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Protein

Short-chain dehydrogenase/reductase family 42E member 1

Gene

SDR42E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptorBy similarity
Binding sitei156 – 1561NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase family 42E member 11 Publication (EC:1.1.1.-)
Gene namesi
Name:SDR42E1
ORF Names:HSPC105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29834. SDR42E1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725636.

Polymorphism and mutation databases

BioMutaiSDR42E1.
DMDMi187661956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Short-chain dehydrogenase/reductase family 42E member 1PRO_0000331754Add
BLAST

Proteomic databases

PaxDbiQ8WUS8.
PRIDEiQ8WUS8.

PTM databases

iPTMnetiQ8WUS8.
PhosphoSiteiQ8WUS8.

Expressioni

Gene expression databases

BgeeiQ8WUS8.
ExpressionAtlasiQ8WUS8. baseline and differential.
GenevisibleiQ8WUS8. HS.

Organism-specific databases

HPAiHPA014388.

Interactioni

Protein-protein interaction databases

BioGridi125032. 1 interaction.
IntActiQ8WUS8. 1 interaction.
STRINGi9606.ENSP00000332407.

Structurei

3D structure databases

ProteinModelPortaliQ8WUS8.
SMRiQ8WUS8. Positions 10-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-beta-HSD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiQ8WUS8.
OMAiNVTCVFH.
OrthoDBiEOG77M8NP.
PhylomeDBiQ8WUS8.
TreeFamiTF313574.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8WUS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPKRSQKES VLITGGSGYF GFRLGCALNQ NGVHVILFDI SSPAQTIPEG
60 70 80 90 100
IKFIQGDIRH LSDVEKAFQD ADVTCVFHIA SYGMSGREQL NRNLIKEVNV
110 120 130 140 150
RGTDNILQVC QRRRVPRLVY TSTFNVIFGG QVIRNGDESL PYLPLHLHPD
160 170 180 190 200
HYSRTKSIAE QKVLEANATP LDRGDGVLRT CALRPAGIYG PGEQRHLPRI
210 220 230 240 250
VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR ADKGHIASGQ
260 270 280 290 300
PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI
310 320 330 340 350
LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF
360 370 380 390
KAHGHGRSSG SRDSECFVWD GLLVFLLIIA VLMWLPSSVI LSL
Length:393
Mass (Da):44,284
Last modified:April 29, 2008 - v2
Checksum:iA559F1F04C9A5355
GO

Sequence cautioni

The sequence EAW95521.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti380 – 3801A → E in AAF28928 (PubMed:11042152).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101S → T.
Corresponds to variant rs6564956 [ dbSNP | Ensembl ].
VAR_055344
Natural varianti96 – 961K → E.
Corresponds to variant rs16956174 [ dbSNP | Ensembl ].
VAR_055345
Natural varianti320 – 3201G → D.
Corresponds to variant rs3813012 [ dbSNP | Ensembl ].
VAR_055346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA. Translation: EAW95521.1. Sequence problems.
AK315652 mRNA. Translation: BAG38018.1.
BC019670 mRNA. Translation: AAH19670.1.
AF161368 mRNA. Translation: AAF28928.1.
CCDSiCCDS42205.1.
RefSeqiNP_660151.2. NM_145168.2.
XP_005256314.1. XM_005256257.2.
XP_011521772.1. XM_011523470.1.
UniGeneiHs.87779.

Genome annotation databases

EnsembliENST00000328945; ENSP00000332407; ENSG00000184860.
GeneIDi93517.
KEGGihsa:93517.
UCSCiuc002fgu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA. Translation: EAW95521.1. Sequence problems.
AK315652 mRNA. Translation: BAG38018.1.
BC019670 mRNA. Translation: AAH19670.1.
AF161368 mRNA. Translation: AAF28928.1.
CCDSiCCDS42205.1.
RefSeqiNP_660151.2. NM_145168.2.
XP_005256314.1. XM_005256257.2.
XP_011521772.1. XM_011523470.1.
UniGeneiHs.87779.

3D structure databases

ProteinModelPortaliQ8WUS8.
SMRiQ8WUS8. Positions 10-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125032. 1 interaction.
IntActiQ8WUS8. 1 interaction.
STRINGi9606.ENSP00000332407.

PTM databases

iPTMnetiQ8WUS8.
PhosphoSiteiQ8WUS8.

Polymorphism and mutation databases

BioMutaiSDR42E1.
DMDMi187661956.

Proteomic databases

PaxDbiQ8WUS8.
PRIDEiQ8WUS8.

Protocols and materials databases

DNASUi93517.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328945; ENSP00000332407; ENSG00000184860.
GeneIDi93517.
KEGGihsa:93517.
UCSCiuc002fgu.4. human.

Organism-specific databases

CTDi93517.
GeneCardsiSDR42E1.
HGNCiHGNC:29834. SDR42E1.
HPAiHPA014388.
MIMi616164. gene.
neXtProtiNX_Q8WUS8.
PharmGKBiPA164725636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiQ8WUS8.
OMAiNVTCVFH.
OrthoDBiEOG77M8NP.
PhylomeDBiQ8WUS8.
TreeFamiTF313574.

Miscellaneous databases

GenomeRNAii93517.
NextBioi78110.
PROiQ8WUS8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUS8.
ExpressionAtlasiQ8WUS8. baseline and differential.
GenevisibleiQ8WUS8. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-383.
    Tissue: Mammary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-383.
    Tissue: Urinary bladder.
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-393.
    Tissue: Umbilical cord blood.
  5. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiD42E1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUS8
Secondary accession number(s): B2RDS1, Q9P0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 16, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.