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Protein

Charged multivesicular body protein 7

Gene

CHMP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).2 Publications

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • cell separation after cytokinesis Source: UniProtKB
  • endosomal transport Source: Reactome
  • ESCRT III complex disassembly Source: ParkinsonsUK-UCL
  • exit from mitosis Source: UniProtKB
  • late endosome to vacuole transport Source: UniProtKB
  • mitotic metaphase plate congression Source: UniProtKB
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • nuclear envelope reassembly Source: UniProtKB
  • nucleus organization Source: UniProtKB
  • protein localization to chromatin Source: ARUK-UCL
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-1632852 Macroautophagy
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 7
Alternative name(s):
Chromatin-modifying protein 7
Gene namesi
Name:CHMP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147457.13
HGNCiHGNC:28439 CHMP7
MIMi611130 gene
neXtProtiNX_Q8WUX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147457
PharmGKBiPA142672115

Polymorphism and mutation databases

BioMutaiCHMP7
DMDMi73917782

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115161 – 453Charged multivesicular body protein 7Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei408PhosphothreonineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUX9
MaxQBiQ8WUX9
PaxDbiQ8WUX9
PeptideAtlasiQ8WUX9
PRIDEiQ8WUX9
ProteomicsDBi74719

PTM databases

iPTMnetiQ8WUX9
PhosphoSitePlusiQ8WUX9

Expressioni

Gene expression databases

BgeeiENSG00000147457
CleanExiHS_CHMP7
ExpressionAtlasiQ8WUX9 baseline and differential
GenevisibleiQ8WUX9 HS

Organism-specific databases

HPAiHPA036119

Interactioni

Subunit structurei

Interacts with CHMP4B, but not with VPS25.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CHMP4BQ9H4443EBI-749253,EBI-749627

Protein-protein interaction databases

BioGridi124879, 11 interactors
ComplexPortaliCPX-329 ESCRT-III complex
IntActiQ8WUX9, 7 interactors
STRINGi9606.ENSP00000324491

Structurei

3D structure databases

ProteinModelPortaliQ8WUX9
SMRiQ8WUX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili243 – 312Sequence analysisAdd BLAST70

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2911 Eukaryota
ENOG4110IXB LUCA
GeneTreeiENSGT00720000108860
HOGENOMiHOG000290682
HOVERGENiHBG081151
InParanoidiQ8WUX9
KOiK15053
OMAiMAKTYLR
OrthoDBiEOG091G09H0
PhylomeDBiQ8WUX9
TreeFamiTF312851

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSPEREAEA PAGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD
60 70 80 90 100
SKMGFWAPLV LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR
110 120 130 140 150
RGELQRESDF MASVDSSWIS WGVGVFLLKP LKWTLSNMLG DNKVPAEEVL
160 170 180 190 200
VAVELLKEKA EEVYRLYQNS PLSSHPVVAL SELSTLCANS CPDERTFYLV
210 220 230 240 250
LLQLQKEKRV TVLEQNGEKI VKFARGPRAK VSPVNDVDVG VYQLMQSEQL
260 270 280 290 300
LSRKVESLSQ EAERCKEEAR RACRAGKKQL ALRSLKAKQR TEKRIEALHA
310 320 330 340 350
KLDTVQGILD RIYASQTDQM VFNAYQAGVG ALKLSMKDVT VEKAESLVDQ
360 370 380 390 400
IQELCDTQDE VSQTLAGGVT NGLDFDSEEL EKELDILLQD TTKEPLDLPD
410 420 430 440 450
NPRNRHFTNS VPNPRISDAE LEAELEKLSL SEGGLVPSSK SPKRQLEPTL

KPL
Length:453
Mass (Da):50,911
Last modified:March 1, 2002 - v1
Checksum:iCF91D562B918AEA1
GO
Isoform 2 (identifier: Q8WUX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-162: RGELQRESDF...VELLKEKAEE → KRLRRCIVCI...SQSSSRTGRR
     163-452: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,625
Checksum:iA06F4E6BFBE7375C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433 – 434GG → E in CAD38703 (PubMed:17974005).Curated2
Sequence conflicti440 – 442KSP → NLQ in CAD38703 (PubMed:17974005).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056945101 – 162RGELQ…EKAEE → KRLRRCIVCIRTRPSPPTPW WPCQSSAPSVLTPAQMRGPS TWCCCSCRRRRGSQSSSRTG RR in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_056946163 – 452Missing in isoform 2. 1 PublicationAdd BLAST290

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296592 mRNA Translation: BAG59208.1
AK315664 mRNA Translation: BAG38030.1
AL833843 mRNA Translation: CAD38703.2
AC100861 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63632.1
CH471080 Genomic DNA Translation: EAW63634.1
BC004344 mRNA Translation: AAH04344.1
BC019110 mRNA Translation: AAH19110.1
BC042050 mRNA Translation: AAH42050.1
CCDSiCCDS6040.1 [Q8WUX9-1]
RefSeqiNP_689485.1, NM_152272.4 [Q8WUX9-1]
UniGeneiHs.5019

Genome annotation databases

EnsembliENST00000313219; ENSP00000324491; ENSG00000147457 [Q8WUX9-1]
ENST00000397677; ENSP00000380794; ENSG00000147457 [Q8WUX9-1]
ENST00000519503; ENSP00000427948; ENSG00000147457 [Q8WUX9-2]
GeneIDi91782
KEGGihsa:91782
UCSCiuc003xdc.3 human [Q8WUX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCHMP7_HUMAN
AccessioniPrimary (citable) accession number: Q8WUX9
Secondary accession number(s): B2RDT3
, B4DKJ6, D3DSS1, Q8NDM1, Q9BT50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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