Q8WUW7 (Q8WUW7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyruvate kinase RuleBase RU000504
EC=2.7.1.40 RuleBase RU000504

Gene names

Name:

PKM2 EMBL AAH19265.2

Organism

Homo sapiens (Human) EMBL AAH19265.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504
Sequence similarities	Belongs to the pyruvate kinase family. RuleBase RU000504

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000504
Ligand	Magnesium RuleBase RU000504
Molecular function	Kinase RuleBase RU000504 Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro potassium ion binding Inferred from electronic annotation. Source: InterPro pyruvate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH19265.2

Sequences

	Sequence		Length	Mass (Da)
	Q8WUW7 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: 38A021AA4958AD9F	FASTA	343	37,276
	10 20 30 40 50 60 GADFLVTEVE NGGSLGSKKG VNLPGAAVDL PAVSEKDIQD LKFGVEQDVD MVFASFIRKA 70 80 90 100 110 120 SDVHEVRKVL GEKGKNIKII SKIENHEGVR RFDEILEASD GIMVARGDLG IEIPAEKVFL 130 140 150 160 170 180 AQKMMIGRCN RAGKPVICAT QMLESMIKKP RPTRAEGSDV ANAVLDGADC IMLSGETAKG 190 200 210 220 230 240 DYPLEAVRMQ HLIAREAEAA IYHLQLFEEL RRLAPITSDP TEATAVGAVE ASFKCCSGAI 250 260 270 280 290 300 IVLTKSGRSA HQVARYRPRA PIIAVTRNPQ TARQAHLYRG IFPVLCKDPV QEAWAEDVDL 310 320 330 340 RVNFAMNVGK ARGFFKKGDV VIVLTGWRPG SGFTNTMRVV PVP

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH19265.2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC019265 mRNA. Translation: AAH19265.2.
IPI	IPI00847989.
UniGene	Hs.534770.
3D structure databases
HSSP	HSSP built from PDB template 1PKM based on UniProtKB P11979.
ProteinModelPortal	Q8WUW7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WUW7.
Proteomic databases
PRIDE	Q8WUW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000941.
Enzyme and pathway databases
UniPathway	UPA00109; UER00188.
Gene expression databases
ArrayExpress	Q8WUW7.
Bgee	Q8WUW7.
Family and domain databases
Gene3D	2.40.33.10. 1 hit. 3.20.20.60. 1 hit. 3.40.1380.20. 1 hit.
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR015793. Pyrv_Knase_brl. IPR015795. Pyrv_Knase_C. IPR015806. Pyrv_Knase_insert_dom. [Graphical view]
PANTHER	PTHR11817. PTHR11817. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
SUPFAM	SSF52935. Pyruvate_kinase. 1 hit. SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PKM2. human.

Entry information

Entry name

Q8WUW7_HUMAN

Accession

Primary (citable) accession number: Q8WUW7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2004
Last modified:	March 6, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.