Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione-specific gamma-glutamylcyclotransferase 2

Gene

CHAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.1 Publication

Catalytic activityi

Glutathione = 5-oxo-L-proline + L-cysteinylglycine.1 Publication

Kineticsi

kcat is 15.9 min(-1) for glutathione.1 Publication
  1. KM=3.7 mM for glutathione1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei83Proton acceptorBy similarity1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionLyase

    Enzyme and pathway databases

    ReactomeiR-HSA-174403. Glutathione synthesis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione-specific gamma-glutamylcyclotransferase 21 Publication (EC:4.3.2.-1 Publication)
    Short name:
    Gamma-GCG 2Curated
    Alternative name(s):
    Cation transport regulator-like protein 2By similarity
    Gene namesi
    Name:CHAC2Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 2

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000143942.4.
    HGNCiHGNC:32363. CHAC2.

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    OpenTargetsiENSG00000143942.
    PharmGKBiPA142672120.

    Polymorphism and mutation databases

    BioMutaiCHAC2.
    DMDMi74730779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003149121 – 184Glutathione-specific gamma-glutamylcyclotransferase 2Add BLAST184

    Proteomic databases

    EPDiQ8WUX2.
    MaxQBiQ8WUX2.
    PaxDbiQ8WUX2.
    PeptideAtlasiQ8WUX2.
    PRIDEiQ8WUX2.

    PTM databases

    iPTMnetiQ8WUX2.
    PhosphoSitePlusiQ8WUX2.

    Expressioni

    Gene expression databases

    BgeeiENSG00000143942.
    CleanExiHS_CHAC2.
    GenevisibleiQ8WUX2. HS.

    Organism-specific databases

    HPAiHPA049235.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi138943. 13 interactors.
    IntActiQ8WUX2. 1 interactor.
    STRINGi9606.ENSP00000295304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUX2.
    SMRiQ8WUX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni3 – 8Substrate bindingBy similarity6

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG3182. Eukaryota.
    COG3703. LUCA.
    GeneTreeiENSGT00390000003855.
    HOGENOMiHOG000264264.
    HOVERGENiHBG056733.
    InParanoidiQ8WUX2.
    OMAiDFPYEEK.
    OrthoDBiEOG091G0MZM.
    PhylomeDBiQ8WUX2.
    TreeFamiTF313048.

    Family and domain databases

    CDDicd06661. GGCT_like. 1 hit.
    InterProiView protein in InterPro
    IPR006840. ChaC.
    IPR013024. GGCT-like.
    IPR036568. GGCT-like_sf.
    PANTHERiPTHR12192. PTHR12192. 1 hit.
    PfamiView protein in Pfam
    PF04752. ChaC. 1 hit.
    SUPFAMiSSF110857. SSF110857. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8WUX2-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV
    60 70 80 90 100
    TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT
    110 120 130 140 150
    TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN
    160 170 180
    SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
    Length:184
    Mass (Da):20,875
    Last modified:March 1, 2002 - v1
    Checksum:iE0F10C446A105E22
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_03812382R → G1 PublicationCorresponds to variant dbSNP:rs17851583Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC007883 Genomic DNA. Translation: AAY24351.1.
    CH471053 Genomic DNA. Translation: EAX00172.1.
    BC017941 mRNA. Translation: AAH17941.1.
    BC019239 mRNA. Translation: AAH19239.1.
    BC025376 mRNA. Translation: AAH25376.1.
    BC053896 mRNA. Translation: AAH53896.1.
    CCDSiCCDS33196.1.
    RefSeqiNP_001008708.1. NM_001008708.3.
    NP_001333056.1. NM_001346127.1.
    UniGeneiHs.585944.

    Genome annotation databases

    EnsembliENST00000295304; ENSP00000295304; ENSG00000143942.
    GeneIDi494143.
    KEGGihsa:494143.
    UCSCiuc002rxk.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiCHAC2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUX2
    Secondary accession number(s): Q8WVI8
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2002
    Last modified: November 22, 2017
    This is version 114 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families