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Protein

Leucine-rich repeat neuronal protein 4

Gene

LRRN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in hippocampus-dependent long-lasting memory.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 4
Alternative name(s):
Neuronal leucine-rich repeat protein 4
Short name:
NLRR-4
Gene namesi
Name:LRRN4
Synonyms:C20orf75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16208. LRRN4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 679ExtracellularSequence analysisAdd BLAST661
Transmembranei680 – 700HelicalSequence analysisAdd BLAST21
Topological domaini701 – 740CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi164312.
OpenTargetsiENSG00000125872.
PharmGKBiPA162394670.

Polymorphism and mutation databases

BioMutaiLRRN4.
DMDMi90110015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002102919 – 740Leucine-rich repeat neuronal protein 4Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi442N-linked (GlcNAc...)Sequence analysis1
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WUT4.
PeptideAtlasiQ8WUT4.
PRIDEiQ8WUT4.
TopDownProteomicsiQ8WUT4.

PTM databases

iPTMnetiQ8WUT4.
PhosphoSitePlusiQ8WUT4.

Expressioni

Gene expression databases

BgeeiENSG00000125872.
CleanExiHS_LRRN4.
GenevisibleiQ8WUT4. HS.

Organism-specific databases

HPAiHPA009431.

Interactioni

Protein-protein interaction databases

BioGridi127893. 1 interactor.
IntActiQ8WUT4. 4 interactors.
MINTiMINT-1472324.
STRINGi9606.ENSP00000368135.

Structurei

3D structure databases

ProteinModelPortaliQ8WUT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 74LRR 1Add BLAST24
Repeati75 – 97LRR 2Add BLAST23
Repeati98 – 123LRR 3Add BLAST26
Repeati125 – 144LRR 4Add BLAST20
Repeati145 – 168LRR 5Add BLAST24
Repeati174 – 197LRR 6Add BLAST24
Repeati203 – 226LRR 7Add BLAST24
Repeati228 – 251LRR 8Add BLAST24
Repeati253 – 276LRR 9Add BLAST24
Repeati277 – 300LRR 10Add BLAST24
Domaini579 – 679Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi529 – 532Poly-Glu4

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000231713.
HOVERGENiHBG051176.
InParanoidiQ8WUT4.
OMAiEGDIFKM.
OrthoDBiEOG091G02GQ.
PhylomeDBiQ8WUT4.
TreeFamiTF351118.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WUT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG
60 70 80 90 100
LPAADATALT LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ
110 120 130 140 150
LQVLTLRHNR IAALRWGPGG PAGLHTLDLS YNQLAALPPC TGPALSSLRA
160 170 180 190 200
LALAGNPLRA LQPRAFACFP ALQLLNLSCT ALGRGAQGGI AEAAFAGEDG
210 220 230 240 250
APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR LTTLEGDIFK
260 270 280 290 300
MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS
310 320 330 340 350
SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS
360 370 380 390 400
ASLSLSQLPG VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA
410 420 430 440 450
GDQQSVSKAP NVGSRTIAAW PHSDAREGTA PSTTNSVAGH SNSSVFPRAA
460 470 480 490 500
STTRTQHRGE HAPELVLEPD ISAASTPLAS KLLGPFPTSW DRSISSPQPG
510 520 530 540 550
QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT PHQDVPCDYH
560 570 580 590 600
PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW
610 620 630 640 650
CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC
660 670 680 690 700
VLAANRAGLS QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV
710 720 730 740
LSACLCRRGQ TLGLQRCDTH LVAYKNPAFD DYPLGLQTVS
Length:740
Mass (Da):78,843
Last modified:March 21, 2006 - v3
Checksum:i3920447BB8665668
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025548138P → L.1 PublicationCorresponds to variant rs6107751dbSNPEnsembl.1
Natural variantiVAR_051143141T → A.Corresponds to variant rs1884643dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290123 mRNA. Translation: BAF82812.1.
AL035461, AL118505 Genomic DNA. Translation: CAI23479.1.
AL118505, AL035461 Genomic DNA. Translation: CAI42165.1.
CH471133 Genomic DNA. Translation: EAX10397.1.
BC027720 mRNA. Translation: AAH27720.1.
CCDSiCCDS13097.1.
RefSeqiNP_689824.2. NM_152611.4.
UniGeneiHs.149133.
Hs.741648.
Hs.741928.

Genome annotation databases

EnsembliENST00000378858; ENSP00000368135; ENSG00000125872.
GeneIDi164312.
KEGGihsa:164312.
UCSCiuc002wmo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290123 mRNA. Translation: BAF82812.1.
AL035461, AL118505 Genomic DNA. Translation: CAI23479.1.
AL118505, AL035461 Genomic DNA. Translation: CAI42165.1.
CH471133 Genomic DNA. Translation: EAX10397.1.
BC027720 mRNA. Translation: AAH27720.1.
CCDSiCCDS13097.1.
RefSeqiNP_689824.2. NM_152611.4.
UniGeneiHs.149133.
Hs.741648.
Hs.741928.

3D structure databases

ProteinModelPortaliQ8WUT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127893. 1 interactor.
IntActiQ8WUT4. 4 interactors.
MINTiMINT-1472324.
STRINGi9606.ENSP00000368135.

PTM databases

iPTMnetiQ8WUT4.
PhosphoSitePlusiQ8WUT4.

Polymorphism and mutation databases

BioMutaiLRRN4.
DMDMi90110015.

Proteomic databases

PaxDbiQ8WUT4.
PeptideAtlasiQ8WUT4.
PRIDEiQ8WUT4.
TopDownProteomicsiQ8WUT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378858; ENSP00000368135; ENSG00000125872.
GeneIDi164312.
KEGGihsa:164312.
UCSCiuc002wmo.4. human.

Organism-specific databases

CTDi164312.
DisGeNETi164312.
GeneCardsiLRRN4.
HGNCiHGNC:16208. LRRN4.
HPAiHPA009431.
neXtProtiNX_Q8WUT4.
OpenTargetsiENSG00000125872.
PharmGKBiPA162394670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000231713.
HOVERGENiHBG051176.
InParanoidiQ8WUT4.
OMAiEGDIFKM.
OrthoDBiEOG091G02GQ.
PhylomeDBiQ8WUT4.
TreeFamiTF351118.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125872-MONOMER.

Miscellaneous databases

GenomeRNAii164312.
PROiQ8WUT4.

Gene expression databases

BgeeiENSG00000125872.
CleanExiHS_LRRN4.
GenevisibleiQ8WUT4. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN4_HUMAN
AccessioniPrimary (citable) accession number: Q8WUT4
Secondary accession number(s): A8K258, Q5JWV6, Q9H419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.