCLEL.
OrthoDBiEOG72RMX4.
PhylomeDBiQ8WUY3.
TreeFamiTF323914.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
IPR004097. DHHA2.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEFLQRAKS KLNRSKRLEK VHVVIGPKSC DLDSLISTFT YAYFLDKVSP
60 70 80 90 100
PGVLCLPVLN IPRTEFNYFT ETRFILEELN ISESFHIFRD EINLHQLNDE
110 120 130 140 150
GKLSITLVGS SVLASEDKTL ESAVVKVINP VEQSDANVEF RESSSSLVLK
160 170 180 190 200
EILQEAPELI TEQLAHRLRG SILFKWMTME SEKISEKQEE ILSILEEKFP
210 220 230 240 250
NLPPREDIIN VLQETQFSAQ GLSIEQTMLK DLKELSDGEI KVAISTVSMN
260 270 280 290 300
LENCLFHSNI TSDLKAFTDK FGFDVLILFS SYLSEEQQPR RQIAVYSENM
310 320 330 340 350
ELCSQICCEL EECQNPCLEL EPFDCGCDEI LVYQQEDPSV TCDQVVLVVK
360 370 380 390 400
EVINRRCPEM VSNSRTSSTE AVAGSAPLSQ GSSGIMELYG SDIEPQPSSV
410 420 430 440 450
NFIENPPDLN DSNQAQVDAN VDLVSPDSGL ATIRSSRSSK ESSVFLSDDS
460 470 480 490 500
PVGEGAGPHH TLLPGLDSYS PIPEGAVAEE HAWSGEHGEH FDLFNFDPAP
510 520 530 540 550
MASGQSQQSS HSADYSPADD FFPNSDLSEG QLPAGPEGLD GMGTNMSNYS
560 570 580 590 600
SSSLLSGAGK DSLVEHDEEF VQRQDSPRDN SERNLSLTDF VGDESPSPER
610 620 630 640 650
LKNTGKRIPP TPMNSLVESS PSTEEPASLY TEDMTQKATD TGHMGPPQTH
660 670 680 690 700
ARCSSWWGGL EIDSKNIADA WSSSEQESVF QSPESWKEHK PSSIDRRASD
710 720 730 740 750
SVFQPKSLEF TKSGPWESEF GQPELGSNDI QDKNEESLPF QNLPMEKSPL
760 770 780 790 800
PNTSPQGTNH LIEDFASLWH SGRSPTAMPE PWGNPTDDGE PAAVAPFPAW
810 820 830 840 850
SAFGKEDHDE ALKNTWNLHP TSSKTPSVRD PNEWAMAKSG FAFSSSELLD
860 870 880 890 900
NSPSEINNEA APEIWGKKNN DSRDHIFAPG NPSSDLDHTW TNSKPPKEDQ
910 920 930 940 950
NGLVDPKTRG KVYEKVDSWN LFEENMKKGG SDVLVPWEDS FLSYKCSDYS
960 970 980 990 1000
ASNLGEDSVP SPLDTNYSTS DSYTSPTFAG DEKETEHKPF AKEEGFESKD
1010 1020 1030 1040 1050
GNSTAEETDI PPQSLQQSSR NRISSGPGNL DMWASPHTDN SSEINTTHNL
1060 1070 1080 1090 1100
DENELKTEHT DGKNISMEDD VGESSQSSYD DPSMMQLYNE TNRQLTLLHS
1110 1120 1130 1140 1150
STNSRQTAPD SLDLWNRVIL EDTQSTATIS DMDNDLDWDD CSGGAAIPSD
1160 1170 1180 1190 1200
GQTEGYMAEG SEPETRFTVR QLEPWGLEYQ EANQVDWELP ASDEHTKDSA
1210 1220 1230 1240 1250
PSEHHTLNEK SGQLIANSIW DSVMRDKDMS SFMLPGSSHI TDSEQRELPP
1260 1270 1280 1290 1300
EIPSHSANVK DTHSPDAPAA SGTSESEALI SHLDKQDTER ETLQSDAASL
1310 1320 1330 1340 1350
ATRLENPGYF PHPDPWKGHG DGQSESEKEA QGATDRGHLD EEEVIASGVE
1360 1370 1380 1390 1400
NASGISEKGQ SDQELSSLVA SEHQEICIKS GKISSLAVTF SPQTEEPEEV
1410 1420 1430 1440 1450
LEYEEGSYNL DSRDVQTGMS ADNLQPKDTH EKHLMSQRNS GETTETSDGM
1460 1470 1480 1490 1500
NFTKYVSVPE KDLEKTEECN FLEPENVGGG PPHRVPRSLD FGDVPIDSDV
1510 1520 1530 1540 1550
HVSSTCSEIT KNLDVKGSEN SLPGAGSSGN FDRDTISSEY THSSASSPEL
1560 1570 1580 1590 1600
NDSSVALSSW GQQPSSGYQE ENQGNWSEQN HQESELITTD GQVEIVTKVK
1610 1620 1630 1640 1650
DLEKNRINEF EKSFDRKTPT FLEIWNDSVD GDSFSSLSSP ETGKYSEHSG
1660 1670 1680 1690 1700
THQESNLIAS YQEKNEHDIS ATVQPEDARV ISTSSGSDDD SVGGEESIEE
1710 1720 1730 1740 1750
EIQVANCHVA EDESRAWDSL NESNKFLVTA DPKSENIYDY LDSSEPAENE
1760 1770 1780 1790 1800
NKSNPFCDNQ QSSPDPWTFS PLTETEMQIT AVEKEKRSSP ETGTTGDVAW
1810 1820 1830 1840 1850
QISPKASFPK NEDNSQLEML GFSADSTEWW KASPQEGRLI ESPFERELSD
1860 1870 1880 1890 1900
SSGVLEINSS VHQNASPWGV PVQGDIEPVE THYTNPFSDN HQSPFLEGNG
1910 1920 1930 1940 1950
KNSHEQLWNI QPRQPDPDAD KFSQLVKLDQ IKEKDSREQT FVSAAGDELT
1960 1970 1980 1990 2000
PETPTQEQCQ DTMLPVCDHP DTAFTHAEEN SCVTSNVSTN EGQETNQWEQ
2010 2020 2030 2040 2050
EKSYLGEMTN SSIATENFPA VSSPTQLIMK PGSEWDGSTP SEDSRGTFVP
2060 2070 2080 2090 2100
DILHGNFQEG GQLASAAPDL WIDAKKPFSL KADGENPDIL THCEHDSNSQ
2110 2120 2130 2140 2150
ASDSPDICHD SEAKQETEKH LSACMGPEVE SSELCLTEPE IDEEPIYEPG
2160 2170 2180 2190 2200
REFVPSNAEL DSENATVLPP IGYQADIKGS SQPASHKGSP EPSEINGDNS
2210 2220 2230 2240 2250
TGLQVSEKGA SPDMAPILEP VDRRIPRIEN VATSIFVTHQ EPTPEGDGSW
2260 2270 2280 2290 2300
ISDSFSPESQ PGARALFDGD PHLSTENPAL VPDALLASDT CLDISEAAFD
2310 2320 2330 2340 2350
HSFSDASGLN TSTGTIDDMS KLTLSEGHPE TPVDGDLGKQ DICSSEASWG
2360 2370 2380 2390 2400
DFEYDVMGQN IDEDLLREPE HFLYGGDPPL EEDSLKQSLA PYTPPFDLSY
2410 2420 2430 2440 2450
LTEPAQSAET IEEAGSPEDE SLGCRAAEIV LSALPDRRSE GNQAETKNRL
2460 2470 2480 2490 2500
PGSQLAVLHI REDPESVYLP VGAGSNILSP SNVDWEVETD NSDLPAGGDI
2510 2520 2530 2540 2550
GPPNGASKEI SELEEEKTIP TKEPEQIKSE YKEERCTEKN EDRHALHMDY
2560 2570 2580 2590 2600
ILVNREENSH SKPETCEERE SIAELELYVG SKETGLQGTQ LASFPDTCQP
2610 2620 2630 2640 2650
ASLNERKGLS AEKMSSKSDT RSSFESPAQD QSWMFLGHSE VGDPSLDARD
2660 2670 2680 2690 2700
SGPGWSGKTV EPFSELGLGE GPQLQILEEM KPLESLALEE ASGPVSQSQK
2710 2720 2730 2740 2750
SKSRGRAGPD AVTLQAVTHD NEWEMLSPQP VQKNMIPDTE MEEETEFLEL
2760 2770 2780 2790 2800
GTRISRPNGL LSEDVGMDIP FEEGVLSPSA ADMRPEPPNS LDLNDTHPRR
2810 2820 2830 2840 2850
IKLTAPNINL SLDQSEGSIL SDDNLDSPDE IDINVDELDT PDEADSFEYT
2860 2870 2880 2890 2900
GHDPTANKDS GQESESIPEY TAEEEREDNR LWRTVVIGEQ EQRIDMKVIE
2910 2920 2930 2940 2950
PYRRVISHGG YYGDGLNAII VFAACFLPDS SRADYHYVME NLFLYVISTL
2960 2970 2980 2990 3000
ELMVAEDYMI VYLNGATPRR RMPGLGWMKK CYQMIDRRLR KNLKSFIIVH
3010 3020 3030 3040 3050
PSWFIRTILA VTRPFISSKF SSKIKYVNSL SELSGLIPMD CIHIPESIIK
3060 3070 3080
LDEELREASE AAKTSCLYND PEMSSMEKDI DLKLKEKP
Length:3,088
Mass (Da):340,635
Last modified:June 15, 2010 - v3
Checksum:i8C946594BAACB10A
GO
Isoform 2 (identifier: Q8WUY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2852-2852: H → HE

Show »
Length:3,089
Mass (Da):340,764
Checksum:i6CE5F0192FA5E4B7
GO
Isoform 3 (identifier: Q8WUY3-3) [UniParc]FASTAAdd to basket

Also known as: BNIPXL-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     2852-2852: H → HE
     2909-2909: G → GGLR

Show »
Length:3,092
Mass (Da):341,091
Checksum:i55C58CEE70BCC4CC
GO
Isoform 4 (identifier: Q8WUY3-4) [UniParc]FASTAAdd to basket

Also known as: BNIPXL-beta

The sequence of this isoform differs from the canonical sequence as follows:
     2852-2852: H → HE
     2909-2909: G → GGLR
     3051-3088: LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP → Y

Show »
Length:3,055
Mass (Da):336,914
Checksum:i6B621F9597F5AB49
GO
Isoform 5 (identifier: Q8WUY3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2736: Missing.
     2737-2759: PDTEMEEETEFLELGTRISRPNG → MLKSCSRASFSPSVRKPPLILRR

Show »
Length:352
Mass (Da):40,093
Checksum:iC683D27D03D4934C
GO

Sequence cautioni

The sequence AAH22571.1 differs from that shown.Aberrant splicing.Curated
The sequence AAH22571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAR15150.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAR15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD93351.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI10915.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI16084.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI39750.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1675 – 16751P → S in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2401 – 24011L → I in AAR15150 (Ref. 5) Curated
Sequence conflicti2401 – 24011L → I in AAR15151 (Ref. 5) Curated
Sequence conflicti2511 – 25111S → P in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2511 – 25111S → P in BAA20822 (PubMed:9205841).Curated
Sequence conflicti2618 – 26181S → G in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2618 – 26181S → G in BAA20822 (PubMed:9205841).Curated
Sequence conflicti2711 – 27155Missing in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2711 – 27155Missing in AAR15150 (Ref. 5) Curated
Sequence conflicti2711 – 27155Missing in AAR15151 (Ref. 5) Curated
Sequence conflicti2711 – 27155Missing in BAA20822 (PubMed:9205841).Curated
Sequence conflicti2721 – 27211N → S in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2721 – 27211N → S in BAA20822 (PubMed:9205841).Curated
Sequence conflicti2737 – 27371P → S in BAD93351 (PubMed:16288218).Curated
Sequence conflicti2737 – 27371P → S in BAA20822 (PubMed:9205841).Curated
Sequence conflicti2857 – 28571N → T in AAR15150 (Ref. 5) Curated
Sequence conflicti2857 – 28571N → T in AAR15151 (Ref. 5) Curated
Sequence conflicti2889 – 28891E → D in AAR15150 (Ref. 5) Curated
Sequence conflicti2889 – 28891E → D in AAR15151 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti806 – 8061E → K.1 Publication
Corresponds to variant rs375315668 [ dbSNP | Ensembl ].
VAR_069436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 27362736Missing in isoform 5. 2 PublicationsVSP_039339Add
BLAST
Alternative sequencei2737 – 275923PDTEM…SRPNG → MLKSCSRASFSPSVRKPPLI LRR in isoform 5. 2 PublicationsVSP_039340Add
BLAST
Alternative sequencei2852 – 28521H → HE in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_039341
Alternative sequencei2909 – 29091G → GGLR in isoform 3 and isoform 4. 1 PublicationVSP_039342
Alternative sequencei3051 – 308838LDEEL…LKEKP → Y in isoform 4. 1 PublicationVSP_039343Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298805 mRNA. Translation: BAG60940.1.
AL161626, AL359314, AL390239 Genomic DNA. Translation: CAI39749.3.
AL161626, AL359314 Genomic DNA. Translation: CAI39750.2. Sequence problems.
AL359314, AL161626 Genomic DNA. Translation: CAI10915.2. Sequence problems.
AL390239 Genomic DNA. Translation: CAI16084.1. Sequence problems.
AL359314, AL161626, AL390239 Genomic DNA. Translation: CAQ68519.2.
AL390239, AL161626, AL359314 Genomic DNA. Translation: CAX14933.1.
BC022571 mRNA. Translation: AAH22571.1. Sequence problems.
AB050197 mRNA. Translation: BAD93351.1. Different initiation.
AY439213 mRNA. Translation: AAR15150.1. Different initiation.
AY439214 mRNA. Translation: AAR15151.1. Different initiation.
AB002365 mRNA. Translation: BAA20822.2.
CCDSiCCDS47982.1. [Q8WUY3-1]
RefSeqiNP_001294976.1. NM_001308047.1.
NP_001294977.1. NM_001308048.1.
NP_001294978.1. NM_001308049.1.
NP_001294979.1. NM_001308050.1. [Q8WUY3-5]
NP_001294980.1. NM_001308051.1.
NP_056040.2. NM_015225.2. [Q8WUY3-1]
XP_011516625.1. XM_011518323.1. [Q8WUY3-2]
UniGeneiHs.262857.

Genome annotation databases

EnsembliENST00000376718; ENSP00000365908; ENSG00000106772. [Q8WUY3-1]
GeneIDi158471.
KEGGihsa:158471.
UCSCiuc010mpk.4. human. [Q8WUY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298805 mRNA. Translation: BAG60940.1.
AL161626, AL359314, AL390239 Genomic DNA. Translation: CAI39749.3.
AL161626, AL359314 Genomic DNA. Translation: CAI39750.2. Sequence problems.
AL359314, AL161626 Genomic DNA. Translation: CAI10915.2. Sequence problems.
AL390239 Genomic DNA. Translation: CAI16084.1. Sequence problems.
AL359314, AL161626, AL390239 Genomic DNA. Translation: CAQ68519.2.
AL390239, AL161626, AL359314 Genomic DNA. Translation: CAX14933.1.
BC022571 mRNA. Translation: AAH22571.1. Sequence problems.
AB050197 mRNA. Translation: BAD93351.1. Different initiation.
AY439213 mRNA. Translation: AAR15150.1. Different initiation.
AY439214 mRNA. Translation: AAR15151.1. Different initiation.
AB002365 mRNA. Translation: BAA20822.2.
CCDSiCCDS47982.1. [Q8WUY3-1]
RefSeqiNP_001294976.1. NM_001308047.1.
NP_001294977.1. NM_001308048.1.
NP_001294978.1. NM_001308049.1.
NP_001294979.1. NM_001308050.1. [Q8WUY3-5]
NP_001294980.1. NM_001308051.1.
NP_056040.2. NM_015225.2. [Q8WUY3-1]
XP_011516625.1. XM_011518323.1. [Q8WUY3-2]
UniGeneiHs.262857.

3D structure databases

ProteinModelPortaliQ8WUY3.
SMRiQ8WUY3. Positions 3-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127687. 16 interactions.
IntActiQ8WUY3. 2 interactions.
MINTiMINT-1483115.
STRINGi9606.ENSP00000365908.

PTM databases

iPTMnetiQ8WUY3.
PhosphoSiteiQ8WUY3.

Polymorphism and mutation databases

BioMutaiPRUNE2.
DMDMi298286907.

Proteomic databases

EPDiQ8WUY3.
MaxQBiQ8WUY3.
PaxDbiQ8WUY3.
PeptideAtlasiQ8WUY3.
PRIDEiQ8WUY3.

Protocols and materials databases

DNASUi158471.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376718; ENSP00000365908; ENSG00000106772. [Q8WUY3-1]
GeneIDi158471.
KEGGihsa:158471.
UCSCiuc010mpk.4. human. [Q8WUY3-1]

Organism-specific databases

CTDi158471.
GeneCardsiPRUNE2.
H-InvDBHIX0008112.
HGNCiHGNC:25209. PRUNE2.
HPAiHPA022470.
HPA031079.
MIMi610691. gene.
neXtProtiNX_Q8WUY3.
PharmGKBiPA162400198.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFIP. Eukaryota.
ENOG410ZS9Z. LUCA.
GeneTreeiENSGT00420000029688.
HOVERGENiHBG054692.
InParanoidiQ8WUY3.
KOiK18449.
OMAiQNPCLEL.
OrthoDBiEOG72RMX4.
PhylomeDBiQ8WUY3.
TreeFamiTF323914.

Miscellaneous databases

ChiTaRSiPRUNE2. human.
GeneWikiiPRUNE2.
GenomeRNAii158471.
PROiQ8WUY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUY3.
CleanExiHS_PRUNE2.
ExpressionAtlasiQ8WUY3. baseline and differential.
GenevisibleiQ8WUY3. HS.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
IPR004097. DHHA2.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Hypothalamus.
  4. "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas."
    Machida T., Fujita T., Ooo M.L., Ohira M., Isogai E., Mihara M., Hirato J., Tomotsune D., Hirata T., Fujimori M., Adachi W., Nakagawara A.
    Oncogene 25:1931-1942(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 253-3088 (ISOFORM 1), FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Neuroblastoma.
  5. "BNIPXL, an extra long member of the BNIP-2 family."
    Soh J.K.U., Zhou Y.T., Low B.C.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2265-3088 (ISOFORMS 3 AND 4).
    Tissue: Brain and Kidney.
  6. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2265-3088 (ISOFORM 2).
    Tissue: Brain.
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer."
    Salagierski M., Verhaegh G.W., Jannink S.A., Smit F.P., Hessels D., Schalken J.A.
    Prostate 70:70-78(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE REGULATION.
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. Cited for: VARIANT LYS-806.

Entry informationi

Entry nameiPRUN2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY3
Secondary accession number(s): B3KYC4
, B4DQH8, O15073, Q58A63, Q5JUB6, Q5T304, Q5T476, Q6T2V6, Q6T2V7, Q8N665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 15, 2010
Last modified: July 6, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

PRUNE2/BMCC1 and PCA3, one of the most prostate cancer specific markers are overlapping genes in reverse orientation. However, they do not appear to be coregulated.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.