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Protein

Charged multivesicular body protein 7

Gene

CHMP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).2 Publications

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • cell separation after cytokinesis Source: UniProtKB
  • endosomal transport Source: Reactome
  • ESCRT III complex disassembly Source: ParkinsonsUK-UCL
  • exit from mitosis Source: UniProtKB
  • late endosome to vacuole transport Source: UniProtKB
  • mitotic metaphase plate congression Source: UniProtKB
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • nuclear envelope reassembly Source: UniProtKB
  • nucleus organization Source: UniProtKB
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-1632852. Macroautophagy.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 7
Alternative name(s):
Chromatin-modifying protein 7
Gene namesi
Name:CHMP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28439. CHMP7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • ESCRT III complex Source: UniProtKB
  • nuclear envelope Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672115.

Polymorphism and mutation databases

BioMutaiCHMP7.
DMDMi73917782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Charged multivesicular body protein 7PRO_0000211516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321PhosphoserineBy similarity
Modified residuei408 – 4081PhosphothreonineCombined sources
Modified residuei410 – 4101PhosphoserineCombined sources
Modified residuei417 – 4171PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineCombined sources
Modified residuei441 – 4411PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUX9.
MaxQBiQ8WUX9.
PaxDbiQ8WUX9.
PeptideAtlasiQ8WUX9.
PRIDEiQ8WUX9.

PTM databases

iPTMnetiQ8WUX9.
PhosphoSiteiQ8WUX9.

Expressioni

Gene expression databases

BgeeiENSG00000147457.
CleanExiHS_CHMP7.
ExpressionAtlasiQ8WUX9. baseline and differential.
GenevisibleiQ8WUX9. HS.

Organism-specific databases

HPAiHPA036119.

Interactioni

Subunit structurei

Interacts with CHMP4B, but not with VPS25.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CHMP4BQ9H4443EBI-749253,EBI-749627

Protein-protein interaction databases

BioGridi124879. 11 interactions.
IntActiQ8WUX9. 6 interactions.
MINTiMINT-1460844.
STRINGi9606.ENSP00000324491.

Structurei

3D structure databases

ProteinModelPortaliQ8WUX9.
SMRiQ8WUX9. Positions 238-313, 339-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili243 – 31270Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2911. Eukaryota.
ENOG4110IXB. LUCA.
GeneTreeiENSGT00720000108860.
HOGENOMiHOG000290682.
HOVERGENiHBG081151.
InParanoidiQ8WUX9.
KOiK15053.
OMAiMAKTYLR.
OrthoDBiEOG091G09H0.
PhylomeDBiQ8WUX9.
TreeFamiTF312851.

Family and domain databases

InterProiIPR005024. Snf7_fam.
[Graphical view]
PfamiPF03357. Snf7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSPEREAEA PAGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD
60 70 80 90 100
SKMGFWAPLV LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR
110 120 130 140 150
RGELQRESDF MASVDSSWIS WGVGVFLLKP LKWTLSNMLG DNKVPAEEVL
160 170 180 190 200
VAVELLKEKA EEVYRLYQNS PLSSHPVVAL SELSTLCANS CPDERTFYLV
210 220 230 240 250
LLQLQKEKRV TVLEQNGEKI VKFARGPRAK VSPVNDVDVG VYQLMQSEQL
260 270 280 290 300
LSRKVESLSQ EAERCKEEAR RACRAGKKQL ALRSLKAKQR TEKRIEALHA
310 320 330 340 350
KLDTVQGILD RIYASQTDQM VFNAYQAGVG ALKLSMKDVT VEKAESLVDQ
360 370 380 390 400
IQELCDTQDE VSQTLAGGVT NGLDFDSEEL EKELDILLQD TTKEPLDLPD
410 420 430 440 450
NPRNRHFTNS VPNPRISDAE LEAELEKLSL SEGGLVPSSK SPKRQLEPTL

KPL
Length:453
Mass (Da):50,911
Last modified:March 1, 2002 - v1
Checksum:iCF91D562B918AEA1
GO
Isoform 2 (identifier: Q8WUX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-162: RGELQRESDF...VELLKEKAEE → KRLRRCIVCI...SQSSSRTGRR
     163-452: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,625
Checksum:iA06F4E6BFBE7375C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti433 – 4342GG → E in CAD38703 (PubMed:17974005).Curated
Sequence conflicti440 – 4423KSP → NLQ in CAD38703 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 16262RGELQ…EKAEE → KRLRRCIVCIRTRPSPPTPW WPCQSSAPSVLTPAQMRGPS TWCCCSCRRRRGSQSSSRTG RR in isoform 2. 1 PublicationVSP_056945Add
BLAST
Alternative sequencei163 – 452290Missing in isoform 2. 1 PublicationVSP_056946Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296592 mRNA. Translation: BAG59208.1.
AK315664 mRNA. Translation: BAG38030.1.
AL833843 mRNA. Translation: CAD38703.2.
AC100861 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63632.1.
CH471080 Genomic DNA. Translation: EAW63634.1.
BC004344 mRNA. Translation: AAH04344.1.
BC019110 mRNA. Translation: AAH19110.1.
BC042050 mRNA. Translation: AAH42050.1.
CCDSiCCDS6040.1. [Q8WUX9-1]
RefSeqiNP_689485.1. NM_152272.4. [Q8WUX9-1]
UniGeneiHs.5019.

Genome annotation databases

EnsembliENST00000313219; ENSP00000324491; ENSG00000147457. [Q8WUX9-1]
ENST00000397677; ENSP00000380794; ENSG00000147457. [Q8WUX9-1]
ENST00000519503; ENSP00000427948; ENSG00000147457. [Q8WUX9-2]
GeneIDi91782.
KEGGihsa:91782.
UCSCiuc003xdc.3. human. [Q8WUX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296592 mRNA. Translation: BAG59208.1.
AK315664 mRNA. Translation: BAG38030.1.
AL833843 mRNA. Translation: CAD38703.2.
AC100861 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63632.1.
CH471080 Genomic DNA. Translation: EAW63634.1.
BC004344 mRNA. Translation: AAH04344.1.
BC019110 mRNA. Translation: AAH19110.1.
BC042050 mRNA. Translation: AAH42050.1.
CCDSiCCDS6040.1. [Q8WUX9-1]
RefSeqiNP_689485.1. NM_152272.4. [Q8WUX9-1]
UniGeneiHs.5019.

3D structure databases

ProteinModelPortaliQ8WUX9.
SMRiQ8WUX9. Positions 238-313, 339-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124879. 11 interactions.
IntActiQ8WUX9. 6 interactions.
MINTiMINT-1460844.
STRINGi9606.ENSP00000324491.

PTM databases

iPTMnetiQ8WUX9.
PhosphoSiteiQ8WUX9.

Polymorphism and mutation databases

BioMutaiCHMP7.
DMDMi73917782.

Proteomic databases

EPDiQ8WUX9.
MaxQBiQ8WUX9.
PaxDbiQ8WUX9.
PeptideAtlasiQ8WUX9.
PRIDEiQ8WUX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313219; ENSP00000324491; ENSG00000147457. [Q8WUX9-1]
ENST00000397677; ENSP00000380794; ENSG00000147457. [Q8WUX9-1]
ENST00000519503; ENSP00000427948; ENSG00000147457. [Q8WUX9-2]
GeneIDi91782.
KEGGihsa:91782.
UCSCiuc003xdc.3. human. [Q8WUX9-1]

Organism-specific databases

CTDi91782.
GeneCardsiCHMP7.
HGNCiHGNC:28439. CHMP7.
HPAiHPA036119.
MIMi611130. gene.
neXtProtiNX_Q8WUX9.
PharmGKBiPA142672115.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2911. Eukaryota.
ENOG4110IXB. LUCA.
GeneTreeiENSGT00720000108860.
HOGENOMiHOG000290682.
HOVERGENiHBG081151.
InParanoidiQ8WUX9.
KOiK15053.
OMAiMAKTYLR.
OrthoDBiEOG091G09H0.
PhylomeDBiQ8WUX9.
TreeFamiTF312851.

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-1632852. Macroautophagy.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

ChiTaRSiCHMP7. human.
GenomeRNAii91782.
PROiQ8WUX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147457.
CleanExiHS_CHMP7.
ExpressionAtlasiQ8WUX9. baseline and differential.
GenevisibleiQ8WUX9. HS.

Family and domain databases

InterProiIPR005024. Snf7_fam.
[Graphical view]
PfamiPF03357. Snf7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHMP7_HUMAN
AccessioniPrimary (citable) accession number: Q8WUX9
Secondary accession number(s): B2RDT3
, B4DKJ6, D3DSS1, Q8NDM1, Q9BT50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.