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Protein

Solute carrier family 25 member 43

Gene

SLC25A43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.23.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 43
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30557. SLC25A43.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403704.

Polymorphism and mutation databases

BioMutaiSLC25A43.
DMDMi209572673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Solute carrier family 25 member 43PRO_0000291823Add
BLAST

Proteomic databases

PaxDbiQ8WUT9.
PeptideAtlasiQ8WUT9.
PRIDEiQ8WUT9.

PTM databases

iPTMnetiQ8WUT9.
PhosphoSiteiQ8WUT9.

Expressioni

Gene expression databases

BgeeiQ8WUT9.
CleanExiHS_SLC25A43.
GenevisibleiQ8WUT9. HS.

Organism-specific databases

HPAiHPA035188.

Interactioni

Protein-protein interaction databases

BioGridi128469. 6 interactions.
STRINGi9606.ENSP00000217909.

Structurei

3D structure databases

ProteinModelPortaliQ8WUT9.
SMRiQ8WUT9. Positions 16-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10191Solcar 1Add
BLAST
Repeati105 – 18581Solcar 2Add
BLAST
Repeati200 – 29899Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00830000128432.
HOGENOMiHOG000007857.
HOVERGENiHBG108441.
InParanoidiQ8WUT9.
KOiK15120.
OMAiCFRQTVK.
OrthoDBiEOG741Z34.
PhylomeDBiQ8WUT9.
TreeFamiTF354298.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATWRRDGRL TGGQRLLCAG LAGTLSLSLT APLELATVLA QVGVVRGHAR
60 70 80 90 100
GPWATGHRVW RAEGLRALWK GNAVACLRLF PCSAVQLAAY RKFVVLFTDD
110 120 130 140 150
LGHISQWSSI MAGSLAGMVS TIVTYPTDLI KTRLIMQNIL EPSYRGLLHA
160 170 180 190 200
FSTIYQQEGF LALYRGVSLT VVGALPFSAG SLLVYMNLEK IWNGPRDQFS
210 220 230 240 250
LPQNFANVCL AAAVTQTLSF PFETVKRKMQ AQSPYLPHSG GVDVHFSGAV
260 270 280 290 300
DCFRQIVKAQ GVLGLWNGLT ANLLKIVPYF GIMFSTFEFC KRICLYQNGY
310 320 330 340
ILSPLSYKLT PGVDQSLQPQ ELRELKKFFK TRKPKPKKPT L
Length:341
Mass (Da):37,718
Last modified:October 14, 2008 - v2
Checksum:iBF47E6EF9D672CC9
GO
Isoform 2 (identifier: Q8WUT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-85: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,128
Checksum:iEC5CC58AE5444A6D
GO

Sequence cautioni

The sequence AAC62432.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951V → A in BAC04318 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341P → L.1 Publication
Corresponds to variant rs3810755 [ dbSNP | Ensembl ].
VAR_032865

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 8552Missing in isoform 2. 1 PublicationVSP_026245Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094254 mRNA. Translation: BAC04318.1.
AC004973 Genomic DNA. Translation: AAC62432.1. Sequence problems.
AC004000 Genomic DNA. No translation available.
BC019584 mRNA. Translation: AAH19584.1.
BC071871 mRNA. Translation: AAH71871.1.
CCDSiCCDS14577.1. [Q8WUT9-1]
RefSeqiNP_660348.2. NM_145305.2. [Q8WUT9-1]
UniGeneiHs.496658.

Genome annotation databases

EnsembliENST00000217909; ENSP00000217909; ENSG00000077713. [Q8WUT9-1]
GeneIDi203427.
KEGGihsa:203427.
UCSCiuc004erd.4. human. [Q8WUT9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094254 mRNA. Translation: BAC04318.1.
AC004973 Genomic DNA. Translation: AAC62432.1. Sequence problems.
AC004000 Genomic DNA. No translation available.
BC019584 mRNA. Translation: AAH19584.1.
BC071871 mRNA. Translation: AAH71871.1.
CCDSiCCDS14577.1. [Q8WUT9-1]
RefSeqiNP_660348.2. NM_145305.2. [Q8WUT9-1]
UniGeneiHs.496658.

3D structure databases

ProteinModelPortaliQ8WUT9.
SMRiQ8WUT9. Positions 16-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128469. 6 interactions.
STRINGi9606.ENSP00000217909.

Protein family/group databases

TCDBi2.A.29.23.7. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ8WUT9.
PhosphoSiteiQ8WUT9.

Polymorphism and mutation databases

BioMutaiSLC25A43.
DMDMi209572673.

Proteomic databases

PaxDbiQ8WUT9.
PeptideAtlasiQ8WUT9.
PRIDEiQ8WUT9.

Protocols and materials databases

DNASUi203427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217909; ENSP00000217909; ENSG00000077713. [Q8WUT9-1]
GeneIDi203427.
KEGGihsa:203427.
UCSCiuc004erd.4. human. [Q8WUT9-1]

Organism-specific databases

CTDi203427.
GeneCardsiSLC25A43.
H-InvDBHIX0203284.
HGNCiHGNC:30557. SLC25A43.
HPAiHPA035188.
MIMi300641. gene.
neXtProtiNX_Q8WUT9.
PharmGKBiPA162403704.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00830000128432.
HOGENOMiHOG000007857.
HOVERGENiHBG108441.
InParanoidiQ8WUT9.
KOiK15120.
OMAiCFRQTVK.
OrthoDBiEOG741Z34.
PhylomeDBiQ8WUT9.
TreeFamiTF354298.

Miscellaneous databases

ChiTaRSiSLC25A43. human.
GenomeRNAii203427.
PROiQ8WUT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUT9.
CleanExiHS_SLC25A43.
GenevisibleiQ8WUT9. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-334.
    Tissue: Brain and Lung.
  4. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2543_HUMAN
AccessioniPrimary (citable) accession number: Q8WUT9
Secondary accession number(s): O75854, Q8N9L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 14, 2008
Last modified: July 6, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.