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Q8WUX2

- CHAC2_HUMAN

UniProt

Q8WUX2 - CHAC2_HUMAN

Protein

Cation transport regulator-like protein 2

Gene

CHAC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation transport regulator-like protein 2
    Gene namesi
    Name:CHAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:32363. CHAC2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672120.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184Cation transport regulator-like protein 2PRO_0000314912Add
    BLAST

    Proteomic databases

    MaxQBiQ8WUX2.
    PaxDbiQ8WUX2.
    PRIDEiQ8WUX2.

    PTM databases

    PhosphoSiteiQ8WUX2.

    Expressioni

    Gene expression databases

    BgeeiQ8WUX2.
    CleanExiHS_CHAC2.
    GenevestigatoriQ8WUX2.

    Organism-specific databases

    HPAiHPA049235.

    Interactioni

    Protein-protein interaction databases

    BioGridi138943. 4 interactions.
    STRINGi9606.ENSP00000295304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ChaC family.Curated

    Phylogenomic databases

    eggNOGiCOG3703.
    HOGENOMiHOG000264264.
    HOVERGENiHBG056733.
    InParanoidiQ8WUX2.
    OMAiYIVFGYG.
    OrthoDBiEOG7F7W9F.
    PhylomeDBiQ8WUX2.
    TreeFamiTF313048.

    Family and domain databases

    Gene3Di3.10.490.10. 1 hit.
    InterProiIPR013024. Butirosin_synth_BtrG-like.
    IPR006840. ChaC.
    [Graphical view]
    PANTHERiPTHR12192. PTHR12192. 1 hit.
    PfamiPF04752. ChaC. 1 hit.
    [Graphical view]
    SUPFAMiSSF110857. SSF110857. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8WUX2-1 [UniParc]FASTAAdd to Basket

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    MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV    50
    TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT 100
    TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN 150
    SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI 184
    Length:184
    Mass (Da):20,875
    Last modified:March 1, 2002 - v1
    Checksum:iE0F10C446A105E22
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821R → G.1 Publication
    Corresponds to variant rs17851583 [ dbSNP | Ensembl ].
    VAR_038123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007883 Genomic DNA. Translation: AAY24351.1.
    CH471053 Genomic DNA. Translation: EAX00172.1.
    BC017941 mRNA. Translation: AAH17941.1.
    BC019239 mRNA. Translation: AAH19239.1.
    BC025376 mRNA. Translation: AAH25376.1.
    BC053896 mRNA. Translation: AAH53896.1.
    CCDSiCCDS33196.1.
    RefSeqiNP_001008708.1. NM_001008708.2.
    UniGeneiHs.585944.

    Genome annotation databases

    EnsembliENST00000295304; ENSP00000295304; ENSG00000143942.
    GeneIDi494143.
    KEGGihsa:494143.
    UCSCiuc002rxk.1. human.

    Polymorphism databases

    DMDMi74730779.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007883 Genomic DNA. Translation: AAY24351.1 .
    CH471053 Genomic DNA. Translation: EAX00172.1 .
    BC017941 mRNA. Translation: AAH17941.1 .
    BC019239 mRNA. Translation: AAH19239.1 .
    BC025376 mRNA. Translation: AAH25376.1 .
    BC053896 mRNA. Translation: AAH53896.1 .
    CCDSi CCDS33196.1.
    RefSeqi NP_001008708.1. NM_001008708.2.
    UniGenei Hs.585944.

    3D structure databases

    ProteinModelPortali Q8WUX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 138943. 4 interactions.
    STRINGi 9606.ENSP00000295304.

    PTM databases

    PhosphoSitei Q8WUX2.

    Polymorphism databases

    DMDMi 74730779.

    Proteomic databases

    MaxQBi Q8WUX2.
    PaxDbi Q8WUX2.
    PRIDEi Q8WUX2.

    Protocols and materials databases

    DNASUi 494143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295304 ; ENSP00000295304 ; ENSG00000143942 .
    GeneIDi 494143.
    KEGGi hsa:494143.
    UCSCi uc002rxk.1. human.

    Organism-specific databases

    CTDi 494143.
    GeneCardsi GC02P053994.
    HGNCi HGNC:32363. CHAC2.
    HPAi HPA049235.
    neXtProti NX_Q8WUX2.
    PharmGKBi PA142672120.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3703.
    HOGENOMi HOG000264264.
    HOVERGENi HBG056733.
    InParanoidi Q8WUX2.
    OMAi YIVFGYG.
    OrthoDBi EOG7F7W9F.
    PhylomeDBi Q8WUX2.
    TreeFami TF313048.

    Miscellaneous databases

    GenomeRNAii 494143.
    NextBioi 111820.
    PROi Q8WUX2.

    Gene expression databases

    Bgeei Q8WUX2.
    CleanExi HS_CHAC2.
    Genevestigatori Q8WUX2.

    Family and domain databases

    Gene3Di 3.10.490.10. 1 hit.
    InterProi IPR013024. Butirosin_synth_BtrG-like.
    IPR006840. ChaC.
    [Graphical view ]
    PANTHERi PTHR12192. PTHR12192. 1 hit.
    Pfami PF04752. ChaC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110857. SSF110857. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-82.
      Tissue: Brain, Kidney and Uterus.

    Entry informationi

    Entry nameiCHAC2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUX2
    Secondary accession number(s): Q8WVI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3