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Protein

Zinc finger protein 296

Gene

ZNF296

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional corepressor with KLF4.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 468C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 296
Short name:
ZFP296
Alternative name(s):
Zinc finger protein 342
Gene namesi
Name:ZNF296
Synonyms:ZNF342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170684.8
HGNCiHGNC:15981 ZNF296
MIMi613226 gene
neXtProtiNX_Q8WUU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi162979
OpenTargetsiENSG00000170684
PharmGKBiPA37660

Polymorphism and mutation databases

BioMutaiZNF296
DMDMi23396987

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475421 – 475Zinc finger protein 296Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8WUU4
PaxDbiQ8WUU4
PeptideAtlasiQ8WUU4
PRIDEiQ8WUU4

PTM databases

iPTMnetiQ8WUU4
PhosphoSitePlusiQ8WUU4

Expressioni

Gene expression databases

BgeeiENSG00000170684
CleanExiHS_ZNF296
ExpressionAtlasiQ8WUU4 baseline and differential
GenevisibleiQ8WUU4 HS

Organism-specific databases

HPAiHPA046940
HPA049576

Interactioni

Subunit structurei

Interacts with KLF4.By similarity

Protein-protein interaction databases

BioGridi127837, 2 interactors
IntActiQ8WUU4, 2 interactors
STRINGi9606.ENSP00000302770

Structurei

3D structure databases

ProteinModelPortaliQ8WUU4
SMRiQ8WUU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 468C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063542
HOGENOMiHOG000152395
HOVERGENiHBG071356
InParanoidiQ8WUU4
OMAiCQLFRGP
OrthoDBiEOG091G09UH
PhylomeDBiQ8WUU4
TreeFamiTF318131

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q8WUU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKAGSAP RRVEPAPAAN PDDEMEMQDL VIELKPEPDA QPQQAPRLGP
60 70 80 90 100
FSPKEVSSAG RFGGEPHHSP GPMPAGAALL ALGPRNPWTL WTPLTPNYPD
110 120 130 140 150
RQPWTDKHPD LLTCGRCLQT FPLEAITAFM DHKKLGCQLF RGPSRGQGSE
160 170 180 190 200
REELKALSCL RCGKQFTVAW KLLRHAQWDH GLSIYQTESE APEAPLLGLA
210 220 230 240 250
EVAAAVSAVV GPAAEAKSPR ASGSGLTRRS PTCPVCKKTL SSFSNLKVHM
260 270 280 290 300
RSHTGERPYA CDQCPYACAQ SSKLNRHKKT HRQVPPQSPL MADTSQEQAS
310 320 330 340 350
AAPPEPAVHA AAPTSTLPCS GGEGAGAAAT AGVQEPGAPG SGAQAGPGGD
360 370 380 390 400
TWGAITTEQR TDPANSQKAS PKKMPKSGGK SRGPGGSCEF CGKHFTNSSN
410 420 430 440 450
LTVHRRSHTG ERPYTCEFCN YACAQSSKLN RHRRMHGMTP GSTRFECPHC
460 470
HVPFGLRATL DKHLRQKHPE AAGEA
Length:475
Mass (Da):50,810
Last modified:March 1, 2002 - v1
Checksum:i44C47A6C9C29BF93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019352 mRNA Translation: AAH19352.1
CCDSiCCDS12653.1
RefSeqiNP_660331.1, NM_145288.2
UniGeneiHs.192237

Genome annotation databases

EnsembliENST00000303809; ENSP00000302770; ENSG00000170684
GeneIDi162979
KEGGihsa:162979
UCSCiuc002pao.4 human

Similar proteinsi

Entry informationi

Entry nameiZN296_HUMAN
AccessioniPrimary (citable) accession number: Q8WUU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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