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Q8WUX2

- CHAC2_HUMAN

UniProt

Q8WUX2 - CHAC2_HUMAN

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Protein

Cation transport regulator-like protein 2

Gene

CHAC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cation transport regulator-like protein 2
Gene namesi
Name:CHAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:32363. CHAC2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Cation transport regulator-like protein 2PRO_0000314912Add
BLAST

Proteomic databases

MaxQBiQ8WUX2.
PaxDbiQ8WUX2.
PRIDEiQ8WUX2.

PTM databases

PhosphoSiteiQ8WUX2.

Expressioni

Gene expression databases

BgeeiQ8WUX2.
CleanExiHS_CHAC2.
GenevestigatoriQ8WUX2.

Organism-specific databases

HPAiHPA049235.

Interactioni

Protein-protein interaction databases

BioGridi138943. 6 interactions.
STRINGi9606.ENSP00000295304.

Structurei

3D structure databases

ProteinModelPortaliQ8WUX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ChaC family.Curated

Phylogenomic databases

eggNOGiCOG3703.
GeneTreeiENSGT00390000003855.
HOGENOMiHOG000264264.
HOVERGENiHBG056733.
InParanoidiQ8WUX2.
OMAiYIVFGYG.
OrthoDBiEOG7F7W9F.
PhylomeDBiQ8WUX2.
TreeFamiTF313048.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERiPTHR12192. PTHR12192. 1 hit.
PfamiPF04752. ChaC. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WUX2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV
60 70 80 90 100
TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT
110 120 130 140 150
TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN
160 170 180
SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
Length:184
Mass (Da):20,875
Last modified:March 1, 2002 - v1
Checksum:iE0F10C446A105E22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821R → G.1 Publication
Corresponds to variant rs17851583 [ dbSNP | Ensembl ].
VAR_038123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007883 Genomic DNA. Translation: AAY24351.1.
CH471053 Genomic DNA. Translation: EAX00172.1.
BC017941 mRNA. Translation: AAH17941.1.
BC019239 mRNA. Translation: AAH19239.1.
BC025376 mRNA. Translation: AAH25376.1.
BC053896 mRNA. Translation: AAH53896.1.
CCDSiCCDS33196.1.
RefSeqiNP_001008708.1. NM_001008708.2.
UniGeneiHs.585944.

Genome annotation databases

EnsembliENST00000295304; ENSP00000295304; ENSG00000143942.
GeneIDi494143.
KEGGihsa:494143.
UCSCiuc002rxk.1. human.

Polymorphism databases

DMDMi74730779.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007883 Genomic DNA. Translation: AAY24351.1 .
CH471053 Genomic DNA. Translation: EAX00172.1 .
BC017941 mRNA. Translation: AAH17941.1 .
BC019239 mRNA. Translation: AAH19239.1 .
BC025376 mRNA. Translation: AAH25376.1 .
BC053896 mRNA. Translation: AAH53896.1 .
CCDSi CCDS33196.1.
RefSeqi NP_001008708.1. NM_001008708.2.
UniGenei Hs.585944.

3D structure databases

ProteinModelPortali Q8WUX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 138943. 6 interactions.
STRINGi 9606.ENSP00000295304.

PTM databases

PhosphoSitei Q8WUX2.

Polymorphism databases

DMDMi 74730779.

Proteomic databases

MaxQBi Q8WUX2.
PaxDbi Q8WUX2.
PRIDEi Q8WUX2.

Protocols and materials databases

DNASUi 494143.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295304 ; ENSP00000295304 ; ENSG00000143942 .
GeneIDi 494143.
KEGGi hsa:494143.
UCSCi uc002rxk.1. human.

Organism-specific databases

CTDi 494143.
GeneCardsi GC02P053994.
HGNCi HGNC:32363. CHAC2.
HPAi HPA049235.
neXtProti NX_Q8WUX2.
PharmGKBi PA142672120.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3703.
GeneTreei ENSGT00390000003855.
HOGENOMi HOG000264264.
HOVERGENi HBG056733.
InParanoidi Q8WUX2.
OMAi YIVFGYG.
OrthoDBi EOG7F7W9F.
PhylomeDBi Q8WUX2.
TreeFami TF313048.

Miscellaneous databases

GenomeRNAii 494143.
NextBioi 111820.
PROi Q8WUX2.

Gene expression databases

Bgeei Q8WUX2.
CleanExi HS_CHAC2.
Genevestigatori Q8WUX2.

Family and domain databases

Gene3Di 3.10.490.10. 1 hit.
InterProi IPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view ]
PANTHERi PTHR12192. PTHR12192. 1 hit.
Pfami PF04752. ChaC. 1 hit.
[Graphical view ]
SUPFAMi SSF110857. SSF110857. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-82.
    Tissue: Brain, Kidney and Uterus.

Entry informationi

Entry nameiCHAC2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUX2
Secondary accession number(s): Q8WVI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3