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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

SLC38A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.1 Publication

Enzyme regulationi

Not inhibited by lithium.1 Publication

Kineticsi

  1. KM=0.6 mM for histidine (at pH 8.0)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Enzyme and pathway databases

    ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.18.6.15. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 5
    Alternative name(s):
    Solute carrier family 38 member 5
    System N transporter 2
    Gene namesi
    Name:SLC38A5
    Synonyms:JM24, SN2, SNAT5
    ORF Names:PP7194
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome X

    Organism-specific databases

    HGNCiHGNC:18070. SLC38A5.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei49 – 7123HelicalSequence analysisAdd
    BLAST
    Topological domaini72 – 8716ExtracellularSequence analysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence analysisAdd
    BLAST
    Topological domaini109 – 12517CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence analysisAdd
    BLAST
    Topological domaini147 – 16620ExtracellularSequence analysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence analysisAdd
    BLAST
    Topological domaini188 – 1925CytoplasmicSequence analysis
    Transmembranei193 – 21321HelicalSequence analysisAdd
    BLAST
    Topological domaini214 – 25744ExtracellularSequence analysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence analysisAdd
    BLAST
    Topological domaini279 – 29517CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence analysisAdd
    BLAST
    Topological domaini317 – 33418ExtracellularSequence analysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence analysisAdd
    BLAST
    Topological domaini356 – 37621CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence analysisAdd
    BLAST
    Topological domaini398 – 3992ExtracellularSequence analysis
    Transmembranei400 – 42021HelicalSequence analysisAdd
    BLAST
    Topological domaini421 – 43919CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei440 – 46021HelicalSequence analysisAdd
    BLAST
    Topological domaini461 – 47212ExtracellularSequence analysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38289.

    Polymorphism and mutation databases

    BioMutaiSLC38A5.
    DMDMi74730778.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Sodium-coupled neutral amino acid transporter 5PRO_0000312115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineCombined sources
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    EPDiQ8WUX1.
    MaxQBiQ8WUX1.
    PaxDbiQ8WUX1.
    PRIDEiQ8WUX1.

    PTM databases

    iPTMnetiQ8WUX1.
    PhosphoSiteiQ8WUX1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in stomach, brain, liver, lung and intestinal tract.1 Publication

    Gene expression databases

    BgeeiQ8WUX1.
    CleanExiHS_SLC38A5.
    ExpressionAtlasiQ8WUX1. baseline and differential.
    GenevisibleiQ8WUX1. HS.

    Organism-specific databases

    HPAiHPA047411.

    Interactioni

    Protein-protein interaction databases

    BioGridi124974. 8 interactions.
    IntActiQ8WUX1. 8 interactions.
    STRINGi9606.ENSP00000313740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1305. Eukaryota.
    COG0814. LUCA.
    GeneTreeiENSGT00760000119147.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ8WUX1.
    KOiK14992.
    OMAiFQLGCAV.
    OrthoDBiEOG7WHH9J.
    PhylomeDBiQ8WUX1.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8WUX1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF
    60 70 80 90 100
    GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL
    110 120 130 140 150
    TCAGIAGIRA YEQLGQRAFG PAGKVVVATV ICLHNVGAMS SYLFIIKSEL
    160 170 180 190 200
    PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL IILPLALMKH LGYLGYTSGL
    210 220 230 240 250
    SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS QGLNSSCEAQ
    260 270 280 290 300
    MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA
    310 320 330 340 350
    MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV
    360 370 380 390 400
    PVVLFPIRRA LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI
    410 420 430 440 450
    FGVIGSTSAP SLIFILPSIF YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF
    460 470
    MAVSLGFMFA NWATGQSRMS GH
    Length:472
    Mass (Da):51,457
    Last modified:March 1, 2002 - v1
    Checksum:i2DDB4C03E5E78734
    GO
    Isoform 2 (identifier: Q8WUX1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:421
    Mass (Da):45,916
    Checksum:i23856C0AB7955E30
    GO

    Sequence cautioni

    The sequence AAL55865.1 differs from that shown. Reason: Frameshift at positions 161 and 466. Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti456 – 4561G → S in AAK61856 (PubMed:11243884).Curated
    Sequence conflicti465 – 4651G → S in AAK61856 (PubMed:11243884).Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti451 – 4511M → T.1 Publication
    Corresponds to variant rs17281188 [ dbSNP | Ensembl ].
    VAR_037396

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5151Missing in isoform 2. 1 PublicationVSP_029702Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF276889 mRNA. Translation: AAK61856.1.
    AF318358 mRNA. Translation: AAL55865.1. Frameshift.
    AK094788 mRNA. Translation: BAG52932.1.
    CH471224 Genomic DNA. Translation: EAW50785.1.
    AF196972 Genomic DNA. No translation available.
    BC019246 mRNA. Translation: AAH19246.1.
    BC027721 mRNA. Translation: AAH27721.1.
    CCDSiCCDS14293.1. [Q8WUX1-1]
    PIRiJC7626.
    RefSeqiNP_277053.2. NM_033518.3. [Q8WUX1-1]
    XP_005272752.2. XM_005272695.3. [Q8WUX1-1]
    UniGeneiHs.195155.

    Genome annotation databases

    EnsembliENST00000595796; ENSP00000471683; ENSG00000017483. [Q8WUX1-1]
    ENST00000619100; ENSP00000478807; ENSG00000017483. [Q8WUX1-2]
    ENST00000620913; ENSP00000481291; ENSG00000017483. [Q8WUX1-1]
    GeneIDi92745.
    KEGGihsa:92745.
    UCSCiuc033ecl.2. human. [Q8WUX1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF276889 mRNA. Translation: AAK61856.1.
    AF318358 mRNA. Translation: AAL55865.1. Frameshift.
    AK094788 mRNA. Translation: BAG52932.1.
    CH471224 Genomic DNA. Translation: EAW50785.1.
    AF196972 Genomic DNA. No translation available.
    BC019246 mRNA. Translation: AAH19246.1.
    BC027721 mRNA. Translation: AAH27721.1.
    CCDSiCCDS14293.1. [Q8WUX1-1]
    PIRiJC7626.
    RefSeqiNP_277053.2. NM_033518.3. [Q8WUX1-1]
    XP_005272752.2. XM_005272695.3. [Q8WUX1-1]
    UniGeneiHs.195155.

    3D structure databases

    ProteinModelPortaliQ8WUX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi124974. 8 interactions.
    IntActiQ8WUX1. 8 interactions.
    STRINGi9606.ENSP00000313740.

    Protein family/group databases

    TCDBi2.A.18.6.15. the amino acid/auxin permease (aaap) family.

    PTM databases

    iPTMnetiQ8WUX1.
    PhosphoSiteiQ8WUX1.

    Polymorphism and mutation databases

    BioMutaiSLC38A5.
    DMDMi74730778.

    Proteomic databases

    EPDiQ8WUX1.
    MaxQBiQ8WUX1.
    PaxDbiQ8WUX1.
    PRIDEiQ8WUX1.

    Protocols and materials databases

    DNASUi92745.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000595796; ENSP00000471683; ENSG00000017483. [Q8WUX1-1]
    ENST00000619100; ENSP00000478807; ENSG00000017483. [Q8WUX1-2]
    ENST00000620913; ENSP00000481291; ENSG00000017483. [Q8WUX1-1]
    GeneIDi92745.
    KEGGihsa:92745.
    UCSCiuc033ecl.2. human. [Q8WUX1-1]

    Organism-specific databases

    CTDi92745.
    GeneCardsiSLC38A5.
    H-InvDBHIX0016773.
    HGNCiHGNC:18070. SLC38A5.
    HPAiHPA047411.
    MIMi300649. gene.
    neXtProtiNX_Q8WUX1.
    PharmGKBiPA38289.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1305. Eukaryota.
    COG0814. LUCA.
    GeneTreeiENSGT00760000119147.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ8WUX1.
    KOiK14992.
    OMAiFQLGCAV.
    OrthoDBiEOG7WHH9J.
    PhylomeDBiQ8WUX1.
    TreeFamiTF328787.

    Enzyme and pathway databases

    ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSiSLC38A5. human.
    GenomeRNAii92745.
    NextBioi77865.
    PROiQ8WUX1.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ8WUX1.
    CleanExiHS_SLC38A5.
    ExpressionAtlasiQ8WUX1. baseline and differential.
    GenevisibleiQ8WUX1. HS.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N."
      Nakanishi T., Sugawara M., Huang W., Martindale R.G., Leibach F.H., Ganapathy M.E., Prasad P.D., Ganapathy V.
      Biochem. Biophys. Res. Commun. 281:1343-1348(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-451, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Kidney.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS38A5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUX1
    Secondary accession number(s): B3KT20
    , B5MDE6, B7WPJ9, Q6PIW9, Q8WYU2, Q96PQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: March 1, 2002
    Last modified: April 13, 2016
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.