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Protein

Short-chain dehydrogenase/reductase family 42E member 1

Gene

SDR42E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Proton acceptorBy similarity1
Binding sitei156NADBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase family 42E member 11 Publication (EC:1.1.1.-)
Gene namesi
Name:SDR42E1
ORF Names:HSPC105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29834. SDR42E1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi93517.
OpenTargetsiENSG00000184860.
PharmGKBiPA164725636.

Polymorphism and mutation databases

BioMutaiSDR42E1.
DMDMi187661956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003317541 – 393Short-chain dehydrogenase/reductase family 42E member 1Add BLAST393

Proteomic databases

EPDiQ8WUS8.
PaxDbiQ8WUS8.
PRIDEiQ8WUS8.

PTM databases

iPTMnetiQ8WUS8.
PhosphoSitePlusiQ8WUS8.

Expressioni

Gene expression databases

BgeeiENSG00000184860.
ExpressionAtlasiQ8WUS8. baseline and differential.
GenevisibleiQ8WUS8. HS.

Organism-specific databases

HPAiHPA014388.

Interactioni

Protein-protein interaction databases

BioGridi125032. 1 interactor.
IntActiQ8WUS8. 1 interactor.
STRINGi9606.ENSP00000332407.

Structurei

3D structure databases

ProteinModelPortaliQ8WUS8.
SMRiQ8WUS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-beta-HSD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiQ8WUS8.
OMAiWFRSQGC.
OrthoDBiEOG091G0BI4.
PhylomeDBiQ8WUS8.
TreeFamiTF313574.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8WUS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPKRSQKES VLITGGSGYF GFRLGCALNQ NGVHVILFDI SSPAQTIPEG
60 70 80 90 100
IKFIQGDIRH LSDVEKAFQD ADVTCVFHIA SYGMSGREQL NRNLIKEVNV
110 120 130 140 150
RGTDNILQVC QRRRVPRLVY TSTFNVIFGG QVIRNGDESL PYLPLHLHPD
160 170 180 190 200
HYSRTKSIAE QKVLEANATP LDRGDGVLRT CALRPAGIYG PGEQRHLPRI
210 220 230 240 250
VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR ADKGHIASGQ
260 270 280 290 300
PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI
310 320 330 340 350
LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF
360 370 380 390
KAHGHGRSSG SRDSECFVWD GLLVFLLIIA VLMWLPSSVI LSL
Length:393
Mass (Da):44,284
Last modified:April 29, 2008 - v2
Checksum:iA559F1F04C9A5355
GO

Sequence cautioni

The sequence EAW95521 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti380A → E in AAF28928 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05534410S → T.Corresponds to variant rs6564956dbSNPEnsembl.1
Natural variantiVAR_05534596K → E.Corresponds to variant rs16956174dbSNPEnsembl.1
Natural variantiVAR_055346320G → D.Corresponds to variant rs3813012dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA. Translation: EAW95521.1. Sequence problems.
AK315652 mRNA. Translation: BAG38018.1.
BC019670 mRNA. Translation: AAH19670.1.
AF161368 mRNA. Translation: AAF28928.1.
CCDSiCCDS42205.1.
RefSeqiNP_660151.2. NM_145168.2.
XP_005256314.1. XM_005256257.3.
UniGeneiHs.87779.

Genome annotation databases

EnsembliENST00000328945; ENSP00000332407; ENSG00000184860.
GeneIDi93517.
KEGGihsa:93517.
UCSCiuc002fgu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA. Translation: EAW95521.1. Sequence problems.
AK315652 mRNA. Translation: BAG38018.1.
BC019670 mRNA. Translation: AAH19670.1.
AF161368 mRNA. Translation: AAF28928.1.
CCDSiCCDS42205.1.
RefSeqiNP_660151.2. NM_145168.2.
XP_005256314.1. XM_005256257.3.
UniGeneiHs.87779.

3D structure databases

ProteinModelPortaliQ8WUS8.
SMRiQ8WUS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125032. 1 interactor.
IntActiQ8WUS8. 1 interactor.
STRINGi9606.ENSP00000332407.

PTM databases

iPTMnetiQ8WUS8.
PhosphoSitePlusiQ8WUS8.

Polymorphism and mutation databases

BioMutaiSDR42E1.
DMDMi187661956.

Proteomic databases

EPDiQ8WUS8.
PaxDbiQ8WUS8.
PRIDEiQ8WUS8.

Protocols and materials databases

DNASUi93517.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328945; ENSP00000332407; ENSG00000184860.
GeneIDi93517.
KEGGihsa:93517.
UCSCiuc002fgu.4. human.

Organism-specific databases

CTDi93517.
DisGeNETi93517.
GeneCardsiSDR42E1.
HGNCiHGNC:29834. SDR42E1.
HPAiHPA014388.
MIMi616164. gene.
neXtProtiNX_Q8WUS8.
OpenTargetsiENSG00000184860.
PharmGKBiPA164725636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiQ8WUS8.
OMAiWFRSQGC.
OrthoDBiEOG091G0BI4.
PhylomeDBiQ8WUS8.
TreeFamiTF313574.

Miscellaneous databases

GenomeRNAii93517.
PROiQ8WUS8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184860.
ExpressionAtlasiQ8WUS8. baseline and differential.
GenevisibleiQ8WUS8. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiD42E1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUS8
Secondary accession number(s): B2RDS1, Q9P0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.