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Protein

Putative glutathione-specific gamma-glutamylcyclotransferase 2

Gene

CHAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.By similarity

Catalytic activityi

Glutathione = 5-oxoproline + cysteinylglycine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutathione-specific gamma-glutamylcyclotransferase 2By similarity (EC:2.3.2.-By similarity)
Short name:
Gamma-GCG 2By similarity
Alternative name(s):
Cation transport regulator-like protein 2By similarity
Gene namesi
Name:CHAC2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32363. CHAC2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672120.

Polymorphism and mutation databases

BioMutaiCHAC2.
DMDMi74730779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Putative glutathione-specific gamma-glutamylcyclotransferase 2PRO_0000314912Add
BLAST

Proteomic databases

MaxQBiQ8WUX2.
PaxDbiQ8WUX2.
PRIDEiQ8WUX2.

PTM databases

PhosphoSiteiQ8WUX2.

Expressioni

Gene expression databases

BgeeiQ8WUX2.
CleanExiHS_CHAC2.
GenevestigatoriQ8WUX2.

Organism-specific databases

HPAiHPA049235.

Interactioni

Protein-protein interaction databases

BioGridi138943. 4 interactions.
STRINGi9606.ENSP00000295304.

Structurei

3D structure databases

ProteinModelPortaliQ8WUX2.
SMRiQ8WUX2. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 86Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3703.
GeneTreeiENSGT00390000003855.
HOGENOMiHOG000264264.
HOVERGENiHBG056733.
InParanoidiQ8WUX2.
OMAiREMLTGC.
OrthoDBiEOG7F7W9F.
PhylomeDBiQ8WUX2.
TreeFamiTF313048.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERiPTHR12192. PTHR12192. 1 hit.
PfamiPF04752. ChaC. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WUX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV
60 70 80 90 100
TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT
110 120 130 140 150
TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN
160 170 180
SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
Length:184
Mass (Da):20,875
Last modified:March 1, 2002 - v1
Checksum:iE0F10C446A105E22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821R → G.1 Publication
Corresponds to variant rs17851583 [ dbSNP | Ensembl ].
VAR_038123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007883 Genomic DNA. Translation: AAY24351.1.
CH471053 Genomic DNA. Translation: EAX00172.1.
BC017941 mRNA. Translation: AAH17941.1.
BC019239 mRNA. Translation: AAH19239.1.
BC025376 mRNA. Translation: AAH25376.1.
BC053896 mRNA. Translation: AAH53896.1.
CCDSiCCDS33196.1.
RefSeqiNP_001008708.1. NM_001008708.2.
UniGeneiHs.585944.

Genome annotation databases

EnsembliENST00000295304; ENSP00000295304; ENSG00000143942.
GeneIDi494143.
KEGGihsa:494143.
UCSCiuc002rxk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007883 Genomic DNA. Translation: AAY24351.1.
CH471053 Genomic DNA. Translation: EAX00172.1.
BC017941 mRNA. Translation: AAH17941.1.
BC019239 mRNA. Translation: AAH19239.1.
BC025376 mRNA. Translation: AAH25376.1.
BC053896 mRNA. Translation: AAH53896.1.
CCDSiCCDS33196.1.
RefSeqiNP_001008708.1. NM_001008708.2.
UniGeneiHs.585944.

3D structure databases

ProteinModelPortaliQ8WUX2.
SMRiQ8WUX2. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138943. 4 interactions.
STRINGi9606.ENSP00000295304.

PTM databases

PhosphoSiteiQ8WUX2.

Polymorphism and mutation databases

BioMutaiCHAC2.
DMDMi74730779.

Proteomic databases

MaxQBiQ8WUX2.
PaxDbiQ8WUX2.
PRIDEiQ8WUX2.

Protocols and materials databases

DNASUi494143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295304; ENSP00000295304; ENSG00000143942.
GeneIDi494143.
KEGGihsa:494143.
UCSCiuc002rxk.1. human.

Organism-specific databases

CTDi494143.
GeneCardsiGC02P053994.
HGNCiHGNC:32363. CHAC2.
HPAiHPA049235.
neXtProtiNX_Q8WUX2.
PharmGKBiPA142672120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG3703.
GeneTreeiENSGT00390000003855.
HOGENOMiHOG000264264.
HOVERGENiHBG056733.
InParanoidiQ8WUX2.
OMAiREMLTGC.
OrthoDBiEOG7F7W9F.
PhylomeDBiQ8WUX2.
TreeFamiTF313048.

Miscellaneous databases

GenomeRNAii494143.
NextBioi111820.
PROiQ8WUX2.

Gene expression databases

BgeeiQ8WUX2.
CleanExiHS_CHAC2.
GenevestigatoriQ8WUX2.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERiPTHR12192. PTHR12192. 1 hit.
PfamiPF04752. ChaC. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-82.
    Tissue: Brain, Kidney and Uterus.

Entry informationi

Entry nameiCHAC2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUX2
Secondary accession number(s): Q8WVI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.