ID   Q8WUW6_HUMAN            Unreviewed;       334 AA.
AC   Q8WUW6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   08-NOV-2023, entry version 155.
DE   SubName: Full=DMWD protein {ECO:0000313|EMBL:AAH19266.1};
DE   SubName: Full=Dystrophia myotonica-containing WD repeat motif {ECO:0000313|EMBL:AAP35444.1};
GN   Name=DMWD {ECO:0000313|EMBL:AAH19266.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH19266.1};
RN   [1] {ECO:0000313|EMBL:AAP35444.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAH19266.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH19266.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC019266; AAH19266.1; -; mRNA.
DR   EMBL; BT006798; AAP35444.1; -; mRNA.
DR   RefSeq; NP_004934.1; NM_004943.1.
DR   AlphaFoldDB; Q8WUW6; -.
DR   IntAct; Q8WUW6; 1.
DR   PeptideAtlas; Q8WUW6; -.
DR   DNASU; 1762; -.
DR   GeneID; 1762; -.
DR   KEGG; hsa:1762; -.
DR   CTD; 1762; -.
DR   PharmGKB; PA27390; -.
DR   OrthoDB; 1513505at2759; -.
DR   BioGRID-ORCS; 1762; 15 hits in 1154 CRISPR screens.
DR   GenomeRNAi; 1762; -.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR14107:SF15; DYSTROPHIA MYOTONICA WD REPEAT-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR14107; WD REPEAT PROTEIN; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   REPEAT          7..48
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          69..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  34742 MW;  1D4050B2A901CCD7 CRC64;
     MLLRGLMKSY FGGLLCVCWS PDGRYVVTGG EDDLVTVWSF TEGRVVARGH GHKSWVNAVA
     FDPYTTRAEE AATAAGADGE RSGEEEEEEP EAAGTGSAGG APLSPLPKAG SITYRFGSAG
     QDTQFCLWDL TEDVLYPHPP LARTRTLPGT PGTTPPAASS SRGGEPGPGP LPRSLSRSNS
     LPHPAGGGKA GGPGVAAEPG TPFSIGRFAT LTLQERRDRG AEKEHKRYHS LGNISRGGSG
     GSGSGGEKPS GPVPRSRLDP AKVLGTALCP RIHEVPLLEP LVCKKIAQER LTVLLFLEDC
     IITACQEGLI CTWARPGKAG ISSQPGNSPS GTVV
//