Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WUX2 (CHAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation transport regulator-like protein 2
Gene names
Name:CHAC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ChaC family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Cation transport regulator-like protein 2
PRO_0000314912

Natural variations

Natural variant821R → G. Ref.3
Corresponds to variant rs17851583 [ dbSNP | Ensembl ].
VAR_038123

Sequences

Sequence LengthMass (Da)Tools
Q8WUX2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E0F10C446A105E22

FASTA18420,875
        10         20         30         40         50         60 
MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV TLVEDPAGCV 

        70         80         90        100        110        120 
WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT TKPFSVLLYI GTCDNPDYLG 

       130        140        150        160        170        180 
PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN SIRNLVPEEA DEHLFALEKL VKERLEGKQN 


LNCI 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-82.
Tissue: Brain, Kidney and Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC007883 Genomic DNA. Translation: AAY24351.1.
CH471053 Genomic DNA. Translation: EAX00172.1.
BC017941 mRNA. Translation: AAH17941.1.
BC019239 mRNA. Translation: AAH19239.1.
BC025376 mRNA. Translation: AAH25376.1.
BC053896 mRNA. Translation: AAH53896.1.
CCDSCCDS33196.1.
RefSeqNP_001008708.1. NM_001008708.2.
UniGeneHs.585944.

3D structure databases

ProteinModelPortalQ8WUX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid138943. 4 interactions.
STRING9606.ENSP00000295304.

PTM databases

PhosphoSiteQ8WUX2.

Polymorphism databases

DMDM74730779.

Proteomic databases

MaxQBQ8WUX2.
PaxDbQ8WUX2.
PRIDEQ8WUX2.

Protocols and materials databases

DNASU494143.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295304; ENSP00000295304; ENSG00000143942.
GeneID494143.
KEGGhsa:494143.
UCSCuc002rxk.1. human.

Organism-specific databases

CTD494143.
GeneCardsGC02P053994.
HGNCHGNC:32363. CHAC2.
HPAHPA049235.
neXtProtNX_Q8WUX2.
PharmGKBPA142672120.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3703.
HOGENOMHOG000264264.
HOVERGENHBG056733.
InParanoidQ8WUX2.
OMAYIVFGYG.
OrthoDBEOG7F7W9F.
PhylomeDBQ8WUX2.
TreeFamTF313048.

Gene expression databases

BgeeQ8WUX2.
CleanExHS_CHAC2.
GenevestigatorQ8WUX2.

Family and domain databases

Gene3D3.10.490.10. 1 hit.
InterProIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERPTHR12192. PTHR12192. 1 hit.
PfamPF04752. ChaC. 1 hit.
[Graphical view]
SUPFAMSSF110857. SSF110857. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi494143.
NextBio111820.
PROQ8WUX2.

Entry information

Entry nameCHAC2_HUMAN
AccessionPrimary (citable) accession number: Q8WUX2
Secondary accession number(s): Q8WVI8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM