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Protein

Leucine-rich repeat neuronal protein 4

Gene

LRRN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in hippocampus-dependent long-lasting memory.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 4
Alternative name(s):
Neuronal leucine-rich repeat protein 4
Short name:
NLRR-4
Gene namesi
Name:LRRN4
Synonyms:C20orf75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000125872.7
HGNCiHGNC:16208 LRRN4
neXtProtiNX_Q8WUT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 679ExtracellularSequence analysisAdd BLAST661
Transmembranei680 – 700HelicalSequence analysisAdd BLAST21
Topological domaini701 – 740CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi164312
OpenTargetsiENSG00000125872
PharmGKBiPA162394670

Polymorphism and mutation databases

BioMutaiLRRN4
DMDMi90110015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002102919 – 740Leucine-rich repeat neuronal protein 4Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WUT4
PeptideAtlasiQ8WUT4
PRIDEiQ8WUT4
TopDownProteomicsiQ8WUT4

PTM databases

iPTMnetiQ8WUT4
PhosphoSitePlusiQ8WUT4

Expressioni

Gene expression databases

BgeeiENSG00000125872
CleanExiHS_LRRN4
GenevisibleiQ8WUT4 HS

Organism-specific databases

HPAiHPA075974

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSF2BPO750314EBI-745046,EBI-7116203

Protein-protein interaction databases

BioGridi127893, 1 interactor
IntActiQ8WUT4, 6 interactors
STRINGi9606.ENSP00000368135

Structurei

3D structure databases

ProteinModelPortaliQ8WUT4
SMRiQ8WUT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 74LRR 1Add BLAST24
Repeati75 – 97LRR 2Add BLAST23
Repeati98 – 123LRR 3Add BLAST26
Repeati125 – 144LRR 4Add BLAST20
Repeati145 – 168LRR 5Add BLAST24
Repeati174 – 197LRR 6Add BLAST24
Repeati203 – 226LRR 7Add BLAST24
Repeati228 – 251LRR 8Add BLAST24
Repeati253 – 276LRR 9Add BLAST24
Repeati277 – 300LRR 10Add BLAST24
Domaini579 – 679Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi529 – 532Poly-Glu4

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064159
HOGENOMiHOG000231713
HOVERGENiHBG051176
InParanoidiQ8WUT4
OMAiGDIFKMT
OrthoDBiEOG091G02GQ
PhylomeDBiQ8WUT4
TreeFamiTF351118

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00369 LRR_TYP, 7 hits
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WUT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG
60 70 80 90 100
LPAADATALT LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ
110 120 130 140 150
LQVLTLRHNR IAALRWGPGG PAGLHTLDLS YNQLAALPPC TGPALSSLRA
160 170 180 190 200
LALAGNPLRA LQPRAFACFP ALQLLNLSCT ALGRGAQGGI AEAAFAGEDG
210 220 230 240 250
APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR LTTLEGDIFK
260 270 280 290 300
MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS
310 320 330 340 350
SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS
360 370 380 390 400
ASLSLSQLPG VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA
410 420 430 440 450
GDQQSVSKAP NVGSRTIAAW PHSDAREGTA PSTTNSVAGH SNSSVFPRAA
460 470 480 490 500
STTRTQHRGE HAPELVLEPD ISAASTPLAS KLLGPFPTSW DRSISSPQPG
510 520 530 540 550
QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT PHQDVPCDYH
560 570 580 590 600
PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW
610 620 630 640 650
CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC
660 670 680 690 700
VLAANRAGLS QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV
710 720 730 740
LSACLCRRGQ TLGLQRCDTH LVAYKNPAFD DYPLGLQTVS
Length:740
Mass (Da):78,843
Last modified:March 21, 2006 - v3
Checksum:i3920447BB8665668
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025548138P → L1 PublicationCorresponds to variant dbSNP:rs6107751Ensembl.1
Natural variantiVAR_051143141T → A. Corresponds to variant dbSNP:rs1884643Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290123 mRNA Translation: BAF82812.1
AL035461 Genomic DNA No translation available.
AL118505 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10397.1
BC027720 mRNA Translation: AAH27720.1
CCDSiCCDS13097.1
RefSeqiNP_689824.2, NM_152611.4
UniGeneiHs.149133
Hs.741648
Hs.741928

Genome annotation databases

EnsembliENST00000378858; ENSP00000368135; ENSG00000125872
GeneIDi164312
KEGGihsa:164312
UCSCiuc002wmo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRRN4_HUMAN
AccessioniPrimary (citable) accession number: Q8WUT4
Secondary accession number(s): A8K258, Q5JWV6, Q9H419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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