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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

SLC38A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.1 Publication

Enzyme regulationi

Not inhibited by lithium.1 Publication

Kineticsi

  1. KM=0.6 mM for histidine (at pH 8.0)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Enzyme and pathway databases

    ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

    Protein family/group databases

    TCDBi2.A.18.6.15 the amino acid/auxin permease (aaap) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 5
    Alternative name(s):
    Solute carrier family 38 member 5
    System N transporter 2
    Gene namesi
    Name:SLC38A5
    Synonyms:JM24, SN2, SNAT5
    ORF Names:PP7194
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome X

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000017483.14
    HGNCiHGNC:18070 SLC38A5
    MIMi300649 gene
    neXtProtiNX_Q8WUX1

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
    Transmembranei49 – 71HelicalSequence analysisAdd BLAST23
    Topological domaini72 – 87ExtracellularSequence analysisAdd BLAST16
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 125CytoplasmicSequence analysisAdd BLAST17
    Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
    Topological domaini147 – 166ExtracellularSequence analysisAdd BLAST20
    Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
    Topological domaini188 – 192CytoplasmicSequence analysis5
    Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
    Topological domaini214 – 257ExtracellularSequence analysisAdd BLAST44
    Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
    Topological domaini279 – 295CytoplasmicSequence analysisAdd BLAST17
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 334ExtracellularSequence analysisAdd BLAST18
    Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
    Topological domaini356 – 376CytoplasmicSequence analysisAdd BLAST21
    Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
    Topological domaini398 – 399ExtracellularSequence analysis2
    Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
    Topological domaini421 – 439CytoplasmicSequence analysisAdd BLAST19
    Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
    Topological domaini461 – 472ExtracellularSequence analysisAdd BLAST12

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi92745
    OpenTargetsiENSG00000017483
    PharmGKBiPA38289

    Polymorphism and mutation databases

    BioMutaiSLC38A5
    DMDMi74730778

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003121151 – 472Sodium-coupled neutral amino acid transporter 5Add BLAST472

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionineCombined sources1
    Disulfide bondi221 ↔ 247PROSITE-ProRule annotation
    Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    EPDiQ8WUX1
    MaxQBiQ8WUX1
    PaxDbiQ8WUX1
    PeptideAtlasiQ8WUX1
    PRIDEiQ8WUX1

    PTM databases

    iPTMnetiQ8WUX1
    PhosphoSitePlusiQ8WUX1

    Expressioni

    Tissue specificityi

    Predominantly expressed in stomach, brain, liver, lung and intestinal tract.1 Publication

    Gene expression databases

    BgeeiENSG00000017483
    CleanExiHS_SLC38A5
    ExpressionAtlasiQ8WUX1 baseline and differential
    GenevisibleiQ8WUX1 HS

    Organism-specific databases

    HPAiHPA047411

    Interactioni

    Protein-protein interaction databases

    BioGridi124974, 9 interactors
    IntActiQ8WUX1, 8 interactors
    STRINGi9606.ENSP00000313740

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUX1
    SMRiQ8WUX1
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1305 Eukaryota
    COG0814 LUCA
    GeneTreeiENSGT00760000119147
    HOGENOMiHOG000013088
    HOVERGENiHBG059571
    InParanoidiQ8WUX1
    KOiK14992
    OMAiHNVGAMS
    OrthoDBiEOG091G0GP8
    PhylomeDBiQ8WUX1
    TreeFamiTF328787

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8WUX1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF
    60 70 80 90 100
    GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL
    110 120 130 140 150
    TCAGIAGIRA YEQLGQRAFG PAGKVVVATV ICLHNVGAMS SYLFIIKSEL
    160 170 180 190 200
    PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL IILPLALMKH LGYLGYTSGL
    210 220 230 240 250
    SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS QGLNSSCEAQ
    260 270 280 290 300
    MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA
    310 320 330 340 350
    MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV
    360 370 380 390 400
    PVVLFPIRRA LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI
    410 420 430 440 450
    FGVIGSTSAP SLIFILPSIF YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF
    460 470
    MAVSLGFMFA NWATGQSRMS GH
    Length:472
    Mass (Da):51,457
    Last modified:March 1, 2002 - v1
    Checksum:i2DDB4C03E5E78734
    GO
    Isoform 2 (identifier: Q8WUX1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:421
    Mass (Da):45,916
    Checksum:i23856C0AB7955E30
    GO

    Sequence cautioni

    The sequence AAL55865 differs from that shown. Reason: Frameshift at positions 161 and 466.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti456G → S in AAK61856 (PubMed:11243884).Curated1
    Sequence conflicti465G → S in AAK61856 (PubMed:11243884).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_037396451M → T1 PublicationCorresponds to variant dbSNP:rs17281188Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0297021 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF276889 mRNA Translation: AAK61856.1
    AF318358 mRNA Translation: AAL55865.1 Frameshift.
    AK094788 mRNA Translation: BAG52932.1
    CH471224 Genomic DNA Translation: EAW50785.1
    AF196972 Genomic DNA No translation available.
    BC019246 mRNA Translation: AAH19246.1
    BC027721 mRNA Translation: AAH27721.1
    CCDSiCCDS14293.1 [Q8WUX1-1]
    PIRiJC7626
    RefSeqiNP_277053.2, NM_033518.3 [Q8WUX1-1]
    XP_016885450.1, XM_017029961.1 [Q8WUX1-1]
    UniGeneiHs.195155

    Genome annotation databases

    EnsembliENST00000595796; ENSP00000471683; ENSG00000017483 [Q8WUX1-1]
    ENST00000619100; ENSP00000478807; ENSG00000017483 [Q8WUX1-2]
    ENST00000620913; ENSP00000481291; ENSG00000017483 [Q8WUX1-1]
    GeneIDi92745
    KEGGihsa:92745
    UCSCiuc033ecl.2 human [Q8WUX1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiS38A5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUX1
    Secondary accession number(s): B3KT20
    , B5MDE6, B7WPJ9, Q6PIW9, Q8WYU2, Q96PQ4
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: March 1, 2002
    Last modified: March 28, 2018
    This is version 118 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health