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Protein

Protein THEM6

Gene

THEM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein THEM6
Alternative name(s):
Mesenchymal stem cell protein DSCD75
Thioesterase superfamily member 6
Gene namesi
Name:THEM6
Synonyms:C8orf55
ORF Names:PSEC0098
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29656. THEM6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51337.
OpenTargetsiENSG00000130193.
PharmGKBiPA142672318.

Polymorphism and mutation databases

BioMutaiTHEM6.
DMDMi146286068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028563618 – 208Protein THEM6Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUY1.
MaxQBiQ8WUY1.
PaxDbiQ8WUY1.
PeptideAtlasiQ8WUY1.
PRIDEiQ8WUY1.

PTM databases

iPTMnetiQ8WUY1.
PhosphoSitePlusiQ8WUY1.
SwissPalmiQ8WUY1.

Expressioni

Gene expression databases

BgeeiENSG00000130193.
CleanExiHS_C8orf55.
ExpressionAtlasiQ8WUY1. baseline and differential.
GenevisibleiQ8WUY1. HS.

Organism-specific databases

HPAiHPA023255.

Interactioni

Protein-protein interaction databases

BioGridi119484. 14 interactors.
IntActiQ8WUY1. 11 interactors.
STRINGi9606.ENSP00000338607.

Structurei

3D structure databases

ProteinModelPortaliQ8WUY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEM6 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4366. Eukaryota.
ENOG4111RKY. LUCA.
GeneTreeiENSGT00390000004859.
HOGENOMiHOG000249151.
HOVERGENiHBG059534.
InParanoidiQ8WUY1.
OMAiRDIDMCH.
OrthoDBiEOG091G11QD.
PhylomeDBiQ8WUY1.
TreeFamiTF324625.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WUY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF
60 70 80 90 100
PGRVLPSDLD LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL
110 120 130 140 150
AASCARHRRS LRLLEPFEVR TRLLGWDDRA FYLEARFVSL RDGFVCALLR
160 170 180 190 200
FRQHLLGTSP ERVVQHLCQR RVEPPELPAD LQHWISYNEA SSQLLRMESG

LSDVTKDQ
Length:208
Mass (Da):23,865
Last modified:May 1, 2007 - v2
Checksum:i6F9808DB345194D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20D → G in BAC11600 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03203493E → Q.1 PublicationCorresponds to variant rs17851711dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242773 mRNA. Translation: AAF65450.1.
AK315614 mRNA. Translation: BAG37983.1.
AK075407 mRNA. Translation: BAC11600.1.
BC001311 mRNA. Translation: AAH01311.1.
BC019104 mRNA. Translation: AAH19104.1.
CCDSiCCDS6386.1.
RefSeqiNP_057731.1. NM_016647.2.
UniGeneiHs.368402.

Genome annotation databases

EnsembliENST00000336138; ENSP00000338607; ENSG00000130193.
GeneIDi51337.
KEGGihsa:51337.
UCSCiuc003yww.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242773 mRNA. Translation: AAF65450.1.
AK315614 mRNA. Translation: BAG37983.1.
AK075407 mRNA. Translation: BAC11600.1.
BC001311 mRNA. Translation: AAH01311.1.
BC019104 mRNA. Translation: AAH19104.1.
CCDSiCCDS6386.1.
RefSeqiNP_057731.1. NM_016647.2.
UniGeneiHs.368402.

3D structure databases

ProteinModelPortaliQ8WUY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119484. 14 interactors.
IntActiQ8WUY1. 11 interactors.
STRINGi9606.ENSP00000338607.

PTM databases

iPTMnetiQ8WUY1.
PhosphoSitePlusiQ8WUY1.
SwissPalmiQ8WUY1.

Polymorphism and mutation databases

BioMutaiTHEM6.
DMDMi146286068.

Proteomic databases

EPDiQ8WUY1.
MaxQBiQ8WUY1.
PaxDbiQ8WUY1.
PeptideAtlasiQ8WUY1.
PRIDEiQ8WUY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336138; ENSP00000338607; ENSG00000130193.
GeneIDi51337.
KEGGihsa:51337.
UCSCiuc003yww.2. human.

Organism-specific databases

CTDi51337.
DisGeNETi51337.
GeneCardsiTHEM6.
HGNCiHGNC:29656. THEM6.
HPAiHPA023255.
neXtProtiNX_Q8WUY1.
OpenTargetsiENSG00000130193.
PharmGKBiPA142672318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4366. Eukaryota.
ENOG4111RKY. LUCA.
GeneTreeiENSGT00390000004859.
HOGENOMiHOG000249151.
HOVERGENiHBG059534.
InParanoidiQ8WUY1.
OMAiRDIDMCH.
OrthoDBiEOG091G11QD.
PhylomeDBiQ8WUY1.
TreeFamiTF324625.

Miscellaneous databases

ChiTaRSiTHEM6. human.
GenomeRNAii51337.
PROiQ8WUY1.

Gene expression databases

BgeeiENSG00000130193.
CleanExiHS_C8orf55.
ExpressionAtlasiQ8WUY1. baseline and differential.
GenevisibleiQ8WUY1. HS.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHEM6_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY1
Secondary accession number(s): B2RDN6, Q8NBN2, Q9NYI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.