ID   Q8WUV3_HUMAN            Unreviewed;       548 AA.
AC   Q8WUV3;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=PRMT3 protein {ECO:0000313|EMBL:AAH19339.1};
DE   Flags: Fragment;
GN   Name=PRMT3 {ECO:0000313|EMBL:AAH19339.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH19339.1};
RN   [1] {ECO:0000313|EMBL:AAH19339.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle {ECO:0000313|EMBL:AAH19339.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC019339; AAH19339.1; -; mRNA.
DR   RefSeq; NP_001138638.1; NM_001145166.1.
DR   RefSeq; NP_001138639.1; NM_001145167.1.
DR   AlphaFoldDB; Q8WUV3; -.
DR   IntAct; Q8WUV3; 1.
DR   PeptideAtlas; Q8WUV3; -.
DR   DNASU; 10196; -.
DR   GeneID; 10196; -.
DR   CTD; 10196; -.
DR   PharmGKB; PA29462; -.
DR   OrthoDB; 197898at2759; -.
DR   BioGRID-ORCS; 10196; 17 hits in 1172 CRISPR screens.
DR   ChiTaRS; PRMT3; human.
DR   GenomeRNAi; 10196; -.
DR   GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR049482; ANM3-like_C2H2_Zf.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11006:SF114; PROTEIN ARGININE N-METHYLTRANSFERASE 3; 1.
DR   Pfam; PF21137; ANM3_C2H2_Zf; 1.
DR   Pfam; PF06325; PrmA; 1.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
DR   Genevisible; Q8WUV3; HS.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01015};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01015}.
FT   DOMAIN          95..140
FT                   /note="Protein arginine N-methyltransferase 3-like C2H2
FT                   zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF21137"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH19339.1"
SQ   SEQUENCE   548 AA;  61967 MW;  11F5A3F52B105F56 CRC64;
     SDCEPARALR RSRRSAKFPE PRSRRGFALV LALVPGVGGR CARSLPNPVP APRHAGLSGH
     HSHVLVSVRR YRLFTSAEET FSHCKSEHQF NIDSMVHKHG LEFYGYIKLI NFIRLKNPTV
     EYMNSIYNPV PWEKEEYLKP VLEDDLLLQF DVEDLYEPVS VPFSYPNGLS ENTSVVEKLK
     HMEARALSAE AALARAREDL QKMKQFAQDF VMHTDVRTCS SSTSVIADLQ EDEDGVYFSS
     YGHYGIHEEM LKDKIRTESY RDFIYQNPHI FKDKVVLDVG CGTGILSMFA AKAGAKKVLG
     VDQSEILYQA MDIIRLNKLE DTITLIKGKI EEVHLPVEKV DVIISEWMGY FLLFESMLDS
     VLYAKNKYLA KGGSVYPDIC TISLVAVSDV NKHADRIAFW DDVYGFKMSC MKKAVIPEAV
     VEVLDPKTLI SEPCGIKHID CHTTSISDLE FSSDFTLKIT RTSMCTAIAG YFDIYFEKNC
     HNRVVFSTGP QSTKTHWKQT VFLLEKPFSV KAGEALKGKV TVHKNKKDPR SLTVTLTLNN
     STQTYGLQ
//