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Protein

Zinc finger protein 296

Gene

ZNF296

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri157 – 18024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46824C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 296
Short name:
ZFP296
Alternative name(s):
Zinc finger protein 342
Gene namesi
Name:ZNF296
Synonyms:ZNF342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15981. ZNF296.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37660.

Polymorphism and mutation databases

BioMutaiZNF296.
DMDMi23396987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Zinc finger protein 296PRO_0000047542Add
BLAST

Proteomic databases

MaxQBiQ8WUU4.
PaxDbiQ8WUU4.
PRIDEiQ8WUU4.

PTM databases

iPTMnetiQ8WUU4.
PhosphoSiteiQ8WUU4.

Expressioni

Gene expression databases

BgeeiQ8WUU4.
CleanExiHS_ZNF296.
ExpressionAtlasiQ8WUU4. baseline and differential.
GenevisibleiQ8WUU4. HS.

Organism-specific databases

HPAiHPA046940.
HPA049576.

Interactioni

Protein-protein interaction databases

BioGridi127837. 2 interactions.
STRINGi9606.ENSP00000302770.

Structurei

3D structure databases

ProteinModelPortaliQ8WUU4.
SMRiQ8WUU4. Positions 148-184, 233-286, 388-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri157 – 18024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46824C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063542.
HOGENOMiHOG000152395.
HOVERGENiHBG071356.
InParanoidiQ8WUU4.
OMAiCQLFRGP.
OrthoDBiEOG7D85WP.
PhylomeDBiQ8WUU4.
TreeFamiTF318131.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKAGSAP RRVEPAPAAN PDDEMEMQDL VIELKPEPDA QPQQAPRLGP
60 70 80 90 100
FSPKEVSSAG RFGGEPHHSP GPMPAGAALL ALGPRNPWTL WTPLTPNYPD
110 120 130 140 150
RQPWTDKHPD LLTCGRCLQT FPLEAITAFM DHKKLGCQLF RGPSRGQGSE
160 170 180 190 200
REELKALSCL RCGKQFTVAW KLLRHAQWDH GLSIYQTESE APEAPLLGLA
210 220 230 240 250
EVAAAVSAVV GPAAEAKSPR ASGSGLTRRS PTCPVCKKTL SSFSNLKVHM
260 270 280 290 300
RSHTGERPYA CDQCPYACAQ SSKLNRHKKT HRQVPPQSPL MADTSQEQAS
310 320 330 340 350
AAPPEPAVHA AAPTSTLPCS GGEGAGAAAT AGVQEPGAPG SGAQAGPGGD
360 370 380 390 400
TWGAITTEQR TDPANSQKAS PKKMPKSGGK SRGPGGSCEF CGKHFTNSSN
410 420 430 440 450
LTVHRRSHTG ERPYTCEFCN YACAQSSKLN RHRRMHGMTP GSTRFECPHC
460 470
HVPFGLRATL DKHLRQKHPE AAGEA
Length:475
Mass (Da):50,810
Last modified:March 1, 2002 - v1
Checksum:i44C47A6C9C29BF93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019352 mRNA. Translation: AAH19352.1.
CCDSiCCDS12653.1.
RefSeqiNP_660331.1. NM_145288.1.
UniGeneiHs.192237.

Genome annotation databases

EnsembliENST00000303809; ENSP00000302770; ENSG00000170684.
GeneIDi162979.
KEGGihsa:162979.
UCSCiuc002pao.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019352 mRNA. Translation: AAH19352.1.
CCDSiCCDS12653.1.
RefSeqiNP_660331.1. NM_145288.1.
UniGeneiHs.192237.

3D structure databases

ProteinModelPortaliQ8WUU4.
SMRiQ8WUU4. Positions 148-184, 233-286, 388-465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127837. 2 interactions.
STRINGi9606.ENSP00000302770.

PTM databases

iPTMnetiQ8WUU4.
PhosphoSiteiQ8WUU4.

Polymorphism and mutation databases

BioMutaiZNF296.
DMDMi23396987.

Proteomic databases

MaxQBiQ8WUU4.
PaxDbiQ8WUU4.
PRIDEiQ8WUU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303809; ENSP00000302770; ENSG00000170684.
GeneIDi162979.
KEGGihsa:162979.
UCSCiuc002pao.4. human.

Organism-specific databases

CTDi162979.
GeneCardsiZNF296.
HGNCiHGNC:15981. ZNF296.
HPAiHPA046940.
HPA049576.
MIMi613226. gene.
neXtProtiNX_Q8WUU4.
PharmGKBiPA37660.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063542.
HOGENOMiHOG000152395.
HOVERGENiHBG071356.
InParanoidiQ8WUU4.
OMAiCQLFRGP.
OrthoDBiEOG7D85WP.
PhylomeDBiQ8WUU4.
TreeFamiTF318131.

Miscellaneous databases

GenomeRNAii162979.
PROiQ8WUU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUU4.
CleanExiHS_ZNF296.
ExpressionAtlasiQ8WUU4. baseline and differential.
GenevisibleiQ8WUU4. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN296_HUMAN
AccessioniPrimary (citable) accession number: Q8WUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.