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Protein

Leucine-rich repeat neuronal protein 4

Gene

LRRN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in hippocampus-dependent long-lasting memory.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 4
Alternative name(s):
Neuronal leucine-rich repeat protein 4
Short name:
NLRR-4
Gene namesi
Name:LRRN4
Synonyms:C20orf75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16208. LRRN4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 679661ExtracellularSequence analysisAdd
BLAST
Transmembranei680 – 70021HelicalSequence analysisAdd
BLAST
Topological domaini701 – 74040CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394670.

Polymorphism and mutation databases

BioMutaiLRRN4.
DMDMi90110015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 740722Leucine-rich repeat neuronal protein 4PRO_0000021029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WUT4.
PeptideAtlasiQ8WUT4.
PRIDEiQ8WUT4.
TopDownProteomicsiQ8WUT4.

PTM databases

iPTMnetiQ8WUT4.
PhosphoSiteiQ8WUT4.

Expressioni

Gene expression databases

BgeeiQ8WUT4.
CleanExiHS_LRRN4.
GenevisibleiQ8WUT4. HS.

Organism-specific databases

HPAiHPA009431.

Interactioni

Protein-protein interaction databases

BioGridi127893. 1 interaction.
IntActiQ8WUT4. 1 interaction.
MINTiMINT-1472324.
STRINGi9606.ENSP00000368135.

Structurei

3D structure databases

ProteinModelPortaliQ8WUT4.
SMRiQ8WUT4. Positions 42-358, 579-664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 7424LRR 1Add
BLAST
Repeati75 – 9723LRR 2Add
BLAST
Repeati98 – 12326LRR 3Add
BLAST
Repeati125 – 14420LRR 4Add
BLAST
Repeati145 – 16824LRR 5Add
BLAST
Repeati174 – 19724LRR 6Add
BLAST
Repeati203 – 22624LRR 7Add
BLAST
Repeati228 – 25124LRR 8Add
BLAST
Repeati253 – 27624LRR 9Add
BLAST
Repeati277 – 30024LRR 10Add
BLAST
Domaini579 – 679101Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi529 – 5324Poly-Glu

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000231713.
HOVERGENiHBG051176.
InParanoidiQ8WUT4.
OMAiEGDIFKM.
OrthoDBiEOG7FJH01.
PhylomeDBiQ8WUT4.
TreeFamiTF351118.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WUT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG
60 70 80 90 100
LPAADATALT LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ
110 120 130 140 150
LQVLTLRHNR IAALRWGPGG PAGLHTLDLS YNQLAALPPC TGPALSSLRA
160 170 180 190 200
LALAGNPLRA LQPRAFACFP ALQLLNLSCT ALGRGAQGGI AEAAFAGEDG
210 220 230 240 250
APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR LTTLEGDIFK
260 270 280 290 300
MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS
310 320 330 340 350
SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS
360 370 380 390 400
ASLSLSQLPG VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA
410 420 430 440 450
GDQQSVSKAP NVGSRTIAAW PHSDAREGTA PSTTNSVAGH SNSSVFPRAA
460 470 480 490 500
STTRTQHRGE HAPELVLEPD ISAASTPLAS KLLGPFPTSW DRSISSPQPG
510 520 530 540 550
QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT PHQDVPCDYH
560 570 580 590 600
PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW
610 620 630 640 650
CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC
660 670 680 690 700
VLAANRAGLS QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV
710 720 730 740
LSACLCRRGQ TLGLQRCDTH LVAYKNPAFD DYPLGLQTVS
Length:740
Mass (Da):78,843
Last modified:March 21, 2006 - v3
Checksum:i3920447BB8665668
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381P → L.1 Publication
Corresponds to variant rs6107751 [ dbSNP | Ensembl ].
VAR_025548
Natural varianti141 – 1411T → A.
Corresponds to variant rs1884643 [ dbSNP | Ensembl ].
VAR_051143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290123 mRNA. Translation: BAF82812.1.
AL035461, AL118505 Genomic DNA. Translation: CAI23479.1.
AL118505, AL035461 Genomic DNA. Translation: CAI42165.1.
CH471133 Genomic DNA. Translation: EAX10397.1.
BC027720 mRNA. Translation: AAH27720.1.
CCDSiCCDS13097.1.
RefSeqiNP_689824.2. NM_152611.4.
UniGeneiHs.149133.
Hs.741648.
Hs.741928.

Genome annotation databases

EnsembliENST00000378858; ENSP00000368135; ENSG00000125872.
GeneIDi164312.
KEGGihsa:164312.
UCSCiuc002wmo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290123 mRNA. Translation: BAF82812.1.
AL035461, AL118505 Genomic DNA. Translation: CAI23479.1.
AL118505, AL035461 Genomic DNA. Translation: CAI42165.1.
CH471133 Genomic DNA. Translation: EAX10397.1.
BC027720 mRNA. Translation: AAH27720.1.
CCDSiCCDS13097.1.
RefSeqiNP_689824.2. NM_152611.4.
UniGeneiHs.149133.
Hs.741648.
Hs.741928.

3D structure databases

ProteinModelPortaliQ8WUT4.
SMRiQ8WUT4. Positions 42-358, 579-664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127893. 1 interaction.
IntActiQ8WUT4. 1 interaction.
MINTiMINT-1472324.
STRINGi9606.ENSP00000368135.

PTM databases

iPTMnetiQ8WUT4.
PhosphoSiteiQ8WUT4.

Polymorphism and mutation databases

BioMutaiLRRN4.
DMDMi90110015.

Proteomic databases

PaxDbiQ8WUT4.
PeptideAtlasiQ8WUT4.
PRIDEiQ8WUT4.
TopDownProteomicsiQ8WUT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378858; ENSP00000368135; ENSG00000125872.
GeneIDi164312.
KEGGihsa:164312.
UCSCiuc002wmo.4. human.

Organism-specific databases

CTDi164312.
GeneCardsiLRRN4.
HGNCiHGNC:16208. LRRN4.
HPAiHPA009431.
neXtProtiNX_Q8WUT4.
PharmGKBiPA162394670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000231713.
HOVERGENiHBG051176.
InParanoidiQ8WUT4.
OMAiEGDIFKM.
OrthoDBiEOG7FJH01.
PhylomeDBiQ8WUT4.
TreeFamiTF351118.

Miscellaneous databases

GenomeRNAii164312.
NextBioi88459.
PROiQ8WUT4.

Gene expression databases

BgeeiQ8WUT4.
CleanExiHS_LRRN4.
GenevisibleiQ8WUT4. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-138.
    Tissue: Kidney.

Entry informationi

Entry nameiLRRN4_HUMAN
AccessioniPrimary (citable) accession number: Q8WUT4
Secondary accession number(s): A8K258, Q5JWV6, Q9H419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.